CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	AKR1B1;
ATP-binding cassette	ABCC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A2; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCC1	Multidrug resistance-associated protein 1	P33527	CHEMBL3004
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900

Showing 1 to 5 of 5 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	9.986E-10	1.087E-05	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.106E-08	4.580E-05	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.472E-08	4.580E-05	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0017144; drug metabolic process	1.498E-08	4.580E-05	ABCC1, AKR1B1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.292E-07	2.344E-04	AKR1B1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	3.216E-07	4.668E-04	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	1.500E-06	1.593E-03	CYP1A1, CYP1A2
BP	GO:0050896; response to stimulus	GO:0010035; response to inorganic substance	1.585E-06	1.593E-03	AKR1B1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0051186; cofactor metabolic process	1.756E-06	1.593E-03	ABCC1, AKR1B1, CYP1A1, CYP1A2
BP	GO:0009987; cellular process	GO:0071280; cellular response to copper ion	4.177E-06	3.136E-03	CYP1A1, CYP1A2

Showing 1 to 10 of 20 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	7.391E-08	1.330E-06	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.305E-07	2.075E-06	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4.641E-07	2.785E-06	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.034E-04	3.101E-04	CYP1A2, CYP1A1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.250E-03	3.213E-03	CYP1A2
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	6.096E-05	2.195E-04	CYP1A1, CYP1B1
09150 Organismal Systems	09154 Digestive system	hsa04977	Vitamin digestion and absorption	5.986E-03	1.078E-02	ABCC1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	6.604E-07	2.972E-06	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	2.134E-03	4.315E-03	ABCC1, CYP1B1
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.158E-03	4.315E-03	CYP1A2, CYP1A1, AKR1B1

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Goniothalamus thwaitesii

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities