CMAUP Plant Collective Molecular Activities

Plant Name: Garcinia multiflora

Taxonomic Information:

Plant ID: NPO5049
Plant Latin Name: Garcinia multiflora
Taxonomy Genus: Garcinia
Taxonomy Family: Clusiaceae

Plant External Links:

NCBI TaxonomyDB: 1009474
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPR35;
Protein Phosphatase	PTPN1; PTPRS;
Enzyme_unclassified	TDP1; HSD17B10; APEX1; POLB;
Hydrolase	GAA;
Protein Kinase	DAPK1;
Lyase	CA2; CA1; CA12; CA9; CA3; CA14; CA5B; CA5A; CA6; CA7;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Metallo protease	MMP1; MMP2; MMP9;
Transcription Factor	TP53; NFKB1;
SLC superfamily of solute carriers	SLC22A12;
Unclassified	LMNA; MCL1; THPO;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Protein Kinase	DAPK1	Death-associated protein kinase 1	P53355	CHEMBL2558
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPRS	Receptor-type tyrosine-protein phosphatase S	Q13332	CHEMBL2396508
SLC superfamily of solute carriers	SLC22A12	Solute carrier family 22 member 12	Q96S37	CHEMBL6120
Small molecule receptor (family A GPCR)	GPR35	G-protein coupled receptor 35	Q9HC97	CHEMBL1293267
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	CHEMBL4361
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	5.882E-13	1.830E-09	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9, ESR2, MMP1, MMP2, MMP9, PTPN1, TP53
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.695E-26	2.111E-21	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	2.659E-06	4.825E-03	APEX1, POLB
BP	GO:0009987; cellular process	GO:0033554; cellular response to stress	2.952E-06	4.944E-03	APEX1, CA2, CA9, DAPK1, LMNA, MCL1, MMP9, NFKB1, POLB, PTPN1, TDP1, TP53
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	7.968E-06	9.505E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	7.773E-20	5.642E-16	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.491E-18	1.085E-14	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	3.972E-05	2.883E-02	CA1, CA2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.425E-25	4.558E-23	CA12, CA1, CA3, CA5B, CA2, CA5A, CA7, CA6, CA9, CA14
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	5.437E-09	2.800E-07	MMP1, DAPK1, MMP2, MMP9, TP53
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	3.448E-05	1.184E-03	MMP1, DAPK1, MMP2, TP53, MMP9, NFKB1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	7.102E-05	1.829E-03	LMNA, TP53, NFKB1, MCL1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	5.258E-04	1.083E-02	MMP2, MMP9, ESR2
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.235E-03	1.868E-02	TP53, MMP9, NFKB1, MCL1
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	1.619E-03	2.084E-02	TP53, MMP9, NFKB1
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	4.114E-03	3.960E-02	MMP2, TP53, MMP9
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	2.935E-03	3.359E-02	TP53, MMP9, NFKB1
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	1.270E-03	1.868E-02	POLB, APEX1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2;
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2;
C00-D49: Neoplasms	Solid tumours	C00-D48	MMP9; MMP2;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	MMP9;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; MMP9; MMP2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1;
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MMP1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases