CMAUP Plant Collective Molecular Activities

Plant Name: Astilbe chinensis

Taxonomic Information:

Plant ID: NPO6947
Plant Latin Name: Astilbe chinensis
Taxonomy Genus: Astilbe
Taxonomy Family: Saxifragaceae

Plant External Links:

NCBI TaxonomyDB: 268493
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA1; CA9;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Toll-like and Il-1 receptors	TLR2;
ATP-binding cassette	ABCG2;
Unclassified	FABP3; FABP4; FABP5; FABP2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	4.557E-10	3.308E-06	FABP2, FABP3, FABP4, FABP5
BP	GO:0051179; localization	GO:0015711; organic anion transport	1.068E-06	1.550E-03	CA1, CA9, FABP3, PPARA, PPARD
BP	GO:0051179; localization	GO:0015908; fatty acid transport	4.704E-06	5.391E-03	FABP3, PPARA, PPARD
BP	GO:0008152; metabolic process	GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter	1.323E-05	1.201E-02	PPARA, PPARD
MF	GO:0005488; binding	GO:0036041; long-chain fatty acid binding	1.323E-05	1.201E-02	FABP3, PPARD
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.524E-05	2.198E-02	CA1, CA9
BP	GO:0050896; response to stimulus	GO:0050727; regulation of inflammatory response	3.059E-05	2.562E-02	FABP4, PPARA, PPARD, TLR2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.804E-13	8.692E-12	FABP2, FABP3, FABP4, FABP5, PPARA, PPARD
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.048E-05	4.724E-04	CA1, CA9
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	3.591E-02	9.161E-02	TLR2
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	3.495E-02	9.161E-02	ABCG2
09150 Organismal Systems	09152 Endocrine system	hsa04922	Glucagon signaling pathway	4.938E-02	9.161E-02	PPARA
09160 Human Diseases	09167 Infectious diseases	hsa05146	Amoebiasis	4.890E-02	9.161E-02	TLR2
09160 Human Diseases	09162 Immune diseases	hsa05323	Rheumatoid arthritis	4.411E-02	9.161E-02	TLR2
09150 Organismal Systems	09151 Immune system	hsa04620	Toll-like receptor signaling pathway	5.177E-02	9.161E-02	TLR2
09160 Human Diseases	09167 Infectious diseases	hsa05142	Chagas disease (American trypanosomiasis)	5.081E-02	9.161E-02	TLR2
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	5.319E-02	9.161E-02	PPARA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1;
C00-D49: Neoplasms	Cancer	C00-C96	CA1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases