Plant Name: Spiraea japonica
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa05215 | Prostate cancer_Homo sapiens_hsa05215 | 2.069E-06 | 1.759E-04 | GSK3B; CDK2; TP53; MTOR |
| hsa05162 | Measles_Homo sapiens_hsa05162 | 1.119E-05 | 3.171E-04 | GSK3B; CDK2; RAB9A; TP53 |
| hsa04110 | Cell cycle_Homo sapiens_hsa04110 | 7.764E-06 | 3.171E-04 | GSK3B; CDK2; CDK1; TP53 |
| hsa05169 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 5.284E-05 | 8.982E-04 | GSK3B; CDK2; CDK1; TP53 |
| hsa04115 | p53 signaling pathway_Homo sapiens_hsa04115 | 4.999E-05 | 8.982E-04 | CDK2; CDK1; TP53 |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 2.113E-04 | 2.992E-03 | HTR6; CYP2D6; CYP2C19 |
| hsa04151 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 3.950E-04 | 4.197E-03 | GSK3B; CDK2; TP53; MTOR |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 2.464E-04 | 2.992E-03 | GSK3B; TP53; MTOR |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 7.002E-04 | 6.613E-03 | GSK3B; CDK2; TP53; MTOR |
| hsa05203 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.232E-03 | 9.518E-03 | CDK2; CDK1; TP53 |
| hsa05168 | Herpes simplex infection_Homo sapiens_hsa05168 | 9.160E-04 | 7.786E-03 | CDK2; CDK1; TP53 |
| hsa05213 | Endometrial cancer_Homo sapiens_hsa05213 | 1.349E-03 | 9.555E-03 | GSK3B; TP53 |
| hsa05214 | Glioma_Homo sapiens_hsa05214 | 2.099E-03 | 1.181E-02 | TP53; MTOR |
| hsa05210 | Colorectal cancer_Homo sapiens_hsa05210 | 1.912E-03 | 1.161E-02 | GSK3B; TP53 |
| hsa05217 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.508E-03 | 9.859E-03 | GSK3B; TP53 |
| hsa05230 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 2.228E-03 | 1.181E-02 | TP53; MTOR |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.361E-03 | 1.181E-02 | CYP2D6; CYP2C19 |
| hsa04012 | ErbB signaling pathway_Homo sapiens_hsa04012 | 3.723E-03 | 1.665E-02 | GSK3B; MTOR |
| hsa05222 | Small cell lung cancer_Homo sapiens_hsa05222 | 3.639E-03 | 1.665E-02 | CDK2; TP53 |
| hsa04211 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 4.330E-03 | 1.840E-02 | TP53; MTOR |
| hsa04914 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 4.697E-03 | 1.901E-02 | CDK2; CDK1 |
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 5.776E-03 | 2.232E-02 | GSK3B; MTOR |
| hsa04722 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 6.959E-03 | 2.572E-02 | GSK3B; TP53 |
| hsa04114 | Oocyte meiosis_Homo sapiens_hsa04114 | 7.299E-03 | 2.585E-02 | CDK2; CDK1 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 9.364E-03 | 2.921E-02 | LMNA; TP53 |
| hsa05160 | Hepatitis C_Homo sapiens_hsa05160 | 8.485E-03 | 2.885E-02 | GSK3B; TP53 |
| hsa05161 | Hepatitis B_Homo sapiens_hsa05161 | 1.015E-02 | 2.975E-02 | CDK2; TP53 |
| hsa04310 | Wnt signaling pathway_Homo sapiens_hsa04310 | 9.622E-03 | 2.921E-02 | GSK3B; TP53 |
| hsa04910 | Insulin signaling pathway_Homo sapiens_hsa04910 | 9.236E-03 | 2.921E-02 | GSK3B; MTOR |
| hsa03013 | RNA transport_Homo sapiens_hsa03013 | 1.387E-02 | 3.803E-02 | SMN2; SMN1 |
| hsa05010 | Alzheimer's disease_Homo sapiens_hsa05010 | 1.326E-02 | 3.758E-02 | GSK3B; MAPT |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.897E-02 | 4.885E-02 | TP53; MTOR |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.827E-02 | 4.853E-02 | HTR6; TSHR |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| G00-G99: Diseases of the nervous system G00-G99 | Migraine | G43 | CYP2D6 |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Emesis | R11 | HTR6 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Schizophrenia | F20 | HTR6 |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53 |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6 |
| C00-D49: Neoplasms | Solid tumors | NA | MTOR |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CDK2; TP53; MTOR |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2 |
| NA: NA | Coronary artery restenosis | NA | MTOR |
| C00-D49: Neoplasms | Breast cancer | C50 | CDK1 |
| C00-D49: Neoplasms | Bladder cancer | C67 | MTOR |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | MTOR |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | GSK3B |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CYP2D6 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | HTR6; HTR6 |
| C00-D49: Neoplasms | Non-hodgkin's lymphoma | C85 | MTOR |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MTOR |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; TP53 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | MAPT; HTR6 |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAPT; GSK3B; HTR6; HTR6; HTR6 |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| C00-D49: Neoplasms | Thymoma | C37, D15.0 | CDK2 |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53 |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Organ rejection | D89.8, T86 | MTOR |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Transplant rejection | D89.8, T86 | MTOR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Dementia | F01-F07 | HTR6 |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | MTOR |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | CDK1; MTOR |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | MTOR |
| C00-D49: Neoplasms | Advanced kidney cancer | C64 | MTOR |
| C00-D49: Neoplasms | Multiple myeloma | C90 | AHR; MTOR; MTOR |
| C00-D49: Neoplasms | Osteosarcoma | C40-C41 | GSK3B |
| C00-D49: Neoplasms | Cancer | C00-C96 | CDK2; GSK3B; TP53; CDK1; MTOR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53 |
| C00-D49: Neoplasms | Acute lymphoblastic leukemia | C91.0 | CDK2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | HTR6 |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | CDK2; MTOR |
| NA: NA | HIV infections | NA | AHR |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53 |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MTOR |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | MAPT; HTR6 |
| I00-I99: Diseases of the circulatory system | Neurological disease | I21, I22, R52, R52.1-R52.2, R60.9, G89 | HTR6 |
| C00-D49: Neoplasms | Renal cancer | C64 | MTOR |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53 |
| A00-B99: Certain infectious and parasitic diseases | Dutch elm disease | B81-B83 | MTOR |
| C00-D49: Neoplasms | Sarcoma | C81-C86 | MTOR |