CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	4.557E-10	3.308E-06	FABP2, FABP3, FABP4, FABP5
BP	GO:0051179; localization	GO:0015711; organic anion transport	1.068E-06	1.550E-03	CA1, CA9, FABP3, PPARA, PPARD
BP	GO:0051179; localization	GO:0015908; fatty acid transport	4.704E-06	5.391E-03	FABP3, PPARA, PPARD

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa03320	PPAR signaling pathway_Homo sapiens_hsa03320	2.804E-13	8.692E-12	FABP2; FABP3; FABP4; FABP5; PPARA; PPARD
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	3.048E-05	4.724E-04	CA1; CA9

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	TLR2
C00-D49: Neoplasms	Renal cancer	C64	CA9
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9; TLR2
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
S00-T88: Injury, poisoning and certain other consequences of external causes	Radiation sickness	T66	TLR2
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	PPARD
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	PPARD
C00-D49: Neoplasms	Prostate cancer	C61	TLR2
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
C00-D49: Neoplasms	Melanoma	C43	TLR2
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	PPARD
C00-D49: Neoplasms	Pancreatic cancer	C25	TLR2
C00-D49: Neoplasms	Breast cancer	C50	CA9
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PPARD; PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PPARD
C00-D49: Neoplasms	Cancer	C00-C96	CA1; CA9; TLR2
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	TLR2
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD; PPARD
NA: NA	Dyslipidemia	NA	PPARD
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Astilbe chinensis

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases