Plant Name: Ficus septica
Taxonomic Information:
Plant ID: NPO6257
Plant Latin Name: Ficus septica
Taxonomy Genus: Ficus
Taxonomy Family: Moraceae
Plant External Links:
NCBI TaxonomyDB:
100573
Plant-of-the-World-Online:
853688-1
Used in Medicines:
Country/Region:
Guinea; Philippines; IndonesiaTraditional Medicine System:
Geographical Distribution:
Australia; Guinea; Philippines; Indonesia; Papua New Guinea; Vanuatu; Taiwan
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| KDM4E; | |
| ALDH1A1; | |
| HIF1A; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 1.205E-06 | 1.225E-02 | CYP1A2, CYP2D6 |
| BP | GO:0008152; metabolic process | GO:0009820; alkaloid metabolic process | 1.687E-06 | 1.225E-02 | CYP1A2, CYP2D6 |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 5.300E-06 | 1.923E-02 | CYP1A2, CYP2D6 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 2.028E-05 | 6.310E-02 | CYP1A2, CYP2D6 |
| MF | GO:0003824; catalytic activity | GO:0032451; demethylase activity | 5.928E-05 | 1.278E-01 | CYP1A2, KDM4E |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 7.913E-05 | 1.436E-01 | CYP1A2, CYP2D6 |
| BP | GO:0008152; metabolic process | GO:0019369; arachidonic acid metabolic process | 1.142E-04 | 1.777E-01 | CYP1A2, CYP2D6 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 6.423E-04 | 4.113E-01 | CYP1A2, CYP2D6 |
| CC | GO:0043226; organelle | GO:0016607; nuclear speck | 5.189E-03 | 8.999E-01 | HIF1A, LMNA |
| CC | GO:0016020; membrane | GO:0031090; organelle membrane | 3.989E-02 | 1.000E+00 | CYP1A2, CYP2D6, LMNA |
| CC | GO:0032991; macromolecular complex | GO:0090575; RNA polymerase II transcription factor complex | 4.001E-02 | 1.000E+00 | HIF1A |
| CC | GO:0043226; organelle | GO:0043231; intracellular membrane-bounded organelle | 4.289E-02 | 1.000E+00 | CYP1A2, CYP2D6, HIF1A, KDM4E, LMNA |
| CC | GO:0044464; cell part | GO:0005635; nuclear envelope | 4.958E-02 | 1.000E+00 | LMNA |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 1.547E-04 | 1.432E-03 | CYP1A2, ALDH1A1 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.744E-04 | 1.432E-03 | CYP2D6, CYP1A2 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 1.953E-04 | 1.432E-03 | CYP2D6, CYP1A2 |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 1.194E-02 | 4.171E-02 | CYP1A2 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 8.670E-03 | 3.815E-02 | CYP1A2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04150 | mTOR signaling pathway | 1.787E-02 | 4.171E-02 | HIF1A |
| 09160 Human Diseases | 09161 Cancers | hsa05211 | Renal cell carcinoma | 1.964E-02 | 4.171E-02 | HIF1A |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 1.993E-02 | 4.171E-02 | HIF1A |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 2.200E-02 | 4.171E-02 | LMNA |
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 1.499E-03 | 8.246E-03 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
