CMAUP Plant Collective Molecular Activities

Plant Name: Tussilago farfara

Taxonomic Information:

Plant ID: NPO523
Plant Latin Name: Tussilago farfara
Taxonomy Genus: Tussilago
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 118778
Plant-of-the-World-Online: 256904-1

Used in Medicines:

Country/Region:

Turkey; India; Romania; Albania; Italy; Lebanon; Finland; Lithuania; Sweden; China; Bulgaria

Traditional Medicine System:

Indian Folk; TCM; Homeopathy

Medicinal Functions:

Antitussive; Astringent; Bitter; Demulcent; Diaphoretic; Emollient; Expectorant; Skin; Stimulant; Tonic

Geographical Distribution:

Canada; Afghanistan; Italy; Turkmenistan; Lebanon; Nepal; Lithuania; France; Netherlands; Ireland; Norway; Uzbekistan; Belarus; Iran; Algeria; Turkey; China; Belgium; Germany; Kazakhstan; Spain; Ukraine; Georgia; Libya; Denmark; Poland; Finland; United States; Morocco; Sweden; Switzerland; New Zealand; Russia; Bulgaria; Pakistan; Romania; Albania; Portugal; Egypt; Tajikistan; India; United Kingdom; Tunisia; Austria; Greece; Hungary; Cyprus

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Small molecule receptor (family A GPCR)	ADORA3; ADORA2A; ADORA1;
Small molecule receptor (family C GPCR)	GRM1; GRM8;
Hydrolase	ACHE;
Enzyme_unclassified	CDA; ADK; PKM; ALOX12; AKR1B1; HSD17B2; HSD17B10; AKR1B10; NOX4; POLB;
Ionotropic glutamate receptor	GRIA4; GRIA2; GRIK3; GRIK5; GRIK1;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB;
Lyase	CA2; CA12; CA7; CA4;
Oxidoreductase	TYR;
Lysine demethylase	KDM4E;
Metallo protease	MMP9; MMP1; MMP2;
Transcription Factor	AHR; TP53; NFKB1;
Transferase	FUT7;
SLC superfamily of solute carriers	SLC1A1;
Unclassified	LMNA; APP;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	CDA	Cytidine deaminase	P32320	CHEMBL4502
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	PKM	Pyruvate kinase isozymes M1/M2	P14618	CHEMBL1075189
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Ionotropic glutamate receptor	GRIA4	Glutamate receptor ionotropic, AMPA 4	P48058	CHEMBL3190
Ionotropic glutamate receptor	GRIA2	Glutamate receptor ionotropic, AMPA 2	P42262	CHEMBL4016
Ionotropic glutamate receptor	GRIK3	Glutamate receptor ionotropic kainate 3	Q13003	CHEMBL3684
Ionotropic glutamate receptor	GRIK5	Glutamate receptor ionotropic kainate 5	Q16478	CHEMBL2675
Ionotropic glutamate receptor	GRIK1	Glutamate receptor ionotropic kainate 1	P39086	CHEMBL1918
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
SLC superfamily of solute carriers	SLC1A1	Excitatory amino acid transporter 3	P43005	CHEMBL2721
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	ADORA2A	Adenosine A2a receptor	P29274	CHEMBL251
Small molecule receptor (family A GPCR)	ADORA1	Adenosine A1 receptor	P30542	CHEMBL226
Small molecule receptor (family C GPCR)	GRM1	Metabotropic glutamate receptor 1	Q13255	CHEMBL3772
Small molecule receptor (family C GPCR)	GRM8	Metabotropic glutamate receptor 8	O00222	CHEMBL3228
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	APP	Beta amyloid A4 protein	P05067	CHEMBL2487

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0035235; ionotropic glutamate receptor signaling pathway	4.881E-11	3.543E-07	APP, GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
BP	GO:0023052; signaling	GO:0060079; excitatory postsynaptic potential	4.802E-10	1.162E-06	ADORA1, ADORA2A, GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
MF	GO:0005215; transporter activity	GO:0005234; extracellularly glutamate-gated ion channel activity	1.071E-09	1.793E-06	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	2.177E-08	1.354E-05	ADORA1, ADORA2A, AKR1B1, ALOX12, AURKB, AXL, CDK1, IGF1R, KDR, LMNA, MMP9, NFKB1, PIM1, TP53
MF	Unclassified;	GO:0004872; receptor activity	2.722E-08	1.560E-05	ADORA1, ADORA2A, ADORA3, AHR, AXL, FLT3, GRIA2, GRIA4, GRIK1, GRIK3, GRIK5, GRM1, GRM8, IGF1R, KDR, MET, NPSR1, TSHR
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.309E-08	2.688E-05	CA12, CA2, CA4, CA7
MF	GO:0005215; transporter activity	GO:0015277; kainate selective glutamate receptor activity	1.626E-07	7.377E-05	GRIK1, GRIK3, GRIK5
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	5.670E-07	1.871E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0050896; response to stimulus	GO:1901653; cellular response to peptide	1.024E-06	2.972E-04	AKR1B1, APP, IGF1R, NFKB1, PKM, TP53, TSHR
BP	GO:0009987; cellular process	GO:0007196; adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway	1.356E-06	3.691E-04	GRIK3, GRM1, GRM8
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	1.356E-06	3.691E-04	ADORA1, ADORA2A, ADORA3
CC	GO:0032991; macromolecular complex	GO:0043235; receptor complex	1.596E-06	4.188E-04	AHR, APP, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, TSHR
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.934E-06	4.839E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.201E-06	5.210E-04	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	2.242E-06	5.250E-04	AKR1B1, AKR1B10, ALOX12, CYP1A1, CYP1A2, CYP1B1, HSD17B10, HSD17B2, KDM4E, NOX4, PKM, TYR
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	3.210E-06	7.282E-04	AKR1B1, AKR1B10, APP, CYP1A1, CYP1A2, CYP1B1, HSD17B2
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	4.388E-06	9.461E-04	ADORA1, CYP1A1, LMNA, MMP2, NOX4, PKM, TP53
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	4.583E-06	9.784E-04	ADORA2A, CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.996E-06	1.056E-03	CA12, CA2, CA4, CA7
MF	GO:0005488; binding	GO:0019825; oxygen binding	5.473E-06	1.124E-03	CYP1A1, CYP1A2, CYP1B1, NOX4
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	1.553E-05	2.795E-03	ADORA1, ADORA2A, CA2, CA7, KDR, NPSR1
BP	GO:0040011; locomotion	GO:0030335; positive regulation of cell migration	1.631E-05	2.887E-03	ALOX12, APP, IGF1R, KDR, MET, MMP9, NOX4, TP53
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	1.859E-05	3.188E-03	AKR1B1, AXL, CDK1, CYP1B1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.967E-05	3.269E-03	CA2, CA7
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	1.967E-05	3.269E-03	ADORA1, ADORA2A
CC	GO:0044456; synapse part	GO:0043195; terminal bouton	1.984E-05	3.272E-03	ADORA1, APP, GRIK3, GRIK5
BP	GO:0050896; response to stimulus	GO:0055093; response to hyperoxia	2.100E-05	3.396E-03	CYP1A1, POLB, TP53
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	2.100E-05	3.396E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	2.787E-05	4.334E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.787E-05	4.334E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0050896; response to stimulus	GO:0014074; response to purine-containing compound	3.711E-05	5.316E-03	ADORA2A, APP, NOX4, TP53, TYR
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	3.927E-05	5.481E-03	CYP1A1, CYP1A2
MF	GO:0005215; transporter activity	GO:0004971; AMPA glutamate receptor activity	3.927E-05	5.481E-03	GRIA2, GRIA4
BP	GO:0009987; cellular process	GO:0051289; protein homotetramerization	3.999E-05	5.547E-03	CDA, HSD17B10, PKM, TP53
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	4.442E-05	5.969E-03	AXL, CDK1, FLT3, PKM
MF	GO:0005488; binding	GO:0042802; identical protein binding	4.511E-05	5.990E-03	ACHE, ADORA2A, APP, CDA, FLT3, GRIK5, IGF1R, KDR, MET, MMP9, NFKB1, PKM, TP53, TYR
BP	GO:0008152; metabolic process	GO:0017144; drug metabolic process	5.777E-05	7.487E-03	ACHE, ADK, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, PKM
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	7.638E-05	9.559E-03	AKR1B1, ALOX12, CDK1, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, TSHR

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6.830E-11	1.079E-08	GRIA2, ADORA2A, GRIK5, ADORA3, GRM8, GRIK3, ADORA1, GRIK1, TSHR, GRM1, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04724	Glutamatergic synapse	3.822E-10	3.019E-08	GRIA2, GRIK5, SLC1A1, GRM8, GRIK3, GRIK1, GRM1, GRIA4
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	5.817E-06	1.532E-04	FLT3, MMP1, MMP2, MET, TP53, MMP9, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	3.269E-06	1.291E-04	MMP1, MMP2, MMP9, TP53
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	8.030E-08	4.229E-06	CA12, CA2, CA4, CA7
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	7.312E-06	1.650E-04	HSD17B2, CYP1A1, CYP1B1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.112E-05	1.953E-04	MMP2, KDR, TP53, MMP9, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	9.933E-06	1.953E-04	GRIA2, ADORA2A, ADORA1, NFKB1, TSHR, GRIA4
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	5.593E-06	1.532E-04	FLT3, TP53, MMP9, MET, NFKB1, IGF1R
Unclassified	Unclassified	hsa01100	Metabolic pathways	4.079E-05	5.371E-04	CDA, FUT7, PKM, AKR1B10, HSD17B2, CYP1A2, CYP1A1, ADK, AKR1B1, ALOX12, TYR, HSD17B10
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	2.359E-05	3.388E-04	PKM, FLT3, TP53, MET
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.327E-05	2.097E-04	CYP1A2, HSD17B2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	9.355E-05	1.137E-03	PIM1, CYP1B1, TP53, MMP9, MET, NFKB1
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	1.569E-04	1.653E-03	POLB, PKM, CDK1, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	2.293E-04	2.265E-03	ADORA3, ADORA1, TP53, NFKB1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.361E-04	1.536E-03	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	3.912E-04	3.636E-03	FLT3, PIM1, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04730	Long-term depression	4.551E-04	3.995E-03	GRIA2, GRM1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	7.455E-04	6.200E-03	TP53, MET, IGF1R
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	8.085E-04	6.387E-03	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.133E-03	8.525E-03	CYP1A2, CYP1A1, CYP1B1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
I00-I99: Diseases of the circulatory system	Orthostatic hypotension	I95.1	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	ADORA2A;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE; ADK;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	ADK; GRIK1;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Amyloidosis	E85	APP;
NA: NA	Upper abdominal bloating	NA	ACHE;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2;
I00-I99: Diseases of the circulatory system	Acute and chronic heart failure	I50	ADORA1;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
G00-G99: Diseases of the nervous system G00-G99	Mild to moderate alzheimer disease	G30	APP;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE; APP;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Brain injury	S09.90	APP;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	GRM1; NPSR1; GRIK1; APP;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR; ADORA3;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; AKR1B1; TP53;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; NFKB1; FLT3; ACHE; ADORA3; MMP9; TP53; MMP2; APP;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR; TYR;
G00-G99: Diseases of the nervous system G00-G99	Diagnostic imaging	G30, I73.9	APP;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADORA1;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR; APP;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; ADORA1; ADORA2A; ADORA3; AKR1B1;
NA: NA	GIST	NA	FLT3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
I00-I99: Diseases of the circulatory system	Cardiac disease	I00-I99	ADORA1;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE; CA2;
I00-I99: Diseases of the circulatory system	Cerebral amyloid angiopathy	I68.0	APP;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
H00-H59: Diseases of the eye and adnexa	Macular degeneration	H35.3	APP;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypertriglyceridemia	E78.1, E78.2, E78.3, I47-I49	ADORA1;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADORA1; ADORA2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ADORA1;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADORA2A;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB; TP53;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; MMP2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADORA1; AKR1B1;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ADORA2A;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
NA: NA	HIV infections	NA	AHR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3; MMP2;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	GRM1; CDK1; IGF1R; ACHE; ADORA2A; ADK; GRIK1; PKM;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE; ADORA1; ADORA2A; GRIA2; GRIA4;
C00-D49: Neoplasms	CLL	NA	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Huntington's disease	F02.2, G10	GRM1;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
I00-I99: Diseases of the circulatory system	Coronary disorder diagnosis	I20-I25	ADORA2A;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	ADORA2A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	ADORA1;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
N00-N99: Diseases of the genitourinary system	Renal failure	N17, N18, N19	ADORA1;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR; MMP2;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	GRM1; ADORA1; ADORA2A; GRIK1;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3; TP53;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Radionuclide imaging	W88	ADORA2A;
C00-D49: Neoplasms	Refractory renal cell carcinoma	C64	PKM;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADORA1;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	GRM1;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1; MMP1; TYR;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
J00-J99: Diseases of the respiratory system	Asthma	J45	ADORA1; ADORA2A;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; MMP9; TP53;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3; MMP9; CDA; PKM; TP53; MMP2;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; AHR;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ADORA1;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	GRM1; ACHE; APP;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADORA1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Convulsions	R56.0	ADK;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	GRIK1;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
H00-H59: Diseases of the eye and adnexa	Age related macular degeneration	H35.3	APP;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
NA: NA	Geographic retinal atrophy	NA	APP;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases