CMAUP Plant Collective Molecular Activities

Plant Name: Citrus aurantium

Taxonomic Information:

Plant ID: NPO7317
Plant Latin Name: Citrus aurantium
Taxonomy Genus: Citrus
Taxonomy Family: Rutaceae

Plant External Links:

NCBI TaxonomyDB: 43166
Plant-of-the-World-Online: 551142-1

Used in Medicines:

Country/Region:

Brazil; Ghana; Netherlands; Italy; Portugal; Tanzania; Indonesia; India; Rwanda; Jordan; China; Kenya; Nigeria

Traditional Medicine System:

Indian Folk; Unani; Siddha; Ayurveda; Kampo; TCM

Medicinal Functions:

Antianxiety; Antibacterial; Antiemetic; Antifungal; Antispasmodic; Antitussive; Appetizer; Aromatherapy; Carminative; Contraceptive; Diaphoretic; Digestive; Miscellany; Sedative; Stimulant; Stomachic; Tonic; Vitamin C

Geographical Distribution:

Brazil; Ghana; Netherlands; Angola; Portugal; Liberia; Togo; Guinea; Italy; Indonesia; India; Jordan; Tanzania; Rwanda; China; Kenya; Gabon; Nigeria; Cameroon; Cote d'Ivoire; Benin

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CHRM1; ADRA2B; CHRM2; CHRM3; CHRM4; CHRM5; TAAR1;
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Hydrolase	ACHE;
Enzyme_unclassified	TDP1; BLM; ALOX12; HSD17B2; HSD17B10; NOX4; ALOX15; HSD17B1; POLB;
5HT3 receptor	HTR3A;
Protein Kinase	LCK; AURKB; AXL; MET; FLT3; CDK1; MAPK1; MAPK14; FYN; PIM1; KDR; IGF1R; CSNK2A1;
Transferase	POLA1;
Lyase	CA2; CA12; CA9; CA7; CA4;
Nuclear hormone receptor subfamily 1 group A	THRB;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Oxidoreductase	TYR;
Transcription Factor	AHR; HIF1A; TP53;
SLC superfamily of solute carriers	SLCO1B1;
Unclassified	LMNA; FABP4; MAPT; THPO;
Methyl-lysine/arginine binding protein	L3MBTL1; SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	TBXAS1; CYP2C9; CYP19A1; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
5HT3 receptor	HTR3A	Serotonin 3a (5-HT3a) receptor	P46098	CHEMBL1899
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 5	TBXAS1	Thromboxane-A synthase	P24557	CHEMBL1835
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group A	THRB	Thyroid hormone receptor beta-1	P10828	CHEMBL1947
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Protein Kinase	LCK	Tyrosine-protein kinase LCK	P06239	CHEMBL258
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	MAPK14	MAP kinase p38 alpha	Q16539	CHEMBL260
Protein Kinase	FYN	Tyrosine-protein kinase FYN	P06241	CHEMBL1841
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Small molecule receptor (family A GPCR)	CHRM1	Muscarinic acetylcholine receptor M1	P11229	CHEMBL216
Small molecule receptor (family A GPCR)	ADRA2B	Alpha-2b adrenergic receptor	P18089	CHEMBL1942
Small molecule receptor (family A GPCR)	CHRM2	Muscarinic acetylcholine receptor M2	P08172	CHEMBL211
Small molecule receptor (family A GPCR)	CHRM3	Muscarinic acetylcholine receptor M3	P20309	CHEMBL245
Small molecule receptor (family A GPCR)	CHRM4	Muscarinic acetylcholine receptor M4	P08173	CHEMBL1821
Small molecule receptor (family A GPCR)	CHRM5	Muscarinic acetylcholine receptor M5	P08912	CHEMBL2035
Small molecule receptor (family A GPCR)	TAAR1	Trace amine-associated receptor 1	Q96RJ0	CHEMBL5857
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transferase	POLA1	DNA polymerase alpha subunit	P09884	CHEMBL1828
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0007197; adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway	2.235E-13	2.434E-09	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
MF	GO:0060089; molecular transducer activity	GO:0016907; G-protein coupled acetylcholine receptor activity	2.235E-13	2.434E-09	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
BP	GO:0050896; response to stimulus	GO:0007207; phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway	1.338E-12	9.712E-09	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	6.558E-10	1.020E-06	CA12, CA2, CA4, CA7, CA9
MF	GO:0005488; binding	GO:0019825; oxygen binding	4.644E-09	5.057E-06	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C9, NOX4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.626E-08	1.180E-05	CYP1A1, CYP1A2, CYP1B1, CYP2C9
BP	GO:0023052; signaling	GO:0007271; synaptic transmission, cholinergic	1.714E-08	1.204E-05	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.881E-08	1.661E-05	ALOX12, ALOX15, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C9, TBXAS1
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	4.227E-08	2.001E-05	AHR, CSNK2A1, HIF1A, KDR, MAPT
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	7.839E-08	3.281E-05	CA12, CA2, CA4, CA7, CA9
MF	GO:0005488; binding	GO:0020037; heme binding	1.219E-07	4.656E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C9, NOX4, TBXAS1
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.217E-07	7.425E-05	CA12, CA2, CA4, CA7, CA9
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	4.519E-07	1.295E-04	CYP1A1, CYP1A2, CYP1B1, CYP2C9
MF	Unclassified;	GO:0004872; receptor activity	4.846E-07	1.353E-04	ADRA2B, AHR, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, ESR2, FLT3, HTR3A, IGF1R, KDR, MET, NPSR1, TAAR1, THRB, TSHR
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	6.656E-07	1.789E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0043548; phosphatidylinositol 3-kinase binding	1.761E-06	3.759E-04	AXL, FYN, IGF1R, LCK
BP	Unclassified;	GO:0003056; regulation of vascular smooth muscle contraction	2.244E-06	4.654E-04	ADRA2B, CHRM1, CHRM3
MF	GO:0005488; binding	GO:0042802; identical protein binding	4.621E-06	8.527E-04	ACHE, BLM, CSNK2A1, ESR2, FLT3, FYN, IGF1R, KDR, L3MBTL1, LCK, MAPK1, MAPT, MET, SMN1, SMN2, TP53, TYR
MF	GO:0005488; binding	GO:0042562; hormone binding	6.085E-06	1.043E-03	ACHE, CHRM3, HSD17B1, IGF1R, THRB
BP	GO:0009987; cellular process	GO:0051897; positive regulation of protein kinase B signaling	6.871E-06	1.142E-03	AXL, FYN, LCK, MET, NOX4, THPO
BP	GO:0008152; metabolic process	GO:0006703; estrogen biosynthetic process	7.575E-06	1.220E-03	CYP19A1, HSD17B1, HSD17B2
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	9.172E-06	1.387E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	9.172E-06	1.387E-03	ALOX12, ALOX15
MF	GO:0005488; binding	GO:0042610; CD8 receptor binding	9.172E-06	1.387E-03	FYN, LCK
BP	GO:0050896; response to stimulus	GO:0033993; response to lipid	1.004E-05	1.476E-03	AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FLT3, HSD17B2, MAPK14, TP53, TYR
BP	GO:0008152; metabolic process	GO:0038083; peptidyl-tyrosine autophosphorylation	1.269E-05	1.795E-03	FYN, IGF1R, KDR, LCK
BP	GO:0009987; cellular process	GO:1901796; regulation of signal transduction by p53 class mediator	1.587E-05	2.116E-03	AURKB, BLM, CSNK2A1, L3MBTL1, MAPK14, TP53
BP	GO:0009987; cellular process	GO:0030168; platelet activation	2.142E-05	2.650E-03	ADRA2B, AXL, FYN, LCK, MAPK1
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	2.169E-05	2.668E-03	CA2, CA4, CA9, CHRM3, SLCO1B1, TSHR
MF	GO:0005488; binding	GO:0005524; ATP binding	2.665E-05	3.154E-03	AURKB, AXL, BLM, CDK1, CSNK2A1, FLT3, FYN, IGF1R, KDR, LCK, MAPK1, MAPK14, MET, PIM1, TP53
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	2.746E-05	3.185E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	2.746E-05	3.185E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	2.746E-05	3.185E-03	ALOX12, ALOX15
BP	GO:0050896; response to stimulus	GO:0045471; response to ethanol	2.768E-05	3.189E-03	CDK1, FYN, HTR3A, POLB, TP53
MF	GO:0005488; binding	GO:0019903; protein phosphatase binding	3.006E-05	3.409E-03	LCK, MAPK14, MAPT, MET, TP53
BP	GO:0050896; response to stimulus	GO:0055093; response to hyperoxia	3.462E-05	3.788E-03	CYP1A1, POLB, TP53
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	4.063E-05	4.295E-03	CA2, CA7, FYN, KDR, LCK, NPSR1
BP	GO:0050896; response to stimulus	GO:0071479; cellular response to ionizing radiation	4.350E-05	4.532E-03	BLM, MAPK14, NOX4, TP53
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	4.401E-05	4.542E-03	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, HTR3A
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	4.590E-05	4.619E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0007569; cell aging	4.625E-05	4.619E-03	CDK1, MAPK14, NOX4, TP53
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	5.482E-05	5.235E-03	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	5.482E-05	5.235E-03	CYP1A2, CYP2C9
BP	GO:0032501; multicellular organismal process	GO:0007399; nervous system development	5.654E-05	5.353E-03	ACHE, CHRM1, CHRM2, CHRM3, SMN1, SMN2, TSHR
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	6.678E-05	6.161E-03	ADRA2B, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FLT3, IGF1R, KDR, MET, NPSR1, SLCO1B1, TSHR
BP	GO:0009987; cellular process	GO:0048010; vascular endothelial growth factor receptor signaling pathway	6.917E-05	6.302E-03	AXL, FYN, KDR, MAPK14
BP	GO:0009987; cellular process	GO:0030154; cell differentiation	7.234E-05	6.536E-03	AXL, CDK1, CYP1A1, FABP4, FLT3, FYN, HIF1A, KDR, LCK, MAPK1, MAPK14, MAPT, NOX4, THPO, THRB, TP53
MF	GO:0003824; catalytic activity	GO:0004435; phosphatidylinositol phospholipase C activity	7.515E-05	6.734E-03	CHRM1, CHRM3, CHRM5
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	8.547E-05	7.505E-03	AXL, CDK1, CSNK2A1, FLT3
BP	GO:0032501; multicellular organismal process	GO:0046541; saliva secretion	9.118E-05	7.775E-03	CHRM1, CHRM3
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	9.118E-05	7.775E-03	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:0030258; lipid modification	9.615E-05	8.084E-03	ALOX12, CYP1A1, FYN, LCK, MAPK14, MET
BP	GO:0009987; cellular process	GO:0010638; positive regulation of organelle organization	9.736E-05	8.122E-03	ALOX15, AURKB, HIF1A, KDR, MAPK1, MAPT, MET, NOX4, TP53
BP	GO:0009987; cellular process	GO:0071345; cellular response to cytokine stimulus	1.002E-04	8.327E-03	ALOX15, AXL, FABP4, FLT3, HIF1A, MAPK1, MAPK14

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	1.222E-09	9.593E-08	CHRM2, CHRM3, ACHE, CHRM1, CHRM4, CHRM5, MAPK1, FYN
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	7.293E-09	3.817E-07	HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.131E-09	9.593E-08	CA12, CA2, CA4, CA7, CA9
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.824E-08	7.160E-07	HSD17B1, CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP19A1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.130E-07	3.547E-06	CHRM2, CHRM3, CHRM1, THRB, CHRM4, CHRM5, TAAR1, ADRA2B, TSHR
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	2.184E-06	4.898E-05	KDR, MAPK1, MAPK14, TP53, HIF1A, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.578E-06	4.128E-05	FLT3, MAPK1, TP53, MET, HIF1A
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	2.590E-06	5.084E-05	CSNK2A1, MAPK1, FYN, MET, IGF1R
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.981E-05	3.455E-04	CYP2C9, ALOX15, MAPK1, ALOX12, HTR3A
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	6.277E-05	7.162E-04	CHRM2, CHRM1, KDR, MAPK1, TP53, MET, IGF1R
09140 Cellular Processes	09142 Cell motility	hsa04810	Regulation of actin cytoskeleton	3.929E-05	5.608E-04	CHRM2, CHRM3, CHRM1, CHRM4, CHRM5, MAPK1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	3.353E-05	5.265E-04	CYP2C9, ALOX15, TBXAS1, ALOX12
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	5.726E-05	7.162E-04	MAPK1, TP53, MET, IGF1R
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6.386E-05	7.162E-04	CYP2C9, CYP1A2, CYP1A1, CYP1B1
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.244E-04	1.855E-03	CYP2C9, POLA1, HSD17B1, TBXAS1, HSD17B2, CYP1A2, ALOX15, CYP1A1, ALOX12, TYR, CYP19A1, HSD17B10
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2.006E-04	1.853E-03	CDK1, MAPK1, MAPK14, IGF1R
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.006E-04	9.873E-04	CYP2C9, CYP1A2, CYP1A1, CYP1B1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	3.216E-04	2.405E-03	KDR, MAPK1, FYN, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	3.928E-04	2.785E-03	KDR, MAPK1, MAPK14, MET, IGF1R
09150 Organismal Systems	09151 Immune system	hsa04660	T cell receptor signaling pathway	2.521E-04	1.979E-03	LCK, MAPK1, FYN, MAPK14
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	4.080E-04	2.785E-03	THRB, MAPK1, TP53, HIF1A
09150 Organismal Systems	09151 Immune system	hsa04611	Platelet activation	4.629E-04	2.907E-03	TBXAS1, MAPK1, FYN, MAPK14
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	4.348E-04	2.844E-03	MAPK1, FYN, MAPK14, TP53
09150 Organismal Systems	09158 Development	hsa04380	Osteoclast differentiation	6.230E-04	3.705E-03	LCK, MAPK1, FYN, MAPK14
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.229E-04	1.855E-03	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.093E-03	5.198E-03	FLT3, MAPK1, HIF1A, MET, TP53, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	8.437E-05	8.831E-04	CYP2C9, CYP1A2, ALOX15
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	6.371E-04	3.705E-03	FLT3, PIM1, MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	7.772E-04	4.358E-03	KDR, MAPK1, MAPK14
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	9.354E-04	4.895E-03	MAPK1, TP53, IGF1R
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.816E-03	8.144E-03	PIM1, CYP1B1, MAPK1, TP53, MET
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	1.964E-03	8.332E-03	CHRM2, CHRM3, CHRM1, CHRM5
09150 Organismal Systems	09151 Immune system	hsa04664	Fc epsilon RI signaling pathway	1.066E-03	5.198E-03	MAPK1, FYN, MAPK14
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	9.778E-04	4.952E-03	MAPK1, MET, HIF1A
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	1.964E-03	8.332E-03	FLT3, TP53, MET, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	1.259E-03	5.812E-03	MAPK1, MAPK14, ESR2
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9.354E-04	4.895E-03	CYP2C9, CYP1A2, CYP1A1
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	2.313E-03	9.312E-03	MAPK1, TP53, IGF1R
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2.080E-03	8.593E-03	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
J00-J99: Diseases of the respiratory system	Asthma	J45	CHRM2; TBXAS1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MAPK14;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3; MAPK14;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
N00-N99: Diseases of the genitourinary system	Nephritis	N00-N19, N25-N29	TBXAS1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nausea	R11	CHRM2; CHRM4; HTR3A;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	CHRM3;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR; CHRM2;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nocturia	R35	CHRM4;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE; MAPT;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADRA2B; CHRM1;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
H00-H59: Diseases of the eye and adnexa	Produce mydriasis and cycloplegia for diagnostic purposes	H57.04	CHRM4;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypothyroidism	E03	THRB;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; CHRM1; CHRM2; CHRM3; CHRM4; MAPT;
L00-L99: Diseases of the skin and subcutaneous tissue	Seborrhea	L21	CHRM3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	CHRM1; CHRM5;
NA: NA	Schizoaffective disorders	NA	CHRM1;
NA: NA	Rheumatold arthritis	NA	MAPK14;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MAPK14; TYR;
C00-D49: Neoplasms	Renal cancer	C64	KDR; CA9;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
NA: NA	Addiction	NA	CHRM2;
NA: NA	Acute respiratory distress syndrome	NA	MAPK14;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; TP53;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	CHRM4;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3; HIF1A; CHRM4; MAPK1; TP53; CA9;
NA: NA	Spasms	NA	CHRM3;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB; TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	THRB;
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	MAPK14;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Sjogren's syndrome	M35.0	CHRM3;
NA: NA	Moderate and severe psychomotor agitation	NA	CHRM4;
N00-N99: Diseases of the genitourinary system	Overactive bladder	N32.81	CHRM3;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	TBXAS1;
I00-I99: Diseases of the circulatory system	Thromboembolism	I80-I82	TBXAS1;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE; CHRM4;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Wound healing	T14.0-T14.1	THRB;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Stabilize muscle contractions	M00-M99	CHRM2;
K00-K95: Diseases of the digestive system	Stomach ulcer	K25-K27	CHRM1; CHRM5;
NA: NA	Suprapubic pain	NA	CHRM4;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Postoperative nausea and vomiting	R11	CHRM3;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	CHRM4; HTR3A;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1; CHRM1; CHRM5;
NA: NA	GIST	NA	FLT3;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; CHRM1; CHRM3; CHRM4;
NA: NA	Uveitis	NA	CHRM4;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	CHRM5;
NA: NA	Dysuria	NA	CHRM4;
I00-I99: Diseases of the circulatory system	Acute coronary syndrome	I74	MAPK14;
NA: NA	Abdominal stomach pain	NA	CHRM1;
A00-B99: Certain infectious and parasitic diseases	Viral infections	B01, B02, A60, B00, B27, G05.1, P35.2	POLA1;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
NA: NA	Vomiting	NA	CHRM4; HTR3A;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Urinary retention	R33	CHRM4;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
NA: NA	Excessive sweating	NA	CHRM1;
NA: NA	Extrapyramidal disorders secondary to neuroleptic drug therapy	NA	CHRM1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	TBXAS1;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
NA: NA	Urgency	NA	CHRM4;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	CHRM1; CHRM2; CHRM3; CHRM5;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3; TP53;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; AHR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	CHRM4;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	CHRM1;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
I00-I99: Diseases of the circulatory system	Heart failure	I50	CHRM2;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	CHRM4;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Visceral spasms	R25.2	CHRM1;
G00-G99: Diseases of the nervous system G00-G99	Brain diseases	G00-G99	CHRM5;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3; CYP19A1; CA9;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
K00-K95: Diseases of the digestive system	Gastroesophageal reflux disease	K21	HTR3A;
NA: NA	Gastritis	NA	CHRM4;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	TBXAS1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; CSNK2A1; FLT3; ACHE; HIF1A; MAPK1; MAPK14; TP53; CA9;
J00-J99: Diseases of the respiratory system	Bronchodilator	J45	CHRM4;
C00-D49: Neoplasms	Melanoma	C43	KDR; TYR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	CHRM4;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	CHRM1;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	LCK;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
C00-D49: Neoplasms	Glioma	C71	KDR;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnosing bronchial hyperreactivity	W88	CHRM3;
H00-H59: Diseases of the eye and adnexa	Diabetic retinopathy	H36, E10.3, E11.3, E13.3	MAPK14;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	TBXAS1;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Amnesia	F04	CHRM5;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	CHRM5;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE; CA2;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
J00-J99: Diseases of the respiratory system	Obstructive lung diseases	J40-J44, J47	CHRM3;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Local anaesthetic	R20.0	HTR3A;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; CA9;
G00-G99: Diseases of the nervous system G00-G99	Central and peripheral nervous diseases	G96.9	CHRM4; CHRM5;
NA: NA	Upper abdominal bloating	NA	ACHE;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
NA: NA	Dystonia	NA	CHRM1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2B;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperthyroidism	E05	THRB;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
S00-T88: Injury, poisoning and certain other consequences of external causes	Organophosphate poisoning	T60.0	CHRM4;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	CHRM4;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
H00-H59: Diseases of the eye and adnexa	Mydriasis diagnosis	H57.0	CHRM4;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	CHRM1; CHRM3; CHRM4;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	CHRM1; CHRM3; CHRM4; CHRM5; MAPK14;
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	CHRM1; CHRM4; CHRM5; HTR3A;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	High cholesterol levels in blood	E78.0	THRB;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
NA: NA	HIV infections	NA	AHR;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	CHRM1; CHRM2; CHRM4;
K00-K95: Diseases of the digestive system	Pancreatitis	K85, K86.0K86.1	CHRM4;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE; CHRM1; CHRM2; CHRM4;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R; ACHE; CHRM3;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3;
NA: NA	Peptic ulcer disease	NA	CHRM4;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	CLL	NA	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; CHRM1; CHRM5; MAPT;
K00-K95: Diseases of the digestive system	Colitis	K50-K52	CHRM5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	MAPK14; TBXAS1;
NA: NA	Inflammatory diseases	NA	MAPK14;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MAPK14;
H00-H59: Diseases of the eye and adnexa	Acquired nystagmus	H55	CHRM4;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
K00-K95: Diseases of the digestive system	Gastric motility disorder	K22.4	CHRM4;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	HTR3A;
NA: NA	Functional bowel syndrome	NA	CHRM1;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE; CHRM5;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
J00-J99: Diseases of the respiratory system	Acute lung injury	J80	MAPK14;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases