Plant Name: Eschscholzia californica
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| DRD1; | |
| OPRD1; | |
| AURKB; AURKA; KDR; | |
| ABCG2; | |
| F3; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Peptide receptor (family A GPCR) | OPRD1 | Delta opioid receptor | P41143 | CHEMBL236 |
| Protein Kinase | AURKB | Serine/threonine-protein kinase Aurora-B | Q96GD4 | CHEMBL2185 |
| Protein Kinase | AURKA | Serine/threonine-protein kinase Aurora-A | O14965 | CHEMBL4722 |
| Protein Kinase | KDR | Vascular endothelial growth factor receptor 2 | P35968 | CHEMBL279 |
| Small molecule receptor (family A GPCR) | DRD1 | Dopamine D1 receptor | P21728 | CHEMBL2056 |
| Unclassified | F3 | Coagulation factor III | P13726 | CHEMBL4081 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0007210; serotonin receptor signaling pathway | 5.653E-12 | 3.077E-08 | HTR1A, HTR2B, HTR5A, HTR6, HTR7 |
| MF | GO:0060089; molecular transducer activity | GO:0004993; G-protein coupled serotonin receptor activity | 5.653E-12 | 3.077E-08 | HTR1A, HTR2B, HTR5A, HTR6, HTR7 |
| MF | GO:0005488; binding | GO:0051378; serotonin binding | 7.744E-11 | 2.409E-07 | HTR1A, HTR2B, HTR5A, HTR7 |
| BP | GO:0009987; cellular process | GO:0007198; adenylate cyclase-inhibiting serotonin receptor signaling pathway | 1.515E-09 | 3.298E-06 | HTR1A, HTR5A, HTR7 |
| MF | Unclassified; | GO:0099600; transmembrane receptor activity | 7.024E-08 | 1.020E-04 | DRD1, F3, HTR1A, HTR2B, HTR5A, HTR6, HTR7, KDR, OPRD1 |
| BP | GO:0008152; metabolic process | GO:0035404; histone-serine phosphorylation | 8.300E-08 | 1.130E-04 | AURKA, AURKB, DRD1 |
| MF | Unclassified; | GO:0004872; receptor activity | 4.446E-07 | 4.400E-04 | DRD1, F3, HTR1A, HTR2B, HTR5A, HTR6, HTR7, KDR, OPRD1 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 6.647E-07 | 6.031E-04 | CYP1A1, CYP1B1, CYP2D6 |
| BP | Unclassified; | GO:0042310; vasoconstriction | 1.368E-06 | 1.027E-03 | HTR1A, HTR2B, HTR7 |
| BP | GO:0032501; multicellular organismal process | GO:0097746; regulation of blood vessel diameter | 2.091E-06 | 1.423E-03 | DRD1, HTR1A, HTR2B, HTR7 |
| CC | GO:0044425; membrane part | GO:0005887; integral component of plasma membrane | 3.179E-06 | 1.978E-03 | DRD1, HTR1A, HTR2B, HTR5A, HTR6, HTR7, KDR, OPRD1 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 5.272E-06 | 2.943E-03 | CYP1A1, CYP1B1, CYP2D6 |
| CC | GO:0032991; macromolecular complex | GO:0032133; chromosome passenger complex | 5.621E-06 | 3.060E-03 | AURKA, AURKB |
| MF | GO:0003824; catalytic activity | GO:0035174; histone serine kinase activity | 8.428E-06 | 4.268E-03 | AURKA, AURKB |
| BP | GO:0050896; response to stimulus | GO:0042493; response to drug | 1.126E-05 | 5.331E-03 | ABCG2, CYP1A1, CYP1B1, DRD1, HTR2B, KDR |
| BP | GO:0008152; metabolic process | GO:0009804; coumarin metabolic process | 1.179E-05 | 5.350E-03 | CYP1A1, CYP2D6 |
| MF | GO:0005488; binding | GO:0043167; ion binding | 1.753E-05 | 7.634E-03 | ABCG2, AURKA, AURKB, CYP1A1, CYP1B1, CYP2D6, DRD1, F3, HTR1A, HTR2B, HTR5A, HTR7, KDR |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.294E-10 | 4.788E-09 | HTR6; HTR7; CYP2D6; HTR1A; HTR2B; HTR5A |
| hsa04080 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 5.305E-10 | 9.814E-09 | OPRD1; HTR6; HTR7; HTR1A; HTR2B; DRD1; HTR5A |
| hsa04020 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.559E-07 | 1.923E-06 | HTR6; HTR7; HTR2B; DRD1; HTR5A |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 2.057E-05 | 1.903E-04 | CYP2D6; CYP1A1; CYP1B1 |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 4.042E-04 | 2.493E-03 | HTR6; HTR1A; DRD1 |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 4.028E-04 | 2.493E-03 | CYP1A1; CYP1B1 |
| hsa04913 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 6.299E-04 | 3.330E-03 | CYP1A1; CYP1B1 |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 8.471E-04 | 3.918E-03 | CYP1A1; CYP1B1 |
| hsa04540 | Gap junction_Homo sapiens_hsa04540 | 1.936E-03 | 7.164E-03 | HTR2B; DRD1 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.684E-03 | 6.924E-03 | CYP1A1; CYP1B1 |
| hsa04014 | Ras signaling pathway_Homo sapiens_hsa04014 | 1.222E-02 | 4.110E-02 | HTR7; KDR |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| N00-N99: Diseases of the genitourinary system | Urinary incontinence | N39.3, N39.4, R32 | OPRD1 |
| C00-D49: Neoplasms | Medullary thyroid cancer | C73 | KDR |
| C00-D49: Neoplasms | Melanoma | C43 | KDR; KDR |
| C00-D49: Neoplasms | Squamous cell cancer of head and neck | NA | KDR |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | AURKA |
| C00-D49: Neoplasms | Liver cancer | C22 | KDR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Substance dependence | F10-F19 | DRD1 |
| C00-D49: Neoplasms | Haematological malignancies | C81-C86 | AURKA |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Psychiatric disorder | F01-F99 | DRD1 |
| C00-D49: Neoplasms | Glioma | C71 | KDR |
| C00-D49: Neoplasms | Non-small-cell lung cancer | NA | KDR |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | KDR |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | KDR |
| C00-D49: Neoplasms | Gastrointestinal cancers | C15-C26 | KDR |
| C00-D49: Neoplasms | Renal cancer | C64 | KDR |
| C00-D49: Neoplasms | Renal cell carcinoma | NA | KDR; KDR |
| C00-D49: Neoplasms | AML | NA | KDR |
| C00-D49: Neoplasms | Cutaneous Melanoma | C43-C44 | KDR |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Cough | R05 | OPRD1 |
| I00-I99: Diseases of the circulatory system | Hypertension | I10-I16 | DRD1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Dementia | F01-F07 | DRD1 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | AURKB; AURKA; KDR; KDR; KDR |
| I00-I99: Diseases of the circulatory system | Ischemic heart diseases | I20-I25 | OPRD1 |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | AURKB; AURKA |
| G00-G99: Diseases of the nervous system G00-G99 | Acute migraine | G43 | OPRD1 |
| NA: NA | Acute nonspecific diarrhea | NA | OPRD1 |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | F3; KDR |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | DRD1; OPRD1 |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | DRD1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | OPRD1 |
| K00-K95: Diseases of the digestive system | Diarrhea-predominant IBS | K58.0 | OPRD1 |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | KDR |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | KDR |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | AURKB |
| J00-J99: Diseases of the respiratory system | Adult respiratory distress syndrome | J80 | F3 |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | KDR; KDR |
| C00-D49: Neoplasms | Advanced malignancies | C00-C96 | KDR |
| C00-D49: Neoplasms | Ovarian cancer | C56 | KDR; KDR; KDR; KDR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | OPRD1 |
| C00-D49: Neoplasms | Advanced solid tumor | C00-C75, C7A, C7B | AURKA |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Moderate-to-severe pain | R52, G89 | OPRD1 |
| O00-O9A: Pregnancy, childbirth and the puerperium | Excessive bleeding following childbirth and spontaneous or elective abortion | O04 | DRD1 |
| C00-D49: Neoplasms | Peritoneal cavity cancer | NA | KDR |
| C00-D49: Neoplasms | Fallopian tube cancer | C57.0, D28.2 | KDR |
| C00-D49: Neoplasms | Biliary cancer | C22, C24 | KDR |
| C00-D49: Neoplasms | Metastatic breast cancer | C50 | KDR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | DRD1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cocaine addiction | F14.2 | DRD1 |
| I00-I99: Diseases of the circulatory system | Angiogenesis disorder | I00-I99 | KDR |
| C00-D49: Neoplasms | Gastric cancer | C16 | KDR; KDR |
| C00-D49: Neoplasms | Advanced renal cell carcinoma | C64 | KDR; KDR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Premature ejaculation | F52.4 | OPRD1 |
| C00-D49: Neoplasms | Breast cancer | C50 | KDR; KDR; KDR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Schizophrenia | F20 | DRD1 |
| N00-N99: Diseases of the genitourinary system | Bladder disease | N30-N32 | OPRD1 |
| I00-I99: Diseases of the circulatory system | Bleeding | I74, I80-I82 | F3 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | KDR |
| I00-I99: Diseases of the circulatory system | Cardiovascular disorder | I00-I99 | KDR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Psychotic disorders | F20-F29 | DRD1 |
| C00-D49: Neoplasms | Cancer | C00-C96 | AURKA; KDR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | DRD1 |
| C00-D49: Neoplasms | Metastatic castration-resistant prostate cancer | C61 | KDR |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | OPRD1 |
| NA: NA | Chronic diarrhea associated with inflammatory bowel disease | NA | OPRD1 |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | KDR |
| C00-D49: Neoplasms | Overactive bladder disorder | C67, N32.81 | OPRD1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | OPRD1 |