CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	ALPL; TDP1; TERT; PGD; POLB;
Miscellaneous ion channel	BCL2;
Lyase	CA2; CA7; CA4; CA12; CA9;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Transcription Factor	NFKB1;
DNA methyltransferase	DNMT1;
ATP-binding cassette	ABCB1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCB1	P-glycoprotein 1	P08183	CHEMBL4302
DNA methyltransferase	DNMT1	DNA (cytosine-5)-methyltransferase 1	P26358	CHEMBL1993
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Enzyme_unclassified	PGD	6-phosphogluconate dehydrogenase	P52209	CHEMBL3404
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729

Showing 1 to 10 of 15 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.988E-11	3.620E-07	CA12, CA2, CA4, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.432E-10	7.795E-07	CA12, CA2, CA4, CA7, CA9
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	4.532E-08	1.096E-04	ABCB1, CA2, CA7
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.688E-06	2.827E-03	CA2, CA7
BP	GO:0019740; nitrogen utilization	GO:0006808; regulation of nitrogen utilization	1.688E-06	2.827E-03	BCL2, NR1H4
BP	GO:0009987; cellular process	GO:0051716; cellular response to stimulus	3.432E-06	4.982E-03	ALPL, BCL2, CA2, CA9, DNMT1, NFKB1, NR1H4, POLB, TDP1, TERT
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.009E-13	8.730E-09	CA12, CA2, CA4, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.091E-06	2.160E-03	CA12, CA2, CA4, CA7, CA9, DNMT1, NR1H4

Showing 1 to 8 of 8 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	6.937E-13	5.064E-11	CA12, CA2, CA4, CA7, CA9
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.892E-05	6.905E-04	ABCB1, CA2, NR1H4
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.316E-04	2.402E-03	CA2, CA4
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	5.717E-05	1.391E-03	DNMT1, ABCB1, BCL2, NFKB1

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	ABCB1;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TERT;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TERT; DNMT1;
C00-D49: Neoplasms	Breast cancer	C50	TERT; CA9; BCL2;
C00-D49: Neoplasms	Pancreatic cancer	C25	TERT;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; DNMT1; ABCB1; CA9; BCL2;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	DNMT1;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9; BCL2;
C00-D49: Neoplasms	Liver cancer	C22	TERT;

Showing 1 to 10 of 40 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Picea mariana

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities