CMAUP Plant Collective Molecular Activities

Plant Name: Citrus aurantium

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CHRM1; CHRM2; CHRM3; CHRM4; CHRM5; TAAR1; ADRA2C; ADRB2; ADRA2A; ADRA2B; DRD4;
Peptide receptor (family A GPCR)	TSHR; NPSR1; CXCR1; NMUR2;
Enzyme_unclassified	RECQL; TDP1; PLA2G1B; BLM; CTDSP1; NT5E; PKM; PIK3R1; GLO1; MPO; HSD17B1; AKR1B1; HSD17B2; HSD17B10; ALOX15; ALDH1A1; ALOX12; NOX4; USP2; UBE2N; TNKS; TNKS2; PYGL; POLB;
Phosphodiesterase 5	PDE5A;
Hydrolase	ACHE; GAA;
Chloride channel	CFTR;
Transient receptor potential channel	TRPA1;
5HT3 receptor	HTR3A;
Protein Kinase	NEK6; AKT1; MET; CAMK2B; CSNK2A1; DAPK1; SYK; AXL; NEK2; FLT3; PKN1; SRC; IGF1R; PTK2; AURKB; GSK3B; KDR; CDK1; MAPK1; MAPK14; MAPK3; PIM1; NUAK1; ALK; LCK; FYN; CDK6;
Transferase	POLA1;
Lyase	CA9; CA3; CA14; CA7; CA5A; CA4; CA6; CA2; CA12; CA5B; CA1;
Nuclear hormone receptor subfamily 3 group C	AR;
Nuclear hormone receptor subfamily 1 group A	THRB;
Nuclear hormone receptor subfamily 3 group B	ESRRA;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Nuclear hormone receptor subfamily 3 group A	ESR1; ESR2;
Oxidoreductase	HMGCR; MAOA; PTGS1; PTGS2; ALOX5; TYR; XDH;
Lysine demethylase	KDM4E;
Cysteine protease	CASP7; CASP1;
Metallo protease	MMP13; MMP3; MMP2; MMP9;
Aspartic protease	BACE1;
Toll-like and Il-1 receptors	TLR2;
Transcription Factor	AHR; STAT6; HIF1A; NFKB1; TP53;
ATP-binding cassette	ABCC1; ABCB1; ABCG2;
SLC superfamily of solute carriers	SLC22A8; SLC22A6; SLCO1B3; SLCO1B1;
Unclassified	LMNA; FABP4; MAPT; FABP3; FABP5; THPO; RAB9A; NPC1; FABP2; XPO1; TTR;
Methyl-lysine/arginine binding protein	L3MBTL1; SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	TBXAS1; CYP19A1; CYP1A2; CYP2C19; CYP2C9; CYP2D6; CYP2C8; CYP3A4; CYP1B1; CYP1A1;

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
5HT3 receptor	HTR3A	Serotonin 3a (5-HT3a) receptor	P46098	CHEMBL1899
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
ATP-binding cassette	ABCC1	Multidrug resistance-associated protein 1	P33527	CHEMBL3004
ATP-binding cassette	ABCB1	P-glycoprotein 1	P08183	CHEMBL4302
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
Chloride channel	CFTR	Cystic fibrosis transmembrane conductance regulator	P13569	CHEMBL4051
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C8	Cytochrome P450 2C8	P10632	CHEMBL3721
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Cytochrome P450 family 5	TBXAS1	Thromboxane-A synthase	P24557	CHEMBL1835
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Enzyme_unclassified	UBE2N	Ubiquitin-conjugating enzyme E2 N	P61088	CHEMBL6089
Enzyme_unclassified	TNKS	Tankyrase-1	O95271	CHEMBL6164
Enzyme_unclassified	TNKS2	Tankyrase-2	Q9H2K2	CHEMBL6154
Enzyme_unclassified	PYGL	Liver glycogen phosphorylase	P06737	CHEMBL2568
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	CTDSP1	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1	Q9GZU7	CHEMBL1795098
Enzyme_unclassified	NT5E	5'-nucleotidase	P21589	CHEMBL5957
Enzyme_unclassified	PKM	Pyruvate kinase isozymes M1/M2	P14618	CHEMBL1075189
Enzyme_unclassified	PIK3R1	PI3-kinase p85-alpha subunit	P27986	CHEMBL2506
Enzyme_unclassified	GLO1	Glyoxalase I	Q04760	CHEMBL2424
Enzyme_unclassified	MPO	Myeloperoxidase	P05164	CHEMBL2439
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Metallo protease	MMP13	Matrix metalloproteinase 13	P45452	CHEMBL280
Metallo protease	MMP3	Matrix metalloproteinase 3	P08254	CHEMBL283
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group A	THRB	Thyroid hormone receptor beta-1	P10828	CHEMBL1947
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Nuclear hormone receptor subfamily 3 group B	ESRRA	Estrogen-related receptor alpha	P11474	CHEMBL3429
Nuclear hormone receptor subfamily 3 group C	AR	Androgen Receptor	P10275	CHEMBL1871
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Oxidoreductase	HMGCR	HMG-CoA reductase	P04035	CHEMBL402
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Oxidoreductase	PTGS2	Cyclooxygenase-2	P35354	CHEMBL230
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Peptide receptor (family A GPCR)	CXCR1	Interleukin-8 receptor A	P25024	CHEMBL4029
Peptide receptor (family A GPCR)	NMUR2	Neuromedin-U receptor 2	Q9GZQ4	CHEMBL1075144
Phosphodiesterase 5	PDE5A	Phosphodiesterase 5A	O76074	CHEMBL1827
Protein Kinase	NEK6	Serine/threonine-protein kinase NEK6	Q9HC98	CHEMBL4309
Protein Kinase	AKT1	Serine/threonine-protein kinase AKT	P31749	CHEMBL4282
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	CAMK2B	CaM kinase II beta	Q13554	CHEMBL4121
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Protein Kinase	DAPK1	Death-associated protein kinase 1	P53355	CHEMBL2558
Protein Kinase	SYK	Tyrosine-protein kinase SYK	P43405	CHEMBL2599
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	NEK2	Serine/threonine-protein kinase NEK2	P51955	CHEMBL3835
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	PKN1	Protein kinase N1	Q16512	CHEMBL3384
Protein Kinase	SRC	Tyrosine-protein kinase SRC	P12931	CHEMBL267
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	PTK2	Focal adhesion kinase 1	Q05397	CHEMBL2695
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	GSK3B	Glycogen synthase kinase-3 beta	P49841	CHEMBL262
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	MAPK14	MAP kinase p38 alpha	Q16539	CHEMBL260
Protein Kinase	MAPK3	MAP kinase ERK1	P27361	CHEMBL3385
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	NUAK1	NUAK family SNF1-like kinase 1	O60285	CHEMBL5784
Protein Kinase	ALK	ALK tyrosine kinase receptor	Q9UM73	CHEMBL4247
Protein Kinase	LCK	Tyrosine-protein kinase LCK	P06239	CHEMBL258
Protein Kinase	FYN	Tyrosine-protein kinase FYN	P06241	CHEMBL1841
Protein Kinase	CDK6	Cyclin-dependent kinase 6	Q00534	CHEMBL2508
SLC superfamily of solute carriers	SLC22A8	Solute carrier family 22 member 8	Q8TCC7	CHEMBL1641348
SLC superfamily of solute carriers	SLC22A6	Solute carrier family 22 member 6	Q4U2R8	CHEMBL1641347
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Small molecule receptor (family A GPCR)	CHRM1	Muscarinic acetylcholine receptor M1	P11229	CHEMBL216
Small molecule receptor (family A GPCR)	CHRM2	Muscarinic acetylcholine receptor M2	P08172	CHEMBL211
Small molecule receptor (family A GPCR)	CHRM3	Muscarinic acetylcholine receptor M3	P20309	CHEMBL245
Small molecule receptor (family A GPCR)	CHRM4	Muscarinic acetylcholine receptor M4	P08173	CHEMBL1821
Small molecule receptor (family A GPCR)	CHRM5	Muscarinic acetylcholine receptor M5	P08912	CHEMBL2035
Small molecule receptor (family A GPCR)	TAAR1	Trace amine-associated receptor 1	Q96RJ0	CHEMBL5857
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Small molecule receptor (family A GPCR)	ADRB2	Beta-2 adrenergic receptor	P07550	CHEMBL210
Small molecule receptor (family A GPCR)	ADRA2A	Alpha-2a adrenergic receptor	P08913	CHEMBL1867
Small molecule receptor (family A GPCR)	ADRA2B	Alpha-2b adrenergic receptor	P18089	CHEMBL1942
Small molecule receptor (family A GPCR)	DRD4	Dopamine D4 receptor	P21917	CHEMBL219
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transcription Factor	STAT6	Signal transducer and activator of transcription 6	P42226	CHEMBL5401
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transferase	POLA1	DNA polymerase alpha subunit	P09884	CHEMBL1828
Transient receptor potential channel	TRPA1	Transient receptor potential cation channel subfamily A member 1	O75762	CHEMBL6007
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	XPO1	Exportin-1	O14980	CHEMBL5661
Unclassified	TTR	Transthyretin	P02766	CHEMBL3194

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0019825; oxygen binding	9.199E-13	2.636E-10	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, NOX4
BP	Unclassified;	GO:0032846; positive regulation of homeostatic process	1.191E-11	2.430E-09	AURKB, CA2, CA7, CFTR, HIF1A, MAPK1, MAPK14, MAPK3, NEK2, NPC1, NPSR1, PLA2G1B, PTGS2, SYK, TNKS, TNKS2
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.426E-11	2.769E-09	ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, TBXAS1, XDH
BP	GO:0050896; response to stimulus	GO:0007197; adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway	2.073E-11	3.731E-09	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
MF	GO:0060089; molecular transducer activity	GO:0016907; G-protein coupled acetylcholine receptor activity	2.073E-11	3.731E-09	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
MF	GO:0005488; binding	GO:0005524; ATP binding	2.630E-11	4.619E-09	ABCB1, ABCC1, ABCG2, AKT1, ALK, AURKB, AXL, BLM, CAMK2B, CDK1, CDK6, CFTR, CSNK2A1, DAPK1, FLT3, FYN, GSK3B, IGF1R, KDR, LCK, MAPK1, MAPK14, MAPK3, MET, NEK2, NEK6, NUAK1, PIM1, PKM, PKN1, PTK2, PYGL, RECQL, SRC, SYK, TP53, UBE2N
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.036E-11	5.289E-09	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
BP	GO:0009987; cellular process	GO:0030168; platelet activation	3.214E-11	5.511E-09	ADRA2A, ADRA2B, ADRA2C, AKT1, AXL, FYN, LCK, MAPK1, MAPK3, PIK3R1, SRC, SYK
BP	GO:0050896; response to stimulus	GO:0007207; phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway	1.236E-10	1.844E-08	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.236E-10	1.844E-08	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.334E-10	3.279E-08	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.552E-10	3.540E-08	AR, BLM, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, GLO1, L3MBTL1, MMP13, MMP2, MMP3, MMP9, PPARA, PPARD, THRB, TNKS, TP53
BP	GO:0008152; metabolic process	GO:0018105; peptidyl-serine phosphorylation	2.937E-10	4.022E-08	AKT1, AURKB, CAMK2B, CDK1, GSK3B, MAPK1, MAPK14, MAPK3, NEK6, PKN1, SRC, SYK, TNKS
MF	GO:0005488; binding	GO:0051379; epinephrine binding	1.140E-09	1.372E-07	ADRA2A, ADRA2B, ADRA2C, ADRB2, DRD4
BP	GO:0065007; biological regulation	GO:1904355; positive regulation of telomere capping	1.715E-09	1.962E-07	AURKB, MAPK1, MAPK3, NEK2, TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0038083; peptidyl-tyrosine autophosphorylation	1.826E-09	2.068E-07	FYN, IGF1R, KDR, LCK, MAPK3, PTK2, SRC, SYK
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	2.880E-09	3.131E-07	CYP1A2, CYP2C8, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	7.337E-09	7.536E-07	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
BP	GO:0065007; biological regulation	GO:0000187; activation of MAPK activity	9.318E-09	9.181E-07	ADRA2B, ALK, CDK1, DRD4, MAPK1, MAPK14, MAPK3, PKN1, PLA2G1B, SYK, UBE2N
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.575E-08	1.478E-06	CYP1A2, CYP2C19, CYP2C8, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.575E-08	1.478E-06	CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP3A4
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	7.562E-08	6.353E-06	AHR, AR, ESR1, ESR2, ESRRA, PIM1, PPARA, PPARD, SRC, THRB, UBE2N
MF	Unclassified;	GO:0004872; receptor activity	8.824E-08	7.278E-06	ADRA2A, ADRA2B, ADRA2C, ADRB2, AHR, ALK, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CXCR1, DRD4, ESR1, ESR2, ESRRA, FLT3, HTR3A, IGF1R, KDR, MET, NMUR2, NPC1, NPSR1, PPARA, PPARD, TAAR1, THRB, TLR2, TSHR
BP	GO:0008152; metabolic process	GO:0018107; peptidyl-threonine phosphorylation	1.123E-07	9.087E-06	AKT1, CAMK2B, CDK1, CSNK2A1, GSK3B, MAPK1, PKN1, TNKS
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.407E-07	1.102E-05	ABCC1, ADRA2A, CA2, CA4, CA9, CHRM3, SLC22A6, SLC22A8, SLCO1B1, SLCO1B3, TSHR
BP	GO:0065007; biological regulation	GO:0032212; positive regulation of telomere maintenance via telomerase	1.680E-07	1.297E-05	AURKB, MAPK1, MAPK3, NEK2, TNKS, TNKS2
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	3.973E-07	2.846E-05	ADRA2A, ADRA2B, ADRA2C
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	5.843E-07	4.065E-05	ABCB1, CA2, CA7, CFTR
CC	GO:0044464; cell part	GO:0005829; cytosol	8.185E-07	5.451E-05	AHR, AKR1B1, AKT1, ALDH1A1, ALOX12, ALOX15, ALOX5, AR, AURKB, BLM, CA1, CA2, CA3, CA7, CAMK2B, CASP1, CASP7, CDK1, CDK6, CFTR, CSNK2A1, FABP2, FABP3, FABP4, FABP5, FLT3, FYN, GLO1, GSK3B, HIF1A, HSD17B1, LCK, LMNA, MAPK1, MAPK14, MAPK3, MAPT, NEK2, NEK6, NFKB1, NT5E, PDE5A, PIK3R1, PIM1, PKM, PKN1, PLA2G1B, POLA1, PTK2, PYGL, RAB9A, SMN1, SMN2, SRC, STAT6, SYK, TNKS, TNKS2, TP53, TYR, UBE2N, XDH, XPO1
BP	GO:0009987; cellular process	GO:0048010; vascular endothelial growth factor receptor signaling pathway	1.037E-06	6.719E-05	AXL, FYN, KDR, MAPK14, PIK3R1, PTK2, SRC
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	1.334E-06	8.471E-05	ABCC1, ADRA2A, ADRA2B, ADRA2C, ADRB2, ALK, AXL, BACE1, CFTR, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD4, FLT3, IGF1R, KDR, MET, NPC1, NPSR1, SLC22A6, SLC22A8, SLCO1B1, SLCO1B3, TLR2, TRPA1, TSHR
BP	GO:0023052; signaling	GO:0007271; synaptic transmission, cholinergic	1.468E-06	9.184E-05	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
MF	GO:0005488; binding	GO:0005504; fatty acid binding	1.468E-06	9.184E-05	FABP2, FABP3, FABP4, FABP5, PPARD
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	1.581E-06	9.778E-05	ADRA2A, ADRA2B, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	1.581E-06	9.778E-05	ADRA2A, ADRA2B, ADRA2C
BP	GO:0009987; cellular process	GO:0051897; positive regulation of protein kinase B signaling	1.983E-06	1.183E-04	AXL, FYN, LCK, MET, NOX4, PIK3R1, PTK2, SRC, THPO
MF	GO:0005488; binding	GO:0043548; phosphatidylinositol 3-kinase binding	2.134E-06	1.259E-04	AXL, FYN, IGF1R, LCK, PIK3R1
CC	GO:0043226; organelle	GO:0005654; nucleoplasm	2.176E-06	1.281E-04	AHR, AKR1B1, AKT1, ALOX5, AR, AURKB, BLM, CAMK2B, CASP7, CDK1, CDK6, CSNK2A1, CTDSP1, ESR1, ESR2, ESRRA, FABP5, GSK3B, HIF1A, L3MBTL1, LMNA, MAPK1, MAPK14, MAPK3, NEK2, NEK6, NFKB1, NUAK1, PIM1, PKN1, POLA1, POLB, PPARA, PPARD, RECQL, SMN1, SMN2, SRC, STAT6, THRB, TNKS, TP53, UBE2N, USP2, XPO1
BP	GO:0050896; response to stimulus	GO:0031663; lipopolysaccharide-mediated signaling pathway	3.017E-06	1.715E-04	AKT1, MAPK1, MAPK14, MAPK3, TLR2
BP	GO:0009987; cellular process	GO:0071276; cellular response to cadmium ion	3.017E-06	1.715E-04	AKT1, CYP1A2, MAPK1, MAPK3, MMP9
MF	GO:0005488; binding	GO:0005496; steroid binding	3.469E-06	1.937E-04	AR, CYP3A4, ESR1, ESR2, ESRRA, HSD17B1, NPC1
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	3.554E-06	1.979E-04	AHR, CSNK2A1, HIF1A, KDR, MAPT
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	3.930E-06	2.164E-04	CYP1A1, CYP2C8, CYP3A4
MF	GO:0005488; binding	GO:0051380; norepinephrine binding	3.930E-06	2.164E-04	ADRA2A, ADRB2, DRD4
BP	GO:0008152; metabolic process	GO:2000379; positive regulation of reactive oxygen species metabolic process	4.707E-06	2.543E-04	AKT1, MAPK14, MAPT, NOX4, PTGS2, TP53, XDH
BP	GO:0065007; biological regulation	GO:0032148; activation of protein kinase B activity	4.853E-06	2.616E-04	ADRA2A, ADRA2B, ADRA2C, AKT1, SRC
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	4.892E-06	2.623E-04	ALOX12, ALOX15, ALOX5, PTGS2
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	5.629E-06	2.987E-04	AR, ESR1, ESR2, ESRRA, PPARA, PPARD, SRC, THRB
MF	GO:0005488; binding	GO:0001784; phosphotyrosine residue binding	5.628E-06	2.987E-04	LCK, MAPK1, MAPK3, PIK3R1, SYK
MF	GO:0005488; binding	GO:0019901; protein kinase binding	6.134E-06	3.226E-04	ADRA2A, AKT1, ESR1, GSK3B, HIF1A, LCK, MAPK1, MAPK14, NEK6, PIK3R1, PKN1, POLA1, PTK2, SRC, SYK, TP53
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	7.818E-06	3.968E-04	CYP1A1, CYP2C8, CYP3A4
BP	GO:0008152; metabolic process	GO:0016579; protein deubiquitination	8.879E-06	4.424E-04	ADRB2, AR, CDK1, CFTR, ESR1, HIF1A, POLB, TNKS, TNKS2, TP53, USP2
BP	GO:0009987; cellular process	GO:0071456; cellular response to hypoxia	1.228E-05	5.941E-04	AKT1, HIF1A, LMNA, PPARD, PTGS2, SRC, TP53
BP	GO:0009987; cellular process	GO:0071880; adenylate cyclase-activating adrenergic receptor signaling pathway	1.273E-05	6.144E-04	ADRA2A, ADRA2B, ADRA2C, ADRB2
MF	GO:0005488; binding	GO:0070324; thyroid hormone binding	1.361E-05	6.498E-04	PKM, THRB, TTR
MF	GO:0005215; transporter activity	GO:0008559; xenobiotic transmembrane transporting ATPase activity	1.361E-05	6.498E-04	ABCB1, ABCC1, ABCG2
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	1.391E-05	6.615E-04	ADRB2, HIF1A, MMP13, MMP2, MMP3, MMP9, PLA2G1B
CC	GO:0044464; cell part	GO:0031234; extrinsic component of cytoplasmic side of plasma membrane	1.549E-05	7.271E-04	ALOX15, FYN, LCK, PTK2, SRC, SYK
BP	GO:0032501; multicellular organismal process	GO:0043536; positive regulation of blood vessel endothelial cell migration	1.785E-05	8.216E-04	AKT1, HIF1A, KDR, MAPK14, PTGS2
BP	GO:0008283; cell proliferation	GO:0048661; positive regulation of smooth muscle cell proliferation	2.116E-05	9.619E-04	AKR1B1, AKT1, HMGCR, MMP2, MMP9, PTGS2
BP	GO:0009987; cellular process	GO:0010700; negative regulation of norepinephrine secretion	2.165E-05	9.802E-04	ADRA2A, ADRA2B, ADRA2C
BP	GO:0050896; response to stimulus	GO:0045471; response to ethanol	2.503E-05	1.119E-03	CA3, CDK1, FYN, HMGCR, HTR3A, POLB, TP53
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	2.513E-05	1.121E-03	CA2, CA7, FYN, KDR, LCK, NPSR1, PLA2G1B, SRC, TRPA1
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	2.566E-05	1.143E-03	AR, CDK1, ESR1, ESR2, ESRRA, PPARA, PPARD, THRB
MF	GO:0005215; transporter activity	GO:0015347; sodium-independent organic anion transmembrane transporter activity	2.727E-05	1.200E-03	SLC22A6, SLC22A8, SLCO1B1, SLCO1B3
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	3.228E-05	1.385E-03	FABP2, FABP3, FABP4, FABP5
BP	GO:0009987; cellular process	GO:0000733; DNA strand renaturation	3.230E-05	1.385E-03	BLM, RECQL, TP53
BP	Unclassified;	GO:0003056; regulation of vascular smooth muscle contraction	3.230E-05	1.385E-03	ADRA2B, CHRM1, CHRM3
MF	GO:0003824; catalytic activity	GO:0004715; non-membrane spanning protein tyrosine kinase activity	3.703E-05	1.563E-03	FYN, LCK, PTK2, SRC, SYK
BP	GO:0008152; metabolic process	GO:0050731; positive regulation of peptidyl-tyrosine phosphorylation	4.483E-05	1.853E-03	ADRA2A, ADRA2B, ADRA2C, FLT3, FYN, SRC, SYK, TP53
BP	GO:0051179; localization	GO:0042908; xenobiotic transport	4.590E-05	1.893E-03	ABCB1, ABCC1, ABCG2
BP	GO:0051179; localization	GO:0015850; organic hydroxy compound transport	4.955E-05	2.020E-03	ABCG2, CFTR, CHRM5, NPC1, SLCO1B1, SLCO1B3, SYK
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	5.036E-05	2.050E-03	CAMK2B, CDK1, CFTR, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, HMGCR, HSD17B2, NOX4, PTGS1, PTGS2, RAB9A, TBXAS1
BP	GO:0009987; cellular process	GO:1901796; regulation of signal transduction by p53 class mediator	5.063E-05	2.053E-03	AKT1, AURKB, BLM, CSNK2A1, L3MBTL1, MAPK14, NUAK1, TP53
BP	GO:0051179; localization	GO:0043252; sodium-independent organic anion transport	5.136E-05	2.075E-03	SLC22A6, SLC22A8, SLCO1B1, SLCO1B3
MF	GO:0005488; binding	GO:0051721; protein phosphatase 2A binding	5.136E-05	2.075E-03	AKT1, HMGCR, MAPT, TP53
BP	GO:0048511; rhythmic process	GO:0048511; rhythmic process	5.161E-05	2.077E-03	AHR, AXL, CSNK2A1, DRD4, ESR1, GSK3B, PPARA, SRC, TP53, USP2
BP	GO:0009987; cellular process	GO:0038096; Fc-gamma receptor signaling pathway involved in phagocytosis	5.205E-05	2.087E-03	FYN, MAPK1, MAPK3, PIK3R1, PTK2, SRC, SYK
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	5.443E-05	2.155E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0004666; prostaglandin-endoperoxide synthase activity	5.443E-05	2.155E-03	PTGS1, PTGS2
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	5.443E-05	2.155E-03	ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	5.443E-05	2.155E-03	ALOX12, ALOX15
MF	GO:0005488; binding	GO:0042610; CD8 receptor binding	5.443E-05	2.155E-03	FYN, LCK
BP	GO:0002376; immune system process	GO:0043312; neutrophil degranulation	6.215E-05	2.425E-03	ALOX5, CXCR1, FABP5, GAA, MAPK1, MAPK14, MMP9, MPO, NFKB1, PKM, PYGL, TLR2, TTR
BP	GO:0032501; multicellular organismal process	GO:0060736; prostate gland growth	6.277E-05	2.441E-03	AR, CYP19A1, ESR1
BP	GO:0008152; metabolic process	GO:0019371; cyclooxygenase pathway	6.277E-05	2.441E-03	PTGS1, PTGS2, TBXAS1
BP	GO:0065007; biological regulation	GO:0030641; regulation of cellular pH	7.497E-05	2.869E-03	CA2, CA7, CFTR, MAPK1, MAPK3, TP53
BP	GO:0051179; localization	GO:0034502; protein localization to chromosome	7.526E-05	2.875E-03	AURKB, CDK1, ESR1, TNKS, TNKS2
BP	GO:0008283; cell proliferation	GO:0033598; mammary gland epithelial cell proliferation	8.323E-05	3.147E-03	ESR1, MAPK1, STAT6
MF	GO:0005488; binding	GO:0042803; protein homodimerization activity	8.369E-05	3.153E-03	ABCG2, ACHE, ADRA2A, ADRA2C, ADRB2, AKT1, BLM, CAMK2B, FLT3, HMGCR, MAPT, NFKB1, PTGS2, PYGL, SLC22A6, TYR, XDH
MF	Unclassified;	GO:0032403; protein complex binding	8.369E-05	3.153E-03	ACHE, ADRA2A, ADRB2, FLT3, FYN, IGF1R, KDR, LCK, MMP13, MMP9, PIK3R1, PKM, PPARA, SRC, SYK, TLR2, TSHR
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	8.838E-05	3.284E-03	AKR1B1, AXL, CDK1, CYP1B1, STAT6
BP	GO:0051179; localization	GO:0042307; positive regulation of protein import into nucleus	8.917E-05	3.302E-03	CDK1, MAPK1, MAPK14, PIK3R1, PTGS2, TLR2
BP	Unclassified;	GO:0032845; negative regulation of homeostatic process	9.933E-05	3.624E-03	ADRA2A, HMGCR, LCK, SRC, TNKS, TNKS2, TRPA1
BP	GO:0008152; metabolic process	GO:1902893; regulation of pri-miRNA transcription from RNA polymerase II promoter	9.974E-05	3.624E-03	HIF1A, PPARA, PPARD, TP53
BP	GO:0008152; metabolic process	GO:0006703; estrogen biosynthetic process	1.076E-04	3.880E-03	CYP19A1, HSD17B1, HSD17B2
BP	GO:0065007; biological regulation	GO:0051881; regulation of mitochondrial membrane potential	1.113E-04	3.981E-03	AKT1, CASP1, KDR, MAPT, SRC
BP	GO:0022610; biological adhesion	GO:0001952; regulation of cell-matrix adhesion	1.175E-04	4.181E-03	CDK6, GSK3B, KDR, PIK3R1, PTK2, SRC
BP	GO:0009987; cellular process	GO:2001237; negative regulation of extrinsic apoptotic signaling pathway	1.175E-04	4.181E-03	AKT1, AR, DAPK1, FYN, LMNA, SRC
CC	GO:0044464; cell part	GO:0005739; mitochondrion	1.239E-04	4.375E-03	AKT1, CA5A, CA5B, CASP1, CDK1, CYP1A1, CYP1B1, CYP2D6, ESR2, FYN, GSK3B, HSD17B10, MAOA, MAPK1, MAPK14, MAPK3, MMP2, MPO, NFKB1, NOX4, PKM, SRC, TP53
BP	GO:0009987; cellular process	GO:0014068; positive regulation of phosphatidylinositol 3-kinase signaling	1.289E-04	4.519E-03	FLT3, FYN, KDR, PPARD, PTK2
BP	GO:0008152; metabolic process	GO:0010605; negative regulation of macromolecule metabolic process	1.362E-04	4.739E-03	AHR, AKT1, AR, AURKB, BLM, CDK1, CSNK2A1, CTDSP1, DAPK1, ESR1, ESR2, ESRRA, FABP4, FYN, GSK3B, HIF1A, HMGCR, IGF1R, KDR, L3MBTL1, MAPK14, MAPT, MMP9, NFKB1, PKN1, PPARA, PPARD, PTGS2, SRC, STAT6, THRB, TNKS, TNKS2, TP53, USP2, XDH, XPO1
BP	GO:0032502; developmental process	GO:0060065; uterus development	1.362E-04	4.739E-03	CYP19A1, ESR1, SRC
MF	Unclassified;	GO:0004707; MAP kinase activity	1.362E-04	4.739E-03	MAPK1, MAPK14, MAPK3
BP	GO:0022610; biological adhesion	GO:0045785; positive regulation of cell adhesion	1.475E-04	5.081E-03	AKT1, ALOX12, ALOX15, CDK6, FYN, GSK3B, KDR, LCK, PIK3R1, SRC, SYK
BP	GO:0008152; metabolic process	GO:0045913; positive regulation of carbohydrate metabolic process	1.486E-04	5.102E-03	AKT1, HIF1A, NFKB1, PPARA, SRC
BP	GO:0051704; multi-organism process	GO:0044419; interspecies interaction between organisms	1.496E-04	5.128E-03	AXL, CDK1, FYN, KDR, LCK, MAPK1, MAPK3, MET, NPC1, PIK3R1, POLA1, RAB9A, SRC, SYK, TP53, XPO1
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	1.625E-04	5.452E-03	CYP2D6, CYP3A4
BP	GO:0051179; localization	GO:0099039; sphingolipid translocation	1.625E-04	5.452E-03	ABCB1, ABCC1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.625E-04	5.452E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0050473; arachidonate 15-lipoxygenase activity	1.625E-04	5.452E-03	ALOX15, PTGS2
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	1.625E-04	5.452E-03	CYP1A1, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	1.625E-04	5.452E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	1.625E-04	5.452E-03	ALOX12, ALOX15
CC	GO:0043226; organelle	GO:0044454; nuclear chromosome part	1.662E-04	5.551E-03	AR, AURKB, BLM, CDK1, CSNK2A1, ESR1, POLA1, PPARD, STAT6, THRB, TNKS, TNKS2, TP53
MF	Unclassified;	GO:0004708; MAP kinase kinase activity	1.694E-04	5.639E-03	MAPK1, MAPK14, MAPK3
MF	GO:0005488; binding	GO:0002039; p53 binding	1.705E-04	5.658E-03	BLM, GSK3B, HIF1A, NUAK1, TP53
BP	GO:0022414; reproductive process	GO:0007566; embryo implantation	1.748E-04	5.768E-03	MMP2, MMP9, PPARD, PTGS2
BP	GO:0009987; cellular process	GO:0097194; execution phase of apoptosis	1.748E-04	5.768E-03	AKT1, CASP1, CASP7, PTK2
CC	GO:0016020; membrane	GO:0005901; caveola	1.823E-04	5.978E-03	MAPK1, MAPK3, PTGS2, SLC22A6, SRC
MF	Unclassified;	GO:0099600; transmembrane receptor activity	2.025E-04	6.573E-03	ADRA2A, ADRA2B, ADRA2C, ADRB2, ALK, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CXCR1, DRD4, FLT3, IGF1R, KDR, MET, NMUR2, NPC1, NPSR1, TAAR1, TSHR
BP	GO:0009987; cellular process	GO:0032872; regulation of stress-activated MAPK cascade	2.032E-04	6.584E-03	AKT1, HMGCR, IGF1R, MAPK1, MAPK3, PKN1, SYK, XDH
BP	GO:0032501; multicellular organismal process	GO:0045986; negative regulation of smooth muscle contraction	2.073E-04	6.675E-03	ADRA2C, ADRB2, PTGS2
BP	Unclassified;	GO:0044243; multicellular organismal catabolic process	2.078E-04	6.675E-03	MMP13, MMP2, MMP3, MMP9, PLA2G1B
CC	GO:0044464; cell part	GO:0005635; nuclear envelope	2.142E-04	6.850E-03	ALOX5, LMNA, MAPK3, NPC1, POLA1, TNKS2, XPO1
BP	GO:0009987; cellular process	GO:1903201; regulation of oxidative stress-induced cell death	2.216E-04	7.033E-03	AKT1, HIF1A, MET, MMP3, TP53
MF	GO:0005488; binding	GO:0001085; RNA polymerase II transcription factor binding	2.255E-04	7.123E-03	AHR, AR, ESR1, GSK3B, PPARA, TP53
BP	GO:0023052; signaling	GO:0007267; cell-cell signaling	2.359E-04	7.435E-03	ADRA2B, ADRA2C, ADRB2, AR, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, ESR2, HTR3A, MAPK1, NMUR2, TSHR
BP	GO:0051179; localization	GO:2000641; regulation of early endosome to late endosome transport	2.504E-04	7.800E-03	MAPK1, MAPK3, SRC
BP	GO:0008152; metabolic process	GO:0046209; nitric oxide metabolic process	2.504E-04	7.800E-03	AKT1, CYP1B1, TLR2
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	2.504E-04	7.800E-03	CYP2C19, CYP2C8, CYP2C9
MF	GO:0003824; catalytic activity	GO:0035173; histone kinase activity	2.504E-04	7.800E-03	AURKB, CDK1, PKN1
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	2.511E-04	7.812E-03	AXL, CDK1, CSNK2A1, FLT3, PKM
BP	GO:0009987; cellular process	GO:0031334; positive regulation of protein complex assembly	2.765E-04	8.515E-03	ALOX15, ESR1, GSK3B, MAPT, MET, MMP3, SRC, TP53
BP	GO:0009987; cellular process	GO:0071356; cellular response to tumor necrosis factor	2.833E-04	8.662E-03	AKT1, FABP4, MAPK1, MAPK14, MAPK3, NFKB1
BP	GO:0023052; signaling	GO:0050806; positive regulation of synaptic transmission	2.833E-04	8.662E-03	ADRB2, CA2, CA7, DRD4, MAPK1, PTGS2
BP	GO:0009987; cellular process	GO:1900034; regulation of cellular response to heat	2.836E-04	8.662E-03	CAMK2B, GSK3B, MAPK1, MAPK3, MAPT
BP	GO:0022610; biological adhesion	GO:0022407; regulation of cell-cell adhesion	3.044E-04	9.155E-03	AKT1, ALOX12, ALOX15, FYN, LCK, PDE5A, PIK3R1, PPARA, PTK2, SRC, SYK
BP	GO:0050896; response to stimulus	GO:0070542; response to fatty acid	3.191E-04	9.542E-03	AKT1, FABP3, PTGS2, SRC, TLR2
BP	GO:0065007; biological regulation	GO:0032431; activation of phospholipase A2 activity	3.234E-04	9.542E-03	NMUR2, PLA2G1B
BP	GO:0008152; metabolic process	GO:0070213; protein auto-ADP-ribosylation	3.234E-04	9.542E-03	TNKS, TNKS2
BP	GO:0009987; cellular process	GO:0090170; regulation of Golgi inheritance	3.234E-04	9.542E-03	MAPK1, MAPK3
BP	GO:0051179; localization	GO:1901529; positive regulation of anion channel activity	3.234E-04	9.542E-03	ABCB1, CFTR
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	3.234E-04	9.542E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	3.234E-04	9.542E-03	ESR1, ESR2
MF	GO:0005488; binding	GO:0005497; androgen binding	3.234E-04	9.542E-03	ALDH1A1, AR
CC	GO:0044421; extracellular region part	GO:0070062; extracellular exosome	3.190E-04	9.542E-03	ABCB1, ABCC1, AKR1B1, ALDH1A1, ALK, ALOX12, AXL, CA1, CA2, CA4, CA6, CDK1, CFTR, CTDSP1, FABP3, FABP4, FABP5, GAA, GLO1, LCK, MAPK1, MAPK14, MAPK3, MMP9, MPO, NPC1, NT5E, PKM, PTGS1, PYGL, RAB9A, SLC22A6, SLC22A8, SRC, THRB, TTR, UBE2N
MF	GO:0005488; binding	GO:0046982; protein heterodimerization activity	3.322E-04	9.749E-03	ADRA2A, ADRA2C, AHR, AXL, HIF1A, NFKB1, PIK3R1, PPARD, TLR2, TP53, TTR, TYR
BP	GO:0050896; response to stimulus	GO:1901655; cellular response to ketone	3.381E-04	9.882E-03	AKR1B1, AKT1, AR, CFTR, SRC
BP	GO:0009987; cellular process	GO:0090199; regulation of release of cytochrome c from mitochondria	3.390E-04	9.882E-03	AKT1, LMNA, MMP9, TP53
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.294E-21	8.967E-18	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.919E-16	2.542E-13	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CFTR
MF	GO:0005488; binding	GO:0020037; heme binding	3.373E-14	1.708E-11	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, MPO, NOX4, PTGS1, PTGS2, SRC, TBXAS1
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	7.756E-14	3.671E-11	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	Unclassified;	GO:0032844; regulation of homeostatic process	1.003E-13	4.548E-11	ADRA2A, AURKB, CA2, CA7, CDK6, CFTR, FYN, HIF1A, HMGCR, KDR, LCK, MAPK1, MAPK14, MAPK3, NEK2, NPC1, NPSR1, PLA2G1B, PTGS2, SRC, SYK, TNKS, TNKS2, TRPA1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	2.014E-20	4.088E-18	CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14
hsa05205	Proteoglycans in cancer_Homo sapiens_hsa05205	9.766E-14	9.912E-12	CAMK2B; SRC; MMP2; PIK3R1; MAPK14; HIF1A; ESR1; MMP9; PTK2; IGF1R; KDR; AKT1; MAPK1; TP53; MET; TLR2; MAPK3
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	1.362E-12	9.214E-11	MAOA; ALOX15; ALOX12; HTR3A; CYP2C19; PTGS2; PTGS1; CYP2C9; CYP2C8; CYP2D6; ALOX5; MAPK1; MAPK3
hsa04725	Cholinergic synapse_Homo sapiens_hsa04725	2.410E-11	9.783E-10	CHRM2; CAMK2B; CHRM3; ACHE; CHRM1; CHRM4; CHRM5; AKT1; MAPK1; FYN; PIK3R1; MAPK3
hsa00590	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.989E-11	9.783E-10	CYP2C9; CYP2C8; PLA2G1B; ALOX5; ALOX15; TBXAS1; ALOX12; CYP2C19; PTGS2; PTGS1
hsa05200	Pathways in cancer_Homo sapiens_hsa05200	6.570E-11	2.223E-09	GSK3B; FLT3; DAPK1; MMP2; PIK3R1; PTGS2; HIF1A; MMP9; NFKB1; PTK2; IGF1R; AR; CDK6; AKT1; MAPK1; MET; TP53; PPARD; MAPK3
hsa04917	Prolactin signaling pathway_Homo sapiens_hsa04917	9.338E-11	2.708E-09	GSK3B; SRC; AKT1; MAPK1; PIK3R1; MAPK14; ESR1; NFKB1; ESR2; MAPK3
hsa04151	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	3.817E-10	9.686E-09	CHRM2; GSK3B; CHRM1; SYK; PIK3R1; PTK2; NFKB1; IGF1R; CDK6; KDR; AKT1; MAPK1; PKN1; TP53; MET; TLR2; MAPK3
hsa04370	VEGF signaling pathway_Homo sapiens_hsa04370	4.792E-10	1.081E-08	SRC; KDR; AKT1; MAPK1; PIK3R1; MAPK14; PTGS2; PTK2; MAPK3
hsa05230	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.139E-09	2.103E-08	PKM; FLT3; AKT1; MAPK1; PIK3R1; TP53; MET; HIF1A; MAPK3
hsa04668	TNF signaling pathway_Homo sapiens_hsa04668	6.486E-09	9.332E-08	CASP7; MMP3; AKT1; MAPK1; PIK3R1; MAPK14; PTGS2; MMP9; NFKB1; MAPK3
hsa04913	Ovarian steroidogenesis_Homo sapiens_hsa04913	2.337E-09	3.649E-08	HSD17B1; ALOX5; HSD17B2; CYP1A1; CYP1B1; PTGS2; CYP19A1; IGF1R
hsa05161	Hepatitis B_Homo sapiens_hsa05161	8.134E-09	1.032E-07	CDK6; SRC; AKT1; MAPK1; STAT6; PIK3R1; TP53; MMP9; NFKB1; TLR2; MAPK3
hsa04976	Bile secretion_Homo sapiens_hsa04976	1.937E-09	3.277E-08	SLCO1B1; ABCB1; CA2; SLCO1B3; HMGCR; SLC22A8; CYP3A4; CFTR; ABCG2
hsa05221	Acute myeloid leukemia_Homo sapiens_hsa05221	6.896E-09	9.332E-08	FLT3; PIM1; AKT1; MAPK1; PIK3R1; NFKB1; PPARD; MAPK3
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.242E-08	1.448E-07	CHRM2; CHRM3; CHRM1; THRB; CHRM4; CHRM5; ADRB2; ADRA2C; TAAR1; ADRA2B; ADRA2A; TSHR; NMUR2; DRD4
hsa05215	Prostate cancer_Homo sapiens_hsa05215	1.483E-08	1.535E-07	GSK3B; AR; AKT1; MAPK1; PIK3R1; TP53; NFKB1; IGF1R; MAPK3
hsa04919	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.284E-08	1.448E-07	GSK3B; THRB; SRC; AKT1; MAPK1; PIK3R1; TP53; ESR1; HIF1A; MAPK3
hsa04611	Platelet activation_Homo sapiens_hsa04611	1.772E-08	1.713E-07	SYK; SRC; TBXAS1; AKT1; MAPK1; FYN; PIK3R1; MAPK14; PTGS1; MAPK3
hsa04024	cAMP signaling pathway_Homo sapiens_hsa04024	2.055E-08	1.814E-07	CHRM2; CAMK2B; CHRM1; AKT1; MAPK1; PIK3R1; ADRB2; PPARA; CFTR; NFKB1; TSHR; MAPK3
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	1.128E-09	2.103E-08	CYP2C9; CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4; CYP2C19
hsa01100	Metabolic pathways_Homo sapiens_hsa01100	4.803E-08	3.750E-07	PLA2G1B; MAOA; ALOX15; AKR1B1; ALOX12; HMGCR; PYGL; PTGS2; CYP2C19; CYP3A4; CYP19A1; HSD17B10; PTGS1; NT5E; HSD17B1; ALOX5; HSD17B2; XDH; GAA; TYR; CYP2C9; POLA1; CYP2C8; PKM; TBXAS1; CYP1A2; ALDH1A1; CYP1A1
hsa05214	Glioma_Homo sapiens_hsa05214	2.008E-08	1.814E-07	CAMK2B; CDK6; AKT1; MAPK1; PIK3R1; TP53; IGF1R; MAPK3
hsa04915	Estrogen signaling pathway_Homo sapiens_hsa04915	3.801E-08	3.215E-07	SRC; MMP2; AKT1; MAPK1; PIK3R1; ESR1; MMP9; ESR2; MAPK3
hsa05162	Measles_Homo sapiens_hsa05162	5.022E-08	3.776E-07	GSK3B; CDK6; CSNK2A1; AKT1; RAB9A; FYN; PIK3R1; TP53; NFKB1; TLR2
hsa05218	Melanoma_Homo sapiens_hsa05218	4.082E-08	3.314E-07	CDK6; AKT1; MAPK1; PIK3R1; TP53; MET; IGF1R; MAPK3
hsa04660	T cell receptor signaling pathway_Homo sapiens_hsa04660	5.854E-08	4.244E-07	GSK3B; LCK; AKT1; MAPK1; FYN; PIK3R1; MAPK14; NFKB1; MAPK3
hsa05219	Bladder cancer_Homo sapiens_hsa05219	1.512E-08	1.535E-07	DAPK1; SRC; MMP2; MAPK1; MMP9; TP53; MAPK3
hsa05203	Viral carcinogenesis_Homo sapiens_hsa05203	2.662E-07	1.461E-06	POLB; CDK6; PKM; SYK; SRC; CDK1; MAPK1; PIK3R1; TP53; NFKB1; MAPK3
hsa04510	Focal adhesion_Homo sapiens_hsa04510	2.296E-07	1.295E-06	GSK3B; SRC; KDR; AKT1; MAPK1; FYN; PIK3R1; MET; PTK2; IGF1R; MAPK3
hsa04722	Neurotrophin signaling pathway_Homo sapiens_hsa04722	2.023E-07	1.181E-06	CAMK2B; GSK3B; AKT1; MAPK1; PIK3R1; MAPK14; TP53; NFKB1; MAPK3
hsa04071	Sphingolipid signaling pathway_Homo sapiens_hsa04071	2.023E-07	1.181E-06	ABCC1; AKT1; MAPK1; FYN; PIK3R1; MAPK14; TP53; NFKB1; MAPK3
hsa04012	ErbB signaling pathway_Homo sapiens_hsa04012	2.036E-07	1.181E-06	CAMK2B; GSK3B; SRC; AKT1; MAPK1; PIK3R1; PTK2; MAPK3
hsa05223	Non-small cell lung cancer_Homo sapiens_hsa05223	1.427E-07	9.342E-07	ALK; CDK6; AKT1; MAPK1; PIK3R1; TP53; MAPK3
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	1.280E-07	8.960E-07	CYP2C9; CYP2C8; CYP1A2; CYP1A1; CYP1B1; CYP3A4; CYP2C19; PTGS2
hsa04380	Osteoclast differentiation_Homo sapiens_hsa04380	4.565E-07	2.376E-06	SYK; LCK; AKT1; MAPK1; FYN; PIK3R1; MAPK14; NFKB1; MAPK3
hsa04933	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	6.475E-07	3.057E-06	MMP2; PIM1; AKT1; MAPK1; PIK3R1; MAPK14; NFKB1; MAPK3
hsa04923	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.427E-07	9.342E-07	FABP4; AKT1; ADRB2; PIK3R1; PTGS2; TSHR; PTGS1
hsa05160	Hepatitis C_Homo sapiens_hsa05160	4.867E-07	2.470E-06	GSK3B; AKT1; MAPK1; PIK3R1; MAPK14; PPARA; TP53; NFKB1; MAPK3
hsa05169	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.969E-06	8.157E-06	GSK3B; XPO1; SYK; CSNK2A1; CDK1; AKT1; PIK3R1; MAPK14; TP53; NFKB1
hsa04066	HIF-1 signaling pathway_Homo sapiens_hsa04066	7.527E-07	3.473E-06	CAMK2B; AKT1; MAPK1; PIK3R1; HIF1A; NFKB1; IGF1R; MAPK3
hsa05212	Pancreatic cancer_Homo sapiens_hsa05212	4.514E-07	2.376E-06	CDK6; AKT1; MAPK1; PIK3R1; TP53; NFKB1; MAPK3
hsa04664	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	5.552E-07	2.749E-06	SYK; AKT1; MAPK1; FYN; PIK3R1; MAPK14; MAPK3
hsa00140	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.828E-07	1.159E-06	HSD17B1; CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1
hsa04810	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	3.303E-06	1.265E-05	CHRM2; CHRM3; CHRM1; SRC; CHRM4; CHRM5; MAPK1; PIK3R1; PTK2; MAPK3
hsa04022	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	3.257E-06	1.265E-05	AKT1; MAPK1; PDE5A; PIK3R1; ADRB2; ADRA2C; ADRA2B; ADRA2A; MAPK3
hsa05145	Toxoplasmosis_Homo sapiens_hsa05145	2.117E-06	8.593E-06	ALOX5; AKT1; MAPK1; PIK3R1; MAPK14; NFKB1; TLR2; MAPK3
hsa05164	Influenza A_Homo sapiens_hsa05164	4.778E-06	1.796E-05	GSK3B; XPO1; CASP1; AKT1; MAPK1; PIK3R1; MAPK14; NFKB1; MAPK3
hsa05220	Chronic myeloid leukemia_Homo sapiens_hsa05220	9.058E-07	3.997E-06	CDK6; AKT1; MAPK1; PIK3R1; TP53; NFKB1; MAPK3
hsa04662	B cell receptor signaling pathway_Homo sapiens_hsa04662	9.058E-07	3.997E-06	GSK3B; SYK; AKT1; MAPK1; PIK3R1; NFKB1; MAPK3
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	6.142E-07	2.969E-06	CYP2C9; CYP2C8; MAOA; CYP2D6; CYP1A2; CYP3A4; CYP2C19
hsa05152	Tuberculosis_Homo sapiens_hsa05152	5.487E-06	1.989E-05	CAMK2B; SYK; SRC; AKT1; MAPK1; MAPK14; NFKB1; TLR2; MAPK3
hsa04210	Apoptosis_Homo sapiens_hsa04210	7.572E-06	2.555E-05	CASP7; LMNA; AKT1; MAPK1; PIK3R1; TP53; NFKB1; MAPK3
hsa05202	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	6.009E-06	2.140E-05	FLT3; MMP3; TP53; MPO; MMP9; MET; NFKB1; PTK2; IGF1R
hsa05206	MicroRNAs in cancer_Homo sapiens_hsa05206	9.794E-06	3.109E-05	ABCC1; CDK6; ABCB1; PIM1; CYP1B1; MAPK1; PTGS2; TP53; MMP9; MET; NFKB1
hsa04520	Adherens junction_Homo sapiens_hsa04520	9.945E-07	4.295E-06	CSNK2A1; SRC; MAPK1; FYN; MET; IGF1R; MAPK3
hsa05222	Small cell lung cancer_Homo sapiens_hsa05222	2.765E-06	1.101E-05	CDK6; AKT1; PIK3R1; PTGS2; TP53; NFKB1; PTK2
hsa04914	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	6.629E-06	2.320E-05	CDK1; AKT1; MAPK1; PIK3R1; MAPK14; IGF1R; MAPK3
hsa04062	Chemokine signaling pathway_Homo sapiens_hsa04062	8.184E-06	2.679E-05	GSK3B; CXCR1; SRC; AKT1; MAPK1; PIK3R1; NFKB1; PTK2; MAPK3
hsa04015	Rap1 signaling pathway_Homo sapiens_hsa04015	2.147E-05	6.227E-05	SRC; KDR; AKT1; MAPK1; PIK3R1; MAPK14; MET; IGF1R; MAPK3
hsa04014	Ras signaling pathway_Homo sapiens_hsa04014	3.812E-05	1.075E-04	PLA2G1B; KDR; AKT1; MAPK1; PIK3R1; MET; NFKB1; IGF1R; MAPK3
hsa04620	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.114E-05	3.425E-05	AKT1; MAPK1; PIK3R1; MAPK14; NFKB1; TLR2; MAPK3
hsa05142	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	9.823E-06	3.109E-05	AKT1; MAPK1; PIK3R1; MAPK14; NFKB1; TLR2; MAPK3
hsa05213	Endometrial cancer_Homo sapiens_hsa05213	1.868E-06	7.899E-06	GSK3B; AKT1; MAPK1; PIK3R1; TP53; MAPK3
hsa04550	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	7.337E-05	1.945E-04	GSK3B; AKT1; MAPK1; PIK3R1; MAPK14; IGF1R; MAPK3
hsa04072	Phospholipase D signaling pathway_Homo sapiens_hsa04072	8.013E-05	2.085E-04	SYK; CXCR1; AKT1; MAPK1; FYN; PIK3R1; MAPK3
hsa04261	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	9.518E-05	2.446E-04	CAMK2B; AKT1; MAPK1; PIK3R1; ADRB2; MAPK14; MAPK3
hsa05210	Colorectal cancer_Homo sapiens_hsa05210	5.318E-06	1.963E-05	GSK3B; AKT1; MAPK1; PIK3R1; TP53; MAPK3
hsa04912	GnRH signaling pathway_Homo sapiens_hsa04912	4.866E-05	1.353E-04	CAMK2B; SRC; MMP2; MAPK1; MAPK14; MAPK3
hsa04750	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	7.376E-05	1.945E-04	CAMK2B; TRPA1; SRC; ALOX12; PIK3R1; MAPK14
hsa05010	Alzheimer's disease_Homo sapiens_hsa05010	2.090E-04	5.050E-04	BACE1; GSK3B; CASP7; MAPK1; MAPT; HSD17B10; MAPK3
hsa04931	Insulin resistance_Homo sapiens_hsa04931	1.331E-04	3.294E-04	GSK3B; AKT1; PIK3R1; PYGL; PPARA; NFKB1
hsa05211	Renal cell carcinoma_Homo sapiens_hsa05211	7.678E-06	2.555E-05	AKT1; MAPK1; PIK3R1; MET; HIF1A; MAPK3
hsa04114	Oocyte meiosis_Homo sapiens_hsa04114	2.573E-04	6.146E-04	CAMK2B; AR; CDK1; MAPK1; IGF1R; MAPK3
hsa05166	HTLV-I infection_Homo sapiens_hsa05166	5.468E-04	1.156E-03	POLB; GSK3B; XPO1; LCK; AKT1; PIK3R1; TP53; NFKB1
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	7.021E-06	2.416E-05	CYP2C9; CYP2C8; CYP1A2; ALDH1A1; CYP1A1; CYP3A4
hsa04068	FoxO signaling pathway_Homo sapiens_hsa04068	3.917E-04	8.836E-04	AKT1; MAPK1; PIK3R1; MAPK14; IGF1R; MAPK3
hsa04650	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	4.242E-04	9.463E-04	SYK; LCK; MAPK1; FYN; PIK3R1; MAPK3
hsa04728	Dopaminergic synapse_Homo sapiens_hsa04728	3.326E-04	7.674E-04	CAMK2B; GSK3B; MAOA; AKT1; MAPK14; DRD4
hsa05140	Leishmaniasis_Homo sapiens_hsa05140	1.381E-05	4.122E-05	MAPK1; MAPK14; PTGS2; NFKB1; TLR2; MAPK3
hsa04360	Axon guidance_Homo sapiens_hsa04360	3.058E-04	7.136E-04	GSK3B; MAPK1; FYN; MET; PTK2; MAPK3
hsa04910	Insulin signaling pathway_Homo sapiens_hsa04910	4.954E-04	1.093E-03	GSK3B; AKT1; MAPK1; PIK3R1; PYGL; MAPK3
hsa05132	Salmonella infection_Homo sapiens_hsa05132	3.534E-05	1.010E-04	CASP1; MAPK1; PKN1; MAPK14; NFKB1; MAPK3
hsa04932	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	7.661E-04	1.555E-03	GSK3B; CASP7; AKT1; PIK3R1; PPARA; NFKB1
hsa04020	Calcium signaling pathway_Homo sapiens_hsa04020	1.888E-03	3.616E-03	CHRM2; CAMK2B; CHRM3; CHRM1; CHRM5; ADRB2
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.381E-05	4.122E-05	CYP2C9; CYP2D6; CYP1A2; CYP1A1; CYP1B1; CYP3A4
hsa04144	Endocytosis_Homo sapiens_hsa04144	1.090E-02	1.785E-02	CXCR1; SRC; KDR; ADRB2; MET; IGF1R
hsa04921	Oxytocin signaling pathway_Homo sapiens_hsa04921	9.697E-04	1.911E-03	CAMK2B; SRC; MAPK1; PIK3R1; PTGS2; MAPK3
hsa04010	MAPK signaling pathway_Homo sapiens_hsa04010	2.427E-03	4.438E-03	AKT1; MAPK1; MAPT; MAPK14; TP53; NFKB1; MAPK3
hsa00230	Purine metabolism_Homo sapiens_hsa00230	8.733E-03	1.477E-02	POLA1; NT5E; PKM; PDE5A; XDH
hsa05133	Pertussis_Homo sapiens_hsa05133	1.614E-05	4.749E-05	CASP7; CASP1; MAPK1; MAPK14; NFKB1; MAPK3
hsa05168	Herpes simplex infection_Homo sapiens_hsa05168	1.068E-02	1.778E-02	CSNK2A1; CDK1; TP53; NFKB1; TLR2
hsa04630	Jak-STAT signaling pathway_Homo sapiens_hsa04630	5.598E-03	9.797E-03	THPO; PIM1; AKT1; STAT6; PIK3R1
hsa03320	PPAR signaling pathway_Homo sapiens_hsa03320	9.954E-06	3.109E-05	FABP2; FABP3; FABP4; FABP5; PPARA; PPARD
hsa04310	Wnt signaling pathway_Homo sapiens_hsa04310	3.567E-03	6.408E-03	CAMK2B; GSK3B; CSNK2A1; TP53; PPARD
hsa04666	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	5.465E-04	1.156E-03	SYK; AKT1; MAPK1; PIK3R1; MAPK3
hsa04916	Melanogenesis_Homo sapiens_hsa04916	7.608E-04	1.555E-03	CAMK2B; GSK3B; MAPK1; TYR; MAPK3
hsa04152	AMPK signaling pathway_Homo sapiens_hsa04152	1.985E-03	3.697E-03	AKT1; PIK3R1; HMGCR; CFTR; IGF1R
hsa04670	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.596E-03	3.085E-03	MMP2; PIK3R1; MAPK14; MMP9; PTK2
hsa05231	Choline metabolism in cancer_Homo sapiens_hsa05231	7.958E-04	1.584E-03	AKT1; MAPK1; PIK3R1; HIF1A; MAPK3
hsa04211	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	5.740E-04	1.201E-03	AKT1; PIK3R1; TP53; NFKB1; IGF1R
hsa04922	Glucagon signaling pathway_Homo sapiens_hsa04922	7.958E-04	1.584E-03	CAMK2B; PKM; AKT1; PYGL; PPARA
hsa04110	Cell cycle_Homo sapiens_hsa04110	1.214E-02	1.925E-02	GSK3B; CDK6; CDK1; TP53
hsa04064	NF-kappa B signaling pathway_Homo sapiens_hsa04064	5.465E-04	1.156E-03	SYK; CSNK2A1; LCK; PTGS2; NFKB1
hsa04713	Circadian entrainment_Homo sapiens_hsa04713	3.075E-02	4.658E-02	CAMK2B; MAPK1; MAPK3
hsa05146	Amoebiasis_Homo sapiens_hsa05146	5.783E-03	9.979E-03	PIK3R1; NFKB1; PTK2; TLR2
hsa04972	Pancreatic secretion_Homo sapiens_hsa04972	5.007E-03	8.839E-03	CHRM3; CA2; PLA2G1B; CFTR
hsa04723	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	5.988E-03	1.022E-02	MAPK1; MAPK14; PTGS2; MAPK3
hsa04150	mTOR signaling pathway_Homo sapiens_hsa04150	6.935E-05	1.877E-04	AKT1; MAPK1; PIK3R1; HIF1A; MAPK3
hsa04540	Gap junction_Homo sapiens_hsa04540	3.672E-03	6.539E-03	SRC; CDK1; MAPK1; MAPK3
hsa05120	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.264E-04	3.169E-04	CXCR1; SRC; MAPK14; MET; NFKB1
hsa05100	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	2.373E-03	4.379E-03	SRC; PIK3R1; MET; PTK2
hsa04971	Gastric acid secretion_Homo sapiens_hsa04971	1.957E-03	3.697E-03	CAMK2B; CHRM3; CA2; CFTR
hsa05131	Shigellosis_Homo sapiens_hsa05131	1.019E-04	2.586E-04	SRC; MAPK1; MAPK14; NFKB1; MAPK3
hsa04621	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	5.409E-05	1.484E-04	CASP1; MAPK1; MAPK14; NFKB1; MAPK3
hsa04920	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.382E-02	2.158E-02	AKT1; PPARA; NFKB1
hsa04720	Long-term potentiation_Homo sapiens_hsa04720	1.180E-02	1.885E-02	CAMK2B; MAPK1; MAPK3
hsa04115	p53 signaling pathway_Homo sapiens_hsa04115	1.330E-02	2.093E-02	CDK6; CDK1; TP53
hsa04213	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.085E-02	1.785E-02	AKT1; PIK3R1; IGF1R
hsa04730	Long-term depression_Homo sapiens_hsa04730	9.098E-03	1.526E-02	MAPK1; IGF1R; MAPK3
hsa05321	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.132E-02	1.838E-02	STAT6; NFKB1; TLR2
hsa05134	Legionellosis_Homo sapiens_hsa05134	6.440E-04	1.334E-03	CASP7; CASP1; NFKB1; TLR2
hsa05014	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	5.801E-03	9.979E-03	CASP1; MAPK14; TP53
hsa04930	Type II diabetes mellitus_Homo sapiens_hsa04930	3.819E-04	8.711E-04	PKM; MAPK1; PIK3R1; MAPK3
hsa00620	Pyruvate metabolism_Homo sapiens_hsa00620	3.317E-02	4.988E-02	PKM; GLO1
hsa02010	ABC transporters_Homo sapiens_hsa02010	2.724E-04	6.430E-04	ABCC1; ABCB1; CFTR; ABCG2
hsa04960	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	2.709E-03	4.911E-03	MAPK1; PIK3R1; MAPK3
hsa00380	Tryptophan metabolism_Homo sapiens_hsa00380	1.875E-04	4.586E-04	MAOA; CYP1A2; CYP1A1; CYP1B1
hsa00052	Galactose metabolism_Homo sapiens_hsa00052	1.937E-02	2.979E-02	GAA; AKR1B1
hsa00350	Tyrosine metabolism_Homo sapiens_hsa00350	2.589E-02	3.952E-02	MAOA; TYR
hsa04320	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.585E-02	2.456E-02	MAPK1; MAPK3
hsa05020	Prion diseases_Homo sapiens_hsa05020	1.981E-03	3.697E-03	MAPK1; FYN; MAPK3
hsa05216	Thyroid cancer_Homo sapiens_hsa05216	1.141E-03	2.228E-03	MAPK1; TP53; MAPK3
hsa04964	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.164E-02	1.875E-02	CA2; CA4
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	5.006E-04	1.093E-03	CYP1A2; XDH

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HMGCR; ALOX5; PPARD
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	HMGCR; PLA2G1B
J00-J99: Diseases of the respiratory system	Asthma	J45	TBXAS1; CHRM2; PLA2G1B; ESRRA; SYK; SYK; PDE5A; PTGS2; ALOX5; ALOX5; ADRA2C; ADRB2; ADRB2; ADRB2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PLA2G1B; ABCC1; ESRRA; PTGS2; PTGS2; ALOX5; MAPK14
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthralgia	M25.5	ESR1
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3; ALOX5; MAPK14
O00-O9A: Pregnancy, childbirth and the puerperium	Premature labour	O60.1, P07.3	ADRB2
C00-D49: Neoplasms	Prostate cancer	C61	AR; AR; FLT3; TLR2; ESR1
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1
N00-N99: Diseases of the genitourinary system	Prostate hyperplasia	N40	AR
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	PLA2G1B; ALOX5
C00-D49: Neoplasms	Female androgenresponsive recurrent mammary cancer	C50	AR
H00-H59: Diseases of the eye and adnexa	Eye disorders	H00-H59	ESR1
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR
E00-E89: Endocrine, nutritional and metabolic diseases	Female hypogonadism	E23, E28	ESR1
N00-N99: Diseases of the genitourinary system	Nephritis	N00-N19, N25-N29	TBXAS1
S00-T88: Injury, poisoning and certain other consequences of external causes	Nerve injury	T14.4	PLA2G1B
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nausea	R11	CHRM2; CHRM4; HTR3A; HTR3A
I00-I99: Diseases of the circulatory system	Myocardial infarction	I21, I22	HMGCR; MMP3
S00-T88: Injury, poisoning and certain other consequences of external causes	Myocardial reperfusion injury	T86.4	AKT1
I00-I99: Diseases of the circulatory system	Hypotension	I95	ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	AR; ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricaemia in gout	E79.0, M10	XDH
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricemia	E79.0	XDH
N00-N99: Diseases of the genitourinary system	Infertility	N97.0	ESR1
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2; KDR; KDR
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	CHRM3; ALOX5
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	AR; HMGCR; CHRM2; PDE5A; KDR
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nocturia	R35	CHRM4
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT; ACHE
N00-N99: Diseases of the genitourinary system	Neurogenic bladder dysfunction	N31.9	ADRB2
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	MAOA; CHRM1; PTGS1; PTGS2; PTGS2; ADRA2B
H00-H59: Diseases of the eye and adnexa	Corneal ulcers	H16.0	MMP3
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR
A00-B99: Certain infectious and parasitic diseases	Leishmaniasis	B55.0	PLA2G1B
H00-H59: Diseases of the eye and adnexa	Produce mydriasis and cycloplegia for diagnostic purposes	H57.04	CHRM4
A00-B99: Certain infectious and parasitic diseases	Infections disease	A00-B99	MPO
E00-E89: Endocrine, nutritional and metabolic diseases	Hypothyroidism	E03	THRB
NA: NA	Raynaud's disease	NA	PDE5A; PDE5A
S00-T88: Injury, poisoning and certain other consequences of external causes	Radiation sickness	T66	TLR2
C00-D49: Neoplasms	Refractory renal cell carcinoma	C64	PKM
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARD
C00-D49: Neoplasms	Non-hodgkin's lymphoma	C85	SYK
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; ABCB1; AXL; PTGS2; IGF1R; IGF1R; KDR
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAOA; CHRM1; CHRM2; CHRM3; CHRM4; MAPT; ACHE; ACHE; ACHE; PTGS2; GSK3B; ADRA2C
L00-L99: Diseases of the skin and subcutaneous tissue	Seborrhea	L21	CHRM3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	CHRM1; CHRM1; CHRM1; CHRM5; ESRRA; DRD4
NA: NA	Schizoaffective disorders	NA	CHRM1
NA: NA	Rheumatold arthritis	NA	PTGS1; PTGS2; PTGS2; PTGS2; MAPK14
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	ALOX5
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	CAMK2B; AKR1B1; PLA2G1B; ESRRA; SYK; CASP1; MMP3; PTGS2; PTGS2; PTGS2; PTGS2; ALOX5; MAPK14; TYR
C00-D49: Neoplasms	Renal cancer	C64	CA9; KDR
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
NA: NA	Addiction	NA	CHRM2
NA: NA	Acute respiratory distress syndrome	NA	MAPK14
L00-L99: Diseases of the skin and subcutaneous tissue	Contact dermatitis	L23, L24, L25	PLA2G1B
C00-D49: Neoplasms	Colorectal cancer	C18-C21	PDE5A; FLT3; PTGS1; IGF1R; MMP9; TP53; KDR
K00-K95: Diseases of the digestive system	Colon polyps	K63.5	PTGS2
C00-D49: Neoplasms	Colon cancer	C50	FLT3
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	CHRM4; CHRM4; PDE5A
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9; AKT1; MET; CHRM4; PKM; ABCB1; SYK; FLT3; MMP2; SRC; IGF1R; PTK2; AURKB; HIF1A; MAPK1; MMP9; TLR2; TP53; XPO1; KDR; KDR; KDR
NA: NA	Spasms	NA	CHRM3
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	MPO; ESR1; ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Muscle atrophy	M62.5	AR
C00-D49: Neoplasms	Hematological malignancies	C81-C86	SYK; SRC; AURKB; TP53
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	HMGCR; THRB; PPARD; ESR1
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	AR; ESR1
S00-T88: Injury, poisoning and certain other consequences of external causes	Contusion	S36.220S	ADRA2C
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	MAPK14; MAPK14
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A
M00-M99: Diseases of the musculoskeletal system and connective tissue	Sjogren's syndrome	M35.0	CHRM3
L00-L99: Diseases of the skin and subcutaneous tissue	Skin infections	L00-L99	ADRB2
NA: NA	Moderate and severe psychomotor agitation	NA	CHRM4
M00-M99: Diseases of the musculoskeletal system and connective tissue	Moderate to severe rheumatoid arthritis	M05-M06	PTGS2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	MAOA
N00-N99: Diseases of the genitourinary system	Overactive bladder	N32.81	CHRM3
C00-D49: Neoplasms	Bladder cancer	C67	AR; CYP19A1
C00-D49: Neoplasms	B-cell lymphoma	C85.1	SYK
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	HMGCR; TBXAS1; SYK; ALOX5
I00-I99: Diseases of the circulatory system	Thromboembolism	I80-I82	TBXAS1
J00-J99: Diseases of the respiratory system	Throat irritation	J39.2	TRPA1
E00-E89: Endocrine, nutritional and metabolic diseases	Testosterone deficiency	E29.1	AR
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR; KDR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Atrophy	M62.571	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Amyloidosis	E85	TTR
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	CHRM4; ACHE; ADRA2C
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR
S00-T88: Injury, poisoning and certain other consequences of external causes	Wound healing	T14.0-T14.1	THRB
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HMGCR
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	SYK
NA: NA	Postmenopausal disorder	NA	ESR1
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Stabilize muscle contractions	M00-M99	CHRM2
K00-K95: Diseases of the digestive system	Stomach ulcer	K25-K27	CHRM1; CHRM5
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9
NA: NA	Suprapubic pain	NA	CHRM4
S00-T88: Injury, poisoning and certain other consequences of external causes	Postoperative inflammation	T81	PTGS1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Postoperative nausea and vomiting	R11	CHRM3
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	ADRB2
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1; PTGS2
E00-E89: Endocrine, nutritional and metabolic diseases	Endocrine disease	E00-E35	AR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	CHRM4; HTR3A
E00-E89: Endocrine, nutritional and metabolic diseases	Elevated CRP	E78.0	HMGCR
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
NA: NA	Edema	NA	CA2
N00-N99: Diseases of the genitourinary system	Post-menopausal vaginal atrophy	N95.2	ESR1
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	CHRM1; CHRM5; ADRA2C; NPSR1; ESR1
NA: NA	GIST	NA	FLT3
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1; CHRM1; CHRM3; CHRM4; ACHE; ADRA2C; CA1; CA1
N00-N99: Diseases of the genitourinary system	Vagina disease	N76.0	ESR1
NA: NA	Uveitis	NA	CHRM4
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	HMGCR; PPARD; PPARD
NA: NA	Dyslipidemia	NA	HMGCR; PPARD
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	CHRM5; PTGS1; PTGS2; PTGS2; PTGS2; PTGS2; ESR1
N00-N99: Diseases of the genitourinary system	Dyspareunia	N94.1	ESR1
NA: NA	Dysuria	NA	CHRM4
J00-J99: Diseases of the respiratory system	Acute asthma	J45	ADRB2
I00-I99: Diseases of the circulatory system	Acute coronary syndrome	I74	MAPK14
NA: NA	Abdominal stomach pain	NA	CHRM1
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	AR; AR; ESRRA; MMP2; PTGS1; ESR1
A00-B99: Certain infectious and parasitic diseases	Viral infections	B01, B02, A60, B00, B27, G05.1, P35.2	POLA1
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	MAOA; TYR
NA: NA	Vomiting	NA	CHRM4; HTR3A
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR; KDR
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ESR1
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	SRC
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Urinary retention	R33	CHRM4
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3
NA: NA	Excessive sweating	NA	CHRM1
E00-E89: Endocrine, nutritional and metabolic diseases	Estrogen deficiency	E28.39	ESR1
NA: NA	Exacerbations of acute asthma	NA	ADRB2
NA: NA	Extrapyramidal disorders secondary to neuroleptic drug therapy	NA	CHRM1
E00-E89: Endocrine, nutritional and metabolic diseases	Male hormonal deficiencies	E20-E35	AR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	MAOA; MAOA
G00-G99: Diseases of the nervous system G00-G99	Encephalopathy	G93.4	XDH
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53
E00-E89: Endocrine, nutritional and metabolic diseases	TTR amyloidosis	E85	TTR
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	TBXAS1; PTGS2; NFKB1; PPARD
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ABCB1; ESR1
L00-L99: Diseases of the skin and subcutaneous tissue	Erythema	L51-L54	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Erectile dysfunction	F52.2, N48.4	PDE5A; PDE5A; DRD4
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	MAOA; CASP1
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
NA: NA	Urgency	NA	CHRM4
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	PTGS1; MMP9
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	CHRM1; CHRM2; CHRM3; CHRM5
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	FLT3; FLT3; AURKB; TP53; TP53
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R
C00-D49: Neoplasms	Multiple myeloma	C90	AHR; HMGCR; SRC; IGF1R
A00-B99: Certain infectious and parasitic diseases	HBV infection	B16, B18.0, B18.1	HMGCR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	MAOA; CHRM4; ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	CHRM1
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ESRRA; PTGS1; ALOX5
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1; GSK3B
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatological disease	L00-L99	AR; ESRRA
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6
C00-D49: Neoplasms	Metastatic prostate cancer	C61	AR
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR
L00-L99: Diseases of the skin and subcutaneous tissue	Alopecia	L65.9	AR
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1; SRC
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET
I00-I99: Diseases of the circulatory system	Heart failure	I50	AR; CHRM2; XDH; ADRA2C
A00-B99: Certain infectious and parasitic diseases	HCV infection	B17.1, B18.2	MMP3
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1; TP53; KDR; KDR
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53
NA: NA	Heart block	NA	ADRB2
E00-E89: Endocrine, nutritional and metabolic diseases	Cystic fibrosis	E84	AR; CFTR
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	CHRM4
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Visceral spasms	R25.2	CHRM1
NA: NA	Bradycardia	NA	ADRB2
G00-G99: Diseases of the nervous system G00-G99	Brain diseases	G00-G99	CHRM5
C00-D49: Neoplasms	Breast cancer	C50	AR; CA9; CYP19A1; FLT3; FLT3; IGF1R; CDK1; ESR1; ESR1; KDR; KDR; KDR
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	AR; KDR
N00-N99: Diseases of the genitourinary system	Menopause symptoms	N95.0	ESR1; ESR1
N00-N99: Diseases of the genitourinary system	Menorrhagia	N92.0	ESR1
C00-D49: Neoplasms	Mesothelioma	C45	PTK2
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	PPARD
C00-D49: Neoplasms	Metastasis	C00-C97	AXL
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Ankylosing spondylitis	M08.1, M45	PTGS2
C00-D49: Neoplasms	Brain cancer	C71, D33	SRC; ESR1
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR
K00-K95: Diseases of the digestive system	Gastroesophageal reflux disease	K21	HTR3A
NA: NA	Gastritis	NA	CHRM4
A00-B99: Certain infectious and parasitic diseases	Diarrhea	A09, K59.1	CFTR
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
E00-E89: Endocrine, nutritional and metabolic diseases	Dietary shortage	E40-E46	PTGS1
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	TBXAS1; PDE5A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CAMK2B; MAOA; ACHE; CYP3A4
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cachexia	R64	AR; ESRRA; ADRB2
C00-D49: Neoplasms	Cancer	C00-C96	AR; CA9; AKT1; MET; CSNK2A1; ABCB1; SYK; FLT3; FLT3; MMP2; ACHE; PTGS2; SRC; IGF1R; PTK2; GSK3B; HIF1A; CDK1; MAPK1; MAPK14; MMP9; NFKB1; PIM1; TLR2; TP53; ESR1; ESR1; CA1; XPO1; KDR
J00-J99: Diseases of the respiratory system	Bronchodilator	J45	CHRM4; ADRB2
C00-D49: Neoplasms	Melanoma	C43	TLR2; TYR; KDR; KDR
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR
NA: NA	Menopausal disorder	NA	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	ADRA2C; ADRB2; PPARD; PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	ESRRA
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2; KDR
Z00-Z99: Factors influencing health status and contact with health services	Hormone replacement therapy	Z79.890	ESR1
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	CHRM4; PDE5A; PDE5A; ADRA2C; ADRB2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	CHRM1
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	SYK; LCK; TLR2; ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	ADRA2A
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR
C00-D49: Neoplasms	Glioma	C71	KDR
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3
C00-D49: Neoplasms	Glioblastoma multiforme	C71	SRC
NA: NA	Gonorrheal vaginitis	NA	ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1; ABCC1; ABCC1; PTGS2; XDH
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnosing bronchial hyperreactivity	W88	CHRM3
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1; PTGS1
H00-H59: Diseases of the eye and adnexa	Diabetic retinopathy	H36, E10.3, E11.3, E13.3	MAPK14
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C
C00-D49: Neoplasms	Castration-resistant prostate cancer	C61	AR
NA: NA	Cardiovascular disease	NA	HMGCR
I00-I99: Diseases of the circulatory system	Cardiomyopathy	I42.0	TTR
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	TBXAS1
NA: NA	Male hypogonadism	NA	AR
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	ADRA2C
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R
C00-D49: Neoplasms	AML	NA	FLT3; KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Amnesia	F04	CHRM5
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	CHRM5; PLA2G1B; ESRRA; ADRA2C
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	PLA2G1B; SYK; ALOX5
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE; CA4; CA2
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	ADRA2C; ADRB2; CA4; CA4
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	ADRA2C
J00-J99: Diseases of the respiratory system	Obstructive lung diseases	J40-J44, J47	CHRM3
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	HMGCR
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT; PPARD
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Local anaesthetic	R20.0	HTR3A
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9; AKT1; HIF1A
G00-G99: Diseases of the nervous system G00-G99	Central and peripheral nervous diseases	G96.9	CHRM4; CHRM5
NA: NA	Upper abdominal bloating	NA	ACHE
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2
NA: NA	Dystonia	NA	CHRM1
K00-K95: Diseases of the digestive system	Alcoholic hepatitis	K70.1	AR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	MAOA; ADRA2C; ADRA2B
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	THRB
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperthyroidism	E05	THRB
S00-T88: Injury, poisoning and certain other consequences of external causes	Hyperthermia	T68	PTGS2
NA: NA	Hyperlipidemia	NA	HMGCR
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Osteopetrosis	Q78.2	ESR1
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53
Z00-Z99: Factors influencing health status and contact with health services	Oral contraceptive	Z30	ESR1
S00-T88: Injury, poisoning and certain other consequences of external causes	Organophosphate poisoning	T60.0	CHRM4
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP13; MMP3; MMP2; PTGS1; PTGS2; PTGS2; PTGS2; PTGS2; PTGS2; PTGS2; ALOX5
H00-H59: Diseases of the eye and adnexa	Choroidal neovascularisation	H35	ESRRA
J00-J99: Diseases of the respiratory system	Chronic breathing disorders	J44-J47	ADRB2
K00-K95: Diseases of the digestive system	Chemotherapy or radiotherapy-induced mucositis	K12.3, R52, G89	HMGCR
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE; CA1
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	PTK2; TP53
C00-D49: Neoplasms	Leukemia	C90-C95	AKT1; FLT3; ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Knee osteoarthritis	M15-M19, M47	PTGS2
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	CHRM4; CHRM4; ESRRA
NA: NA	Miosis during ocular surgery	NA	PTGS1
N00-N99: Diseases of the genitourinary system	Female infertility due to anovulation	N97.0	ESR1
N00-N99: Diseases of the genitourinary system	Female infertility	N97.0	ESR1; ESR1
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET; CASP1
H00-H59: Diseases of the eye and adnexa	Mydriasis diagnosis	H57.0	CHRM4
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	TLR2; KDR
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR
C00-D49: Neoplasms	Hematologic malignancies	C81-C86	AKT1
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3
C00-D49: Neoplasms	Ovarian cancer	C56	ABCB1; MMP2; KDR; KDR; KDR; KDR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis in post-menopausal women	M80-M81	AR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	AR; SRC; ESR1
C00-D49: Neoplasms	Osteosarcoma	C40-C41	SRC; GSK3B
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	CHRM1; CHRM3; CHRM4
C00-D49: Neoplasms	Chronic myelogenous leukaemia	C92.1	SRC
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MPO; CHRM1; CHRM3; CHRM4; CHRM5; PDE5A; ALOX5; MAPK14; ADRB2; ADRB2; ADRB2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	PTGS2
NA: NA	Joint and muscular pain	NA	PTGS2
N00-N99: Diseases of the genitourinary system	Irregularities	N92.6	ESR1
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	CHRM1; CHRM1; CHRM4; CHRM4; CHRM5; HTR3A
I00-I99: Diseases of the circulatory system	Ischemic stroke	I61-I63	MMP3
L00-L99: Diseases of the skin and subcutaneous tissue	Aging skin	L00-L99	ADRB2
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	AR; IGF1R; ESR1; ESR1
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	AR; ESR1
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	High cholesterol levels in blood	E78.0	THRB
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1
NA: NA	HIV infections	NA	AHR
A00-B99: Certain infectious and parasitic diseases	HIV-associated diarrhoea	A09	CFTR
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	CHRM1; CHRM2; CHRM4; CHRM4; CHRM4; ADRA2C
K00-K95: Diseases of the digestive system	Pancreatitis	K85, K86.0K86.1	CHRM4
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	MPO; MAOA; CHRM1; CHRM1; CHRM2; CHRM4; ACHE
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	AR; CHRM3; PKM; MMP13; ACHE; PTGS1; PTGS2; PTGS2; PTGS2; PTGS2; IGF1R; CDK1; ADRA2C; ADRA2A; TRPA1; ESR1
C00-D49: Neoplasms	Pancreatic cancer	C25	AKT1; FLT3; MMP2; PTGS2; TLR2; KDR
NA: NA	Peptic ulcer disease	NA	CHRM4
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
C00-D49: Neoplasms	CLL	NA	FLT3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	CHRM1; CHRM5; MAPT; ACHE
K00-K95: Diseases of the digestive system	Colitis	K50-K52	CHRM5
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6; CA2
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp	L20-L30	PLA2G1B
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	TBXAS1; PTGS1; PTGS2; MAPK14
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	PTGS2; ALOX5
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses	L20-L30	PLA2G1B
NA: NA	Inflammatory diseases	NA	MAPK14
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MPO; PLA2G1B; MMP13; SYK; PTGS1; PTGS2; ALOX5; MAPK14
H00-H59: Diseases of the eye and adnexa	Acquired nystagmus	H55	CHRM4
A00-B99: Certain infectious and parasitic diseases	Visceral leishmaniasis	B55.0	PLA2G1B
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	ABCB1; CYP2C9
N00-N99: Diseases of the genitourinary system	Atrophic vaginitis	N95.2	ESR1
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	ALOX5
C00-D49: Neoplasms	Advanced prostate cancer	C61	AR; ESR1
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD4
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R
K00-K95: Diseases of the digestive system	Gastric motility disorder	K22.4	CHRM4
C00-D49: Neoplasms	Gastric cancer	C16	KDR; KDR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	ADRA2C; HTR3A
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5; RAB9A
NA: NA	Functional bowel syndrome	NA	CHRM1
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	CHRM5; ACHE
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3
J00-J99: Diseases of the respiratory system	Acute lung injury	J80	MAPK14
C00-D49: Neoplasms	Glioblastoma	NA	FLT3

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases