CMAUP Plant Collective Molecular Activities

Plant Name: Clematis chinensis

Taxonomic Information:

Plant ID: NPO6583
Plant Latin Name: Clematis chinensis
Taxonomy Genus: Clematis
Taxonomy Family: Ranunculaceae

Plant External Links:

NCBI TaxonomyDB: 748693
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM; Kampo

Medicinal Functions:

Anodyne; Antidote; Antiperiodic; Antirheumatic; Antispasmodic; Antitumor; Cancer; Carminative; Diuretic

Geographical Distribution:

China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Protein Kinase	MAPK1;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Enzyme_unclassified	ALOX15;
Oxidoreductase	ALOX5;
Unclassified	FABP3; FABP4; LMNA; MPEG1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	MPEG1	Macrophage-expressed gene 1 protein	Q2M385	CHEMBL3414409

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0005504; fatty acid binding	2.904E-07	2.451E-03	FABP3, FABP4, FFAR4

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.994E-05	1.934E-03	ALOX5, ALOX15, MAPK1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ALOX5;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ALOX5;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	ALOX5;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ALOX5;
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	ALOX5;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	ALOX5;
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	ALOX5;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ALOX5;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	ALOX5;
J00-J99: Diseases of the respiratory system	Asthma	J45	ALOX5;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	ALOX5;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ALOX5;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	ALOX5;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	ALOX5;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1;
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	ALOX5;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	ALOX5;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases