CMAUP Plant Collective Molecular Activities

Plant Name: Euphorbia lathyris

Taxonomic Information:

Plant ID: NPO520
Plant Latin Name: Euphorbia lathyris
Taxonomy Genus: Euphorbia
Taxonomy Family: Euphorbiaceae

Plant External Links:

NCBI TaxonomyDB: 212925
Plant-of-the-World-Online: 347072-1

Used in Medicines:

Country/Region:

China; Italy; India

Traditional Medicine System:

Indian Folk; TCM; Unani

Medicinal Functions:

Abortifacient; Antiseptic; Cancer; Diuretic; Emetic; Purgative; Warts

Geographical Distribution:

Brazil; Italy; France; Ethiopia; Argentina; Bolivia; Venezuela; China; Chile; Belgium; Germany; Spain; United States; Morocco; Vietnam; New Zealand; Russia; Pakistan; Albania; Portugal; Mexico; Uruguay; India; United Kingdom

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1; HPGD; HSD17B10; ALOX15; ALDH1A1;
Protein Kinase	PRKCD; EGFR; LCK; FYN;
Lyase	CA2; CA1; CA12; CA9; CA14; CA5B; CA5A; CA3; CA7; CA6;
Nuclear hormone receptor subfamily 1 group A	THRB;
Lysine demethylase	KDM4E;
Cysteine protease	CASP1; CASP7;
Transcription Factor	HIF1A;
Unclassified	LMNA;
Oxidoreductase	XDH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Nuclear hormone receptor subfamily 1 group A	THRB	Thyroid hormone receptor beta-1	P10828	CHEMBL1947
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Protein Kinase	PRKCD	Protein kinase C delta	Q05655	CHEMBL2996
Protein Kinase	EGFR	Epidermal growth factor receptor erbB1	P00533	CHEMBL203
Protein Kinase	LCK	Tyrosine-protein kinase LCK	P06239	CHEMBL258
Protein Kinase	FYN	Tyrosine-protein kinase FYN	P06241	CHEMBL1841
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.259E-08	1.216E-04	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9, THRB
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.269E-26	2.764E-22	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0042610; CD8 receptor binding	1.882E-06	2.410E-03	FYN, LCK
BP	GO:0065007; biological regulation	GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process	4.914E-06	5.223E-03	CASP1, CASP7, LCK, XDH
BP	GO:0050896; response to stimulus	GO:0042493; response to drug	5.037E-06	5.223E-03	CA3, CA9, CASP1, EGFR, FYN, HPGD, LCK, PRKCD
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	5.640E-06	5.500E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.025E-20	1.116E-16	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.189E-19	2.281E-15	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	2.813E-05	1.856E-02	CA1, CA2
MF	GO:0005488; binding	GO:0042609; CD4 receptor binding	3.934E-05	2.225E-02	FYN, LCK
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.228E-04	4.776E-02	CA2, CA9, EGFR, HPGD

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	5.796E-26	5.448E-24	CA12, CA1, CA3, CA5B, CA2, CA5A, CA7, CA6, CA9, CA14
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	2.494E-03	7.380E-02	CASP7, CASP1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	3.676E-03	7.380E-02	HIF1A, EGFR
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	4.465E-03	7.380E-02	FYN, EGFR
09150 Organismal Systems	09152 Endocrine system	hsa04912	GnRH signaling pathway	6.675E-03	7.380E-02	PRKCD, EGFR
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	4.583E-03	7.380E-02	CASP7, CASP1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	7.855E-03	7.380E-02	PRKCD, EGFR
09160 Human Diseases	09161 Cancers	hsa05231	Choline metabolism in cancer	8.163E-03	7.380E-02	HIF1A, EGFR
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	8.477E-03	7.380E-02	HIF1A, EGFR
09150 Organismal Systems	09151 Immune system	hsa04660	T cell receptor signaling pathway	8.636E-03	7.380E-02	LCK, FYN

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
I00-I99: Diseases of the circulatory system	Acute myocardial infarction	I21-I22	PRKCD;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
NA: NA	Reperfusion injury and heart attacks	NA	PRKCD;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases