CMAUP Plant Collective Molecular Activities

Plant Name: Tanacetum cinerariifolium

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	6.595E-09	1.795E-05	FABP2, FABP3, FABP4, FABP5
BP	GO:0051179; localization	GO:0015908; fatty acid transport	3.900E-07	5.661E-04	FABP3, PLA2G1B, PPARA, PPARD
BP	GO:0009987; cellular process	GO:0050714; positive regulation of protein secretion	1.923E-06	1.994E-03	ACHE, NR1H4, PLA2G1B, PPARD, TLR2
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	2.459E-06	2.328E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	2.459E-06	2.328E-03	GPBAR1, NR1H4
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	3.421E-06	2.899E-03	NR1H4, PPARA, PPARD, PTPN2
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	4.916E-06	3.453E-03	PTPN1, PTPN2
BP	GO:0050896; response to stimulus	GO:0032868; response to insulin	7.266E-06	4.794E-03	FABP3, PLA2G1B, PPARA, TLR2
BP	GO:0050896; response to stimulus	GO:0046626; regulation of insulin receptor signaling pathway	1.219E-05	7.371E-03	NR1H4, PTPN1, PTPN2
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	1.219E-05	7.371E-03	NR1H4, PPARA, PPARD
MF	GO:0003824; catalytic activity	GO:0001758; retinal dehydrogenase activity	1.718E-05	9.350E-03	AKR1B10, ALDH1A1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa03320	PPAR signaling pathway_Homo sapiens_hsa03320	2.425E-11	1.407E-09	FABP2; FABP3; FABP4; FABP5; PPARA; PPARD
hsa04975	Fat digestion and absorption_Homo sapiens_hsa04975	6.144E-04	1.782E-02	FABP2; PLA2G1B

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD
NA: NA	Dyslipidemia	NA	PPARD
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD; PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	PPARD
NA: NA	Colour dead tissues	NA	PTPN1
L00-L99: Diseases of the skin and subcutaneous tissue	Contact dermatitis	L23, L24, L25	PLA2G1B
C00-D49: Neoplasms	Melanoma	C43	TLR2
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	PPARD
J00-J99: Diseases of the respiratory system	Asthma	J45	PLA2G1B
C00-D49: Neoplasms	Prostate cancer	C61	TLR2
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; PPARD; GPBAR1
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	PLA2G1B
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Radiation sickness	T66	TLR2
C00-D49: Neoplasms	Solid tumours	C00-D48	TLR2
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	PPARD
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp	L20-L30	PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses	L20-L30	PLA2G1B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	TLR2
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARD
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	PLA2G1B
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PLA2G1B
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE
C00-D49: Neoplasms	Pancreatic cancer	C25	TLR2
A00-B99: Certain infectious and parasitic diseases	Leishmaniasis	B55.0	PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1; PPARD; PPARD
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; ACHE; ACHE
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	PLA2G1B
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	PLA2G1B
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1
C00-D49: Neoplasms	Cancer	C00-C96	CDC25B; ACHE; TLR2
A00-B99: Certain infectious and parasitic diseases	Visceral leishmaniasis	B55.0	PLA2G1B
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	TLR2
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Nerve injury	T14.4	PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	PPARD
NA: NA	Upper abdominal bloating	NA	ACHE
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PLA2G1B

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases