Plant Name: Rogeria adenophylla
Taxonomic Information:
Plant ID: NPO5714
Plant Latin Name: Rogeria adenophylla
Taxonomy Genus: Rogeria
Taxonomy Family: Pedaliaceae
Plant External Links:
NCBI TaxonomyDB:
1503125
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| FAAH; TERT; POLB; | |
| GAA; | |
| PPARA; PPARD; PPARG; | |
| FABP5; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | FAAH | Anandamide amidohydrolase | O00519 | CHEMBL2243 |
| Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group C | PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | CHEMBL235 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 8.514E-07 | 3.708E-03 | PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0010891; negative regulation of sequestering of triglyceride | 1.500E-06 | 4.453E-03 | PPARA, PPARG |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 2.206E-06 | 4.453E-03 | PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 2.250E-06 | 4.453E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0010871; negative regulation of receptor biosynthetic process | 2.250E-06 | 4.453E-03 | PPARA, PPARG |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 1.499E-06 | 4.453E-03 | PPARA, PPARD, PPARG |
| BP | GO:0008152; metabolic process | GO:0006631; fatty acid metabolic process | 3.604E-06 | 6.539E-03 | FAAH, PPARA, PPARD, PPARG |
| BP | GO:0008152; metabolic process | GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter | 8.240E-06 | 1.282E-02 | PPARA, PPARD |
| MF | GO:0005488; binding | GO:0036041; long-chain fatty acid binding | 8.240E-06 | 1.282E-02 | PPARD, PPARG |
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 1.126E-05 | 1.413E-02 | PPARA, PPARD, PPARG |
| MF | GO:0005488; binding | GO:0001223; transcription coactivator binding | 2.841E-05 | 1.933E-02 | PPARA, TERT |
| MF | GO:0005488; binding | GO:0008134; transcription factor binding | 5.469E-05 | 2.615E-02 | PPARA, PPARD, PPARG, TERT |
| CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 3.052E-04 | 9.102E-02 | FABP5, POLB, PPARA, PPARD, PPARG, TERT |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 8.986E-09 | 2.157E-07 | FABP5, PPARG, PPARA, PPARD |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05166 | HTLV-I infection | 4.410E-03 | 5.251E-02 | POLB, TERT |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 1.017E-02 | 5.251E-02 | PPARG, PPARD |
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 1.154E-02 | 5.251E-02 | PPARG |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00500 | Starch and sucrose metabolism | 2.219E-02 | 6.773E-02 | GAA |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 2.258E-02 | 6.773E-02 | PPARD |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 1.194E-02 | 5.251E-02 | GAA |
| 09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 1.313E-02 | 5.251E-02 | POLB |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04920 | Adipocytokine signaling pathway | 2.766E-02 | 7.339E-02 | PPARA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 5.199E-02 | 7.339E-02 | PPARA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
