CMAUP Plant Collective Molecular Activities

Plant Name: Peucedanum praeruptorum

Taxonomic Information:

Plant ID: NPO4340
Plant Latin Name: Peucedanum praeruptorum
Taxonomy Genus: Peucedanum
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: 312531
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM; Kampo

Medicinal Functions:

Analgesic; Antibacterial; Antifungal; Carminative; Expectorant; Febrifuge

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CNR1; ADORA3; ADORA2A; ADORA1; CNR2;
Peptide receptor (family A GPCR)	NPSR1;
Enzyme_unclassified	ALPL; ADK; ALOX12; HSD17B10; NOX4; USP2; BRCA1; POLB;
Hydrolase	ACHE;
Protein Kinase	FLT3; MET; CDK1; PIM1; AXL; KDR; IGF1R; AURKB;
Lyase	CA12; CA9; CA14;
Lysine demethylase	KDM4E;
Cysteine protease	CASP1; CASP7;
Transcription Factor	TP53; NFKB1;
Transferase	FUT7;
Plant homeodomain	KMT2A;
Unclassified	RAB9A; LMNA; NPC1; HTT; FABP4; HBB;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP2A6; CYP1B1; CYP2A13;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 2	CYP2A13	Cytochrome P450 2A13	Q16696	CHEMBL3542436
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Enzyme_unclassified	BRCA1	Breast cancer type 1 susceptibility protein	P38398	CHEMBL5990
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Plant homeodomain	KMT2A	Histone-lysine N-methyltransferase MLL	Q03164	CHEMBL1293299
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Small molecule receptor (family A GPCR)	CNR1	Cannabinoid CB1 receptor	P21554	CHEMBL218
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	ADORA2A	Adenosine A2a receptor	P29274	CHEMBL251
Small molecule receptor (family A GPCR)	ADORA1	Adenosine A1 receptor	P30542	CHEMBL226
Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	HBB	Hemoglobin beta chain	P68871	CHEMBL4331

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	2.431E-09	4.411E-06	ADORA1, ADORA2A, ALOX12, AURKB, AXL, BRCA1, CDK1, HTT, IGF1R, KDR, LMNA, NFKB1, PIM1, TP53
MF	GO:0005488; binding	GO:0019825; oxygen binding	4.917E-08	5.636E-05	CYP1A2, CYP1B1, CYP2A13, HBB, NOX4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.239E-07	1.012E-04	CYP1A2, CYP1B1, CYP2A13, CYP2A6
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	3.574E-07	2.209E-04	ADORA1, ADORA2A, ADORA3
MF	GO:0005488; binding	GO:0020037; heme binding	3.753E-07	2.209E-04	CYP1A2, CYP1B1, CYP2A13, CYP2A6, HBB, NOX4
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	8.552E-07	4.448E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	9.141E-07	4.629E-04	ALPL, BRCA1, CASP7, CYP1B1, FLT3, NFKB1, NOX4, NPC1
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.391E-06	6.312E-04	ALOX12, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HBB
BP	GO:0050896; response to stimulus	GO:0032496; response to lipopolysaccharide	2.396E-06	9.153E-04	ALPL, AXL, CASP1, CNR1, CNR2, CYP1A2, NFKB1
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.708E-06	9.829E-04	CA12, CA14, CA9, HBB
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.589E-06	1.428E-03	CA12, CA14, CA9
MF	GO:0003824; catalytic activity	GO:0008389; coumarin 7-hydroxylase activity	4.841E-06	1.485E-03	CYP2A13, CYP2A6
BP	GO:0051179; localization	GO:0051050; positive regulation of transport	6.083E-06	1.766E-03	ACHE, ADORA1, ADORA2A, AXL, CASP1, CDK1, HTT, KMT2A, NPSR1, RAB9A, TP53
BP	GO:0009987; cellular process	GO:1902533; positive regulation of intracellular signal transduction	6.909E-06	1.929E-03	ADORA1, AXL, CASP1, CDK1, CYP1B1, FLT3, HTT, KDR, MET, NOX4, TP53
MF	GO:0060089; molecular transducer activity	GO:0004949; cannabinoid receptor activity	1.450E-05	3.359E-03	CNR1, CNR2
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	1.450E-05	3.359E-03	ADORA1, ADORA2A
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.764E-05	3.880E-03	CYP1A2, CYP1B1, CYP2A13
BP	GO:0009987; cellular process	GO:0038171; cannabinoid signaling pathway	2.896E-05	5.631E-03	CNR1, CNR2
BP	GO:0008152; metabolic process	GO:0045833; negative regulation of lipid metabolic process	2.977E-05	5.687E-03	ADORA1, BRCA1, CNR1, NFKB1
BP	GO:0065007; biological regulation	GO:0048878; chemical homeostasis	3.346E-05	6.227E-03	ALOX12, CA12, CNR1, FABP4, HTT, MET, NOX4, NPC1, NPSR1, TP53
MF	GO:0005488; binding	GO:0042802; identical protein binding	3.447E-05	6.293E-03	ACHE, ADORA2A, CASP1, FLT3, HTT, IGF1R, KDR, KMT2A, MET, NFKB1, RAB9A, TP53, USP2
BP	GO:0008152; metabolic process	GO:2000377; regulation of reactive oxygen species metabolic process	3.554E-05	6.396E-03	BRCA1, CYP1B1, HBB, NOX4, TP53
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	3.963E-05	6.809E-03	ADORA1, ADORA2A, ADORA3, AXL, CNR1, CNR2, FLT3, IGF1R, KDR, MET, NPC1, NPSR1
BP	GO:0050896; response to stimulus	GO:0043279; response to alkaloid	4.943E-05	7.799E-03	ADORA2A, CASP7, CNR1, TP53
BP	GO:0009987; cellular process	GO:0043065; positive regulation of apoptotic process	5.040E-05	7.896E-03	ADORA2A, CASP1, CASP7, CNR1, CYP1B1, HTT, NOX4, TP53
BP	GO:0009987; cellular process	GO:0007093; mitotic cell cycle checkpoint	5.382E-05	8.112E-03	AURKB, BRCA1, CDK1, TP53
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	5.612E-05	8.202E-03	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0048511; rhythmic process	GO:0042752; regulation of circadian rhythm	6.605E-05	9.279E-03	ADORA1, ADORA2A, TP53, USP2
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	7.194E-05	9.826E-03	AURKB, FLT3, IGF1R, KDR, PIM1
BP	GO:0023052; signaling	GO:0032229; negative regulation of synaptic transmission, GABAergic	7.220E-05	9.826E-03	ADORA1, CNR2

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	2.261E-06	2.961E-04	KMT2A, FLT3, TP53, MET, NFKB1, IGF1R
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.810E-05	7.903E-04	CYP2A6, CYP2A13, CYP1A2, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	3.916E-05	9.818E-04	PIM1, CYP1B1, BRCA1, TP53, MET, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	8.419E-05	1.418E-03	KDR, BRCA1, TP53, MET, NFKB1, IGF1R
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	6.164E-06	4.037E-04	CA12, CA9, CA14
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.868E-05	9.392E-04	CYP2A6, CYP2A13, CYP1A2, CYP1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	8.659E-05	1.418E-03	ADORA2A, CNR1, KDR, MET, IGF1R
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	2.296E-04	2.727E-03	CASP7, LMNA, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	1.269E-04	1.848E-03	ADORA3, ADORA1, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	2.498E-04	2.727E-03	FLT3, PIM1, NFKB1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3.076E-04	3.100E-03	ADORA2A, CNR2, CNR1, ADORA3, ADORA1
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	2.246E-04	2.727E-03	CASP7, CASP1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	4.778E-04	4.173E-03	TP53, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	4.029E-04	3.770E-03	FLT3, TP53, MET
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	9.329E-04	6.670E-03	KDR, TP53, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	9.675E-04	6.670E-03	POLB, CDK1, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	9.243E-04	6.670E-03	TP53, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.556E-03	9.264E-03	FLT3, MET, TP53, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	1.410E-03	8.794E-03	KDR, MET, NFKB1, IGF1R
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	5.612E-04	4.595E-03	CASP7, CASP1, NFKB1
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	1.083E-03	7.092E-03	TP53, NFKB1, IGF1R
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	4.497E-05	9.818E-04	CYP2A6, CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ADORA1;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADORA1; ADORA2A; CNR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypertriglyceridemia	E78.1, E78.2, E78.3, I47-I49	ADORA1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	CNR2;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; CNR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; CNR1;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADORA1;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Convulsions	R56.0	ADK;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CNR2; CDK1; IGF1R; ACHE; ADORA2A; CNR1; ADK;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; NFKB1; FLT3; ACHE; ADORA3; TP53; CA9;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anorexia	F50.0-F50.1	CNR1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR; ADORA3;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB; TP53;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
I00-I99: Diseases of the circulatory system	Coronary disorder diagnosis	I20-I25	ADORA2A;
I00-I99: Diseases of the circulatory system	Orthostatic hypotension	I95.1	ADORA1;
C00-D49: Neoplasms	Colon cancer	C50	FLT3; ALPL;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; TP53;
C00-D49: Neoplasms	CLL	NA	FLT3;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	ADK; CASP1;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3; CA9;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADORA2A;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ADORA1;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; TP53;
I00-I99: Diseases of the circulatory system	Acute and chronic heart failure	I50	ADORA1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chemotherapy-induced nausea	R11	CNR1;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	CNR1;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3; CNR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET; CASP1;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
J00-J99: Diseases of the respiratory system	Asthma	J45	ADORA1; ADORA2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; ADORA1;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADORA1; CNR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	ADORA2A;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3; TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ADORA1;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ADORA2A;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Beta thalassemia	D56.1	HBB;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1;
I00-I99: Diseases of the circulatory system	Cardiac disease	I00-I99	ADORA1;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADORA1;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	CNR1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	CNR2; CASP1;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE; ADK;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CNR1;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	ADORA2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	CNR1;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
NA: NA	Upper abdominal bloating	NA	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	CNR2;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3; TP53; CA9;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADORA1;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	CNR1;
A00-B99: Certain infectious and parasitic diseases	Postherpetic neuralgia	B02.2, G44.847, G53.0	CNR1;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3; CNR1;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	CNR1;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
E00-E89: Endocrine, nutritional and metabolic diseases	Endocrine disease	E00-E35	CNR1;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	CNR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	CNR2; ADORA1; ADORA2A; CNR1;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; ADORA1; ADORA2A; ADORA3;
NA: NA	GIST	NA	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	CNR2;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	CNR1;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE; ADORA1; ADORA2A;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Radionuclide imaging	W88	ADORA2A;
N00-N99: Diseases of the genitourinary system	Renal failure	N17, N18, N19	ADORA1;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Immune disorder	D80-D89	CNR2;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Nicotine dependence	F17	CNR1;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	CNR2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	ADORA1;
C00-D49: Neoplasms	Renal cancer	C64	KDR; CA9;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases