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Plant Name: Arum ternatum thunb




Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins
Small molecule receptor (family C GPCR)
GRM1; GRM5; GABBR1; GRM3; GRM8; GRM4; GRM2;
Small molecule receptor (family A GPCR)
FFAR1; FFAR4; ADORA3;
Peptide receptor (family A GPCR)
TSHR;
Enzyme_unclassified
TDP1; BLM; GLA; FAAH; RECQL; TERT; TK1; HPGD; HSD17B10; ALOX15; ALDH1A1; ALOX12; USP2; UGT1A1; PNP; APEX1;
Protein Phosphatase
PTPN1;
Hydrolase
GAA;
Ionotropic glutamate receptor
GRIK2; GRIA4; GRIA2; GRIK3; GRIK5; GRIK1;
GABA-A receptor
GABRR1;
Transient receptor potential channel
TRPV1;
Protein Kinase
GRK6; IKBKB; CDK1; MAPK1; PIM1;
Lyase
CA3; CA5B; CA5A; CA1; CA12; CA9; CA14; CA7; CA4; CA6; CA2;
Nuclear hormone receptor subfamily 1 group C
PPARA; PPARG; PPARD;
Nuclear hormone receptor subfamily 1 group I
NR1I2;
Lysine demethylase
KDM4E;
Oxidoreductase
ALOX5; PTGS1; MAOB; XDH;
Metallo protease
MMP2; MMP9; MMP1;
Toll-like and Il-1 receptors
TLR2;
Transcription Factor
HIF1A; NFKB1; TP53;
Plant homeodomain
KMT2A;
Transferase
FUT7;
SLC superfamily of solute carriers
SLC6A1; SLC6A11; SLC1A1;
Unclassified
LMNA; FABP5; FABP2; FABP4; MAPT; FABP3; HTT; THPO; RAB9A;
Methyl-lysine/arginine binding protein
SMN1;SMN2;


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes: CYP1A2; CYP2C19; CYP2C9; CYP3A4; CYP2A6; CYP1B1; CYP1A1;

Detailed Information of Human Protein Targets

Protein ClassGene IDProtein NameUniprot IDTarget ChEMBL ID
Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Cytochrome P450 family 2 CYP2C19 Cytochrome P450 2C19 P33261 CHEMBL3622
Cytochrome P450 family 2 CYP2C9 Cytochrome P450 2C9 P11712 CHEMBL3397
Cytochrome P450 family 2 CYP2A6 Cytochrome P450 2A6 P11509 CHEMBL5282
Cytochrome P450 family 3 CYP3A4 Cytochrome P450 3A4 P08684 CHEMBL340
Enzyme_unclassified TDP1 Tyrosyl-DNA phosphodiesterase 1 Q9NUW8 CHEMBL1075138
Enzyme_unclassified BLM Bloom syndrome protein P54132 CHEMBL1293237
Enzyme_unclassified GLA Alpha-galactosidase A P06280 CHEMBL2524
Showing 1 to 10 of 91 entries
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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)


Detailed Information of Enriched Gene Ontolgy
GO TypeGO CategoryEnriched GO Termsp-ValueAdjusted p-ValueEnriched Genes
BP GO:0023052; signaling GO:0051966; regulation of synaptic transmission, glutamatergic 8.734E-12 7.460E-09 GRIK1, GRIK2, GRIK3, GRM1, GRM2, GRM3, GRM4, GRM5, GRM8
BP GO:0050896; response to stimulus GO:0042738; exogenous drug catabolic process 8.933E-12 7.460E-09 CYP1A2, CYP2A6, CYP2C19, CYP2C9, CYP3A4, NR1I2
BP GO:0008152; metabolic process GO:0019373; epoxygenase P450 pathway 5.069E-10 2.299E-07 CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2C9
BP GO:0008152; metabolic process GO:0097267; omega-hydroxylase P450 pathway 5.430E-10 2.413E-07 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP GO:0009987; cellular process GO:0035235; ionotropic glutamate receptor signaling pathway 2.110E-09 7.787E-07 GRIA2, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5
BP GO:0008152; metabolic process GO:0016098; monoterpenoid metabolic process 7.175E-09 2.140E-06 CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP GO:0023052; signaling GO:0060079; excitatory postsynaptic potential 3.742E-08 1.006E-05 GRIA2, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5, TRPV1
BP GO:0008152; metabolic process GO:0008202; steroid metabolic process 2.804E-07 5.654E-05 CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2C9, CYP3A4, NR1I2, PPARD, UGT1A1
BP GO:0008152; metabolic process GO:0019372; lipoxygenase pathway 8.394E-07 1.325E-04 ALOX12, ALOX15, ALOX5, HPGD
BP GO:0008283; cell proliferation GO:1904707; positive regulation of vascular smooth muscle cell proliferation 3.301E-06 4.278E-04 HPGD, MMP2, MMP9, TERT
Showing 1 to 10 of 69 entries
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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways
Pathway IDPathway Namep-ValueAdjusted p-ValueEnriched Genes
hsa00052 Galactose metabolism_Homo sapiens_hsa00052 8.374E-03 2.357E-02 GAA; GLA
hsa00140 Steroid hormone biosynthesis_Homo sapiens_hsa00140 6.976E-06 6.383E-05 UGT1A1; CYP1A2; CYP1A1; CYP1B1; CYP3A4
hsa00232 Caffeine metabolism_Homo sapiens_hsa00232 9.357E-07 1.317E-05 CYP2A6; CYP1A2; XDH
hsa00380 Tryptophan metabolism_Homo sapiens_hsa00380 3.375E-05 2.808E-04 MAOB; CYP1A2; CYP1A1; CYP1B1
hsa00590 Arachidonic acid metabolism_Homo sapiens_hsa00590 4.014E-07 6.382E-06 CYP2C9; ALOX5; ALOX15; ALOX12; CYP2C19; PTGS1
hsa00591 Linoleic acid metabolism_Homo sapiens_hsa00591 2.008E-07 3.675E-06 CYP2C9; CYP1A2; ALOX15; CYP3A4; CYP2C19
hsa00830 Retinol metabolism_Homo sapiens_hsa00830 1.937E-08 5.907E-07 CYP2C9; CYP2A6; UGT1A1; CYP1A2; ALDH1A1; CYP1A1; CYP3A4
hsa00910 Nitrogen metabolism_Homo sapiens_hsa00910 1.271E-22 2.327E-20 CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14
hsa00980 Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 4.400E-08 9.619E-07 CYP2C9; CYP2A6; UGT1A1; CYP1A2; CYP1A1; CYP1B1; CYP3A4
hsa00982 Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 2.957E-08 7.731E-07 CYP2C9; CYP2A6; MAOB; UGT1A1; CYP1A2; CYP3A4; CYP2C19
Showing 1 to 10 of 77 entries
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Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases
ICD10 Disease CategoryDisease NameICD10 CodeLinked Targets
A00-B99: Certain infectious and parasitic diseases Malaria B54 ADORA3
A00-B99: Certain infectious and parasitic diseases Adult varicella zoster virus infection B02 TK1
A00-B99: Certain infectious and parasitic diseases Lymphatic filariasis B74 ALOX5
A00-B99: Certain infectious and parasitic diseases Infections A00-B99 PTPN1
A00-B99: Certain infectious and parasitic diseases Fungal infections B35-B49 ALOX5; RAB9A
A00-B99: Certain infectious and parasitic diseases Postherpetic neuralgia B02.2, G44.847, G53.0 TRPV1
A00-B99: Certain infectious and parasitic diseases Bacterial infections A00-B99 CYP2C9; MAOB
C00-D49: Neoplasms Breast cancer C50 CA9; TERT; CDK1
C00-D49: Neoplasms Overactive bladder disorder C67, N32.81 TRPV1; TRPV1
C00-D49: Neoplasms Oral cavity cancer C00-C08 TP53
Showing 1 to 10 of 150 entries
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Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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Principle Investigator:
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