CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; ADORA3; FFAR4;
Small molecule receptor (family C GPCR)	GRM1; GRM8;
Enzyme_unclassified	BLM; TK1; ALOX12; ALOX15; USP2; APEX1;
Ionotropic glutamate receptor	GRIA4; GRIA2; GRIK3; GRIK5; GRIK1;
GABA-A receptor	GABRR1;
Transient receptor potential channel	TRPV1;
Lyase	CA2; CA14;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Lysine demethylase	KDM4E;
Metallo protease	MMP9; MMP1; MMP2;
Transcription Factor	NFKB1;
Transferase	FUT7;
Plant homeodomain	KMT2A;
SLC superfamily of solute carriers	SLC1A1;
Unclassified	LMNA; FABP3; FABP5; FABP4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP1A2; CYP1B1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	TK1	Thymidine kinase, cytosolic	P04183	CHEMBL2883
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
GABA-A receptor	GABRR1	GABA receptor rho-1 subunit	P24046	CHEMBL3561

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0035235; ionotropic glutamate receptor signaling pathway	1.077E-09	2.930E-06	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
BP	GO:0023052; signaling	GO:0060079; excitatory postsynaptic potential	2.978E-09	5.896E-06	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5, TRPV1
BP	GO:0009987; cellular process	GO:0007196; adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway	4.956E-07	4.316E-04	GRIK3, GRM1, GRM8
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	3.377E-06	1.599E-03	ALOX12, ALOX15
BP	GO:0023052; signaling	GO:0051966; regulation of synaptic transmission, glutamatergic	4.298E-06	1.872E-03	GRIK1, GRIK3, GRM1, GRM8
BP	GO:0050896; response to stimulus	GO:0009628; response to abiotic stimulus	1.032E-05	3.685E-03	BLM, CA2, GRM1, KMT2A, LMNA, MMP2, NFKB1, PPARA, TRPV1, USP2
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	1.329E-05	4.523E-03	FABP3, FABP4, FABP5
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	3.365E-05	7.880E-03	ALOX12, ALOX15
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	4.408E-05	9.696E-03	MMP1, MMP2, MMP9, TRPV1
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	1.072E-07	1.111E-04	GABRR1, GRIA2, GRIA4, GRIK1, GRIK3, GRIK5, TRPV1

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.895E-05	5.259E-04	CYP1A2, ALOX15, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.544E-04	2.142E-03	CYP1A2, CYP1B1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.055E-04	3.768E-03	CYP1A2, CYP1B1, CYP3A4
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.212E-04	4.038E-03	CA2, CA14
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	4.087E-11	2.268E-09	GRIA2, GABRR1, GRIK5, ADORA3, GRM8, GRIK3, GRIK1, TRPV1, GRM1, GRIA4
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	4.366E-04	4.038E-03	GRIA2, PPARA, NFKB1, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04724	Glutamatergic synapse	2.301E-11	2.268E-09	GRIA2, GRIK5, SLC1A1, GRM8, GRIK3, GRIK1, GRM1, GRIA4
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.463E-07	5.414E-06	FABP3, FABP4, FABP5, MMP1, PPARA
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	3.187E-05	7.076E-04	GRIA2, GABRR1, GRM1, GRIA4
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	7.461E-04	6.370E-03	MMP2, MMP9, GRM1

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
A00-B99: Certain infectious and parasitic diseases	Adult varicella zoster virus infection	B02	TK1;
A00-B99: Certain infectious and parasitic diseases	Postherpetic neuralgia	B02.2, G44.847, G53.0	TRPV1;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	TRPV1;
C00-D49: Neoplasms	Ocular cancer	C69	APEX1;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TK1;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2;
C00-D49: Neoplasms	Solid tumours	C00-D48	TK1; MMP9; MMP2;
C00-D49: Neoplasms	Pancreatic cancer	C25	TK1; MMP2;
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Arum ternatum thunb

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities