CMAUP Plant Collective Molecular Activities

Plant Name: Tanacetum cinerariifolium

Taxonomic Information:

Plant ID: NPO4617
Plant Latin Name: Tanacetum cinerariifolium
Taxonomy Genus: Tanacetum
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 118510
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Switzerland; Jordan; Italy; India

Traditional Medicine System:

Indian Folk

Medicinal Functions:

Vermifuge

Geographical Distribution:

Switzerland; Italy; Jordan; India

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; CDC25B;
Enzyme_unclassified	PLA2G1B; ALDH1A1; AKR1B10; POLB;
Hydrolase	ACHE;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Toll-like and Il-1 receptors	TLR2;
Unclassified	FABP3; FABP4; LMNA; FABP5; FABP2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	6.595E-09	1.795E-05	FABP2, FABP3, FABP4, FABP5
BP	GO:0051179; localization	GO:0015908; fatty acid transport	3.900E-07	5.661E-04	FABP3, PLA2G1B, PPARA, PPARD
BP	GO:0009987; cellular process	GO:0050714; positive regulation of protein secretion	1.923E-06	1.994E-03	ACHE, NR1H4, PLA2G1B, PPARD, TLR2
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	2.459E-06	2.328E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	2.459E-06	2.328E-03	GPBAR1, NR1H4
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	3.421E-06	2.899E-03	NR1H4, PPARA, PPARD, PTPN2
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	4.916E-06	3.453E-03	PTPN1, PTPN2
BP	GO:0050896; response to stimulus	GO:0032868; response to insulin	7.266E-06	4.794E-03	FABP3, PLA2G1B, PPARA, TLR2
BP	GO:0050896; response to stimulus	GO:0046626; regulation of insulin receptor signaling pathway	1.219E-05	7.371E-03	NR1H4, PTPN1, PTPN2
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	1.219E-05	7.371E-03	NR1H4, PPARA, PPARD
MF	GO:0003824; catalytic activity	GO:0001758; retinal dehydrogenase activity	1.718E-05	9.350E-03	AKR1B10, ALDH1A1
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	2.138E-05	1.108E-02	NR1H4, PPARA, PPARD
MF	GO:0005488; binding	GO:0032052; bile acid binding	2.941E-05	1.363E-02	NR1H4, PLA2G1B

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.425E-11	1.407E-09	FABP2, FABP3, FABP4, FABP5, PPARA, PPARD
09150 Organismal Systems	09154 Digestive system	hsa04975	Fat digestion and absorption	6.144E-04	1.782E-02	FABP2, PLA2G1B
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	4.254E-03	6.168E-02	PTPN1, PPARA
09100 Metabolism	09103 Lipid metabolism	hsa00564	Glycerophospholipid metabolism	3.251E-03	6.168E-02	ACHE, PLA2G1B
09100 Metabolism	09103 Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2.227E-02	1.561E-01	PLA2G1B
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	2.667E-02	1.561E-01	AKR1B10
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3.192E-02	1.561E-01	AKR1B10
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	6.119E-02	1.561E-01	PPARA
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	6.203E-02	1.561E-01	NR1H4
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	6.457E-02	1.561E-01	LMNA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	CDC25B;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases