CMAUP Plant Collective Molecular Activities

Plant Name: Euphorbia lathyris

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.259E-08	1.216E-04	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9, THRB
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.269E-26	2.764E-22	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0042610; CD8 receptor binding	1.882E-06	2.410E-03	FYN, LCK
BP	GO:0065007; biological regulation	GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process	4.914E-06	5.223E-03	CASP1, CASP7, LCK, XDH
BP	GO:0050896; response to stimulus	GO:0042493; response to drug	5.037E-06	5.223E-03	CA3, CA9, CASP1, EGFR, FYN, HPGD, LCK, PRKCD
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	5.640E-06	5.500E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.025E-20	1.116E-16	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.189E-19	2.281E-15	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	5.796E-26	5.448E-24	CA12; CA1; CA3; CA5B; CA2; CA5A; CA7; CA6; CA9; CA14

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricemia	E79.0	XDH
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricaemia in gout	E79.0, M10	XDH
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	THRB
C00-D49: Neoplasms	Melanoma	C43	EGFR
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; CA9; EGFR
C00-D49: Neoplasms	Locally advanced head and neck cancer	C07-C14, C32, C33	EGFR
C00-D49: Neoplasms	Advanced cancers	C00-C96	EGFR
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	CASP1
S00-T88: Injury, poisoning and certain other consequences of external causes	Wound healing	T14.0-T14.1	THRB
S00-T88: Injury, poisoning and certain other consequences of external causes	Vulnerary	S00-T98	EGFR
C00-D49: Neoplasms	Colorectal cancer	C18-C21	EGFR; EGFR
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	EGFR; EGFR; EGFR
C00-D49: Neoplasms	Colon cancer	C50	EGFR
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	EGFR
I00-I99: Diseases of the circulatory system	Acute myocardial infarction	I21-I22	PRKCD
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	High cholesterol levels in blood	E78.0	THRB
C00-D49: Neoplasms	Refractory breast cancer	C50	EGFR
C00-D49: Neoplasms	Renal cancer	C64	CA9
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A; CA1; CA9; EGFR
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A; CA9; EGFR
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	THRB
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperthyroidism	E05	THRB
C00-D49: Neoplasms	Breast cancer	C50	CA9; EGFR; EGFR; EGFR
C00-D49: Neoplasms	Brain cancer	C71, D33	EGFR; EGFR
C00-D49: Neoplasms	Prostate cancer	C61	EGFR
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	EGFR
C00-D49: Neoplasms	Bladder cancer	C67	EGFR
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	LCK
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	EGFR
NA: NA	Edema	NA	CA2
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
C00-D49: Neoplasms	Glioblastoma multiforme	C71	EGFR; EGFR
C00-D49: Neoplasms	Glioma	C71	EGFR; EGFR
C00-D49: Neoplasms	Pancreatic cancer	C25	EGFR
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	EGFR
C00-D49: Neoplasms	Ovarian cancer	C56	EGFR; EGFR
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	EGFR
I00-I99: Diseases of the circulatory system	Heart failure	I50	XDH
C00-D49: Neoplasms	Head and neck squamous cell carcinoma	C44	EGFR
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	XDH
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
C00-D49: Neoplasms	Gastric cancer	C16	EGFR; EGFR
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2
C00-D49: Neoplasms	Lung cancer	C33-C34	EGFR
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	CASP1
C00-D49: Neoplasms	Esophageal cancer	C15	EGFR
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	EGFR; EGFR
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	EGFR
C00-D49: Neoplasms	Malignant tumor	C00-C75, C7A, C7B	EGFR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	CASP1
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
A00-B99: Certain infectious and parasitic diseases	Cryptosporidium infection	A07.2	EGFR
G00-G99: Diseases of the nervous system G00-G99	Encephalopathy	G93.4	XDH
NA: NA	Reperfusion injury and heart attacks	NA	PRKCD
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	EGFR
C00-D49: Neoplasms	Urethral cancer	NA	EGFR
E00-E89: Endocrine, nutritional and metabolic diseases	Hypothyroidism	E03	THRB
C00-D49: Neoplasms	Inflammatory breast cancer	C50	EGFR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2; CYP2D6

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases