CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	PPARG
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PPARG
C00-D49: Neoplasms	Multiple myeloma	C90	TERT
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	PPARD
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	FAAH
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	PPARG
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	PPARG
H00-H59: Diseases of the eye and adnexa	Ocular inflammation	H16.229	TERT; PPARG
C00-D49: Neoplasms	Pancreatic cancer	C25	TERT
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	FAAH
C00-D49: Neoplasms	Ovarian cancer	C56	TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PPARD; PPARG; PPARG
C00-D49: Neoplasms	Tumors	C00-D48	TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD; PPARG
C00-D49: Neoplasms	Liver cancer	C22	TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	PPARD
C00-D49: Neoplasms	Prostate cancer	C61	TERT
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	FAAH
NA: NA	Dyslipidemia	NA	PPARD
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	FAAH
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PPARD; PPARD; PPARG
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARD; PPARG
C00-D49: Neoplasms	Brain cancer	C71, D33	TERT
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Nicotine dependence	F17	PPARG
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD; PPARD
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TERT
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	PPARG; PPARG
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PPARG
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TERT
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	FAAH
C00-D49: Neoplasms	Melanoma	C43	TERT
C00-D49: Neoplasms	Breast cancer	C50	TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	FAAH

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Rogeria adenophylla

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases