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Plant Name: Peucedanum praeruptorum




Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins
Peptide receptor (family A GPCR)
OPRK1; TSHR; NPSR1; CXCR1; NMUR2;
Small molecule receptor (family A GPCR)
DRD4; ADORA3; ADORA2A; ADORA1; ADRA2C; ADRA2A; CNR1; CNR2;
Enzyme_unclassified
ALPL; TDP1; PLA2G1B; CES1; RECQL; P4HB; TERT; ADK; PIK3R1; GLO1; HPGD; MPO; AKR1B1; HSD17B10; ALOX15; ALDH1A1; HSD17B2; ALOX12; NOX4; USP2; BRCA1; PYGL; POLB; CES2;
Protein Phosphatase
PTPN11; PTPN6;
Hydrolase
ACHE; GAA;
Histone deacetylase
HDAC3;
Transient receptor potential channel
TRPV1; TRPA1;
Protein Kinase
AKT1; MET; CAMK2B; CSNK2A1; DAPK1; NEK2; FLT3; SRC; IGF1R; PTK2; AURKB; GSK3B; KDR; CDK1; MAPK1; PIM1; NUAK1; ALK; AXL; NEK6; ATM; PKN1; PTK2B;
Lyase
CA5B; CA3; CA7; CA5A; CA1; CA9; CA14; CA4; CA6; CA2; CA12;
Nuclear hormone receptor subfamily 1 group C
PPARA; PPARD;
Lysine demethylase
KDM4E;
Oxidoreductase
MAOA; ALOX5; XDH;
Cysteine protease
CASP7; CASP1;
Metallo protease
MMP13; MMP3; MMP2; MMP9;
Aspartic protease
BACE1;
Toll-like and Il-1 receptors
TLR2;
Transcription Factor
STAT6; HIF1A; NFKB1; TP53;
Plant homeodomain
KMT2A;
Transferase
FUT7;
SLC superfamily of solute carriers
SLC28A2; SLC28A1; SLC28A3;
ATP-binding cassette
ABCC1; ABCG2;
Unclassified
LMNA; FABP5; FABP2; FABP4; MAPT; FABP3; HTT; HBB; RAB9A; NPC1; APAF1;
Methyl-lysine/arginine binding protein
L3MBTL1; SMN1;SMN2;


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes: CYP19A1; CYP1A2; CYP2A13; CYP2C19; CYP2C9; CYP2D6; CYP2C8; CYP3A4; CYP2A6; CYP1B1; CYP1A1;

Detailed Information of Human Protein Targets

Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Aspartic protease BACE1 Beta-secretase 1 P56817 CHEMBL4822
ATP-binding cassette ABCC1 Multidrug resistance-associated protein 1 P33527 CHEMBL3004
ATP-binding cassette ABCG2 ATP-binding cassette sub-family G member 2 Q9UNQ0 CHEMBL5393
Cysteine protease CASP7 Caspase-7 P55210 CHEMBL3468
Cysteine protease CASP1 Caspase-1 P29466 CHEMBL4801
Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Cytochrome P450 family 19 CYP19A1 Cytochrome P450 19A1 P11511 CHEMBL1978
Cytochrome P450 family 2 CYP2A13 Cytochrome P450 2A13 Q16696 CHEMBL3542436
Cytochrome P450 family 2 CYP2C19 Cytochrome P450 2C19 P33261 CHEMBL3622
Cytochrome P450 family 2 CYP2C9 Cytochrome P450 2C9 P11712 CHEMBL3397
Cytochrome P450 family 2 CYP2D6 Cytochrome P450 2D6 P10635 CHEMBL289
Cytochrome P450 family 2 CYP2C8 Cytochrome P450 2C8 P10632 CHEMBL3721
Cytochrome P450 family 2 CYP2A6 Cytochrome P450 2A6 P11509 CHEMBL5282
Cytochrome P450 family 3 CYP3A4 Cytochrome P450 3A4 P08684 CHEMBL340
Enzyme_unclassified PIK3R1 PI3-kinase p85-alpha subunit P27986 CHEMBL2506
Enzyme_unclassified GLO1 Glyoxalase I Q04760 CHEMBL2424
Enzyme_unclassified HPGD 15-hydroxyprostaglandin dehydrogenase [NAD+] P15428 CHEMBL1293255
Enzyme_unclassified MPO Myeloperoxidase P05164 CHEMBL2439
Enzyme_unclassified AKR1B1 Aldose reductase P15121 CHEMBL1900
Enzyme_unclassified HSD17B10 Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Q99714 CHEMBL4159
Enzyme_unclassified ALOX15 Arachidonate 15-lipoxygenase P16050 CHEMBL2903
Enzyme_unclassified ALDH1A1 Aldehyde dehydrogenase 1A1 P00352 CHEMBL3577
Enzyme_unclassified HSD17B2 Estradiol 17-beta-dehydrogenase 2 P37059 CHEMBL2789
Enzyme_unclassified ALOX12 Arachidonate 12-lipoxygenase P18054 CHEMBL3687
Enzyme_unclassified NOX4 NADPH oxidase 4 Q9NPH5 CHEMBL1250375
Enzyme_unclassified USP2 Ubiquitin carboxyl-terminal hydrolase 2 O75604 CHEMBL1293227
Enzyme_unclassified BRCA1 Breast cancer type 1 susceptibility protein P38398 CHEMBL5990
Enzyme_unclassified PYGL Liver glycogen phosphorylase P06737 CHEMBL2568
Enzyme_unclassified POLB DNA polymerase beta P06746 CHEMBL2392
Enzyme_unclassified CES2 Carboxylesterase 2 O00748 CHEMBL3180
Enzyme_unclassified ALPL Alkaline phosphatase, tissue-nonspecific isozyme P05186 CHEMBL5979
Enzyme_unclassified TDP1 Tyrosyl-DNA phosphodiesterase 1 Q9NUW8 CHEMBL1075138
Enzyme_unclassified PLA2G1B Phospholipase A2 group 1B P04054 CHEMBL4426
Enzyme_unclassified CES1 Acyl coenzyme A:cholesterol acyltransferase P23141 CHEMBL2265
Enzyme_unclassified RECQL ATP-dependent DNA helicase Q1 P46063 CHEMBL1293236
Enzyme_unclassified P4HB Protein disulfide-isomerase P07237 CHEMBL5422
Enzyme_unclassified TERT Telomerase reverse transcriptase O14746 CHEMBL2916
Enzyme_unclassified ADK Adenosine kinase P55263 CHEMBL3589
Histone deacetylase HDAC3 Histone deacetylase 3 O15379 CHEMBL1829
Hydrolase ACHE Acetylcholinesterase P22303 CHEMBL220
Hydrolase GAA Lysosomal alpha-glucosidase P10253 CHEMBL2608
Lyase CA5B Carbonic anhydrase VB Q9Y2D0 CHEMBL3969
Lyase CA3 Carbonic anhydrase III P07451 CHEMBL2885
Lyase CA7 Carbonic anhydrase VII P43166 CHEMBL2326
Lyase CA5A Carbonic anhydrase VA P35218 CHEMBL4789
Lyase CA1 Carbonic anhydrase I P00915 CHEMBL261
Lyase CA9 Carbonic anhydrase IX Q16790 CHEMBL3594
Lyase CA14 Carbonic anhydrase XIV Q9ULX7 CHEMBL3510
Lyase CA4 Carbonic anhydrase IV P22748 CHEMBL3729
Lyase CA6 Carbonic anhydrase VI P23280 CHEMBL3025
Lyase CA2 Carbonic anhydrase II P00918 CHEMBL205
Lyase CA12 Carbonic anhydrase XII O43570 CHEMBL3242
Lysine demethylase KDM4E Lysine-specific demethylase 4D-like B2RXH2 CHEMBL1293226
Metallo protease MMP13 Matrix metalloproteinase 13 P45452 CHEMBL280
Metallo protease MMP3 Matrix metalloproteinase 3 P08254 CHEMBL283
Metallo protease MMP2 Matrix metalloproteinase-2 P08253 CHEMBL333
Metallo protease MMP9 Matrix metalloproteinase 9 P14780 CHEMBL321
Methyl-lysine/arginine binding protein L3MBTL1 Lethal(3)malignant brain tumor-like protein 1 Q9Y468 CHEMBL1287622
Methyl-lysine/arginine binding protein SMN1;SMN2 Survival motor neuron protein Q16637 CHEMBL1293232
Nuclear hormone receptor subfamily 1 group C PPARA Peroxisome proliferator-activated receptor alpha Q07869 CHEMBL239
Nuclear hormone receptor subfamily 1 group C PPARD Peroxisome proliferator-activated receptor delta Q03181 CHEMBL3979
Oxidoreductase MAOA Monoamine oxidase A P21397 CHEMBL1951
Oxidoreductase ALOX5 Arachidonate 5-lipoxygenase P09917 CHEMBL215
Oxidoreductase XDH Xanthine dehydrogenase P47989 CHEMBL1929
Peptide receptor (family A GPCR) OPRK1 Kappa opioid receptor P41145 CHEMBL237
Peptide receptor (family A GPCR) TSHR Thyroid stimulating hormone receptor P16473 CHEMBL1963
Peptide receptor (family A GPCR) NPSR1 Neuropeptide S receptor Q6W5P4 CHEMBL5162
Peptide receptor (family A GPCR) CXCR1 Interleukin-8 receptor A P25024 CHEMBL4029
Peptide receptor (family A GPCR) NMUR2 Neuromedin-U receptor 2 Q9GZQ4 CHEMBL1075144
Plant homeodomain KMT2A Histone-lysine N-methyltransferase MLL Q03164 CHEMBL1293299
Protein Kinase PIM1 Serine/threonine-protein kinase PIM1 P11309 CHEMBL2147
Protein Kinase NUAK1 NUAK family SNF1-like kinase 1 O60285 CHEMBL5784
Protein Kinase ALK ALK tyrosine kinase receptor Q9UM73 CHEMBL4247
Protein Kinase AXL Tyrosine-protein kinase receptor UFO P30530 CHEMBL4895
Protein Kinase NEK6 Serine/threonine-protein kinase NEK6 Q9HC98 CHEMBL4309
Protein Kinase ATM Serine-protein kinase ATM Q13315 CHEMBL3797
Protein Kinase PKN1 Protein kinase N1 Q16512 CHEMBL3384
Protein Kinase PTK2B Protein tyrosine kinase 2 beta Q14289 CHEMBL5469
Protein Kinase AKT1 Serine/threonine-protein kinase AKT P31749 CHEMBL4282
Protein Kinase MET Hepatocyte growth factor receptor P08581 CHEMBL3717
Protein Kinase CAMK2B CaM kinase II beta Q13554 CHEMBL4121
Protein Kinase CSNK2A1 Casein kinase II alpha P68400 CHEMBL3629
Protein Kinase DAPK1 Death-associated protein kinase 1 P53355 CHEMBL2558
Protein Kinase NEK2 Serine/threonine-protein kinase NEK2 P51955 CHEMBL3835
Protein Kinase FLT3 Tyrosine-protein kinase receptor FLT3 P36888 CHEMBL1974
Protein Kinase SRC Tyrosine-protein kinase SRC P12931 CHEMBL267
Protein Kinase IGF1R Insulin-like growth factor I receptor P08069 CHEMBL1957
Protein Kinase PTK2 Focal adhesion kinase 1 Q05397 CHEMBL2695
Protein Kinase AURKB Serine/threonine-protein kinase Aurora-B Q96GD4 CHEMBL2185
Protein Kinase GSK3B Glycogen synthase kinase-3 beta P49841 CHEMBL262
Protein Kinase KDR Vascular endothelial growth factor receptor 2 P35968 CHEMBL279
Protein Kinase CDK1 Cyclin-dependent kinase 1 P06493 CHEMBL308
Protein Kinase MAPK1 MAP kinase ERK2 P28482 CHEMBL4040
Protein Phosphatase PTPN11 Protein-tyrosine phosphatase 2C Q06124 CHEMBL3864
Protein Phosphatase PTPN6 Protein-tyrosine phosphatase 1C P29350 CHEMBL3166
SLC superfamily of solute carriers SLC28A2 Sodium/nucleoside cotransporter 2 O43868 CHEMBL5780
SLC superfamily of solute carriers SLC28A1 Sodium/nucleoside cotransporter 1 O00337 CHEMBL5551
SLC superfamily of solute carriers SLC28A3 Solute carrier family 28 member 3 Q9HAS3 CHEMBL5707
Small molecule receptor (family A GPCR) DRD4 Dopamine D4 receptor P21917 CHEMBL219
Small molecule receptor (family A GPCR) ADORA3 Adenosine A3 receptor P0DMS8 CHEMBL256
Small molecule receptor (family A GPCR) ADORA2A Adenosine A2a receptor P29274 CHEMBL251
Small molecule receptor (family A GPCR) ADORA1 Adenosine A1 receptor P30542 CHEMBL226
Small molecule receptor (family A GPCR) ADRA2C Alpha-2c adrenergic receptor P18825 CHEMBL1916
Small molecule receptor (family A GPCR) ADRA2A Alpha-2a adrenergic receptor P08913 CHEMBL1867
Small molecule receptor (family A GPCR) CNR1 Cannabinoid CB1 receptor P21554 CHEMBL218
Small molecule receptor (family A GPCR) CNR2 Cannabinoid CB2 receptor P34972 CHEMBL253
Toll-like and Il-1 receptors TLR2 Toll-like receptor 2 O60603 CHEMBL4163
Transcription Factor STAT6 Signal transducer and activator of transcription 6 P42226 CHEMBL5401
Transcription Factor HIF1A Hypoxia-inducible factor 1 alpha Q16665 CHEMBL4261
Transcription Factor NFKB1 Nuclear factor NF-kappa-B p105 subunit P19838 CHEMBL3251
Transcription Factor TP53 Cellular tumor antigen p53 P04637 CHEMBL4096
Transferase FUT7 Alpha-(1,3)-fucosyltransferase 7 Q11130 CHEMBL3596077
Transient receptor potential channel TRPV1 Vanilloid receptor Q8NER1 CHEMBL4794
Transient receptor potential channel TRPA1 Transient receptor potential cation channel subfamily A member 1 O75762 CHEMBL6007
Unclassified LMNA Prelamin-A/C P02545 CHEMBL1293235
Unclassified FABP5 Fatty acid binding protein epidermal Q01469 CHEMBL3674
Unclassified FABP2 Fatty acid binding protein intestinal P12104 CHEMBL4879
Unclassified FABP4 Fatty acid binding protein adipocyte P15090 CHEMBL2083
Unclassified MAPT Microtubule-associated protein tau P10636 CHEMBL1293224
Unclassified FABP3 Fatty acid binding protein muscle P05413 CHEMBL3344
Unclassified HTT Huntingtin P42858 CHEMBL5514
Unclassified HBB Hemoglobin beta chain P68871 CHEMBL4331
Unclassified RAB9A Ras-related protein Rab-9A P51151 CHEMBL1293294
Unclassified NPC1 Niemann-Pick C1 protein O15118 CHEMBL1293277
Unclassified APAF1 Apoptotic protease-activating factor 1 O14727 CHEMBL1795093
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)


Detailed Information of Enriched Gene Ontolgy
GO Type GO Category Enriched GO Terms p-Value Adjusted p-Value Enriched Genes
BP GO:0008152; metabolic process GO:0019373; epoxygenase P450 pathway 5.641E-13 1.706E-10 CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2C8, CYP2C9
BP Unclassified; GO:0032844; regulation of homeostatic process 6.578E-13 1.962E-10 ADORA1, ADORA2A, ADRA2A, ATM, AURKB, CA2, CA7, CNR1, HIF1A, HTT, KDR, MAPK1, NEK2, NPC1, NPSR1, OPRK1, PLA2G1B, PTK2B, PTPN6, SRC, TRPA1, TRPV1
MF GO:0003824; catalytic activity GO:0070330; aromatase activity 1.344E-12 3.801E-10 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C8, CYP2D6, CYP3A4
BP GO:0008152; metabolic process GO:0097267; omega-hydroxylase P450 pathway 1.546E-11 3.783E-09 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
BP GO:0050896; response to stimulus GO:0042738; exogenous drug catabolic process 6.729E-11 1.409E-08 CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0016098; monoterpenoid metabolic process 7.050E-11 1.462E-08 CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP Unclassified; GO:2000021; regulation of ion homeostasis 1.284E-09 1.928E-07 ADORA1, ADORA2A, CA2, CA7, HTT, KDR, NPSR1, PLA2G1B, PTK2B, PTPN6, SRC, TRPA1, TRPV1
MF GO:0003824; catalytic activity GO:0034875; caffeine oxidase activity 1.840E-09 2.653E-07 CYP1A2, CYP2C8, CYP2C9, CYP3A4
BP Unclassified; GO:0032846; positive regulation of homeostatic process 3.524E-09 4.857E-07 ADORA2A, ATM, AURKB, CA2, CA7, CNR1, HIF1A, HTT, MAPK1, NEK2, NPC1, NPSR1, PLA2G1B
MF GO:0005488; binding GO:0005524; ATP binding 5.993E-09 8.006E-07 ABCC1, ABCG2, ADK, AKT1, ALK, APAF1, ATM, AURKB, AXL, CAMK2B, CDK1, CSNK2A1, DAPK1, FLT3, GSK3B, IGF1R, KDR, MAPK1, MET, NEK2, NEK6, NUAK1, PIM1, PKN1, PTK2, PTK2B, PYGL, RECQL, SRC, TP53, TRPV1
BP GO:0008152; metabolic process GO:0070989; oxidative demethylation 9.014E-09 1.155E-06 CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP3A4
BP GO:0008152; metabolic process GO:0006691; leukotriene metabolic process 4.837E-08 5.163E-06 ABCC1, ALOX12, ALOX15, ALOX5, PLA2G1B, TLR2
BP GO:0009987; cellular process GO:0030168; platelet activation 4.903E-08 5.204E-06 ADRA2A, ADRA2C, AKT1, AXL, MAPK1, PIK3R1, PTPN11, PTPN6, SRC
BP GO:0008152; metabolic process GO:0009804; coumarin metabolic process 6.340E-08 6.482E-06 CYP1A1, CYP2A13, CYP2A6, CYP2D6
MF GO:0003824; catalytic activity GO:0008392; arachidonic acid epoxygenase activity 6.858E-08 6.946E-06 CYP2A13, CYP2A6, CYP2C19, CYP2C8, CYP2C9
MF GO:0005488; binding GO:0008270; zinc ion binding 8.624E-08 8.346E-06 BRCA1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, KMT2A, L3MBTL1, MMP13, MMP2, MMP3, MMP9, PPARA, PPARD, TP53
BP GO:0008152; metabolic process GO:0018105; peptidyl-serine phosphorylation 1.502E-07 1.329E-05 AKT1, ATM, AURKB, CAMK2B, CDK1, GSK3B, MAPK1, NEK6, PKN1, SRC
BP GO:0009987; cellular process GO:0071456; cellular response to hypoxia 4.511E-07 3.707E-05 AKT1, HIF1A, LMNA, P4HB, PPARD, SRC, TERT, TP53
BP GO:0009987; cellular process GO:0071407; cellular response to organic cyclic compound 6.098E-07 4.820E-05 AKT1, ALPL, BRCA1, CASP7, CYP1A1, CYP1B1, FLT3, MAPK1, NFKB1, NOX4, NPC1, SRC, TRPV1
BP GO:0008152; metabolic process GO:0018107; peptidyl-threonine phosphorylation 8.505E-07 6.408E-05 AKT1, CAMK2B, CDK1, CSNK2A1, GSK3B, MAPK1, PKN1
BP GO:0050896; response to stimulus GO:0045471; response to ethanol 1.041E-06 7.765E-05 CA3, CDK1, CNR1, HPGD, OPRK1, POLB, PTK2B, TP53
CC GO:0044425; membrane part GO:0005887; integral component of plasma membrane 1.531E-06 1.097E-04 ABCC1, ADORA1, ADORA2A, ADORA3, ADRA2A, ADRA2C, ALK, AXL, BACE1, CNR1, CNR2, DRD4, FLT3, IGF1R, KDR, MET, NPC1, NPSR1, OPRK1, SLC28A1, SLC28A2, SLC28A3, TLR2, TRPA1, TRPV1, TSHR
MF Unclassified; GO:0099600; transmembrane receptor activity 2.252E-06 1.513E-04 ADORA1, ADORA2A, ADORA3, ADRA2A, ADRA2C, ALK, AXL, CNR1, CNR2, CXCR1, DRD4, FLT3, HPGD, IGF1R, KDR, MET, NMUR2, NPC1, NPSR1, OPRK1, PTK2B, PTPN6, TRPV1, TSHR
BP GO:0050896; response to stimulus GO:0043279; response to alkaloid 2.427E-06 1.606E-04 ADORA2A, CASP7, CNR1, OPRK1, PTK2B, TP53, TRPV1
MF GO:0003824; catalytic activity GO:0101020; estrogen 16-alpha-hydroxylase activity 2.815E-06 1.803E-04 CYP1A1, CYP2C8, CYP3A4
MF Unclassified; GO:0004872; receptor activity 2.951E-06 1.885E-04 ADORA1, ADORA2A, ADORA3, ADRA2A, ADRA2C, ALK, AXL, CNR1, CNR2, CXCR1, DRD4, FLT3, HPGD, IGF1R, KDR, MET, NMUR2, NPC1, NPSR1, OPRK1, PPARA, PPARD, PTK2B, PTPN6, TLR2, TRPV1, TSHR
BP GO:0008152; metabolic process GO:0019372; lipoxygenase pathway 3.148E-06 1.998E-04 ALOX12, ALOX15, ALOX5, HPGD
BP GO:0008283; cell proliferation GO:0008285; negative regulation of cell proliferation 4.109E-06 2.499E-04 ADORA1, ADORA2A, ADORA3, ATM, CYP1B1, FABP3, KMT2A, LMNA, NOX4, PKN1, PPARD, PTK2B, PTPN6, TERT, TLR2, TP53, XDH
BP GO:0065007; biological regulation GO:0051881; regulation of mitochondrial membrane potential 4.120E-06 2.499E-04 ADORA2A, AKT1, CASP1, KDR, MAPT, SRC
BP GO:0008152; metabolic process GO:0051000; positive regulation of nitric-oxide synthase activity 5.238E-06 3.083E-04 AKT1, HIF1A, PTK2B, TERT
BP GO:0009987; cellular process GO:2001237; negative regulation of extrinsic apoptotic signaling pathway 5.562E-06 3.256E-04 AKT1, BRCA1, DAPK1, HTT, LMNA, SRC, TERT
BP GO:0008152; metabolic process GO:0002933; lipid hydroxylation 5.603E-06 3.271E-04 CYP1A1, CYP2C8, CYP3A4
BP Unclassified; GO:0044236; multicellular organism metabolic process 6.730E-06 3.877E-04 HIF1A, MMP13, MMP2, MMP3, MMP9, PLA2G1B, TRPV1
BP GO:0009987; cellular process GO:0048010; vascular endothelial growth factor receptor signaling pathway 8.222E-06 4.650E-04 AXL, KDR, PIK3R1, PTK2, PTK2B, SRC
CC GO:0044464; cell part GO:0005829; cytosol 8.545E-06 4.783E-04 ADK, AKR1B1, AKT1, ALDH1A1, ALOX12, ALOX15, ALOX5, APAF1, AURKB, CA1, CA2, CA3, CA7, CAMK2B, CASP1, CASP7, CDK1, CES1, CSNK2A1, FABP2, FABP3, FABP4, FABP5, FLT3, GLO1, GSK3B, HBB, HDAC3, HIF1A, HPGD, HTT, KMT2A, LMNA, MAPK1, MAPT, NEK2, NEK6, NFKB1, PIK3R1, PIM1, PKN1, PLA2G1B, PTK2, PTK2B, PTPN11, PTPN6, PYGL, RAB9A, SMN1, SMN2, SRC, STAT6, TP53, TRPV1, XDH
MF GO:0060089; molecular transducer activity GO:0001609; G-protein coupled adenosine receptor activity 9.757E-06 5.298E-04 ADORA1, ADORA2A, ADORA3
BP GO:0050896; response to stimulus GO:0071498; cellular response to fluid shear stress 1.009E-05 5.465E-04 CA2, HDAC3, PTK2B, SRC
BP GO:0065007; biological regulation GO:0042593; glucose homeostasis 1.095E-05 5.859E-04 ADRA2A, AKT1, CNR1, HIF1A, NOX4, PIK3R1, PTPN11, PYGL
BP GO:0050896; response to stimulus GO:0050728; negative regulation of inflammatory response 1.152E-05 6.132E-04 ADORA1, ADORA2A, CNR2, CYP19A1, NFKB1, PPARA, PPARD
BP GO:0065007; biological regulation GO:0048872; homeostasis of number of cells 1.219E-05 6.412E-04 AXL, FLT3, HIF1A, KMT2A, PKN1, POLB, PTPN11
BP GO:0008283; cell proliferation GO:1904707; positive regulation of vascular smooth muscle cell proliferation 1.227E-05 6.422E-04 HPGD, MMP2, MMP9, TERT
BP GO:0008152; metabolic process GO:0031331; positive regulation of cellular catabolic process 1.272E-05 6.610E-04 ADRA2A, AKT1, ATM, CDK1, DAPK1, GSK3B, HIF1A, HTT, KDR, PPARA, PTK2, PTK2B
BP GO:0008152; metabolic process GO:0038083; peptidyl-tyrosine autophosphorylation 1.450E-05 7.446E-04 IGF1R, KDR, PTK2, PTK2B, SRC
MF GO:0005488; binding GO:0051379; epinephrine binding 1.554E-05 7.836E-04 ADRA2A, ADRA2C, DRD4
BP GO:0002376; immune system process GO:0043312; neutrophil degranulation 1.928E-05 9.477E-04 ALOX5, APAF1, CXCR1, FABP5, GAA, HBB, MAPK1, MMP9, MPO, NFKB1, PTPN6, PYGL, TLR2
MF Unclassified; GO:0032403; protein complex binding 2.002E-05 9.722E-04 ACHE, ADORA1, ADRA2A, ATM, FLT3, IGF1R, KDR, MMP13, MMP9, P4HB, PIK3R1, PPARA, PTK2B, PTPN11, SRC, TLR2, TSHR
BP GO:0008152; metabolic process GO:0019433; triglyceride catabolic process 2.089E-05 1.006E-03 FABP2, FABP3, FABP4, FABP5
CC GO:0043226; organelle GO:0005654; nucleoplasm 2.276E-05 1.092E-03 ADK, AKR1B1, AKT1, ALOX5, ATM, AURKB, BRCA1, CAMK2B, CASP7, CDK1, CSNK2A1, FABP5, GSK3B, HDAC3, HIF1A, HPGD, HTT, KMT2A, L3MBTL1, LMNA, MAPK1, NEK2, NEK6, NFKB1, NUAK1, PIM1, PKN1, POLB, PPARA, PPARD, PTPN11, RECQL, SMN1, SMN2, SRC, STAT6, TERT, TP53, USP2
BP GO:0009987; cellular process GO:1901796; regulation of signal transduction by p53 class mediator 2.287E-05 1.095E-03 AKT1, ATM, AURKB, BRCA1, CSNK2A1, L3MBTL1, NUAK1, TP53
BP GO:0009987; cellular process GO:0001973; adenosine receptor signaling pathway 2.319E-05 1.107E-03 ADORA1, ADORA2A, ADORA3
BP GO:0065007; biological regulation GO:0098771; inorganic ion homeostasis 2.367E-05 1.128E-03 ABCG2, CA12, CA2, CA7, DRD4, HIF1A, HTT, MAPK1, NMUR2, NPSR1, PLA2G1B, PTK2B, TP53, TRPA1, TRPV1
BP GO:0050896; response to stimulus GO:0009314; response to radiation 2.445E-05 1.150E-03 AKT1, ATM, AURKB, BRCA1, HIF1A, KMT2A, NOX4, OPRK1, PIK3R1, POLB, TP53, USP2
BP GO:0050896; response to stimulus GO:0060359; response to ammonium ion 2.616E-05 1.217E-03 CASP7, CNR1, DRD4, MAPK1, OPRK1, PTK2B
BP GO:0050896; response to stimulus GO:2001025; positive regulation of response to drug 2.869E-05 1.318E-03 ADORA2A, DRD4, KMT2A, OPRK1
MF GO:0005488; binding GO:0019901; protein kinase binding 2.992E-05 1.366E-03 ADRA2A, AKT1, GSK3B, HIF1A, MAPK1, NEK6, PIK3R1, PKN1, PTK2, PTK2B, PTPN11, PTPN6, SRC, TP53
BP GO:0051179; localization GO:0043270; positive regulation of ion transport 3.007E-05 1.370E-03 ADORA1, ADORA2A, ADRA2A, AKT1, DRD4, HTT, NPSR1, OPRK1, PLA2G1B
BP GO:0008152; metabolic process GO:0016572; histone phosphorylation 3.330E-05 1.498E-03 ATM, AURKB, CDK1, PKN1
CC GO:0016020; membrane GO:0016323; basolateral plasma membrane 3.398E-05 1.522E-03 ABCC1, ADORA1, ADRA2A, CA2, CA4, CA9, HPGD, TSHR
BP GO:0008152; metabolic process GO:0010506; regulation of autophagy 3.858E-05 1.704E-03 AKT1, ATM, CASP1, DAPK1, HIF1A, HTT, KDR, MAPT, MET, NPC1
BP GO:0051179; localization GO:0043271; negative regulation of ion transport 4.310E-05 1.867E-03 ADORA1, ADRA2A, AKT1, CNR1, DRD4, MMP9, PTK2B
BP GO:0009987; cellular process GO:0033277; abortive mitotic cell cycle 4.357E-05 1.867E-03 PTPN11, PTPN6
BP GO:0051179; localization GO:0015860; purine nucleoside transmembrane transport 4.357E-05 1.867E-03 SLC28A2, SLC28A3
BP GO:0008152; metabolic process GO:2001303; lipoxin A4 biosynthetic process 4.357E-05 1.867E-03 ALOX12, ALOX15
MF GO:0005215; transporter activity GO:0015389; pyrimidine- and adenine-specific:sodium symporter activity 4.357E-05 1.867E-03 SLC28A1, SLC28A3
MF GO:0003824; catalytic activity GO:0047977; hepoxilin-epoxide hydrolase activity 4.357E-05 1.867E-03 ALOX12, ALOX15
MF GO:0003824; catalytic activity GO:0008389; coumarin 7-hydroxylase activity 4.357E-05 1.867E-03 CYP2A13, CYP2A6
MF GO:0005215; transporter activity GO:0015211; purine nucleoside transmembrane transporter activity 4.357E-05 1.867E-03 SLC28A2, SLC28A3
BP GO:0008152; metabolic process GO:0043552; positive regulation of phosphatidylinositol 3-kinase activity 4.411E-05 1.872E-03 FLT3, PTK2, PTK2B, SRC
MF GO:0005488; binding GO:0043560; insulin receptor substrate binding 4.511E-05 1.896E-03 IGF1R, PIK3R1, PTPN11
MF GO:0005488; binding GO:0034452; dynactin binding 4.511E-05 1.896E-03 GSK3B, HTT, MAPT
BP GO:0065007; biological regulation GO:0000187; activation of MAPK activity 4.715E-05 1.970E-03 ALK, CDK1, DRD4, MAPK1, PKN1, PLA2G1B, PTPN11
BP GO:0048511; rhythmic process GO:0042752; regulation of circadian rhythm 4.814E-05 2.002E-03 ADORA1, ADORA2A, DRD4, PPARA, TP53, USP2
BP GO:0009987; cellular process GO:0071276; cellular response to cadmium ion 5.039E-05 2.078E-03 AKT1, CYP1A2, MAPK1, MMP9
BP GO:0009987; cellular process GO:0070301; cellular response to hydrogen peroxide 5.221E-05 2.137E-03 AKR1B1, AXL, CDK1, CYP1B1, STAT6
BP GO:0009987; cellular process GO:0045595; regulation of cell differentiation 5.243E-05 2.142E-03 ADRA2C, AKT1, AXL, CA2, CAMK2B, CDK1, CNR1, GSK3B, HDAC3, HIF1A, KDR, KMT2A, L3MBTL1, MAPK1, MAPT, NFKB1, PIK3R1, PPARA, PPARD, PTK2, PTK2B, PTPN6, TERT, TLR2, TRPV1, XDH
MF GO:0005488; binding GO:0051879; Hsp90 protein binding 5.729E-05 2.323E-03 CSNK2A1, HIF1A, KDR, MAPT
BP GO:0009987; cellular process GO:0090399; replicative senescence 5.986E-05 2.400E-03 ATM, TERT, TP53
BP GO:0022610; biological adhesion GO:0001952; regulation of cell-matrix adhesion 6.365E-05 2.538E-03 GSK3B, KDR, PIK3R1, PTK2, PTK2B, SRC
BP GO:0009987; cellular process GO:0051897; positive regulation of protein kinase B signaling 6.943E-05 2.749E-03 AXL, MET, NOX4, PIK3R1, PTK2, PTPN11, SRC
BP GO:0065007; biological regulation GO:0032148; activation of protein kinase B activity 7.314E-05 2.844E-03 ADRA2A, ADRA2C, AKT1, SRC
BP GO:0032501; multicellular organismal process GO:0051930; regulation of sensory perception of pain 7.314E-05 2.844E-03 ADORA1, ADRA2C, NMUR2, OPRK1
BP GO:0065007; biological regulation GO:0032212; positive regulation of telomere maintenance via telomerase 7.314E-05 2.844E-03 ATM, AURKB, MAPK1, NEK2
BP GO:0032502; developmental process GO:0045766; positive regulation of angiogenesis 7.540E-05 2.916E-03 ALOX12, BRCA1, CYP1B1, HIF1A, KDR, PTK2B, TERT
BP GO:0009987; cellular process GO:0014068; positive regulation of phosphatidylinositol 3-kinase signaling 7.639E-05 2.949E-03 FLT3, KDR, PPARD, PTK2, PTPN6
BP GO:0023052; signaling GO:0032230; positive regulation of synaptic transmission, GABAergic 7.744E-05 2.979E-03 ADORA2A, CA2, CA7
BP GO:0008152; metabolic process GO:0045913; positive regulation of carbohydrate metabolic process 8.816E-05 3.325E-03 AKT1, HIF1A, NFKB1, PPARA, SRC
BP GO:0009987; cellular process GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage 8.816E-05 3.325E-03 ATM, BRCA1, PIK3R1, POLB, TP53
BP GO:0009987; cellular process GO:0032872; regulation of stress-activated MAPK cascade 9.424E-05 3.526E-03 AKT1, HDAC3, IGF1R, MAPK1, OPRK1, PKN1, PTK2B, XDH
MF GO:0005488; binding GO:0002039; p53 binding 1.013E-04 3.757E-03 GSK3B, HIF1A, HTT, NUAK1, TP53
MF GO:0005488; binding GO:0001221; transcription cofactor binding 1.026E-04 3.792E-03 NEK6, PPARA, TERT, TP53
BP GO:0009987; cellular process GO:2000045; regulation of G1/S transition of mitotic cell cycle 1.036E-04 3.824E-03 AKT1, ATM, CDK1, CYP1A1, PTPN6, TERT, TP53
BP GO:0009987; cellular process GO:0097194; execution phase of apoptosis 1.140E-04 4.174E-03 AKT1, CASP1, CASP7, PTK2
CC GO:0044464; cell part GO:0031234; extrinsic component of cytoplasmic side of plasma membrane 1.159E-04 4.233E-03 ALOX15, CNR2, PTK2, PTK2B, SRC
MF GO:0005488; binding GO:0046982; protein heterodimerization activity 1.173E-04 4.280E-03 ADORA1, ADORA2A, ADRA2A, ADRA2C, AXL, HIF1A, NFKB1, P4HB, PIK3R1, PPARD, TLR2, TP53
BP GO:0002376; immune system process GO:0002684; positive regulation of immune system process 1.214E-04 4.420E-03 AKT1, AXL, CA2, CNR1, HIF1A, MAPK1, MMP2, NFKB1, PIK3R1, PLA2G1B, PTK2, PTK2B, PTPN11, PTPN6, SRC, STAT6, TLR2, TP53
BP Unclassified; GO:0044243; multicellular organismal catabolic process 1.237E-04 4.489E-03 MMP13, MMP2, MMP3, MMP9, PLA2G1B
CC GO:0016020; membrane GO:0005789; endoplasmic reticulum membrane 1.239E-04 4.489E-03 CAMK2B, CDK1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, HSD17B2, NOX4, RAB9A, SLC28A3
BP GO:0009987; cellular process GO:0031334; positive regulation of protein complex assembly 1.291E-04 4.563E-03 ALOX15, GSK3B, MAPT, MET, MMP3, PTK2B, SRC, TP53
BP GO:0051179; localization GO:1904823; purine nucleobase transmembrane transport 1.301E-04 4.563E-03 SLC28A1, SLC28A3
BP GO:0032501; multicellular organismal process GO:0050968; detection of chemical stimulus involved in sensory perception of pain 1.301E-04 4.563E-03 TRPA1, TRPV1
BP GO:0008152; metabolic process GO:0009822; alkaloid catabolic process 1.301E-04 4.563E-03 CYP2D6, CYP3A4
BP GO:0009987; cellular process GO:0032849; positive regulation of cellular pH reduction 1.301E-04 4.563E-03 CA2, CA7
BP GO:0051179; localization GO:0015855; pyrimidine nucleobase transport 1.301E-04 4.563E-03 SLC28A1, SLC28A3
BP GO:0032501; multicellular organismal process GO:0050955; thermoception 1.301E-04 4.563E-03 TRPA1, TRPV1
MF GO:0005215; transporter activity GO:0097603; temperature-gated ion channel activity 1.301E-04 4.563E-03 TRPA1, TRPV1
MF GO:0003824; catalytic activity GO:0070576; vitamin D 24-hydroxylase activity 1.301E-04 4.563E-03 CYP1A1, CYP3A4
MF GO:0060089; molecular transducer activity GO:0004949; cannabinoid receptor activity 1.301E-04 4.563E-03 CNR1, CNR2
MF GO:0003824; catalytic activity GO:0004052; arachidonate 12-lipoxygenase activity 1.301E-04 4.563E-03 ALOX12, ALOX15
MF GO:0060089; molecular transducer activity GO:0004938; alpha2-adrenergic receptor activity 1.301E-04 4.563E-03 ADRA2A, ADRA2C
MF GO:0003824; catalytic activity GO:0051120; hepoxilin A3 synthase activity 1.301E-04 4.563E-03 ALOX12, ALOX15
MF GO:0003824; catalytic activity GO:0047374; methylumbelliferyl-acetate deacetylase activity 1.301E-04 4.563E-03 CES1, CES2
CC GO:0044464; cell part GO:0099056; integral component of presynaptic membrane 1.301E-04 4.563E-03 ADORA1, ADORA2A
BP GO:0002376; immune system process GO:0061515; myeloid cell development 1.398E-04 4.846E-03 PTPN11, PTPN6, SRC, TLR2
CC GO:0016020; membrane GO:0045121; membrane raft 1.483E-04 5.104E-03 BACE1, CNR1, KDR, MAPK1, NPC1, PTK2B, SRC, STAT6, TLR2
CC GO:0044464; cell part GO:0030673; axolemma 1.494E-04 5.124E-03 ADORA1, ADORA2A, MAPT
MF GO:0005488; binding GO:0051219; phosphoprotein binding 1.498E-04 5.128E-03 MAPK1, PIK3R1, PTPN6, SRC, TRPV1
BP GO:0008152; metabolic process GO:0045429; positive regulation of nitric oxide biosynthetic process 1.541E-04 5.251E-03 AKT1, HBB, PTK2B, TRPV1
BP GO:0009987; cellular process GO:0071356; cellular response to tumor necrosis factor 1.553E-04 5.275E-03 AKT1, BRCA1, FABP4, MAPK1, NFKB1, TRPV1
BP GO:0008152; metabolic process GO:0050731; positive regulation of peptidyl-tyrosine phosphorylation 1.558E-04 5.284E-03 ADORA1, ADRA2A, ADRA2C, FLT3, PTK2B, SRC, TP53
BP GO:0008152; metabolic process GO:0044283; small molecule biosynthetic process 1.653E-04 5.556E-03 AKR1B1, ALOX12, ALOX15, ALOX5, BRCA1, CES1, CYP19A1, CYP1A1, CYP3A4, MPO, PLA2G1B
BP GO:0009987; cellular process GO:1900034; regulation of cellular response to heat 1.694E-04 5.639E-03 ATM, CAMK2B, GSK3B, MAPK1, MAPT
BP GO:0009987; cellular process GO:0050714; positive regulation of protein secretion 1.739E-04 5.774E-03 ACHE, ADORA2A, CASP1, HIF1A, PLA2G1B, PPARD, SRC, TLR2
BP GO:0032501; multicellular organismal process GO:0097746; regulation of blood vessel diameter 1.775E-04 5.840E-03 ADORA1, ADORA2A, ADRA2A, ADRA2C, AKT1, PPARD
BP GO:0002376; immune system process GO:0001774; microglial cell activation 1.806E-04 5.895E-03 MAPT, TLR2, TRPV1
BP GO:0065007; biological regulation GO:1904355; positive regulation of telomere capping 1.806E-04 5.895E-03 AURKB, MAPK1, NEK2
MF GO:0003824; catalytic activity GO:0035173; histone kinase activity 1.806E-04 5.895E-03 AURKB, CDK1, PKN1
BP GO:0051179; localization GO:0046326; positive regulation of glucose import 1.859E-04 6.051E-03 AKT1, PIK3R1, PTPN11, TERT
BP GO:0007610; behavior GO:0007626; locomotory behavior 1.923E-04 6.249E-03 ADORA2A, ALK, DRD4, GAA, NPC1, OPRK1, USP2
BP GO:0009987; cellular process GO:0000226; microtubule cytoskeleton organization 2.204E-04 7.068E-03 AURKB, CDK1, HDAC3, HTT, LMNA, MAPT, NEK2, NEK6, PTK2
BP GO:0009987; cellular process GO:0090199; regulation of release of cytochrome c from mitochondria 2.221E-04 7.071E-03 AKT1, LMNA, MMP9, TP53
BP GO:0032501; multicellular organismal process GO:0010595; positive regulation of endothelial cell migration 2.536E-04 7.960E-03 AKT1, HIF1A, KDR, MET, PTK2B
BP GO:0032501; multicellular organismal process GO:0035162; embryonic hemopoiesis 2.548E-04 7.985E-03 HIF1A, KDR, KMT2A
BP GO:0022610; biological adhesion GO:0045785; positive regulation of cell adhesion 2.585E-04 8.027E-03 AKT1, ALOX12, ALOX15, GSK3B, KDR, PIK3R1, PTK2B, PTPN11, PTPN6, SRC
BP GO:0065007; biological regulation GO:0032431; activation of phospholipase A2 activity 2.592E-04 8.027E-03 NMUR2, PLA2G1B
BP GO:0065007; biological regulation GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway 2.592E-04 8.027E-03 ADRA2A, ADRA2C
BP GO:0009987; cellular process GO:0032811; negative regulation of epinephrine secretion 2.592E-04 8.027E-03 ADRA2A, ADRA2C
BP GO:0009987; cellular process GO:0038171; cannabinoid signaling pathway 2.592E-04 8.027E-03 CNR1, CNR2
BP GO:0008152; metabolic process GO:0018894; dibenzo-p-dioxin metabolic process 2.592E-04 8.027E-03 CYP1A1, CYP1A2
MF GO:0005488; binding GO:0032795; heterotrimeric G-protein binding 2.592E-04 8.027E-03 ADORA1, ADRA2A
BP Unclassified; GO:0044259; multicellular organismal macromolecule metabolic process 2.679E-04 8.226E-03 HIF1A, MMP13, MMP2, MMP3, MMP9
BP GO:0009987; cellular process GO:0051493; regulation of cytoskeleton organization 2.713E-04 8.321E-03 ALOX15, BRCA1, GSK3B, MAPK1, MAPT, MET, NEK2, NOX4, PIK3R1, PTK2, PTK2B
BP GO:0040007; growth GO:0045927; positive regulation of growth 3.024E-04 9.151E-03 AKT1, ALOX12, CDK1, CSNK2A1, MAPT, PIM1, PPARD, PTK2B
CC GO:0044464; cell part GO:0030424; axon 3.187E-04 9.558E-03 ADRA2C, BACE1, CA2, CNR1, HTT, MAPK1, MAPT, PTK2B
MF GO:0003824; catalytic activity GO:0004089; carbonate dehydratase activity 9.311E-22 4.309E-18 CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP GO:0051179; localization GO:0015701; bicarbonate transport 7.461E-17 7.064E-14 CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, HBB
MF GO:0005488; binding GO:0019825; oxygen binding 1.012E-16 9.180E-14 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, HBB, NOX4
MF GO:0005488; binding GO:0020037; heme binding 6.336E-15 3.631E-12 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, HBB, MPO, NOX4, SRC
MF GO:0005488; binding GO:0005506; iron ion binding 9.639E-15 4.881E-12 ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, HBB, XDH
BP GO:0008152; metabolic process GO:0006730; one-carbon metabolic process 2.509E-14 1.093E-11 CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways
Pathway ID Pathway Name p-Value Adjusted p-Value Enriched Genes
hsa00910 Nitrogen metabolism_Homo sapiens_hsa00910 5.699E-21 1.117E-18 CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14
hsa05205 Proteoglycans in cancer_Homo sapiens_hsa05205 2.410E-13 2.362E-11 CAMK2B; SRC; MMP2; PTPN11; PIK3R1; HIF1A; MMP9; PTK2; IGF1R; KDR; AKT1; MAPK1; PTPN6; TP53; MET; TLR2
hsa05161 Hepatitis B_Homo sapiens_hsa05161 2.516E-09 8.755E-08 APAF1; SRC; AKT1; PTK2B; MAPK1; STAT6; PIK3R1; TP53; MMP9; NFKB1; TLR2
hsa00591 Linoleic acid metabolism_Homo sapiens_hsa00591 5.174E-10 3.381E-08 CYP2C9; CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4; CYP2C19
hsa05202 Transcriptional misregulation in cancer_Homo sapiens_hsa05202 1.873E-09 8.755E-08 HPGD; KMT2A; FLT3; MMP3; ATM; TP53; MPO; MMP9; MET; NFKB1; PTK2; IGF1R
hsa05200 Pathways in cancer_Homo sapiens_hsa05200 3.870E-08 8.385E-07 GSK3B; FLT3; DAPK1; MMP2; PIK3R1; HIF1A; MMP9; NFKB1; PTK2; IGF1R; AKT1; MAPK1; MET; TP53; PPARD
hsa05204 Chemical carcinogenesis_Homo sapiens_hsa05204 2.680E-09 8.755E-08 CYP2C9; CYP2C8; CYP2A6; CYP2A13; CYP1A2; CYP1A1; CYP1B1; CYP3A4; CYP2C19
hsa00982 Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 1.361E-08 3.810E-07 CYP2C9; CYP2C8; CYP2A6; MAOA; CYP2D6; CYP1A2; CYP3A4; CYP2C19
hsa00980 Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 2.141E-08 5.246E-07 CYP2C9; CYP2A6; CYP2A13; CYP2D6; CYP1A2; CYP1A1; CYP1B1; CYP3A4
hsa04726 Serotonergic synapse_Homo sapiens_hsa04726 4.278E-08 8.385E-07 CYP2C9; CYP2C8; CYP2D6; MAOA; ALOX5; ALOX15; MAPK1; ALOX12; CYP2C19
hsa05221 Acute myeloid leukemia_Homo sapiens_hsa05221 7.556E-08 1.346E-06 FLT3; PIM1; AKT1; MAPK1; PIK3R1; NFKB1; PPARD
hsa00590 Arachidonic acid metabolism_Homo sapiens_hsa00590 1.369E-07 2.236E-06 CYP2C9; CYP2C8; PLA2G1B; ALOX5; ALOX15; ALOX12; CYP2C19
hsa04151 PI3K-Akt signaling pathway_Homo sapiens_hsa04151 2.979E-07 3.244E-06 GSK3B; PIK3R1; BRCA1; PTK2; NFKB1; IGF1R; KDR; AKT1; MAPK1; PKN1; TP53; MET; TLR2
hsa04080 Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 2.238E-07 2.887E-06 ADORA2A; CNR2; CNR1; ADORA3; ADORA1; NMUR2; OPRK1; TRPV1; ADRA2C; ADRA2A; DRD4; TSHR
hsa04210 Apoptosis_Homo sapiens_hsa04210 2.934E-07 3.244E-06 CASP7; APAF1; LMNA; AKT1; MAPK1; ATM; PIK3R1; TP53; NFKB1
hsa00830 Retinol metabolism_Homo sapiens_hsa00830 1.907E-07 2.875E-06 CYP2C9; CYP2C8; CYP2A6; CYP1A2; ALDH1A1; CYP1A1; CYP3A4
hsa01100 Metabolic pathways_Homo sapiens_hsa01100 9.794E-07 8.876E-06 PLA2G1B; MAOA; GAA; ALOX15; ADK; AKR1B1; ALOX12; PYGL; CYP2C19; CYP3A4; CYP19A1; HSD17B10; CYP2C9; CYP2C8; CYP2A6; FUT7; ALOX5; HSD17B2; CYP1A2; ALDH1A1; CYP1A1; ALPL; XDH; CES1
hsa05230 Central carbon metabolism in cancer_Homo sapiens_hsa05230 2.357E-07 2.887E-06 FLT3; AKT1; MAPK1; PIK3R1; TP53; MET; HIF1A
hsa04919 Thyroid hormone signaling pathway_Homo sapiens_hsa04919 9.165E-07 8.876E-06 GSK3B; HDAC3; SRC; AKT1; MAPK1; PIK3R1; TP53; HIF1A
hsa05219 Bladder cancer_Homo sapiens_hsa05219 2.286E-07 2.887E-06 DAPK1; SRC; MMP2; MAPK1; MMP9; TP53
hsa04722 Neurotrophin signaling pathway_Homo sapiens_hsa04722 1.042E-06 8.876E-06 CAMK2B; GSK3B; AKT1; MAPK1; PTPN11; PIK3R1; TP53; NFKB1
hsa04913 Ovarian steroidogenesis_Homo sapiens_hsa04913 7.706E-07 7.950E-06 ALOX5; HSD17B2; CYP1A1; CYP1B1; CYP19A1; IGF1R
hsa05215 Prostate cancer_Homo sapiens_hsa05215 1.662E-06 1.303E-05 GSK3B; AKT1; MAPK1; PIK3R1; TP53; NFKB1; IGF1R
hsa04071 Sphingolipid signaling pathway_Homo sapiens_hsa04071 1.042E-06 8.876E-06 ABCC1; ADORA3; ADORA1; AKT1; MAPK1; PIK3R1; TP53; NFKB1
hsa04012 ErbB signaling pathway_Homo sapiens_hsa04012 1.425E-06 1.164E-05 CAMK2B; GSK3B; SRC; AKT1; MAPK1; PIK3R1; PTK2
hsa04062 Chemokine signaling pathway_Homo sapiens_hsa04062 3.300E-06 2.156E-05 GSK3B; CXCR1; SRC; AKT1; PTK2B; MAPK1; PIK3R1; NFKB1; PTK2
hsa05162 Measles_Homo sapiens_hsa05162 2.679E-06 1.810E-05 GSK3B; CSNK2A1; AKT1; RAB9A; PIK3R1; TP53; NFKB1; TLR2
hsa04024 cAMP signaling pathway_Homo sapiens_hsa04024 5.482E-06 3.070E-05 CAMK2B; ADORA2A; ADORA1; AKT1; MAPK1; PIK3R1; PPARA; NFKB1; TSHR
hsa04370 VEGF signaling pathway_Homo sapiens_hsa04370 2.542E-06 1.780E-05 SRC; KDR; AKT1; MAPK1; PIK3R1; PTK2
hsa04510 Focal adhesion_Homo sapiens_hsa04510 6.189E-06 3.297E-05 GSK3B; SRC; KDR; AKT1; MAPK1; PIK3R1; MET; PTK2; IGF1R
hsa05214 Glioma_Homo sapiens_hsa05214 3.704E-06 2.342E-05 CAMK2B; AKT1; MAPK1; PIK3R1; TP53; IGF1R
hsa04066 HIF-1 signaling pathway_Homo sapiens_hsa04066 4.439E-06 2.636E-05 CAMK2B; AKT1; MAPK1; PIK3R1; HIF1A; NFKB1; IGF1R
hsa04931 Insulin resistance_Homo sapiens_hsa04931 6.467E-06 3.336E-05 GSK3B; AKT1; PTPN11; PIK3R1; PYGL; PPARA; NFKB1
hsa04668 TNF signaling pathway_Homo sapiens_hsa04668 6.870E-06 3.366E-05 CASP7; MMP3; AKT1; MAPK1; PIK3R1; MMP9; NFKB1
hsa04015 Rap1 signaling pathway_Homo sapiens_hsa04015 8.800E-06 3.920E-05 ADORA2A; SRC; CNR1; KDR; AKT1; MAPK1; PIK3R1; MET; IGF1R
hsa00140 Steroid hormone biosynthesis_Homo sapiens_hsa00140 1.883E-06 1.419E-05 CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1
hsa05211 Renal cell carcinoma_Homo sapiens_hsa05211 4.053E-06 2.482E-05 AKT1; MAPK1; PTPN11; PIK3R1; MET; HIF1A
hsa04014 Ras signaling pathway_Homo sapiens_hsa04014 1.579E-05 6.727E-05 PLA2G1B; KDR; AKT1; MAPK1; PTPN11; PIK3R1; MET; NFKB1; IGF1R
hsa05218 Melanoma_Homo sapiens_hsa05218 6.224E-06 3.297E-05 AKT1; MAPK1; PIK3R1; TP53; MET; IGF1R
hsa04917 Prolactin signaling pathway_Homo sapiens_hsa04917 6.754E-06 3.366E-05 GSK3B; SRC; AKT1; MAPK1; PIK3R1; NFKB1
hsa05206 MicroRNAs in cancer_Homo sapiens_hsa05206 2.173E-05 8.693E-05 ABCC1; PIM1; CYP1B1; MAPK1; ATM; BRCA1; TP53; MMP9; MET; NFKB1
hsa05220 Chronic myeloid leukemia_Homo sapiens_hsa05220 7.321E-06 3.416E-05 AKT1; MAPK1; PTPN11; PIK3R1; TP53; NFKB1
hsa03320 PPAR signaling pathway_Homo sapiens_hsa03320 5.264E-06 3.035E-05 FABP2; FABP3; FABP4; FABP5; PPARA; PPARD
hsa04662 B cell receptor signaling pathway_Homo sapiens_hsa04662 7.321E-06 3.416E-05 GSK3B; AKT1; MAPK1; PTPN6; PIK3R1; NFKB1
hsa05160 Hepatitis C_Homo sapiens_hsa05160 2.378E-05 9.323E-05 GSK3B; AKT1; MAPK1; PIK3R1; PPARA; TP53; NFKB1
hsa04520 Adherens junction_Homo sapiens_hsa04520 7.925E-06 3.613E-05 CSNK2A1; SRC; MAPK1; PTPN6; MET; IGF1R
hsa05203 Viral carcinogenesis_Homo sapiens_hsa05203 5.310E-05 1.794E-04 POLB; HDAC3; SRC; CDK1; MAPK1; PIK3R1; TP53; NFKB1
hsa05222 Small cell lung cancer_Homo sapiens_hsa05222 1.889E-05 7.879E-05 APAF1; AKT1; PIK3R1; TP53; NFKB1; PTK2
hsa04933 AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 4.710E-05 1.649E-04 MMP2; PIM1; AKT1; MAPK1; PIK3R1; NFKB1
hsa04750 Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 3.974E-05 1.442E-04 CAMK2B; TRPA1; SRC; ALOX12; TRPV1; PIK3R1
hsa04915 Estrogen signaling pathway_Homo sapiens_hsa04915 4.208E-05 1.500E-04 SRC; MMP2; AKT1; MAPK1; PIK3R1; MMP9
hsa04022 cGMP-PKG signaling pathway_Homo sapiens_hsa04022 1.011E-04 3.197E-04 ADORA3; ADORA1; AKT1; MAPK1; PIK3R1; ADRA2C; ADRA2A
hsa04660 T cell receptor signaling pathway_Homo sapiens_hsa04660 5.552E-05 1.844E-04 GSK3B; AKT1; MAPK1; PTPN6; PIK3R1; NFKB1
hsa05010 Alzheimer's disease_Homo sapiens_hsa05010 1.050E-04 3.266E-04 BACE1; GSK3B; CASP7; APAF1; MAPK1; MAPT; HSD17B10
hsa05166 HTLV-I infection_Homo sapiens_hsa05166 2.595E-04 7.480E-04 POLB; GSK3B; TERT; AKT1; ATM; PIK3R1; TP53; NFKB1
hsa05169 Epstein-Barr virus infection_Homo sapiens_hsa05169 3.258E-04 9.123E-04 GSK3B; CSNK2A1; CDK1; AKT1; PIK3R1; TP53; NFKB1
hsa05152 Tuberculosis_Homo sapiens_hsa05152 1.503E-04 4.398E-04 CAMK2B; APAF1; SRC; AKT1; MAPK1; NFKB1; TLR2
hsa05145 Toxoplasmosis_Homo sapiens_hsa05145 1.121E-04 3.380E-04 ALOX5; AKT1; MAPK1; PIK3R1; NFKB1; TLR2
hsa04670 Leukocyte transendothelial migration_Homo sapiens_hsa04670 1.121E-04 3.380E-04 MMP2; PTK2B; PTPN11; PIK3R1; MMP9; PTK2
hsa04072 Phospholipase D signaling pathway_Homo sapiens_hsa04072 3.312E-04 9.142E-04 CXCR1; AKT1; PTK2B; MAPK1; PTPN11; PIK3R1
hsa04932 Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 4.267E-04 1.130E-03 GSK3B; CASP7; AKT1; PIK3R1; PPARA; NFKB1
hsa04630 Jak-STAT signaling pathway_Homo sapiens_hsa04630 5.425E-04 1.418E-03 PIM1; AKT1; PTPN6; STAT6; PTPN11; PIK3R1
hsa05213 Endometrial cancer_Homo sapiens_hsa05213 2.027E-05 8.278E-05 GSK3B; AKT1; MAPK1; PIK3R1; TP53
hsa04912 GnRH signaling pathway_Homo sapiens_hsa04912 2.973E-04 8.445E-04 CAMK2B; SRC; MMP2; PTK2B; MAPK1
hsa05164 Influenza A_Homo sapiens_hsa05164 9.258E-04 2.268E-03 GSK3B; CASP1; AKT1; MAPK1; PIK3R1; NFKB1
hsa04914 Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 4.190E-04 1.125E-03 CDK1; AKT1; MAPK1; PIK3R1; IGF1R
hsa05223 Non-small cell lung cancer_Homo sapiens_hsa05223 2.919E-05 1.080E-04 ALK; AKT1; MAPK1; PIK3R1; TP53
hsa04923 Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 2.919E-05 1.080E-04 FABP4; ADORA1; AKT1; PIK3R1; TSHR
hsa04211 Longevity regulating pathway - mammal_Homo sapiens_hsa04211 3.456E-04 9.408E-04 AKT1; PIK3R1; TP53; NFKB1; IGF1R
hsa05168 Herpes simplex infection_Homo sapiens_hsa05168 1.233E-03 2.890E-03 CSNK2A1; CDK1; PTPN11; TP53; NFKB1; TLR2
hsa04725 Cholinergic synapse_Homo sapiens_hsa04725 7.402E-04 1.836E-03 CAMK2B; ACHE; AKT1; MAPK1; PIK3R1
hsa04620 Toll-like receptor signaling pathway_Homo sapiens_hsa04620 6.003E-04 1.508E-03 AKT1; MAPK1; PIK3R1; NFKB1; TLR2
hsa05142 Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 5.503E-04 1.419E-03 AKT1; MAPK1; PIK3R1; NFKB1; TLR2
hsa05212 Pancreatic cancer_Homo sapiens_hsa05212 6.490E-05 2.120E-04 AKT1; MAPK1; PIK3R1; TP53; NFKB1
hsa05134 Legionellosis_Homo sapiens_hsa05134 2.672E-05 1.027E-04 CASP7; APAF1; CASP1; NFKB1; TLR2
hsa05210 Colorectal cancer_Homo sapiens_hsa05210 4.796E-05 1.649E-04 GSK3B; AKT1; MAPK1; PIK3R1; TP53
hsa04728 Dopaminergic synapse_Homo sapiens_hsa04728 1.451E-03 3.307E-03 CAMK2B; GSK3B; MAOA; AKT1; DRD4
hsa04068 FoxO signaling pathway_Homo sapiens_hsa04068 1.660E-03 3.698E-03 AKT1; MAPK1; ATM; PIK3R1; IGF1R
hsa04650 Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 1.773E-03 3.904E-03 PTK2B; MAPK1; PTPN6; PTPN11; PIK3R1
hsa05120 Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 7.493E-05 2.408E-04 CXCR1; SRC; PTPN11; MET; NFKB1
hsa04550 Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 2.212E-03 4.712E-03 GSK3B; AKT1; MAPK1; PIK3R1; IGF1R
hsa04910 Insulin signaling pathway_Homo sapiens_hsa04910 2.015E-03 4.388E-03 GSK3B; AKT1; MAPK1; PIK3R1; PYGL
hsa04310 Wnt signaling pathway_Homo sapiens_hsa04310 2.212E-03 4.712E-03 CAMK2B; GSK3B; CSNK2A1; TP53; PPARD
hsa04611 Platelet activation_Homo sapiens_hsa04611 7.866E-03 1.542E-02 SRC; AKT1; MAPK1; PIK3R1
hsa04144 Endocytosis_Homo sapiens_hsa04144 2.564E-02 4.215E-02 CXCR1; SRC; KDR; MET; IGF1R
hsa04010 MAPK signaling pathway_Homo sapiens_hsa04010 2.418E-02 4.017E-02 AKT1; MAPK1; MAPT; TP53; NFKB1
hsa04114 Oocyte meiosis_Homo sapiens_hsa04114 8.091E-03 1.555E-02 CAMK2B; CDK1; MAPK1; IGF1R
hsa04261 Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 1.515E-02 2.651E-02 CAMK2B; AKT1; MAPK1; PIK3R1
hsa04921 Oxytocin signaling pathway_Homo sapiens_hsa04921 1.880E-02 3.228E-02 CAMK2B; SRC; MAPK1; PIK3R1
hsa05034 Alcoholism_Homo sapiens_hsa05034 2.811E-02 4.514E-02 HDAC3; ADORA2A; MAOA; MAPK1
hsa04110 Cell cycle_Homo sapiens_hsa04110 8.320E-03 1.564E-02 GSK3B; CDK1; ATM; TP53
hsa04922 Glucagon signaling pathway_Homo sapiens_hsa04922 4.051E-03 8.185E-03 CAMK2B; AKT1; PYGL; PPARA
hsa00983 Drug metabolism - other enzymes_Homo sapiens_hsa00983 1.103E-05 4.803E-05 CYP2A6; CYP3A4; XDH; CES2; CES1
hsa04380 Osteoclast differentiation_Homo sapiens_hsa04380 1.031E-02 1.853E-02 AKT1; MAPK1; PIK3R1; NFKB1
hsa05146 Amoebiasis_Homo sapiens_hsa05146 3.909E-03 8.066E-03 PIK3R1; NFKB1; PTK2; TLR2
hsa05231 Choline metabolism in cancer_Homo sapiens_hsa05231 4.051E-03 8.185E-03 AKT1; MAPK1; PIK3R1; HIF1A
hsa04360 Axon guidance_Homo sapiens_hsa04360 9.032E-03 1.670E-02 GSK3B; MAPK1; MET; PTK2
hsa04916 Melanogenesis_Homo sapiens_hsa04916 2.641E-02 4.279E-02 CAMK2B; GSK3B; MAPK1
hsa04666 Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 2.189E-02 3.667E-02 AKT1; MAPK1; PIK3R1
hsa04064 NF-kappa B signaling pathway_Homo sapiens_hsa04064 2.189E-02 3.667E-02 CSNK2A1; ATM; NFKB1
hsa05100 Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 1.584E-03 3.568E-03 SRC; PIK3R1; MET; PTK2
hsa05140 Leishmaniasis_Homo sapiens_hsa05140 1.239E-03 2.890E-03 MAPK1; PTPN6; NFKB1; TLR2
hsa05132 Salmonella infection_Homo sapiens_hsa05132 2.267E-03 4.778E-03 CASP1; MAPK1; PKN1; NFKB1
hsa04920 Adipocytokine signaling pathway_Homo sapiens_hsa04920 1.059E-03 2.531E-03 AKT1; PTPN11; PPARA; NFKB1
hsa04540 Gap junction_Homo sapiens_hsa04540 1.894E-02 3.228E-02 SRC; CDK1; MAPK1
hsa05133 Pertussis_Homo sapiens_hsa05133 1.370E-03 3.158E-03 CASP7; CASP1; MAPK1; NFKB1
hsa04150 mTOR signaling pathway_Homo sapiens_hsa04150 5.916E-04 1.506E-03 AKT1; MAPK1; PIK3R1; HIF1A
hsa04115 p53 signaling pathway_Homo sapiens_hsa04115 1.003E-03 2.428E-03 APAF1; CDK1; ATM; TP53
hsa04664 Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 9.482E-03 1.721E-02 AKT1; MAPK1; PIK3R1
hsa04213 Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 8.029E-03 1.555E-02 AKT1; PIK3R1; IGF1R
hsa04976 Bile secretion_Homo sapiens_hsa04976 1.066E-02 1.900E-02 CA2; CYP3A4; ABCG2
hsa05131 Shigellosis_Homo sapiens_hsa05131 8.379E-03 1.564E-02 SRC; MAPK1; NFKB1
hsa05321 Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 8.379E-03 1.564E-02 STAT6; NFKB1; TLR2
hsa04621 NOD-like receptor signaling pathway_Homo sapiens_hsa04621 5.824E-03 1.153E-02 CASP1; MAPK1; NFKB1
hsa05144 Malaria_Homo sapiens_hsa05144 3.806E-03 7.936E-03 HBB; MET; TLR2
hsa05014 Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 4.262E-03 8.524E-03 APAF1; CASP1; TP53
hsa04960 Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 2.581E-02 4.215E-02 MAPK1; PIK3R1
hsa00380 Tryptophan metabolism_Homo sapiens_hsa00380 1.224E-04 3.634E-04 MAOA; CYP1A2; CYP1A1; CYP1B1
hsa04975 Fat digestion and absorption_Homo sapiens_hsa04975 2.832E-02 4.514E-02 FABP2; PLA2G1B
hsa05216 Thyroid cancer_Homo sapiens_hsa05216 1.474E-02 2.603E-02 MAPK1; TP53
hsa00052 Galactose metabolism_Homo sapiens_hsa00052 1.573E-02 2.728E-02 GAA; AKR1B1
hsa04964 Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 9.417E-03 1.721E-02 CA2; CA4
hsa00232 Caffeine metabolism_Homo sapiens_hsa00232 2.537E-06 1.780E-05 CYP2A6; CYP1A2; XDH
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases
ICD10 Disease Category Disease Name ICD10 Code Linked Targets
J00-J99: Diseases of the respiratory system Rhinitis J00, J30, J31.0 ALOX5
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Alcohol use disorders F10.2 MAOA; OPRK1; ADRA2C
J00-J99: Diseases of the respiratory system Airway inflammation J00-J99 FLT3
E00-E89: Endocrine, nutritional and metabolic diseases Hyperlipidaemia E78 ADORA1; CES1; PPARD
I00-I99: Diseases of the circulatory system Hypertension I10-I16 ADORA2A; ADORA1; ADRA2C; CNR1
E00-E89: Endocrine, nutritional and metabolic diseases Hypertriglyceridemia E78.1, E78.2, E78.3, I47-I49 ADORA1
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoporosis M80-M81, Z79.890 SRC; CNR2; PTK2B
C00-D49: Neoplasms Ovarian cancer C56 TERT; MMP2; CNR1; KDR; KDR; KDR; KDR
E00-E89: Endocrine, nutritional and metabolic diseases Type 2 diabetes E11 NFKB1; CNR1; PPARD
A00-B99: Certain infectious and parasitic diseases Leishmaniasis B55.0 PLA2G1B
C00-D49: Neoplasms Late-stage solid tumors C00-C75, C7A, C7B, D10-D36, D3A PTK2; TP53
C00-D49: Neoplasms Oral cavity cancer C00-C08 TP53
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoarthritis M15-M19, M47 ALOX5; MMP13; MMP3; MMP2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Musculoskeletal pain R52, G89 TRPV1
C00-D49: Neoplasms Advanced solid tumor C00-C75, C7A, C7B MET
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Depression F30-F39 MAOA; ADRA2C
L00-L99: Diseases of the skin and subcutaneous tissue Dermatitis L20-L30 ALOX5
G00-G99: Diseases of the nervous system G00-G99 Alzheimer disease G30 MAOA; MAPT; ACHE; ACHE; ACHE; GSK3B; ADRA2C
S00-T88: Injury, poisoning and certain other consequences of external causes Allergy T78.4 PLA2G1B; ALOX5; ADORA1
C00-D49: Neoplasms AML NA FLT3; KDR
E00-E89: Endocrine, nutritional and metabolic diseases Hypercholesterolemia E78 CES1
S00-T88: Injury, poisoning and certain other consequences of external causes Myocardial reperfusion injury T86.4 AKT1
H00-H59: Diseases of the eye and adnexa Ocular hypertension H40.0 ADRA2C; CA4; CA4
H00-H59: Diseases of the eye and adnexa Ocular inflammation H16.229 TERT
H00-H59: Diseases of the eye and adnexa Open-angle glaucoma H40-H42 ACHE; CA4; CA2
C00-D49: Neoplasms Liver cancer C22 TERT; IGF1R; KDR
C00-D49: Neoplasms Leukemia C90-C95 AKT1; FLT3
C00-D49: Neoplasms Multiple myeloma C90 TERT; SRC; IGF1R
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis diagnosis G70.0 ACHE
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Convulsions R56.0 ADK
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic nephropathy E11.21 ADRA2C
NA: NA Anaplastic mixed oligoastrocytoma NA FLT3
I00-I99: Diseases of the circulatory system High blood pressure I10-I16 CA2
C00-D49: Neoplasms Hormonally-responsive breast cancer C50 CYP19A1
C00-D49: Neoplasms Cutaneous Melanoma C43-C44 KDR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Cough R05 TRPV1
N00-N99: Diseases of the genitourinary system Prostate disease N42.9 CYP19A1
C00-D49: Neoplasms Pancreatic cancer C25 AKT1; TLR2; TERT; FLT3; MMP2; KDR
G00-G99: Diseases of the nervous system G00-G99 Pain G64, G90.0, R52, G89 MMP13; OPRK1; ADK; ACHE; TRPV1; TRPV1; IGF1R; ADORA2A; CDK1; ADRA2C; ADRA2A; TRPA1; CNR1; CNR2
K00-K95: Diseases of the digestive system Peptic ulcer K25-K27 ADRA2C
A00-B99: Certain infectious and parasitic diseases Pediculus humanus capitis B85.0 ACHE
I00-I99: Diseases of the circulatory system Peripheral vascular disease I73.9 CES1
C00-D49: Neoplasms Peritoneal cavity cancer NA KDR
S00-T88: Injury, poisoning and certain other consequences of external causes Poison intoxication T36-T50 ACHE; ADRA2C
C00-D49: Neoplasms Cancer C00-C96 AKT1; MET; TLR2; CSNK2A1; CA1; FLT3; FLT3; CA9; MMP2; ACHE; SRC; IGF1R; PTK2; GSK3B; ADORA3; HIF1A; CDK1; MAPK1; MMP9; NFKB1; PIM1; TP53; KDR
K00-K95: Diseases of the digestive system Diarrhea-predominant IBS K58.0 OPRK1
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure Diagnostic test to differentiate primary and secondary hypothyroidism W88 TSHR
I00-I99: Diseases of the circulatory system Angiogenesis disorder I00-I99 KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Anorexia F50.0-F50.1 CNR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Anxiety disorder F32, F40-F42 CAMK2B; MAOA; ACHE; CYP3A4
K00-K95: Diseases of the digestive system Duodenal ulcers K25-K27 CA1; CA2
C00-D49: Neoplasms Hepatocellular carcinoma C22.0 MET; IGF1R; ADORA3; KDR
C00-D49: Neoplasms Hematological malignancies C81-C86 SRC; AURKB; TP53
A00-B99: Certain infectious and parasitic diseases Helminth infection A00-B99 ACHE
C00-D49: Neoplasms Hematologic malignancies C81-C86 AKT1
NA: NA Hepatitis C virus infection NA ADORA3
NA: NA Hematopoietic stem cell transplantation NA FLT3
C00-D49: Neoplasms Osteosarcoma C40-C41 SRC; GSK3B
A00-B99: Certain infectious and parasitic diseases Human immunodeficiency virus infection B20-B26 FLT3
S00-T88: Injury, poisoning and certain other consequences of external causes Contusion S36.220S ADRA2C
I00-I99: Diseases of the circulatory system Coronary disorder diagnosis I20-I25 ADORA2A
I00-I99: Diseases of the circulatory system Orthostatic hypotension I95.1 ADORA1
NA: NA Dyslipidemia NA PPARD
E00-E89: Endocrine, nutritional and metabolic diseases Dyslipidaemias E78 PPARD; PPARD
L00-L99: Diseases of the skin and subcutaneous tissue Contact dermatitis L23, L24, L25 PLA2G1B
C00-D49: Neoplasms Colon cancer C50 ALPL; FLT3
C00-D49: Neoplasms Colorectal cancer C18-C21 FLT3; IGF1R; MMP9; TP53; KDR
N00-N99: Diseases of the genitourinary system Endometriosis N80 CYP19A1
I00-I99: Diseases of the circulatory system Edema associated with congestive heart failure I50, R60.9 CA2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Chronic pathological pain R52, G89 TRPV1
C00-D49: Neoplasms CLL NA FLT3
H00-H59: Diseases of the eye and adnexa Corneal ulcers H16.0 MMP3
C00-D49: Neoplasms Fallopian tube cancer C57.0, D28.2 KDR
L00-L99: Diseases of the skin and subcutaneous tissue Erythema L51-L54 OPRK1; ADRA2C
H00-H59: Diseases of the eye and adnexa Ocular disease H00-H59 ADRA2C
C00-D49: Neoplasms Gastrointestinal cancers C15-C26 KDR
NA: NA Esophagus sensitivity NA TRPV1
G00-G99: Diseases of the nervous system G00-G99 Epilepsy G40 MAOA; CASP1; ADK
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mood disorder F30-F39 MAOA
C00-D49: Neoplasms Lung cancer C33-C34 MMP2
A00-B99: Certain infectious and parasitic diseases Lymphatic filariasis B74 ALOX5
C00-D49: Neoplasms Overactive bladder disorder C67, N32.81 TRPV1; TRPV1
C00-D49: Neoplasms Breast cancer C50 TERT; CYP19A1; FLT3; FLT3; CA9; IGF1R; CDK1; KDR; KDR; KDR
J00-J99: Diseases of the respiratory system Allergic rhinitis J00, J30, J31.0, T78.4 PLA2G1B; ADORA2A; ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases Hyperuricaemia in gout E79.0, M10 XDH
I00-I99: Diseases of the circulatory system Hypotension I95 ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases Hyperuricemia E79.0 XDH
G00-G99: Diseases of the nervous system G00-G99 Motor neurone disease G12.2 IGF1R
G00-G99: Diseases of the nervous system G00-G99 Multiple scierosis G35 MPO; ADORA1
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis G70.0 ACHE
C00-D49: Neoplasms Gastric cancer C16 KDR; KDR
C00-D49: Neoplasms Head and neck cancer C07-C14, C32-C33 AKR1B1; TERT; TP53; KDR; KDR
I00-I99: Diseases of the circulatory system Acute and chronic heart failure I50 ADORA1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Chemotherapy-induced nausea R11 CNR1
K00-K95: Diseases of the digestive system Chemotherapy-induced mucositis K12.3 MET
H00-H59: Diseases of the eye and adnexa Chronic glaucoma H40-H42 CA1; ACHE
K00-K95: Diseases of the digestive system Ulcerative colitis K51 MMP9
G00-G99: Diseases of the nervous system G00-G99 Central nervous system disease G00-G99 MAPT; CNR1; PPARD
I00-I99: Diseases of the circulatory system Cerebrovascular ischaemia I61-I63 ADORA3; CNR1
L00-L99: Diseases of the skin and subcutaneous tissue Fibrosis L90.5 MET; CASP1
A00-B99: Certain infectious and parasitic diseases Fungal infections B35-B49 ALOX5; RAB9A
K00-K95: Diseases of the digestive system Xerostomia K11.7, R68.2 ACHE
NA: NA Early satiation associated with functional dyspepsia NA ACHE
G00-G99: Diseases of the nervous system G00-G99 Encephalopathy G93.4 XDH
NA: NA Edema NA CA2
K00-K95: Diseases of the digestive system Liver disease K70-K77 MET
M00-M99: Diseases of the musculoskeletal system and connective tissue Arthritis M00-M25 PLA2G1B; ABCC1; ALOX5
J00-J99: Diseases of the respiratory system Asthma J45 PLA2G1B; ALOX5; ALOX5; TRPV1; ADORA2A; ADORA1; ADRA2C
K00-K95: Diseases of the digestive system Gastroesophageal reflux disease K21 TRPV1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Cognitive disorders F01-F07, F04, F05, R41.3 MAPT; ACHE; ADORA1
C00-D49: Neoplasms Clear cell renal cell carcinoma C64 CA9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Attention deficit hyperactivity disorder F90 ADRA2A
E00-E89: Endocrine, nutritional and metabolic diseases Diabetes E23.2, N25.1 AKR1B1; GSK3B; ADORA1; CNR1; CNR1; CNR1
L00-L99: Diseases of the skin and subcutaneous tissue Diabetic foot ulcer L88-L89 ADORA2A
C00-D49: Neoplasms Prostate cancer C61 TLR2; TERT; FLT3
I00-I99: Diseases of the circulatory system Stroke I61-I63, I80-I82 MMP9
C00-D49: Neoplasms Acute myeloid leukemia C92.0 TERT; FLT3; FLT3; AURKB; TP53; TP53
G00-G99: Diseases of the nervous system G00-G99 Acute migraine G43 TRPV1
C00-D49: Neoplasms Chronic myelogenous leukaemia C92.1 SRC
A00-B99: Certain infectious and parasitic diseases Bacterial infections A00-B99 CYP2C9
E00-E89: Endocrine, nutritional and metabolic diseases Autoimmune diabetes E08-E13 TLR2; ADORA1
J00-J99: Diseases of the respiratory system Chronic obstructive pulmonary disease J40-J44, J47 MPO; ALOX5; ADORA2A
S00-T88: Injury, poisoning and certain other consequences of external causes Poisoning due to pesticides and chemicals T36-T50 ACHE
C00-D49: Neoplasms Thyroid cancer C73 TSHR; KDR
I00-I99: Diseases of the circulatory system Thrombosis I80-I82 ALOX5
J00-J99: Diseases of the respiratory system Throat irritation J39.2 TRPA1
M00-M99: Diseases of the musculoskeletal system and connective tissue Gout M10 AKR1B1; ABCC1; ABCC1; XDH
E00-E89: Endocrine, nutritional and metabolic diseases Hormone deficiency E00-E90 IGF1R
M00-M99: Diseases of the musculoskeletal system and connective tissue Fibromyalgia M79.7 ADRA2C
C00-D49: Neoplasms Brain cancer C71, D33 TERT; SRC
A00-B99: Certain infectious and parasitic diseases Visceral leishmaniasis B55.0 PLA2G1B
C00-D49: Neoplasms Renal cell carcinoma NA MMP2; KDR; KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Opiate dependence F11 OPRK1
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism Beta thalassemia D56.1 HBB
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic neuropathy E11.40 AKR1B1; TRPV1
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic cataract E10.36, E11.36 AKR1B1
C00-D49: Neoplasms Biliary cancer C22, C24 KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Bipolar disorder F31, F40-F42 OPRK1
C00-D49: Neoplasms Bladder cancer C67 CYP19A1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Substance dependence F10-F19 OPRK1
E00-E89: Endocrine, nutritional and metabolic diseases Atrial fibrillation E78, I48 ADORA1; ADORA1
I00-I99: Diseases of the circulatory system Cardiac disease I00-I99 ADORA1
I00-I99: Diseases of the circulatory system Cardiac arrhythmias I47-I49 ADORA1; ADORA1
I00-I99: Diseases of the circulatory system Cardiovascular disorder I00-I99 KDR
C00-D49: Neoplasms Metastatic castration-resistant prostate cancer C61 KDR
C00-D49: Neoplasms Metastatic breast cancer C50 KDR
C00-D49: Neoplasms Metastasis C00-C97 AXL
E00-E89: Endocrine, nutritional and metabolic diseases Metabolic disorders E70-E89 CNR1; CNR1
C00-D49: Neoplasms Mesothelioma C45 PTK2
I00-I99: Diseases of the circulatory system Atherosclerosis I70 ALOX5; CES1; PPARD
M00-M99: Diseases of the musculoskeletal system and connective tissue Rheumatoid arthritis M05-M06 CAMK2B; AKR1B1; PLA2G1B; ALOX5; CASP1; MMP3; CNR2
L00-L99: Diseases of the skin and subcutaneous tissue Vitiligo L80 MAOA
I00-I99: Diseases of the circulatory system Neurological disease I21, I22, R52, R52.1-R52.2, R60.9, G89 ADRA2C; NPSR1
G00-G99: Diseases of the nervous system G00-G99 Epileptic seizures G40, P90, R56 ADK; ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Erectile dysfunction F52.2, N48.4 DRD4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Insomnia F51.0, G47.0 CYP2D6; CA2; CNR1
C00-D49: Neoplasms Metastatic colorectal cancer C18-C21 KDR
C00-D49: Neoplasms Metastatic HER2-negative gastric cancer NA MET
G00-G99: Diseases of the nervous system G00-G99 Migraine G43 CYP2D6
I00-I99: Diseases of the circulatory system Arteriosclerosis I70 PLA2G1B; ADORA2A; CES1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Schizophrenia F20 CNR1; DRD4
A00-B99: Certain infectious and parasitic diseases Sepsis A40, A41 ADORA1
A00-B99: Certain infectious and parasitic diseases Malaria B54 ADORA3; CYP2D6
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Major depressive disorder F32, F33, M32 MAOA; MAOA
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Male sexual disorders F52 ADRA2C
A00-B99: Certain infectious and parasitic diseases Infections disease A00-B99 MPO
NA: NA Upper abdominal bloating NA ACHE
N00-N99: Diseases of the genitourinary system Urinary incontinence N39.3, N39.4, R32 TRPV1
N00-N99: Diseases of the genitourinary system Urinary dysfunction N39.3-N39.4 ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Sexual dysfunction F52 ADRA2A
C00-D49: Neoplasms Medullary thyroid cancer C73 KDR
C00-D49: Neoplasms Melanoma C43 TLR2; TERT; KDR; KDR
C00-D49: Neoplasms Inflammatory disease C11, C44, K75.9, M00-M25 MPO; PLA2G1B; ALOX5; MMP13; CNR2
G00-G99: Diseases of the nervous system G00-G99 Spinal muscular atrophy G00-G99 SMN1;SMN2
C00-D49: Neoplasms Squamous cell cancer of head and neck NA KDR
C00-D49: Neoplasms Solid tumours C00-D48 AKT1; MET; TLR2; FLT3; CA9; MMP2; SRC; IGF1R; PTK2; AURKB; HIF1A; MAPK1; MMP9; TP53; KDR; KDR; KDR
C00-D49: Neoplasms Thyroid cancer diagnosis C73 TSHR
E00-E89: Endocrine, nutritional and metabolic diseases Type 1 diabetes E10 PPARD
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic complication E08-E13 AKR1B1
I00-I99: Diseases of the circulatory system Heart failure I50 ADORA1; XDH; ADRA2C
I00-I99: Diseases of the circulatory system Heart disease I00-I52 MET
E00-E89: Endocrine, nutritional and metabolic diseases Lipid metabolism disorder E75-E78 CNR1
I00-I99: Diseases of the circulatory system Myocardial infarction I21, I22 MMP3
S00-T88: Injury, poisoning and certain other consequences of external causes Nerve injury T14.4 PLA2G1B
A00-B99: Certain infectious and parasitic diseases Postherpetic neuralgia B02.2, G44.847, G53.0 TRPV1; CNR1
E00-E89: Endocrine, nutritional and metabolic diseases Pompe's disease E74.02 GAA
C00-D49: Neoplasms Malignant adrenal gland cancer C74.0 IGF1R
L00-L99: Diseases of the skin and subcutaneous tissue Psoriasis L40 ALOX5; FLT3
L00-L99: Diseases of the skin and subcutaneous tissue Pruritus L29 PLA2G1B; ALOX5
I00-I99: Diseases of the circulatory system Ischemic stroke I61-I63 MMP3
I00-I99: Diseases of the circulatory system Ischemia I99.8 SRC; ADORA3; CNR1
C00-D49: Neoplasms Acute lymphoblastic leukemia C91.0 FLT3; CES1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Acute or chronic pain R52, G89 TRPV1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Drug abuse F10-F19 CNR1
J00-J99: Diseases of the respiratory system Respiratory disease J00-J99 ALOX5
H00-H59: Diseases of the eye and adnexa Graves' ophthalmopathy H06.2 IGF1R
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Growth failure R62.8 IGF1R
A00-B99: Certain infectious and parasitic diseases Anthelmintic B89 ALPL
E00-E89: Endocrine, nutritional and metabolic diseases Endocrine disease E00-E35 CNR1
C00-D49: Neoplasms Lymphoma C81-C86 AKT1; CA9; HIF1A
S00-T88: Injury, poisoning and certain other consequences of external causes Toxicity T36-T50, T51-T65 TP53
C00-D49: Neoplasms Tumors C00-D48 TERT
C00-D49: Neoplasms Myelodysplastic syndrome D46 TLR2; KDR
C00-D49: Neoplasms Myeloid leukemia C92 FLT3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Psychotic disorders F20-F29 CNR1; DRD4
I00-I99: Diseases of the circulatory system Pulmonary arterial hypertension I27.0, I27.2 HIF1A
L00-L99: Diseases of the skin and subcutaneous tissue Psoriatic disorder L40 IGF1R
L00-L99: Diseases of the skin and subcutaneous tissue Acne vulgaris L70.0 MMP2
G00-G99: Diseases of the nervous system G00-G99 Neuropathic pain G64, G90.0 MAOA; TRPV1; ADORA2A; ADORA1; CNR1; CNR2
C00-D49: Neoplasms Advanced breast cancer C50 CYP19A1; SRC
C00-D49: Neoplasms Glioblastoma multiforme C71 SRC
C00-D49: Neoplasms Glioblastoma NA FLT3
C00-D49: Neoplasms Gliosarcoma NA FLT3
C00-D49: Neoplasms Glioma C71 KDR
H00-H59: Diseases of the eye and adnexa Glaucoma H40-H42 AKR1B1; CA1; CA1; ACHE; ADORA3; ADORA2A; ADORA1; ADRA2C
NA: NA GIST NA FLT3
L00-L99: Diseases of the skin and subcutaneous tissue Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses L20-L30 PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases Inflammation E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 ALOX5; ADORA3
K00-K95: Diseases of the digestive system Inflammatory bowel disease K50, K51 OPRK1; CNR2
L00-L99: Diseases of the skin and subcutaneous tissue Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp L20-L30 PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases Obesity E66 OPRK1; ADRA2C; CNR1; CNR1; CNR1; CNR1; CNR1; CNR1; PPARD; PPARD
C00-D49: Neoplasms Non-small-cell lung cancer NA MMP2; KDR
C00-D49: Neoplasms Non-small cell lung cancer C33-C34 MET; IGF1R; IGF1R; ATM; AXL; KDR
K00-K95: Diseases of the digestive system Non-alcoholic fatty liver disease K76.0 PPARD
G00-G99: Diseases of the nervous system G00-G99 Parkinson's disease G20 MPO; MAOA; ACHE; ADORA2A; ADORA1
C00-D49: Neoplasms Myelofibrosis C94.4, D47.4 FLT3
S00-T88: Injury, poisoning and certain other consequences of external causes Radiation sickness T66 TLR2
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure Radionuclide imaging W88 ADORA2A
N00-N99: Diseases of the genitourinary system Renal failure N17, N18, N19 ADORA1
I00-I99: Diseases of the circulatory system Restenosis I51.89 MAPK1
C00-D49: Neoplasms Advanced renal cell carcinoma C64 KDR; KDR
C00-D49: Neoplasms Advanced malignancies C00-C96 KDR
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities Genetic disease Q00-Q99 ALPL
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism Immune disorder D80-D89 CNR2
H60-H95: Diseases of the ear and mastoid process Hearing disorder H90.5 TP53
A00-B99: Certain infectious and parasitic diseases HCV infection B17.1, B18.2 MMP3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Nicotine dependence F17 CNR1
G00-G99: Diseases of the nervous system G00-G99 Neurodegenerative disease G30-G32 MAPT; OPRK1; ACHE
L00-L99: Diseases of the skin and subcutaneous tissue Atopic dermatitis L00-L99 ALOX5; TRPV1; CNR2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Fatigue R53 ADORA1
C00-D49: Neoplasms Renal cancer C64 CA9; KDR
I00-I99: Diseases of the circulatory system Renal artery disease I70.1 TP53
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mild cognitive impairment F06.7 ACHE
Data Section
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1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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Principle Investigator:
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Developer & Maintainer:
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