CMAUP Plant Collective Molecular Activities

Plant Name: Phellodendron japonicum

Taxonomic Information:

Plant ID: NPO5740
Plant Latin Name: Phellodendron japonicum
Taxonomy Genus: Phellodendron
Taxonomy Family: Rutaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Lyase	CA2; CA1; CA7; CA12; CA9; CA14;
Enzyme_unclassified	HSD17B10; ALOX15; GFER; ALDH1A1;
Cysteine protease	CASP7; CASP1;
Transcription Factor	HIF1A;
Oxidoreductase	XDH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	7.711E-13	8.395E-09	CA1, CA12, CA14, CA2, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	7.245E-11	3.155E-07	CA1, CA12, CA2, CA7, CA9
MF	GO:0005488; binding	GO:0046914; transition metal ion binding	7.514E-07	1.818E-03	ALOX15, CA1, CA12, CA2, CA7, CA9, CYP1A2, XDH
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.929E-06	4.200E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.538E-16	1.206E-11	CA1, CA12, CA14, CA2, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	9.631E-06	1.498E-02	CA1, CA2
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	2.884E-05	3.694E-02	CA2, CA7
BP	GO:0065007; biological regulation	GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process	3.968E-05	4.800E-02	CASP1, CASP7, XDH

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.111E-15	4.997E-14	CA12, CA1, CA2, CA7, CA9, CA14
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	5.992E-06	1.348E-04	CYP1A2, XDH
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.406E-04	3.608E-03	CYP1A2, ALOX15
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	8.693E-04	9.779E-03	CASP7, CASP1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.212E-03	1.091E-02	CYP1A2, ALDH1A1
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.223E-03	1.429E-02	CYP1A2, ALOX15, ALDH1A1, HSD17B10, XDH
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	1.609E-03	1.207E-02	CASP7, CASP1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	7.791E-03	4.382E-02	CASP7, HSD17B10
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.825E-02	9.124E-02	CA2
09150 Organismal Systems	09154 Digestive system	hsa04971	Gastric acid secretion	5.761E-02	9.258E-02	CA2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Renal cancer	C64	CA9;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases