Plant Name: Phellodendron japonicum
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 7.711E-13 | 8.395E-09 | CA1, CA12, CA14, CA2, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 7.245E-11 | 3.155E-07 | CA1, CA12, CA2, CA7, CA9 |
| MF | GO:0005488; binding | GO:0046914; transition metal ion binding | 7.514E-07 | 1.818E-03 | ALOX15, CA1, CA12, CA2, CA7, CA9, CYP1A2, XDH |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 1.929E-06 | 4.200E-03 | CA2, CA7 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 5.538E-16 | 1.206E-11 | CA1, CA12, CA14, CA2, CA7, CA9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.111E-15 | 4.997E-14 | CA12; CA1; CA2; CA7; CA9; CA14 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 5.992E-06 | 1.348E-04 | CYP1A2; XDH |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 2.406E-04 | 3.608E-03 | CYP1A2; ALOX15 |
| hsa05134 | Legionellosis_Homo sapiens_hsa05134 | 8.693E-04 | 9.779E-03 | CASP7; CASP1 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 1.212E-03 | 1.091E-02 | CYP1A2; ALDH1A1 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 2.223E-03 | 1.429E-02 | CYP1A2; ALOX15; ALDH1A1; HSD17B10; XDH |
| hsa05133 | Pertussis_Homo sapiens_hsa05133 | 1.609E-03 | 1.207E-02 | CASP7; CASP1 |
| hsa05010 | Alzheimer's disease_Homo sapiens_hsa05010 | 7.791E-03 | 4.382E-02 | CASP7; HSD17B10 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| C00-D49: Neoplasms | Cancer | C00-C96 | CA1; CA9; HIF1A |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2 |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1 |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | CA1; CA1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | XDH |
| I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A |
| I00-I99: Diseases of the circulatory system | Heart failure | I50 | XDH |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9; HIF1A |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CASP1 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | CASP1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricemia | E79.0 | XDH |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricaemia in gout | E79.0, M10 | XDH |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2 |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | CASP1 |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9; HIF1A |
| G00-G99: Diseases of the nervous system G00-G99 | Encephalopathy | G93.4 | XDH |
| NA: NA | Edema | NA | CA2 |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; CA1 |