CMAUP Plant Collective Molecular Activities

Plant Name: Asarum sieboldii

Taxonomic Information:

Plant ID: NPO6336
Plant Latin Name: Asarum sieboldii
Taxonomy Genus: Asarum
Taxonomy Family: Aristolochiaceae

Plant External Links:

NCBI TaxonomyDB: 76098
Plant-of-the-World-Online: 93573-1

Used in Medicines:

Country/Region:

South Korea; China

Traditional Medicine System:

TCM; Kampo

Medicinal Functions:

Anaesthetic; Analgesic; Antibacterial; Antipyretic; Diaphoretic; Diuretic; Emetic; Expectorant; Hypotensive; Odontalgic; Purgative; Sedative; Sternutatory

Geographical Distribution:

Japan; South Korea; China; South Africa

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADRB1;
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	TDP1;
Voltage-gated calcium channel	CACNA1C;
Protein Kinase	EPHB4; IRAK1; SLK; BLK; MAP4K4; MKNK2; MAPK1; MAPK14; SIK2; EGFR; ERBB2; IRAK4; CHEK2; ERBB4; LCK; MAPK10; FRK; HCK; LYN;
Lyase	CA12; CA7; CA4;
Transcription Factor	HIF1A; TP53; NFKB1;
Unclassified	LMNA; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	EPHB4	Ephrin type-B receptor 4	P54760	CHEMBL5147
Protein Kinase	IRAK1	Interleukin-1 receptor-associated kinase 1	P51617	CHEMBL3357
Protein Kinase	SLK	Serine/threonine-protein kinase 2	Q9H2G2	CHEMBL4202
Protein Kinase	BLK	Tyrosine-protein kinase BLK	P51451	CHEMBL2250
Protein Kinase	MAP4K4	Mitogen-activated protein kinase kinase kinase kinase 4	O95819	CHEMBL6166
Protein Kinase	MKNK2	MAP kinase signal-integrating kinase 2	Q9HBH9	CHEMBL4204
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	MAPK14	MAP kinase p38 alpha	Q16539	CHEMBL260
Protein Kinase	SIK2	Serine/threonine-protein kinase SIK2	Q9H0K1	CHEMBL5699
Protein Kinase	EGFR	Epidermal growth factor receptor erbB1	P00533	CHEMBL203
Protein Kinase	ERBB2	Receptor protein-tyrosine kinase erbB-2	P04626	CHEMBL1824
Protein Kinase	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3	CHEMBL3778
Protein Kinase	CHEK2	Serine/threonine-protein kinase Chk2	O96017	CHEMBL2527
Protein Kinase	ERBB4	Receptor protein-tyrosine kinase erbB-4	Q15303	CHEMBL3009
Protein Kinase	LCK	Tyrosine-protein kinase LCK	P06239	CHEMBL258
Protein Kinase	MAPK10	c-Jun N-terminal kinase 3	P53779	CHEMBL2637
Protein Kinase	FRK	Tyrosine-protein kinase FRK	P42685	CHEMBL4223
Protein Kinase	HCK	Tyrosine-protein kinase HCK	P08631	CHEMBL3234
Protein Kinase	LYN	Tyrosine-protein kinase Lyn	P07948	CHEMBL3905
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	ADRB1	Beta-1 adrenergic receptor	P08588	CHEMBL213
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Voltage-gated calcium channel	CACNA1C	Voltage-gated L-type calcium channel alpha-1C subunit	Q13936	CHEMBL1940

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0038083; peptidyl-tyrosine autophosphorylation	1.620E-12	2.015E-09	BLK, EGFR, ERBB4, FRK, HCK, LCK, LYN
MF	Unclassified;	GO:0004716; signal transducer, downstream of receptor, with protein tyrosine kinase activity	1.001E-09	4.543E-07	EGFR, ERBB2, ERBB4, LYN
BP	GO:0050896; response to stimulus	GO:0031663; lipopolysaccharide-mediated signaling pathway	2.043E-09	7.945E-07	HCK, IRAK1, LYN, MAPK1, MAPK14
MF	GO:0003824; catalytic activity	GO:0004715; non-membrane spanning protein tyrosine kinase activity	2.755E-08	7.406E-06	BLK, FRK, HCK, LCK, LYN
MF	GO:0005488; binding	GO:0019903; protein phosphatase binding	5.348E-08	1.338E-05	EGFR, ERBB2, LCK, MAPK14, MAPT, TP53
CC	GO:0044464; cell part	GO:0031234; extrinsic component of cytoplasmic side of plasma membrane	1.598E-07	3.253E-05	BLK, FRK, HCK, LCK, LYN
BP	GO:0065007; biological regulation	GO:0051090; regulation of DNA binding transcription factor activity	2.835E-07	5.322E-05	ADORA3, HCK, IRAK1, IRAK4, MAPK1, MAPK10, MAPK14, NFKB1
MF	GO:0005488; binding	GO:0005102; receptor binding	1.009E-06	1.704E-04	ADRB1, BLK, EGFR, ERBB2, ERBB4, FRK, HCK, HIF1A, IRAK4, LCK, LYN, MAPT, TP53
BP	GO:0009987; cellular process	GO:0034605; cellular response to heat	1.132E-06	1.868E-04	IRAK1, LYN, MAPT, TP53
MF	Unclassified;	GO:0004707; MAP kinase activity	1.790E-06	2.845E-04	MAPK1, MAPK10, MAPK14
MF	Unclassified;	GO:0004708; MAP kinase kinase activity	2.235E-06	3.378E-04	MAPK1, MAPK10, MAPK14
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.235E-06	3.378E-04	CA12, CA4, CA7
MF	GO:0060089; molecular transducer activity	GO:0004714; transmembrane receptor protein tyrosine kinase activity	4.151E-06	5.832E-04	EGFR, EPHB4, ERBB2, ERBB4
MF	GO:0003824; catalytic activity	GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity	5.337E-06	7.355E-04	EGFR, ERBB2, ERBB4, LCK
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	1.230E-05	1.505E-03	EGFR, ERBB4, HCK, HIF1A, IRAK1, LMNA, MAP4K4, NFKB1, TP53
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.740E-05	2.016E-03	CA4, EGFR, ERBB2, ERBB4, TSHR
CC	GO:0032991; macromolecular complex	GO:0043235; receptor complex	1.858E-05	2.119E-03	EGFR, ERBB2, ERBB4, IRAK1, LYN, TSHR
MF	GO:0005488; binding	GO:0046982; protein heterodimerization activity	2.107E-05	2.341E-03	ADRB1, EGFR, ERBB2, HIF1A, IRAK1, NFKB1, TP53
BP	GO:0051179; localization	GO:0042307; positive regulation of protein import into nucleus	2.570E-05	2.799E-03	EGFR, ERBB4, MAPK1, MAPK14
BP	GO:0008152; metabolic process	GO:0046854; phosphatidylinositol phosphorylation	2.675E-05	2.884E-03	EGFR, ERBB2, ERBB4, LCK
MF	GO:0005488; binding	GO:0001784; phosphotyrosine residue binding	3.138E-05	3.254E-03	HCK, LCK, MAPK1
BP	GO:0009987; cellular process	GO:0071456; cellular response to hypoxia	3.248E-05	3.308E-03	HIF1A, IRAK1, LMNA, TP53
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.419E-05	3.447E-03	CA12, CA4, CA7
BP	GO:0065007; biological regulation	GO:0007190; activation of adenylate cyclase activity	3.716E-05	3.695E-03	ADORA3, ADRB1, TSHR
BP	GO:0009987; cellular process	GO:0038128; ERBB2 signaling pathway	4.361E-05	4.201E-03	EGFR, ERBB2, ERBB4
BP	GO:0050896; response to stimulus	GO:0050727; regulation of inflammatory response	5.280E-05	4.913E-03	CYP19A1, EGFR, HCK, LYN, MAPK14, NFKB1
MF	GO:0005488; binding	GO:0019901; protein kinase binding	5.516E-05	5.068E-03	CHEK2, EGFR, HIF1A, LCK, MAPK1, MAPK14, TP53
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	6.281E-05	5.675E-03	CA12, CA4, CA7
MF	GO:0005488; binding	GO:0042802; identical protein binding	6.892E-05	6.126E-03	CHEK2, EGFR, ERBB2, ERBB4, IRAK1, LCK, MAPK1, MAPT, NFKB1, SLK, TP53
BP	GO:0040007; growth	GO:0045927; positive regulation of growth	7.845E-05	6.860E-03	EGFR, ERBB2, ERBB4, MAPK14, MAPT
BP	GO:0009987; cellular process	GO:0090400; stress-induced premature senescence	8.365E-05	7.171E-03	MAPK14, TP53
BP	GO:0050896; response to stimulus	GO:0009314; response to radiation	8.402E-05	7.174E-03	CHEK2, EGFR, HIF1A, MAPK10, MAPK14, TP53
BP	GO:0009987; cellular process	GO:0019896; axonal transport of mitochondrion	1.074E-04	8.997E-03	HIF1A, MAPT
BP	GO:0032501; multicellular organismal process	GO:0048143; astrocyte activation	1.074E-04	8.997E-03	EGFR, MAPT
BP	GO:0040011; locomotion	GO:0030335; positive regulation of cell migration	1.084E-04	9.040E-03	EGFR, HIF1A, LYN, MAPK1, MAPK14, TP53
BP	GO:0009987; cellular process	GO:0070228; regulation of lymphocyte apoptotic process	1.099E-04	9.134E-03	HIF1A, LYN, TP53
BP	GO:0008152; metabolic process	GO:0045893; positive regulation of transcription, DNA-templated	1.109E-04	9.145E-03	CHEK2, EGFR, ERBB2, ERBB4, HIF1A, IRAK1, MAPK1, MAPK14, NFKB1, TP53
BP	GO:0065007; biological regulation	GO:0000187; activation of MAPK activity	1.124E-04	9.200E-03	IRAK1, MAPK1, MAPK10, MAPK14
MF	GO:0005488; binding	GO:0005524; ATP binding	2.031E-14	4.422E-11	BLK, CHEK2, EGFR, EPHB4, ERBB2, ERBB4, FRK, HCK, IRAK1, IRAK4, LCK, LYN, MAP4K4, MAPK1, MAPK10, MAPK14, MKNK2, SIK2, SLK, TP53

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	9.538E-12	1.393E-09	MAPK10, MKNK2, MAPK1, MAPT, CACNA1C, MAPK14, TP53, EGFR, NFKB1, MAP4K4
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	1.280E-09	6.230E-08	MAPK10, ERBB2, MAPK1, TP53, EGFR, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	1.103E-09	6.230E-08	MAPK10, IRAK1, MAPK1, IRAK4, MAPK14, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	2.806E-09	1.024E-07	MAPK10, IRAK1, MAPK1, IRAK4, MAPK14, NFKB1
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	4.267E-08	7.041E-07	ERBB4, ERBB2, MAPK1, MAPK14, TP53, HIF1A, EGFR
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	1.927E-08	4.777E-07	MKNK2, ERBB2, MAPK1, HIF1A, EGFR, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04620	Toll-like receptor signaling pathway	2.290E-08	4.777E-07	MAPK10, IRAK1, MAPK1, IRAK4, MAPK14, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05142	Chagas disease (American trypanosomiasis)	2.042E-08	4.777E-07	MAPK10, IRAK1, MAPK1, IRAK4, MAPK14, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	4.361E-08	7.041E-07	MAPK10, IRAK1, MAPK1, IRAK4, MAPK14, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	4.822E-08	7.041E-07	MAPK10, ADORA3, MAPK1, MAPK14, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	8.912E-08	1.133E-06	MAPK10, MAPK1, MAPK14, TP53, EGFR, NFKB1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	9.354E-08	1.133E-06	ERBB2, MAPK1, TP53, HIF1A, EGFR
09160 Human Diseases	09167 Infectious diseases	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1.008E-07	1.133E-06	LYN, MAPK10, MAPK14, EGFR, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	1.444E-07	1.506E-06	IRAK1, MAPK1, IRAK4, MAPK14, NFKB1
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	3.915E-07	3.572E-06	ERBB2, MAPK1, TP53, EGFR, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04012	ErbB signaling pathway	3.493E-07	3.400E-06	MAPK10, ERBB4, ERBB2, MAPK1, EGFR
09150 Organismal Systems	09152 Endocrine system	hsa04912	GnRH signaling pathway	4.375E-07	3.758E-06	MAPK10, MAPK1, CACNA1C, MAPK14, EGFR
09160 Human Diseases	09167 Infectious diseases	hsa05152	Tuberculosis	4.995E-07	3.838E-06	MAPK10, IRAK1, MAPK1, IRAK4, MAPK14, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	9.595E-07	6.671E-06	MAPK10, MAPK1, ADRB1, CACNA1C, NFKB1, TSHR
09160 Human Diseases	09167 Infectious diseases	hsa05169	Epstein-Barr virus infection	1.047E-06	6.949E-06	MAPK10, LYN, IRAK1, MAPK14, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04064	NF-kappa B signaling pathway	4.878E-07	3.838E-06	LYN, IRAK1, LCK, IRAK4, NFKB1
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	3.901E-06	1.964E-05	MAPK10, ERBB2, MAPK1, HIF1A, TP53, EGFR, NFKB1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	3.697E-06	1.928E-05	MAPK10, LMNA, MAPK1, TP53, NFKB1
09150 Organismal Systems	09158 Development	hsa04380	Osteoclast differentiation	2.769E-06	1.555E-05	MAPK10, LCK, MAPK1, MAPK14, NFKB1
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	2.401E-06	1.461E-05	ERBB2, MAPK1, TP53, EGFR
09160 Human Diseases	09161 Cancers	hsa05213	Endometrial cancer	1.778E-06	1.129E-05	ERBB2, MAPK1, TP53, EGFR
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	6.741E-07	4.921E-06	ERBB2, MAPK1, TP53, EGFR
09160 Human Diseases	09167 Infectious diseases	hsa05164	Influenza A	1.097E-05	4.855E-05	MAPK10, MAPK1, IRAK4, MAPK14, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	1.258E-05	5.401E-05	ERBB4, ERBB2, ADRB1, CACNA1C, EGFR
09150 Organismal Systems	09151 Immune system	hsa04664	Fc epsilon RI signaling pathway	5.248E-06	2.472E-05	LYN, MAPK10, MAPK1, MAPK14
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2.529E-05	9.716E-05	MAPK10, MAPK1, MAPK14, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	6.598E-06	3.010E-05	MAPK10, MAPK1, MAPK14, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	2.579E-06	1.506E-05	MAPK10, MAPK1, MAPK14, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	2.529E-05	9.716E-05	MAPK10, MAPK1, CACNA1C, MAPK14
09160 Human Diseases	09161 Cancers	hsa05231	Choline metabolism in cancer	2.529E-05	9.716E-05	MAPK10, MAPK1, HIF1A, EGFR
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	3.537E-05	1.291E-04	MAPK10, MAPK1, MAPK14, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04660	T cell receptor signaling pathway	2.838E-05	1.062E-04	LCK, MAPK1, MAPK14, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05131	Shigellosis	4.378E-06	2.131E-05	MAPK10, MAPK1, MAPK14, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05132	Salmonella infection	1.339E-05	5.586E-05	MAPK10, MAPK1, MAPK14, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	1.066E-04	3.537E-04	MAPK10, MAPK1, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	8.097E-05	2.749E-04	IRAK1, IRAK4, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04068	FoxO signaling pathway	7.425E-05	2.581E-04	MAPK10, MAPK1, MAPK14, EGFR
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.365E-04	4.332E-04	ERBB2, MAPK1, TP53, EGFR, NFKB1
09150 Organismal Systems	09153 Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	1.123E-04	3.645E-04	MAPK1, ADRB1, CACNA1C, MAPK14
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	1.789E-04	5.436E-04	ADORA3, MAPK1, ADRB1, CACNA1C
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	3.907E-04	1.001E-03	LYN, MAPK1, TP53, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04062	Chemokine signaling pathway	2.756E-04	7.316E-04	LYN, HCK, MAPK1, NFKB1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	3.695E-04	9.632E-04	MAPK10, ERBB2, MAPK1, EGFR
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	5.737E-04	1.373E-03	MAPK10, MAPK1, EGFR, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05166	HTLV-I infection	9.254E-04	2.145E-03	LCK, CHEK2, TP53, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04662	B cell receptor signaling pathway	2.574E-04	7.090E-04	LYN, MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	1.824E-04	5.436E-04	MAPK1, TP53, EGFR
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	2.371E-04	6.786E-04	MAPK1, TP53, EGFR
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	2.574E-04	7.090E-04	MAPK1, TP53, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	6.114E-04	1.440E-03	MAPK10, MAPK1, MAPK14
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	1.585E-04	4.924E-04	MAPK10, MAPK1, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	2.572E-03	5.288E-03	MAPK1, TP53, EGFR, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04666	Fc gamma R-mediated phagocytosis	5.247E-04	1.277E-03	LYN, HCK, MAPK1
09150 Organismal Systems	09151 Immune system	hsa04611	Platelet activation	1.154E-03	2.515E-03	LYN, MAPK1, MAPK14
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	4.766E-04	1.180E-03	LMNA, ADRB1, CACNA1C
09150 Organismal Systems	09152 Endocrine system	hsa04921	Oxytocin signaling pathway	2.419E-03	5.045E-03	MAPK1, CACNA1C, EGFR
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	1.048E-03	2.355E-03	MAPK1, TP53, HIF1A
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	4.463E-04	1.123E-03	MAPK1, ADRB1, EGFR
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	2.679E-04	7.244E-04	ERBB2, MAPK1, EGFR
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	1.355E-03	2.910E-03	MAPK10, CACNA1C, MAPK14
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	1.679E-03	3.553E-03	MAPK10, MKNK2, MAPK1
09150 Organismal Systems	09151 Immune system	hsa04622	RIG-I-like receptor signaling pathway	2.273E-04	6.637E-04	MAPK10, MAPK14, NFKB1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04930	Type II diabetes mellitus	7.368E-05	2.581E-04	MAPK10, MAPK1, CACNA1C
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	2.877E-03	5.835E-03	MAPK1, CACNA1C, MAPT
09160 Human Diseases	09167 Infectious diseases	hsa05168	Herpes simplex infection	3.774E-03	7.446E-03	MAPK10, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	5.445E-03	9.694E-03	MAPK1, MAPK14, EGFR
09130 Environmental Information Processing	09132 Signal transduction	hsa04150	mTOR signaling pathway	4.668E-03	8.627E-03	MAPK1, HIF1A
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4.079E-03	7.940E-03	ADRB1, TSHR
09150 Organismal Systems	09156 Nervous system	hsa04720	Long-term potentiation	5.621E-03	9.770E-03	MAPK1, CACNA1C
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	4.821E-03	8.798E-03	MAPK1, MAPK14
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	5.621E-03	9.770E-03	MAPK1, HIF1A
09150 Organismal Systems	09156 Nervous system	hsa04730	Long-term depression	4.668E-03	8.627E-03	LYN, MAPK1
09150 Organismal Systems	09152 Endocrine system	hsa04924	Renin secretion	5.294E-03	9.542E-03	ADRB1, CACNA1C
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	4.222E-03	8.111E-03	MAPK1, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4.369E-03	8.283E-03	CYP3A4, CYP19A1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05014	Amyotrophic lateral sclerosis (ALS)	3.395E-03	6.789E-03	MAPK14, TP53
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	1.107E-03	2.448E-03	MAPK1, TP53
Unclassified	Unclassified	hsa04320	Dorso-ventral axis formation	9.587E-04	2.187E-03	MAPK1, EGFR
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.003E-06	1.624E-05	CA12, CA4, CA7

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
C00-D49: Neoplasms	Bladder cancer	C67	EGFR; ERBB2; CYP19A1;
J00-J99: Diseases of the respiratory system	Asthma	J45	ERBB2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MAPK14;
I00-I99: Diseases of the circulatory system	Ventricular fibrillation	I49.01	ADRB1;
NA: NA	Ventricular premature beats	NA	ADRB1;
C00-D49: Neoplasms	Urethral cancer	NA	EGFR;
NA: NA	Cardiogenic shock	NA	ADRB1;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	ADRB1;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	EGFR;
C00-D49: Neoplasms	Esophageal cancer	C15	EGFR;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADRB1;
C00-D49: Neoplasms	Melanoma	C43	EGFR;
C00-D49: Neoplasms	Malignant tumor	C00-C75, C7A, C7B	EGFR;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADRB1;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Bone disease	M00-M99	LYN;
C00-D49: Neoplasms	Breast cancer	C50	EGFR; ERBB2; CYP19A1;
C00-D49: Neoplasms	Late-stage non-small cell lung cancer	C33-C34	EPHB4;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	MAPK14; EGFR;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	ERBB2;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4; ADRB1;
C00-D49: Neoplasms	Lung cancer	C33-C34	EGFR;
C00-D49: Neoplasms	Locally advanced head and neck cancer	C07-C14, C32, C33	EGFR;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; EGFR; ERBB2;
C00-D49: Neoplasms	Advanced cancers	C00-C96	EGFR;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	EGFR; ERBB2;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA3; ADRB1;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	EGFR;
I00-I99: Diseases of the circulatory system	Cardiac failure	I50	CACNA1C;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADRB1;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
I00-I99: Diseases of the circulatory system	Acute supraventricular tachycardia	I47.1	ADRB1;
NA: NA	Acute respiratory distress syndrome	NA	MAPK14;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	EGFR; TP53;
NA: NA	Rheumatold arthritis	NA	MAPK14;
P00-P96: Certain conditions originating in the perinatal period	Central nervous system injury	P11.9	MAPK10;
H00-H59: Diseases of the eye and adnexa	Diabetic retinopathy	H36, E10.3, E11.3, E13.3	MAPK14;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3; EGFR;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Central and peripheral nervous diseases	G96.9	ADRB1;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRB1;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
J00-J99: Diseases of the respiratory system	Acute lung injury	J80	MAPK14;
C00-D49: Neoplasms	Pancreatic cancer	C25	EGFR;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	MAPK14;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
NA: NA	Inflammatory diseases	NA	MAPK14;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MAPK14; IRAK4;
C00-D49: Neoplasms	Gastric cancer	C16	EGFR; ERBB2;
C00-D49: Neoplasms	HER2-positive urogenital cancer	NA	ERBB2;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
I00-I99: Diseases of the circulatory system	Heart arrhythmia	I47-I49	ADRB1; CACNA1C;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	EGFR; LYN;
H00-H59: Diseases of the eye and adnexa	Chronic open-angle glaucoma	H40	ADRB1;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MAPK14;
C00-D49: Neoplasms	Ovarian cancer	C56	EGFR;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	ADRB1; CACNA1C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
A00-B99: Certain infectious and parasitic diseases	Cryptosporidium infection	A07.2	EGFR;
I00-I99: Diseases of the circulatory system	Circulatory disorders	I00-I99	ADRB1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
C00-D49: Neoplasms	Prostate cancer	C61	EGFR; ERBB2;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
NA: NA	Angina	NA	ADRB1;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
C00-D49: Neoplasms	Brain cancer	C71, D33	EGFR;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
NA: NA	Neurogenic shock	NA	ADRB1;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADRB1;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Inflammatory breast cancer	C50	EGFR;
C00-D49: Neoplasms	Refractory breast cancer	C50	EGFR;
C00-D49: Neoplasms	Non-hodgkin's lymphoma	C85	ERBB2;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	ERBB4; EGFR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	EGFR;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADRB1;
A00-B99: Certain infectious and parasitic diseases	Septic shock	A41.9	ADRB1;
I00-I99: Diseases of the circulatory system	Acute coronary syndrome	I74	MAPK14;
H00-H59: Diseases of the eye and adnexa	Retinal venous occlusion	H34.8	ERBB2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MAPK14;
C00-D49: Neoplasms	Cancer	C00-C96	ERBB4; NFKB1; CHEK2; HIF1A; ADORA3; EPHB4; MAPK1; MAPK14; EGFR; ERBB2; TP53;
C00-D49: Neoplasms	Solid tumours	C00-D48	ERBB4; CHEK2; HIF1A; MAPK1; EGFR; ERBB2; TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	LCK;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	EGFR; ERBB2; TP53;
C00-D49: Neoplasms	Colon cancer	C50	EGFR;
J00-J99: Diseases of the respiratory system	Bronchodilator	J45	ADRB1;
I00-I99: Diseases of the circulatory system	Maintenance of normal sinus rhythm	I46-I49	ADRB1;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	ADRB1;
NA: NA	Metastatic hormone refractory prostate cancer	NA	LYN;
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	ADRB1; MAPK14;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	ERBB2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ADRB1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Vulnerary	S00-T98	EGFR;
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	EGFR;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
C00-D49: Neoplasms	Head and neck squamous cell carcinoma	C44	EGFR;
C00-D49: Neoplasms	Glioma	C71	EGFR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases