CMAUP Plant Collective Molecular Activities

Plant Name: Tylophora ovata

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0018105; peptidyl-serine phosphorylation	1.006E-09	4.383E-06	PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCQ
MF	GO:0003824; catalytic activity	GO:0004698; calcium-dependent protein kinase C activity	1.212E-09	4.398E-06	PRKCA, PRKCB, PRKCG
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	2.165E-09	5.892E-06	FABP2, FABP3, FABP4, FABP5
BP	GO:0009987; cellular process	GO:0090330; regulation of platelet aggregation	2.457E-07	1.845E-04	PRKCA, PRKCD, PRKCQ
BP	GO:0008152; metabolic process	GO:0050996; positive regulation of lipid catabolic process	4.630E-07	2.951E-04	PPARA, PRKCD, PRKCE
BP	GO:0008152; metabolic process	GO:0035408; histone H3-T6 phosphorylation	4.878E-07	2.951E-04	PRKCA, PRKCB
MF	GO:0003824; catalytic activity	GO:0035403; histone kinase activity (H3-T6 specific)	4.878E-07	2.951E-04	PRKCA, PRKCB
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	7.563E-07	4.223E-04	PPARA, PPARD, PRKCB, PRKCE, TLR2
BP	GO:0050896; response to stimulus	GO:0046627; negative regulation of insulin receptor signaling pathway	1.216E-06	5.758E-04	PRKCB, PRKCD, PRKCQ
BP	GO:0032501; multicellular organismal process	GO:0032613; interleukin-10 production	1.463E-06	6.369E-04	PRKCD, TLR2
MF	GO:0003824; catalytic activity	GO:0004699; calcium-independent protein kinase C activity	1.463E-06	6.369E-04	PRKCD, PRKCE
BP	GO:0050896; response to stimulus	GO:0042493; response to drug	6.982E-06	2.236E-03	FABP3, JUN, PRKCD, PRKCE, PRKCG, TLR2
BP	GO:0050896; response to stimulus	GO:1901701; cellular response to oxygen-containing compound	8.021E-06	2.460E-03	JUN, PPARD, PRKCB, PRKCD, PRKCE, TLR2
BP	GO:0008152; metabolic process	GO:0051054; positive regulation of DNA metabolic process	1.319E-05	3.637E-03	JUN, PRKCD, PRKCG, PRKCQ
BP	GO:0009987; cellular process	GO:0034351; negative regulation of glial cell apoptotic process	1.363E-05	3.663E-03	PRKCA, PRKCD
BP	GO:0051179; localization	GO:0015908; fatty acid transport	1.413E-05	3.706E-03	FABP3, PPARA, PPARD
BP	GO:0002376; immune system process	GO:0045637; regulation of myeloid cell differentiation	2.145E-05	4.915E-03	JUN, PRKCA, PRKCB, PRKCQ
BP	GO:0009987; cellular process	GO:0038093; Fc receptor signaling pathway	2.251E-05	5.054E-03	JUN, PRKCD, PRKCE, PRKCQ
BP	GO:0050896; response to stimulus	GO:0070542; response to fatty acid	2.410E-05	5.354E-03	FABP3, PRKCE, TLR2
BP	GO:0008152; metabolic process	GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter	2.673E-05	5.700E-03	PPARA, PPARD
BP	GO:0007610; behavior	GO:0007610; behavior	2.722E-05	5.700E-03	JUN, PPARA, PRKCE, PRKCG, TLR2
MF	GO:0005488; binding	GO:0036041; long-chain fatty acid binding	2.673E-05	5.700E-03	FABP3, PPARD
CC	GO:0044464; cell part	GO:0005829; cytosol	4.038E-05	7.373E-03	FABP2, FABP3, FABP4, FABP5, JUN, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCQ
BP	GO:0008152; metabolic process	GO:0031400; negative regulation of protein modification process	5.736E-05	9.463E-03	FABP4, JUN, PRKCD, PRKCE, PRKCG

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa04750	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	3.448E-11	1.759E-09	PRKCG; PRKCB; PRKCE; PRKCD; PRKCA; PRKCQ
hsa03320	PPAR signaling pathway_Homo sapiens_hsa03320	3.966E-12	4.046E-10	FABP2; FABP3; FABP4; FABP5; PPARA; PPARD
hsa04270	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.188E-10	4.038E-09	PRKCG; PRKCB; PRKCE; PRKCD; PRKCA; PRKCQ
hsa04933	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	5.739E-09	9.756E-08	JUN; PRKCB; PRKCE; PRKCD; PRKCA
hsa04530	Tight junction_Homo sapiens_hsa04530	2.900E-10	7.396E-09	PRKCG; PRKCB; PRKCE; PRKCD; PRKCA; PRKCQ
hsa04666	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	3.777E-09	7.705E-08	PRKCG; PRKCB; PRKCE; PRKCD; PRKCA
hsa04931	Insulin resistance_Homo sapiens_hsa04931	8.439E-09	1.230E-07	PRKCB; PRKCE; PRKCD; PRKCQ; PPARA
hsa05161	Hepatitis B_Homo sapiens_hsa05161	3.675E-08	4.165E-07	PRKCG; JUN; PRKCB; PRKCA; TLR2
hsa04310	Wnt signaling pathway_Homo sapiens_hsa04310	3.197E-08	4.076E-07	PRKCG; JUN; PRKCB; PRKCA; PPARD
hsa05031	Amphetamine addiction_Homo sapiens_hsa05031	1.123E-07	1.145E-06	PRKCG; JUN; PRKCB; PRKCA
hsa04925	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	2.423E-07	2.247E-06	PRKCG; PRKCB; PRKCE; PRKCA
hsa04912	GnRH signaling pathway_Homo sapiens_hsa04912	3.877E-07	3.042E-06	JUN; PRKCB; PRKCD; PRKCA
hsa04012	ErbB signaling pathway_Homo sapiens_hsa04012	3.234E-07	2.749E-06	PRKCG; JUN; PRKCB; PRKCA
hsa05231	Choline metabolism in cancer_Homo sapiens_hsa05231	5.899E-07	4.011E-06	PRKCG; JUN; PRKCB; PRKCA
hsa05146	Amoebiasis_Homo sapiens_hsa05146	5.667E-07	4.011E-06	PRKCG; PRKCB; PRKCA; TLR2
hsa05200	Pathways in cancer_Homo sapiens_hsa05200	5.191E-06	2.521E-05	PRKCG; JUN; PRKCB; PRKCA; PPARD
hsa04071	Sphingolipid signaling pathway_Homo sapiens_hsa04071	1.178E-06	7.508E-06	PRKCG; PRKCB; PRKCE; PRKCA
hsa04921	Oxytocin signaling pathway_Homo sapiens_hsa04921	3.529E-06	1.894E-05	PRKCG; JUN; PRKCB; PRKCA
hsa05205	Proteoglycans in cancer_Homo sapiens_hsa05205	9.525E-06	3.625E-05	PRKCG; PRKCB; PRKCA; TLR2
hsa04510	Focal adhesion_Homo sapiens_hsa04510	9.341E-06	3.625E-05	PRKCG; JUN; PRKCB; PRKCA
hsa05223	Non-small cell lung cancer_Homo sapiens_hsa05223	7.405E-06	3.433E-05	PRKCG; PRKCB; PRKCA
hsa04961	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	4.348E-06	2.217E-05	PRKCG; PRKCB; PRKCA
hsa04730	Long-term depression_Homo sapiens_hsa04730	9.126E-06	3.625E-05	PRKCG; PRKCB; PRKCA
hsa04150	mTOR signaling pathway_Homo sapiens_hsa04150	9.126E-06	3.625E-05	PRKCG; PRKCB; PRKCA
hsa04960	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	2.459E-06	1.393E-05	PRKCG; PRKCB; PRKCA
hsa04010	MAPK signaling pathway_Homo sapiens_hsa04010	2.337E-05	7.222E-05	PRKCG; JUN; PRKCB; PRKCA
hsa05143	African trypanosomiasis_Homo sapiens_hsa05143	1.764E-06	1.058E-05	PRKCG; PRKCB; PRKCA
hsa05214	Glioma_Homo sapiens_hsa05214	1.163E-05	4.235E-05	PRKCG; PRKCB; PRKCA
hsa04370	VEGF signaling pathway_Homo sapiens_hsa04370	9.594E-06	3.625E-05	PRKCG; PRKCB; PRKCA
hsa04971	Gastric acid secretion_Homo sapiens_hsa04971	1.719E-05	5.479E-05	PRKCG; PRKCB; PRKCA
hsa04720	Long-term potentiation_Homo sapiens_hsa04720	1.217E-05	4.282E-05	PRKCG; PRKCB; PRKCA
hsa05140	Leishmaniasis_Homo sapiens_hsa05140	1.650E-05	5.428E-05	JUN; PRKCB; TLR2
hsa04918	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.517E-05	5.159E-05	PRKCG; PRKCB; PRKCA
hsa04911	Insulin secretion_Homo sapiens_hsa04911	2.607E-05	7.821E-05	PRKCG; PRKCB; PRKCA
hsa05206	MicroRNAs in cancer_Homo sapiens_hsa05206	4.242E-05	1.006E-04	PRKCG; PRKCB; PRKCE; PRKCA
hsa04727	GABAergic synapse_Homo sapiens_hsa04727	2.893E-05	8.197E-05	PRKCG; PRKCB; PRKCA
hsa04713	Circadian entrainment_Homo sapiens_hsa04713	3.638E-05	9.516E-05	PRKCG; PRKCB; PRKCA
hsa05032	Morphine addiction_Homo sapiens_hsa05032	3.199E-05	8.586E-05	PRKCG; PRKCB; PRKCA
hsa04970	Salivary secretion_Homo sapiens_hsa04970	2.993E-05	8.250E-05	PRKCG; PRKCB; PRKCA
hsa04540	Gap junction_Homo sapiens_hsa04540	2.893E-05	8.197E-05	PRKCG; PRKCB; PRKCA
hsa04916	Melanogenesis_Homo sapiens_hsa04916	4.242E-05	1.006E-04	PRKCG; PRKCB; PRKCA
hsa04725	Cholinergic synapse_Homo sapiens_hsa04725	5.792E-05	1.284E-04	PRKCG; PRKCB; PRKCA
hsa04070	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	3.993E-05	9.934E-05	PRKCG; PRKCB; PRKCA
hsa04723	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	4.370E-05	1.013E-04	PRKCG; PRKCB; PRKCA
hsa04972	Pancreatic secretion_Homo sapiens_hsa04972	3.754E-05	9.573E-05	PRKCG; PRKCB; PRKCA
hsa04066	HIF-1 signaling pathway_Homo sapiens_hsa04066	4.633E-05	1.050E-04	PRKCG; PRKCB; PRKCA
hsa04724	Glutamatergic synapse_Homo sapiens_hsa04724	6.272E-05	1.333E-04	PRKCG; PRKCB; PRKCA
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	5.949E-05	1.291E-04	PRKCG; PRKCB; PRKCA
hsa04919	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	6.950E-05	1.418E-04	PRKCG; PRKCB; PRKCA
hsa05164	Influenza A_Homo sapiens_hsa05164	2.233E-04	4.297E-04	JUN; PRKCB; PRKCA
hsa04728	Dopaminergic synapse_Homo sapiens_hsa04728	9.059E-05	1.812E-04	PRKCG; PRKCB; PRKCA
hsa04020	Calcium signaling pathway_Homo sapiens_hsa04020	2.426E-04	4.582E-04	PRKCG; PRKCB; PRKCA
hsa04650	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.037E-04	2.034E-04	PRKCG; PRKCB; PRKCA
hsa04015	Rap1 signaling pathway_Homo sapiens_hsa04015	3.867E-04	7.172E-04	PRKCG; PRKCB; PRKCA
hsa04670	Leukocyte transendothelial migration_Homo sapiens_hsa04670	6.950E-05	1.418E-04	PRKCG; PRKCB; PRKCA
hsa04014	Ras signaling pathway_Homo sapiens_hsa04014	4.788E-04	8.722E-04	PRKCG; PRKCB; PRKCA
hsa04932	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	4.855E-03	7.177E-03	JUN; PPARA
hsa04915	Estrogen signaling pathway_Homo sapiens_hsa04915	2.123E-03	3.438E-03	JUN; PRKCD
hsa05162	Measles_Homo sapiens_hsa05162	3.959E-03	5.939E-03	PRKCQ; TLR2
hsa04620	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	2.429E-03	3.754E-03	JUN; TLR2
hsa04722	Neurotrophin signaling pathway_Homo sapiens_hsa04722	3.099E-03	4.718E-03	JUN; PRKCD
hsa04151	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	2.304E-02	3.219E-02	PRKCA; TLR2
hsa05142	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	2.340E-03	3.672E-03	JUN; TLR2
hsa04660	T cell receptor signaling pathway_Homo sapiens_hsa04660	2.340E-03	3.672E-03	JUN; PRKCQ
hsa05168	Herpes simplex infection_Homo sapiens_hsa05168	7.198E-03	1.049E-02	JUN; TLR2
hsa04062	Chemokine signaling pathway_Homo sapiens_hsa04062	7.349E-03	1.056E-02	PRKCB; PRKCD
hsa04024	cAMP signaling pathway_Homo sapiens_hsa04024	8.286E-03	1.174E-02	JUN; PPARA
hsa05323	Rheumatoid arthritis_Homo sapiens_hsa05323	1.759E-03	2.942E-03	JUN; TLR2
hsa04064	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.877E-03	3.088E-03	PRKCB; PRKCQ
hsa04662	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.162E-03	1.976E-03	JUN; PRKCB
hsa04920	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.069E-03	1.849E-03	PRKCQ; PPARA
hsa05321	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	9.229E-04	1.623E-03	JUN; TLR2
hsa04923	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	3.851E-02	4.849E-02	FABP4
hsa05221	Acute myeloid leukemia_Homo sapiens_hsa05221	3.918E-02	4.874E-02	PPARD
hsa05134	Legionellosis_Homo sapiens_hsa05134	3.783E-02	4.824E-02	TLR2
hsa05130	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	3.783E-02	4.824E-02	PRKCA
hsa05110	Vibrio cholerae infection_Homo sapiens_hsa05110	3.513E-02	4.593E-02	PRKCA
hsa05144	Malaria_Homo sapiens_hsa05144	3.377E-02	4.473E-02	TLR2
hsa05030	Cocaine addiction_Homo sapiens_hsa05030	3.377E-02	4.473E-02	JUN
hsa04930	Type II diabetes mellitus_Homo sapiens_hsa04930	5.039E-04	9.017E-04	PRKCE; PRKCD
hsa04973	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	3.105E-02	4.223E-02	PRKCB
hsa04975	Fat digestion and absorption_Homo sapiens_hsa04975	2.833E-02	3.905E-02	FABP2

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	JUN
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	TLR2
S00-T88: Injury, poisoning and certain other consequences of external causes	Radiation sickness	T66	TLR2
C00-D49: Neoplasms	Cancer	C00-C96	PRKCB; TLR2
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Renal transplantation	D89.8	PRKCB
NA: NA	Reperfusion injury and heart attacks	NA	PRKCD
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	PPARD
C00-D49: Neoplasms	Brain cancer	C71, D33	PRKCB
C00-D49: Neoplasms	Prostate cancer	C61	TLR2
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD
C00-D49: Neoplasms	Glioblastoma multiforme	C71	PRKCB
C00-D49: Neoplasms	Pancreatic cancer	C25	TLR2
C00-D49: Neoplasms	Non-hodgkin's lymphoma	C85	PRKCB
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PPARD; PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD; PPARD
C00-D49: Neoplasms	Central nervous system tumors	NA	PRKCB
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	PPARD
C00-D49: Neoplasms	Melanoma	C43	TLR2
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	PPARD
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	TLR2
NA: NA	Dyslipidemia	NA	PPARD
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PRKCQ
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	PRKCE
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PPARD
I00-I99: Diseases of the circulatory system	Acute myocardial infarction	I21-I22	PRKCD
C00-D49: Neoplasms	Lymphoma	C81-C86	PRKCB
I00-I99: Diseases of the circulatory system	Ischemic reperfusion injury	I00-I99	PRKCE
C00-D49: Neoplasms	Solid tumours	C00-D48	TLR2

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases