CMAUP Plant Collective Molecular Activities

Plant Name: Eschscholzia californica

Taxonomic Information:

Plant ID: NPO4986
Plant Latin Name: Eschscholzia californica
Taxonomy Genus: Eschscholzia
Taxonomy Family: Papaveraceae

Plant External Links:

NCBI TaxonomyDB: 3467
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Anodyne; Antianxiety; Antidepressant; Antispasmodic; Diaphoretic; Diuretic; Galactofuge; Odontalgic

Geographical Distribution:

China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HTR7; HTR5A; HTR2B; DRD1; HTR6; HTR1A;
Protein Kinase	AURKB; AURKA; KDR;
Unclassified	F3;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	AURKA	Serine/threonine-protein kinase Aurora-A	O14965	CHEMBL4722
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Small molecule receptor (family A GPCR)	HTR7	Serotonin 7 (5-HT7) receptor	P34969	CHEMBL3155
Small molecule receptor (family A GPCR)	HTR5A	Serotonin 5a (5-HT5a) receptor	P47898	CHEMBL3426
Small molecule receptor (family A GPCR)	HTR2B	Serotonin 2b (5-HT2b) receptor	P41595	CHEMBL1833
Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Small molecule receptor (family A GPCR)	HTR6	Serotonin 6 (5-HT6) receptor	P50406	CHEMBL3371
Small molecule receptor (family A GPCR)	HTR1A	Serotonin 1a (5-HT1a) receptor	P08908	CHEMBL214
Unclassified	F3	Coagulation factor III	P13726	CHEMBL4081

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0007210; serotonin receptor signaling pathway	2.426E-12	1.321E-08	HTR1A, HTR2B, HTR5A, HTR6, HTR7
MF	GO:0060089; molecular transducer activity	GO:0004993; G-protein coupled serotonin receptor activity	2.426E-12	1.321E-08	HTR1A, HTR2B, HTR5A, HTR6, HTR7
MF	GO:0005488; binding	GO:0051378; serotonin binding	4.058E-11	1.262E-07	HTR1A, HTR2B, HTR5A, HTR7
BP	GO:0009987; cellular process	GO:0007198; adenylate cyclase-inhibiting serotonin receptor signaling pathway	9.522E-10	1.885E-06	HTR1A, HTR5A, HTR7
BP	GO:0008152; metabolic process	GO:0035404; histone-serine phosphorylation	5.221E-08	8.745E-05	AURKA, AURKB, DRD1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	4.185E-07	5.360E-04	CYP1A1, CYP1B1, CYP2D6
BP	Unclassified;	GO:0042310; vasoconstriction	8.614E-07	8.932E-04	HTR1A, HTR2B, HTR7
BP	GO:0032501; multicellular organismal process	GO:0097746; regulation of blood vessel diameter	1.106E-06	1.004E-03	DRD1, HTR1A, HTR2B, HTR7
MF	Unclassified;	GO:0004872; receptor activity	1.544E-06	1.246E-03	DRD1, F3, HTR1A, HTR2B, HTR5A, HTR6, HTR7, KDR
MF	GO:0005488; binding	GO:0019825; oxygen binding	3.325E-06	2.194E-03	CYP1A1, CYP1B1, CYP2D6
CC	GO:0032991; macromolecular complex	GO:0032133; chromosome passenger complex	4.177E-06	2.469E-03	AURKA, AURKB
MF	GO:0003824; catalytic activity	GO:0035174; histone serine kinase activity	6.262E-06	3.409E-03	AURKA, AURKB
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	8.764E-06	4.438E-03	CYP1A1, CYP2D6
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	1.256E-05	5.944E-03	DRD1, HTR1A, HTR2B, HTR5A, HTR6, HTR7, KDR
BP	GO:0009987; cellular process	GO:0019932; second-messenger-mediated signaling	1.401E-05	6.490E-03	DRD1, HTR2B, HTR5A, KDR
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.876E-05	8.336E-03	CYP1A1, CYP1B1

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.477E-11	1.477E-09	HTR6, HTR7, CYP2D6, HTR1A, HTR2B, HTR5A
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.058E-08	1.745E-07	HTR6, HTR7, HTR1A, HTR2B, DRD1, HTR5A
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	6.780E-08	7.459E-07	HTR6, HTR7, HTR2B, DRD1, HTR5A
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.300E-05	1.072E-04	CYP2D6, CYP1A1, CYP1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	2.578E-04	1.650E-03	HTR6, HTR1A, DRD1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	3.000E-04	1.650E-03	CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	4.694E-04	2.213E-03	CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6.316E-04	2.605E-03	CYP1A1, CYP1B1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	1.447E-03	4.774E-03	HTR2B, DRD1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.258E-03	4.612E-03	CYP1A1, CYP1B1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	AURKA;
C00-D49: Neoplasms	Liver cancer	C22	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1;
C00-D49: Neoplasms	Haematological malignancies	C81-C86	AURKA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	DRD1;
C00-D49: Neoplasms	Glioma	C71	KDR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	KDR;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
C00-D49: Neoplasms	AML	NA	KDR;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1;
C00-D49: Neoplasms	Solid tumours	C00-D48	AURKA; AURKB; KDR;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKA; AURKB;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; F3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	DRD1;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	KDR;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
J00-J99: Diseases of the respiratory system	Adult respiratory distress syndrome	J80	F3;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	AURKA;
O00-O9A: Pregnancy, childbirth and the puerperium	Excessive bleeding following childbirth and spontaneous or elective abortion	O04	DRD1;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Breast cancer	C50	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD1;
I00-I99: Diseases of the circulatory system	Bleeding	I74, I80-I82	F3;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD1;
C00-D49: Neoplasms	Cancer	C00-C96	AURKA; KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DRD1;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases