CMAUP Plant Collective Molecular Activities

Plant Name: Phlomis umbrosa

Taxonomic Information:

Plant ID: NPO4838
Plant Latin Name: Phlomis umbrosa
Taxonomy Genus: Phlomis
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: 572134
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Haemostatic; Hepatic

Geographical Distribution:

China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Peptide receptor (family A GPCR)	TSHR;
Protein Phosphatase	PTPN1; PTPN2; CDC25B;
Enzyme_unclassified	PLA2G1B; TDP1; HSD11B1; HSD17B10; AKR1B10; POLB;
Hydrolase	GAA;
Protein Kinase	PRKCA;
Lyase	CA2; CA1; CA12; CA9; CA7; CA3; CA14; CA5B; CA5A; CA4; CA6;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Metallo protease	MMP9; MMP1; MMP12; MMP2;
Transcription Factor	HIF1A; NFKB1;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;
Unclassified	HTT; LMNA; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	PRKCA	Protein kinase C alpha	P17252	CHEMBL299
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	4.034E-08	5.856E-05	HIF1A, MMP1, MMP12, MMP2, MMP9, PLA2G1B
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	5.260E-07	5.454E-04	HIF1A, MMP1, MMP12, MMP2, MMP9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.339E-28	5.094E-24	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.127E-06	1.115E-03	CA2, CA4, CA9, SLCO1B1, SLCO1B3, TSHR
BP	GO:0008152; metabolic process	GO:0030574; collagen catabolic process	6.343E-06	5.755E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.012E-05	7.870E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	1.012E-05	7.870E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	1.012E-05	7.870E-03	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:0022617; extracellular matrix disassembly	1.382E-05	9.706E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.270E-21	1.383E-17	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.148E-20	1.371E-16	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.405E-14	3.688E-11	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP12, MMP2, MMP9, NR1H4, PRKCA, PTPN1
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	5.042E-05	2.815E-02	CA1, CA2
MF	GO:0003824; catalytic activity	GO:0004222; metalloendopeptidase activity	6.062E-05	3.143E-02	MMP1, MMP12, MMP2, MMP9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	1.737E-06	1.337E-04	MMP1, MMP2, MMP9
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	9.218E-06	3.549E-04	CA2, SLCO1B3, NR1H4
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	6.672E-05	1.284E-03	MMP1, MMP2, MMP9, NFKB1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	6.457E-04	9.944E-03	MMP9, NFKB1, CDC25B
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.466E-05	1.146E-03	CA2, CA14

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HSD11B1;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MMP9; MMP2;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	MMP9;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2;
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
NA: NA	Edema	NA	CA2;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HSD11B1;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2;
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	HSD11B1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
J00-J99: Diseases of the respiratory system	Influenza virus	J11.1	HSD11B1;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	HSD11B1; NFKB1;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	HSD11B1;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; MMP9; MMP2; CDC25B;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MMP1;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HSD11B1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases