Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC101139 MAN2B1 2 Median: 50000
Range: 50000 to 50000
IC50 PMID: 18599296
PMID: 18599296
NPC101139 MAN2A1 1 26930 Ki PMID: 23151473
NPC101139 MAN1B1 1 16810 Ki PMID: 23151473
NPC194856 MAOA 1 25000 IC50 PMID: 15482934
NPC194856 FASN 1 17850 IC50 PMID: 20817450
NPC209364 LMNA 1 28183.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC216361 CASP1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC216361 KMT2A 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC216361 ADORA3 1 34000 Ki PMID: 8691424
NPC216361 CYP3A4 2 Median: 31622.8
Range: 31622.8 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC216361 HPGD 2 Median: 33552.05
Range: 31622.8 to 35481.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC216361 APP 1 30300 IC50 PMID: 26719209
NPC216361 SYK 1 28000 IC50 PMID: 22257213
NPC216361 KDM4E 4 Median: 31832.55
Range: 25118.9 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC216361 ABCG2 2 Median: 35000
Range: 21000 to 49000
IC50 PMID: 21354800
PMID: 21354800
NPC216361 ALDH1A1 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC216361 BLM 2 Median: 19952.6
Range: 19952.6 to 19952.6
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC216361 USP2 1 18492.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC216361 CASP7 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC216361 ALOX15 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC294902 HPGD 3 Median: 39810.7
Range: 39810.7 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC294902 ALDH1A1 2 Median: 39810.7
Range: 39810.7 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC294902 APEX1 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC294902 APP 1 32800 IC50 PMID: 22921742
NPC294902 AKR1B1 1 32000 IC50 PMID: 22236472
NPC294902 CYP3A4 2 Median: 25118.9
Range: 25118.9 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC294902 POLB 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC79943 ALOX12 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC194856 MMP1 1 11360 IC50 PMID: 22658537
NPC209364 NPSR1 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC209364 MAPT 1 11220.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC216361 PLK1 1 12600 IC50 PMID: 18762425
NPC216361 HSD17B10 2 Median: 12589.3
Range: 12589.3 to 12589.3
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC216361 BACE1 2 Median: 17000
Range: 12300 to 21700
IC50 PMID: 21511472
DOI: 10.1007/s00044-012-0353-y
NPC216361 MAPT 7 Median: 14125.4
Range: 11220.2 to 15848.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC216361 XDH 1 10100 IC50 PMID: 9461655
NPC294902 THRB 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC294902 CA4 1 10100 Ki PMID: 20185318