Plant Name: Picea mariana
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ALPL; RECQL; TDP1; TERT; PKM; PGD; GFER; HSD17B10; ALDH1A1; POLB; | |
| GAA; | |
| BCL2; | |
| MET; MAPK14; DYRK1A; | |
| CA2; CA12; CA9; CA1; CA4; CA3; CA14; CA5B; CA5A; CA6; CA7; | |
| NR1H4; | |
| ESR2; | |
| KDM4E; | |
| PTGS1; | |
| BACE1; | |
| CASP1; CASP7; | |
| MMP2; MMP14; | |
| NFKB1; | |
| DNMT1; | |
| ABCB1; | |
| SLCO1B3; SLCO1B1; | |
| MAPT; APP; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP1A2; |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
| Cysteine protease | CASP1 | Caspase-1 | P29466 | CHEMBL4801 |
| Cysteine protease | CASP7 | Caspase-7 | P55210 | CHEMBL3468 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| DNA methyltransferase | DNMT1 | DNA (cytosine-5)-methyltransferase 1 | P26358 | CHEMBL1993 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Enzyme_unclassified | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
| Enzyme_unclassified | PKM | Pyruvate kinase isozymes M1/M2 | P14618 | CHEMBL1075189 |
| Enzyme_unclassified | PGD | 6-phosphogluconate dehydrogenase | P52209 | CHEMBL3404 |
| Enzyme_unclassified | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Lyase | CA3 | Carbonic anhydrase III | P07451 | CHEMBL2885 |
| Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Lyase | CA5B | Carbonic anhydrase VB | Q9Y2D0 | CHEMBL3969 |
| Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
| Metallo protease | MMP14 | Matrix metalloproteinase 14 | P50281 | CHEMBL3869 |
| Miscellaneous ion channel | BCL2 | Apoptosis regulator Bcl-2 | P10415 | CHEMBL4860 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Nuclear hormone receptor subfamily 3 group A | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Oxidoreductase | PTGS1 | Cyclooxygenase-1 | P23219 | CHEMBL221 |
| Protein Kinase | MET | Hepatocyte growth factor receptor | P08581 | CHEMBL3717 |
| Protein Kinase | MAPK14 | MAP kinase p38 alpha | Q16539 | CHEMBL260 |
| Protein Kinase | DYRK1A | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Q13627 | CHEMBL2292 |
| SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
| SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | APP | Beta amyloid A4 protein | P05067 | CHEMBL2487 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 1.021E-10 | 2.021E-07 | CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, ESR2, MMP14, MMP2, NR1H4 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 2.237E-27 | 4.870E-23 | CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
| BP | GO:0051179; localization | GO:2001225; regulation of chloride transport | 1.220E-06 | 1.112E-03 | ABCB1, CA2, CA7 |
| BP | GO:0065007; biological regulation | GO:0010952; positive regulation of peptidase activity | 2.266E-06 | 1.898E-03 | APP, CASP1, CASP7, MAPK14, MAPT, MMP14 |
| BP | GO:0050896; response to stimulus | GO:0014070; response to organic cyclic compound | 3.332E-06 | 2.591E-03 | ALPL, APP, BCL2, CA2, CA9, CASP1, CASP7, CYP1A2, MMP14, NFKB1 |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 1.450E-05 | 9.287E-03 | CA2, CA7 |
| BP | GO:0019740; nitrogen utilization | GO:0006808; regulation of nitrogen utilization | 1.450E-05 | 9.287E-03 | BCL2, NR1H4 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 1.202E-20 | 1.309E-16 | CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 2.354E-19 | 1.025E-15 | CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.379E-26 | 1.641E-24 | CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14 |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 4.235E-07 | 2.520E-05 | SLCO1B1; ABCB1; CA2; SLCO1B3; NR1H4 |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 6.499E-05 | 1.547E-03 | MMP2; BCL2; MAPK14; NFKB1 |
| hsa05010 | Alzheimer's disease_Homo sapiens_hsa05010 | 2.930E-05 | 8.716E-04 | BACE1; APP; CASP7; MAPT; HSD17B10 |
| hsa05133 | Pertussis_Homo sapiens_hsa05133 | 2.015E-05 | 7.991E-04 | CASP7; CASP1; MAPK14; NFKB1 |
| hsa04668 | TNF signaling pathway_Homo sapiens_hsa04668 | 9.061E-05 | 1.797E-03 | MMP14; CASP7; MAPK14; NFKB1 |
| hsa05014 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 1.794E-04 | 3.050E-03 | BCL2; CASP1; MAPK14 |
| hsa05134 | Legionellosis_Homo sapiens_hsa05134 | 2.246E-04 | 3.303E-03 | CASP7; CASP1; NFKB1 |
| hsa05206 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 4.234E-04 | 4.580E-03 | DNMT1; ABCB1; BCL2; MET; NFKB1 |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 4.209E-04 | 4.580E-03 | MAPK14; MET; NFKB1 |
| hsa04621 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.498E-04 | 3.303E-03 | CASP1; MAPK14; NFKB1 |
| hsa04917 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 4.979E-04 | 4.937E-03 | MAPK14; NFKB1; ESR2 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 1.084E-03 | 8.256E-03 | DNMT1; PKM; GAA; CYP1A2; ALDH1A1; ALPL; PGD; HSD17B10; PTGS1 |
| hsa04912 | GnRH signaling pathway_Homo sapiens_hsa04912 | 9.858E-04 | 8.256E-03 | MMP14; MMP2; MAPK14 |
| hsa05132 | Salmonella infection_Homo sapiens_hsa05132 | 8.366E-04 | 7.659E-03 | CASP1; MAPK14; NFKB1 |
| hsa05145 | Toxoplasmosis_Homo sapiens_hsa05145 | 2.080E-03 | 1.367E-02 | BCL2; MAPK14; NFKB1 |
| hsa04722 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 2.182E-03 | 1.367E-02 | BCL2; MAPK14; NFKB1 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 3.376E-03 | 2.009E-02 | CASP7; BCL2; NFKB1 |
| hsa04071 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 2.182E-03 | 1.367E-02 | BCL2; MAPK14; NFKB1 |
| hsa05164 | Influenza A_Homo sapiens_hsa05164 | 6.287E-03 | 3.562E-02 | CASP1; MAPK14; NFKB1 |
| hsa05152 | Tuberculosis_Homo sapiens_hsa05152 | 6.588E-03 | 3.564E-02 | BCL2; MAPK14; NFKB1 |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 9.436E-03 | 3.885E-02 | MMP2; MAPK14; MET |
| hsa05169 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 9.310E-03 | 3.885E-02 | BCL2; MAPK14; NFKB1 |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 1.025E-02 | 3.885E-02 | MMP2; BCL2; MET; NFKB1 |
| hsa05203 | Viral carcinogenesis_Homo sapiens_hsa05203 | 9.690E-03 | 3.885E-02 | POLB; PKM; NFKB1 |
| hsa05230 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 9.137E-03 | 3.885E-02 | PKM; MET |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 8.619E-03 | 3.885E-02 | CYP1A2; ALDH1A1 |
| hsa04623 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 8.366E-03 | 3.885E-02 | CASP1; NFKB1 |
| hsa05131 | Shigellosis_Homo sapiens_hsa05131 | 8.619E-03 | 3.885E-02 | MAPK14; NFKB1 |
| hsa05140 | Leishmaniasis_Homo sapiens_hsa05140 | 1.077E-02 | 3.885E-02 | MAPK14; NFKB1 |
| hsa04622 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 9.940E-03 | 3.885E-02 | MAPK14; NFKB1 |
| hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.110E-03 | 8.256E-03 | CA2; CA4 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.070E-02 | 3.885E-02 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| I00-I99: Diseases of the circulatory system | Heart disease | I00-I52 | MET |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TERT |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TERT; DNMT1; DNMT1 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Brain injury | S09.90 | APP |
| C00-D49: Neoplasms | Breast cancer | C50 | BCL2; CA9; TERT |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | TERT; MMP2 |
| Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Genetic disease | Q00-Q99 | ALPL |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | MAPT |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dietary shortage | E40-E46 | PTGS1 |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; CA1 |
| C00-D49: Neoplasms | Cancer | C00-C96 | BCL2; BCL2; ABCB1; MET; CA9; MAPK14; NFKB1; MMP2; CA1; DNMT1; APP |
| C00-D49: Neoplasms | Glioma | C71 | APP |
| C00-D49: Neoplasms | Glioblastoma multiforme | C71 | DNMT1 |
| NA: NA | Geographic retinal atrophy | NA | APP |
| G00-G99: Diseases of the nervous system G00-G99 | Diagnostic imaging | G30, I73.9 | APP |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | PTGS1 |
| H00-H59: Diseases of the eye and adnexa | Diabetic retinopathy | H36, E10.3, E11.3, E13.3 | MAPK14 |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2; CA4 |
| H00-H59: Diseases of the eye and adnexa | Ocular inflammation | H16.229 | TERT |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | CA4; CA4 |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT |
| I00-I99: Diseases of the circulatory system | Cerebral amyloid angiopathy | I68.0 | APP |
| K00-K95: Diseases of the digestive system | Liver disease | K70-K77 | MET |
| C00-D49: Neoplasms | Lung cancer | C33-C34 | MMP2 |
| H00-H59: Diseases of the eye and adnexa | Macular degeneration | H35.3 | APP |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | BCL2; CA9 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Amyloidosis | E85 | APP |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | MMP2; PTGS1 |
| K00-K95: Diseases of the digestive system | Chemotherapy-induced mucositis | K12.3 | MET |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1 |
| C00-D49: Neoplasms | Liver cancer | C22 | TERT |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | DNMT1 |
| C00-D49: Neoplasms | Leukemia | C90-C95 | BCL2 |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | CA1; CA1 |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | MET |
| C00-D49: Neoplasms | Ovarian cancer | C56 | ABCB1; TERT; MMP2 |
| C00-D49: Neoplasms | Chronic lymphocytic leukaemia | C91 | BCL2 |
| J00-J99: Diseases of the respiratory system | Chronic obstructive pulmonary disease | J40-J44, J47 | MAPK14 |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | PKM; PTGS1 |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | MAPK14; PTGS1 |
| NA: NA | Inflammatory diseases | NA | MAPK14 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MAPK14; PTGS1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | CASP1; MET |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | DNMT1; DNMT1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | BCL2; MAPK14 |
| C00-D49: Neoplasms | Prostate cancer | C61 | BCL2; TERT |
| A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL |
| I00-I99: Diseases of the circulatory system | Acute coronary syndrome | I74 | MAPK14 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Acne vulgaris | L70.0 | MMP2; PTGS1 |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | MAPT |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | PTGS1 |
| I00-I99: Diseases of the circulatory system | Neurological disease | I21, I22, R52, R52.1-R52.2, R60.9, G89 | APP |
| C00-D49: Neoplasms | Advanced melanoma | C43 | BCL2 |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | ABCB1; MET; DNMT1 |
| C00-D49: Neoplasms | Non-small-cell lung cancer | NA | MMP2 |
| NA: NA | Acute respiratory distress syndrome | NA | MAPK14 |
| C00-D49: Neoplasms | Adrenocortical carcinoma | C74.0 | ABCB1 |
| C00-D49: Neoplasms | Melanoma | C43 | TERT |
| J00-J99: Diseases of the respiratory system | Acute lung injury | J80 | MAPK14 |
| NA: NA | Rheumatold arthritis | NA | MAPK14; PTGS1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CASP1; MAPK14 |
| C00-D49: Neoplasms | Colon cancer | C50 | ALPL |
| C00-D49: Neoplasms | Soft tissue sarcoma | C00-D49 | DNMT1 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | ABCB1; MET; CA9; MMP2; MMP14; PKM |
| C00-D49: Neoplasms | Multiple myeloma | C90 | BCL2; TERT |
| C00-D49: Neoplasms | Renal cell carcinoma | NA | MMP2 |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
| I00-I99: Diseases of the circulatory system | Coronary artery disease | I20-I25 | MAPK14; MAPK14 |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | PTGS1 |
| NA: NA | Miosis during ocular surgery | NA | PTGS1 |
| G00-G99: Diseases of the nervous system G00-G99 | Amyotrophic lateral sclerosis | G12.2 | BCL2 |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAPT; APP |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Postoperative inflammation | T81 | PTGS1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Pompe's disease | E74.02 | GAA |
| C00-D49: Neoplasms | Refractory renal cell carcinoma | C64 | PKM |
| C00-D49: Neoplasms | Advanced solid tumor | C00-C75, C7A, C7B | MET |
| H00-H59: Diseases of the eye and adnexa | Age related macular degeneration | H35.3 | APP |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
| NA: NA | Edema | NA | CA2 |
| N00-N99: Diseases of the genitourinary system | Dysmenorrhea | N94.4-N94.6 | PTGS1 |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | TERT |
| C00-D49: Neoplasms | Tumors | C00-D48 | TERT |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatitis | L20-L30 | PTGS1 |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | CASP1 |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | ABCB1 |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | PTGS1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthritis | M00-M25 | MAPK14 |
| G00-G99: Diseases of the nervous system G00-G99 | Mild to moderate alzheimer disease | G30 | APP |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mild cognitive impairment | F06.7 | APP |
| C00-D49: Neoplasms | Metastatic HER2-negative gastric cancer | NA | MET |