CMAUP Plant Collective Molecular Activities

Plant Name: Spiraea japonica

Taxonomic Information:

Plant ID: NPO6485
Plant Latin Name: Spiraea japonica
Taxonomy Genus: Spiraea
Taxonomy Family: Rosaceae

Plant External Links:

NCBI TaxonomyDB: 309823
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HTR6;
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	TDP1; RECQL; MTOR; ALDH1A1;
Protein Kinase	CDK2; GSK3B; CDK1;
Oxidoreductase	MT-ND4;
Transcription Factor	TP53; AHR;
Unclassified	MAPT; PMP22; GMNN; LMNA; RAB9A;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	MTOR	Serine/threonine-protein kinase mTOR	P42345	CHEMBL2842
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Oxidoreductase	MT-ND4	NADH-ubiquinone oxidoreductase chain 4	P03905	CHEMBL4499
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	CDK2	Cyclin-dependent kinase 2	P24941	CHEMBL301
Protein Kinase	GSK3B	Glycogen synthase kinase-3 beta	P49841	CHEMBL262
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Small molecule receptor (family A GPCR)	HTR6	Serotonin 6 (5-HT6) receptor	P50406	CHEMBL3371
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	PMP22	Peripheral myelin protein 22	Q01453	CHEMBL1293298
Unclassified	GMNN	Geminin	O75496	CHEMBL1293278
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:1901216; positive regulation of neuron death	1.327E-06	2.889E-02	GSK3B, MAPT, MTOR, TP53
BP	GO:0009987; cellular process	GO:0006281; DNA repair	8.910E-06	3.880E-02	CDK1, CDK2, MTOR, RECQL, TDP1, TP53
BP	Unclassified;	GO:0051534; negative regulation of NFAT protein import into nucleus	1.124E-05	3.991E-02	GSK3B, MTOR
BP	GO:0009987; cellular process	GO:0000733; DNA strand renaturation	4.034E-05	3.992E-02	RECQL, TP53
CC	GO:0043226; organelle	GO:0015030; Cajal body	2.365E-05	3.992E-02	CDK2, SMN1, SMN2
MF	GO:0005488; binding	GO:0034452; dynactin binding	6.155E-05	4.061E-02	GSK3B, MAPT
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	7.381E-05	4.145E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	8.718E-05	4.151E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	HTR6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	HTR6;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
C00-D49: Neoplasms	Solid tumors	NA	MTOR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MTOR;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
NA: NA	Coronary artery restenosis	NA	MTOR;
C00-D49: Neoplasms	Bladder cancer	C67	MTOR;
C00-D49: Neoplasms	Lymphoma	C81-C86	MTOR;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	GSK3B;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	HTR6;
C00-D49: Neoplasms	Non-hodgkin's lymphoma	C85	MTOR;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MTOR;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	HTR6; MAPT;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	HTR6; MAPT; GSK3B;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Organ rejection	D89.8, T86	MTOR;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Transplant rejection	D89.8, T86	MTOR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	HTR6;
C00-D49: Neoplasms	Pancreatic cancer	C25	MTOR;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	MTOR;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MTOR;
C00-D49: Neoplasms	Advanced kidney cancer	C64	MTOR;
C00-D49: Neoplasms	Multiple myeloma	C90	MTOR;
C00-D49: Neoplasms	Osteosarcoma	C40-C41	GSK3B;
C00-D49: Neoplasms	Cancer	C00-C96	GSK3B; MTOR;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HTR6;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MTOR;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MTOR;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	HTR6; MAPT;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	HTR6;
C00-D49: Neoplasms	Renal cancer	C64	MTOR;
A00-B99: Certain infectious and parasitic diseases	Dutch elm disease	B81-B83	MTOR;
C00-D49: Neoplasms	Sarcoma	C81-C86	MTOR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases