CMAUP Plant Collective Molecular Activities

Plant Name: Phlomis umbrosa

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	4.034E-08	5.856E-05	HIF1A, MMP1, MMP12, MMP2, MMP9, PLA2G1B
BP	Unclassified;	GO:0044243; multicellular organismal catabolic process	2.308E-07	2.957E-04	MMP1, MMP12, MMP2, MMP9, PLA2G1B
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	5.260E-07	5.454E-04	HIF1A, MMP1, MMP12, MMP2, MMP9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.339E-28	5.094E-24	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.127E-06	1.115E-03	CA2, CA4, CA9, SLCO1B1, SLCO1B3, TSHR
BP	Unclassified;	GO:0032846; positive regulation of homeostatic process	3.487E-06	3.301E-03	CA2, CA7, HIF1A, HTT, NR1H4, PLA2G1B
BP	GO:0008152; metabolic process	GO:0030574; collagen catabolic process	6.343E-06	5.755E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.012E-05	7.870E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	1.012E-05	7.870E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	1.012E-05	7.870E-03	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:0022617; extracellular matrix disassembly	1.382E-05	9.706E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.270E-21	1.383E-17	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.148E-20	1.371E-16	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.405E-14	3.688E-11	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP12, MMP2, MMP9, NR1H4, PRKCA, PTPN1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	1.443E-27	2.035E-25	CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14
hsa04976	Bile secretion_Homo sapiens_hsa04976	7.882E-06	5.557E-04	SLCO1B1; CA2; SLCO1B3; NR1H4
hsa05200	Pathways in cancer_Homo sapiens_hsa05200	6.930E-05	2.443E-03	MMP1; MMP2; PRKCA; HIF1A; MMP9; NFKB1
hsa05219	Bladder cancer_Homo sapiens_hsa05219	5.447E-05	2.443E-03	MMP1; MMP2; MMP9
hsa05205	Proteoglycans in cancer_Homo sapiens_hsa05205	4.706E-04	1.311E-02	MMP2; PRKCA; HIF1A; MMP9
hsa04933	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	7.907E-04	1.311E-02	MMP2; PRKCA; NFKB1
hsa04010	MAPK signaling pathway_Homo sapiens_hsa04010	1.103E-03	1.555E-02	PRKCA; MAPT; NFKB1; CDC25B
hsa04972	Pancreatic secretion_Homo sapiens_hsa04972	6.821E-04	1.311E-02	CA2; PLA2G1B; PRKCA
hsa04066	HIF-1 signaling pathway_Homo sapiens_hsa04066	8.371E-04	1.311E-02	PRKCA; HIF1A; NFKB1
hsa05206	MicroRNAs in cancer_Homo sapiens_hsa05206	1.931E-03	2.094E-02	PRKCA; MMP9; NFKB1; CDC25B
hsa04670	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.240E-03	1.560E-02	MMP2; PRKCA; MMP9
hsa05161	Hepatitis B_Homo sapiens_hsa05161	2.281E-03	2.297E-02	PRKCA; MMP9; NFKB1
hsa04964	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	7.783E-04	1.311E-02	CA2; CA4
hsa04150	mTOR signaling pathway_Homo sapiens_hsa04150	5.222E-03	4.909E-02	PRKCA; HIF1A
hsa00052	Galactose metabolism_Homo sapiens_hsa00052	1.328E-03	1.560E-02	AKR1B10; GAA

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1; HSD11B1
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A; CA9; MMP9; MMP2
C00-D49: Neoplasms	Colorectal cancer	C18-C21	MMP9
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
NA: NA	Edema	NA	CA2
L00-L99: Diseases of the skin and subcutaneous tissue	Contact dermatitis	L23, L24, L25	PLA2G1B
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1; PLA2G1B
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	PLA2G1B
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HSD11B1; MMP12
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
NA: NA	Colour dead tissues	NA	PTPN1
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2
S00-T88: Injury, poisoning and certain other consequences of external causes	Nerve injury	T14.4	PLA2G1B
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	PLA2G1B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1; HSD11B1; HSD11B1
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MMP12; PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses	L20-L30	PLA2G1B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
J00-J99: Diseases of the respiratory system	Influenza virus	J11.1	HSD11B1
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; CA4
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
C00-D49: Neoplasms	Renal cancer	C64	CA9
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp	L20-L30	PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; GPBAR1; HSD11B1; NFKB1
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	PLA2G1B
A00-B99: Certain infectious and parasitic diseases	Visceral leishmaniasis	B55.0	PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1
A00-B99: Certain infectious and parasitic diseases	Leishmaniasis	B55.0	PLA2G1B
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; CA9
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	HSD11B1; CA4; CA4
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A; CA1; CA9; MMP9; NFKB1; MMP2; CDC25B
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MMP1; PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	GPBAR1; HSD11B1
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
C00-D49: Neoplasms	Breast cancer	C50	CA9
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	PLA2G1B
J00-J99: Diseases of the respiratory system	Asthma	J45	MMP12; PLA2G1B
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MMP12; MMP12

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases