Plant Name: Tylophora ovata
Taxonomic Information:
Plant ID: NPO7170
Plant Latin Name: Tylophora ovata
Taxonomy Genus: Tylophora
Taxonomy Family: Apocynaceae
Plant External Links:
NCBI TaxonomyDB:
228704
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
ChinaTraditional Medicine System:
TCMMedicinal Functions:
Antitussive; Carminative; Emetic; Expectorant
Geographical Distribution:
China
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| PRKCE; PRKCB; PRKCG; PRKCD; PRKCA; PRKCQ; | |
| PPARA; PPARD; | |
| TLR2; | |
| JUN; | |
| FABP3; FABP2; FABP4; FABP5; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Protein Kinase | PRKCE | Protein kinase C epsilon | Q02156 | CHEMBL3582 |
| Protein Kinase | PRKCB | Protein kinase C beta | P05771 | CHEMBL3045 |
| Protein Kinase | PRKCG | Protein kinase C gamma | P05129 | CHEMBL2938 |
| Protein Kinase | PRKCD | Protein kinase C delta | Q05655 | CHEMBL2996 |
| Protein Kinase | PRKCA | Protein kinase C alpha | P17252 | CHEMBL299 |
| Protein Kinase | PRKCQ | Protein kinase C theta | Q04759 | CHEMBL3920 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Transcription Factor | JUN | Proto-oncogene c-JUN | P05412 | CHEMBL4977 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | FABP2 | Fatty acid binding protein intestinal | P12104 | CHEMBL4879 |
| Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0018105; peptidyl-serine phosphorylation | 1.006E-09 | 4.383E-06 | PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCQ |
| MF | GO:0003824; catalytic activity | GO:0004698; calcium-dependent protein kinase C activity | 1.212E-09 | 4.398E-06 | PRKCA, PRKCB, PRKCG |
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 2.165E-09 | 5.892E-06 | FABP2, FABP3, FABP4, FABP5 |
| BP | GO:0009987; cellular process | GO:0090330; regulation of platelet aggregation | 2.457E-07 | 1.845E-04 | PRKCA, PRKCD, PRKCQ |
| BP | GO:0008152; metabolic process | GO:0050996; positive regulation of lipid catabolic process | 4.630E-07 | 2.951E-04 | PPARA, PRKCD, PRKCE |
| BP | GO:0008152; metabolic process | GO:0035408; histone H3-T6 phosphorylation | 4.878E-07 | 2.951E-04 | PRKCA, PRKCB |
| MF | GO:0003824; catalytic activity | GO:0035403; histone kinase activity (H3-T6 specific) | 4.878E-07 | 2.951E-04 | PRKCA, PRKCB |
| BP | GO:0050896; response to stimulus | GO:0001666; response to hypoxia | 7.563E-07 | 4.223E-04 | PPARA, PPARD, PRKCB, PRKCE, TLR2 |
| BP | GO:0050896; response to stimulus | GO:0046627; negative regulation of insulin receptor signaling pathway | 1.216E-06 | 5.758E-04 | PRKCB, PRKCD, PRKCQ |
| BP | GO:0032501; multicellular organismal process | GO:0032613; interleukin-10 production | 1.463E-06 | 6.369E-04 | PRKCD, TLR2 |
| MF | GO:0003824; catalytic activity | GO:0004699; calcium-independent protein kinase C activity | 1.463E-06 | 6.369E-04 | PRKCD, PRKCE |
| BP | GO:0050896; response to stimulus | GO:0042493; response to drug | 6.982E-06 | 2.236E-03 | FABP3, JUN, PRKCD, PRKCE, PRKCG, TLR2 |
| BP | GO:0008152; metabolic process | GO:0051054; positive regulation of DNA metabolic process | 1.319E-05 | 3.637E-03 | JUN, PRKCD, PRKCG, PRKCQ |
| BP | GO:0009987; cellular process | GO:0034351; negative regulation of glial cell apoptotic process | 1.363E-05 | 3.663E-03 | PRKCA, PRKCD |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 1.413E-05 | 3.706E-03 | FABP3, PPARA, PPARD |
| BP | GO:0002376; immune system process | GO:0045637; regulation of myeloid cell differentiation | 2.145E-05 | 4.915E-03 | JUN, PRKCA, PRKCB, PRKCQ |
| BP | GO:0009987; cellular process | GO:0038093; Fc receptor signaling pathway | 2.251E-05 | 5.054E-03 | JUN, PRKCD, PRKCE, PRKCQ |
| BP | GO:0050896; response to stimulus | GO:0070542; response to fatty acid | 2.410E-05 | 5.354E-03 | FABP3, PRKCE, TLR2 |
| BP | GO:0008152; metabolic process | GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter | 2.673E-05 | 5.700E-03 | PPARA, PPARD |
| BP | GO:0007610; behavior | GO:0007610; behavior | 2.722E-05 | 5.700E-03 | JUN, PPARA, PRKCE, PRKCG, TLR2 |
| MF | GO:0005488; binding | GO:0036041; long-chain fatty acid binding | 2.673E-05 | 5.700E-03 | FABP3, PPARD |
| CC | GO:0044464; cell part | GO:0005829; cytosol | 4.038E-05 | 7.373E-03 | FABP2, FABP3, FABP4, FABP5, JUN, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCQ |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 1.901E-04 | 2.250E-02 | PPARA, PPARD, PRKCA, PRKCB, PRKCG |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09157 Sensory system | hsa04750 | Inflammatory mediator regulation of TRP channels | 3.448E-11 | 1.759E-09 | PRKCG, PRKCB, PRKCE, PRKCD, PRKCA, PRKCQ |
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 3.966E-12 | 4.046E-10 | FABP2, FABP3, FABP4, FABP5, PPARA, PPARD |
| 09150 Organismal Systems | 09153 Circulatory system | hsa04270 | Vascular smooth muscle contraction | 1.188E-10 | 4.038E-09 | PRKCG, PRKCB, PRKCE, PRKCD, PRKCA, PRKCQ |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 5.739E-09 | 9.756E-08 | JUN, PRKCB, PRKCE, PRKCD, PRKCA |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04530 | Tight junction | 2.900E-10 | 7.396E-09 | PRKCG, PRKCB, PRKCE, PRKCD, PRKCA, PRKCQ |
| 09150 Organismal Systems | 09151 Immune system | hsa04666 | Fc gamma R-mediated phagocytosis | 3.777E-09 | 7.705E-08 | PRKCG, PRKCB, PRKCE, PRKCD, PRKCA |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 8.439E-09 | 1.230E-07 | PRKCB, PRKCE, PRKCD, PRKCQ, PPARA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 3.675E-08 | 4.165E-07 | PRKCG, JUN, PRKCB, PRKCA, TLR2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04310 | Wnt signaling pathway | 3.197E-08 | 4.076E-07 | PRKCG, JUN, PRKCB, PRKCA, PPARD |
| 09160 Human Diseases | 09164 Substance dependence | hsa05031 | Amphetamine addiction | 1.123E-07 | 1.145E-06 | PRKCG, JUN, PRKCB, PRKCA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04925 | Aldosterone synthesis and secretion | 2.423E-07 | 2.247E-06 | PRKCG, PRKCB, PRKCE, PRKCA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04912 | GnRH signaling pathway | 3.877E-07 | 3.042E-06 | JUN, PRKCB, PRKCD, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04012 | ErbB signaling pathway | 3.234E-07 | 2.749E-06 | PRKCG, JUN, PRKCB, PRKCA |
| 09160 Human Diseases | 09161 Cancers | hsa05231 | Choline metabolism in cancer | 5.899E-07 | 4.011E-06 | PRKCG, JUN, PRKCB, PRKCA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05146 | Amoebiasis | 5.667E-07 | 4.011E-06 | PRKCG, PRKCB, PRKCA, TLR2 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 5.191E-06 | 2.521E-05 | PRKCG, JUN, PRKCB, PRKCA, PPARD |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 1.178E-06 | 7.508E-06 | PRKCG, PRKCB, PRKCE, PRKCA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04921 | Oxytocin signaling pathway | 3.529E-06 | 1.894E-05 | PRKCG, JUN, PRKCB, PRKCA |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 9.525E-06 | 3.625E-05 | PRKCG, PRKCB, PRKCA, TLR2 |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04510 | Focal adhesion | 9.341E-06 | 3.625E-05 | PRKCG, JUN, PRKCB, PRKCA |
| 09160 Human Diseases | 09161 Cancers | hsa05223 | Non-small cell lung cancer | 7.405E-06 | 3.433E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09155 Excretory system | hsa04961 | Endocrine and other factor-regulated calcium reabsorption | 4.348E-06 | 2.217E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04730 | Long-term depression | 9.126E-06 | 3.625E-05 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04150 | mTOR signaling pathway | 9.126E-06 | 3.625E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09155 Excretory system | hsa04960 | Aldosterone-regulated sodium reabsorption | 2.459E-06 | 1.393E-05 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 2.337E-05 | 7.222E-05 | PRKCG, JUN, PRKCB, PRKCA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05143 | African trypanosomiasis | 1.764E-06 | 1.058E-05 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09161 Cancers | hsa05214 | Glioma | 1.163E-05 | 4.235E-05 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04370 | VEGF signaling pathway | 9.594E-06 | 3.625E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09154 Digestive system | hsa04971 | Gastric acid secretion | 1.719E-05 | 5.479E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04720 | Long-term potentiation | 1.217E-05 | 4.282E-05 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 1.650E-05 | 5.428E-05 | JUN, PRKCB, TLR2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 1.517E-05 | 5.159E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04911 | Insulin secretion | 2.607E-05 | 7.821E-05 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 4.242E-05 | 1.006E-04 | PRKCG, PRKCB, PRKCE, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04727 | GABAergic synapse | 2.893E-05 | 8.197E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09159 Environmental adaptation | hsa04713 | Circadian entrainment | 3.638E-05 | 9.516E-05 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09164 Substance dependence | hsa05032 | Morphine addiction | 3.199E-05 | 8.586E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09154 Digestive system | hsa04970 | Salivary secretion | 2.993E-05 | 8.250E-05 | PRKCG, PRKCB, PRKCA |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04540 | Gap junction | 2.893E-05 | 8.197E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04916 | Melanogenesis | 4.242E-05 | 1.006E-04 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04725 | Cholinergic synapse | 5.792E-05 | 1.284E-04 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04070 | Phosphatidylinositol signaling system | 3.993E-05 | 9.934E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04723 | Retrograde endocannabinoid signaling | 4.370E-05 | 1.013E-04 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09154 Digestive system | hsa04972 | Pancreatic secretion | 3.754E-05 | 9.573E-05 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 4.633E-05 | 1.050E-04 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04724 | Glutamatergic synapse | 6.272E-05 | 1.333E-04 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 5.949E-05 | 1.291E-04 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 6.950E-05 | 1.418E-04 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05164 | Influenza A | 2.233E-04 | 4.297E-04 | JUN, PRKCB, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04728 | Dopaminergic synapse | 9.059E-05 | 1.812E-04 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04020 | Calcium signaling pathway | 2.426E-04 | 4.582E-04 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09151 Immune system | hsa04650 | Natural killer cell mediated cytotoxicity | 1.037E-04 | 2.034E-04 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04015 | Rap1 signaling pathway | 3.867E-04 | 7.172E-04 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09151 Immune system | hsa04670 | Leukocyte transendothelial migration | 6.950E-05 | 1.418E-04 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04014 | Ras signaling pathway | 4.788E-04 | 8.722E-04 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) | 4.855E-03 | 7.177E-03 | JUN, PPARA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04915 | Estrogen signaling pathway | 2.123E-03 | 3.438E-03 | JUN, PRKCD |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 3.959E-03 | 5.939E-03 | PRKCQ, TLR2 |
| 09150 Organismal Systems | 09151 Immune system | hsa04620 | Toll-like receptor signaling pathway | 2.429E-03 | 3.754E-03 | JUN, TLR2 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04722 | Neurotrophin signaling pathway | 3.099E-03 | 4.718E-03 | JUN, PRKCD |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05142 | Chagas disease (American trypanosomiasis) | 2.340E-03 | 3.672E-03 | JUN, TLR2 |
| 09150 Organismal Systems | 09151 Immune system | hsa04660 | T cell receptor signaling pathway | 2.340E-03 | 3.672E-03 | JUN, PRKCQ |
| 09160 Human Diseases | 09162 Immune diseases | hsa05323 | Rheumatoid arthritis | 1.759E-03 | 2.942E-03 | JUN, TLR2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04064 | NF-kappa B signaling pathway | 1.877E-03 | 3.088E-03 | PRKCB, PRKCQ |
| 09150 Organismal Systems | 09151 Immune system | hsa04662 | B cell receptor signaling pathway | 1.162E-03 | 1.976E-03 | JUN, PRKCB |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04920 | Adipocytokine signaling pathway | 1.069E-03 | 1.849E-03 | PRKCQ, PPARA |
| 09160 Human Diseases | 09162 Immune diseases | hsa05321 | Inflammatory bowel disease (IBD) | 9.229E-04 | 1.623E-03 | JUN, TLR2 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04930 | Type II diabetes mellitus | 5.039E-04 | 9.017E-04 | PRKCE, PRKCD |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | JUN; |
| C00-D49: Neoplasms | Cancer | C00-C96 | PRKCB; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Renal transplantation | D89.8 | PRKCB; |
| NA: NA | Reperfusion injury and heart attacks | NA | PRKCD; |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | PRKCB; |
| C00-D49: Neoplasms | Glioblastoma multiforme | C71 | PRKCB; |
| C00-D49: Neoplasms | Non-hodgkin's lymphoma | C85 | PRKCB; |
| C00-D49: Neoplasms | Central nervous system tumors | NA | PRKCB; |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | PRKCE; |
| I00-I99: Diseases of the circulatory system | Acute myocardial infarction | I21-I22 | PRKCD; |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | PRKCB; |
| I00-I99: Diseases of the circulatory system | Ischemic reperfusion injury | I00-I99 | PRKCE; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
