CMAUP Plant Collective Molecular Activities

Plant Name: Leucas aspera

Taxonomic Information:

Plant ID: NPO3909
Plant Latin Name: Leucas aspera
Taxonomy Genus: Leucas
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: 483811
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Thailand; Philippines; China; India

Traditional Medicine System:

Indian Folk; TCM; Homeopathy; Ayurveda; Siddha

Geographical Distribution:

India; Philippines; China; Thailand

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	PTPN1;
Enzyme_unclassified	AKR1B10;
Metallo protease	MMP3;
Cysteine protease	CASP1;
Unclassified	MAPT; IL1B;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Metallo protease	MMP3	Matrix metalloproteinase 3	P08254	CHEMBL283
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	IL1B	Interleukin-1 beta	P01584	CHEMBL1909490

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:2000377; regulation of reactive oxygen species metabolic process	1.291E-05	7.529E-02	IL1B, MAPT, MMP3
BP	GO:0009987; cellular process	GO:0080135; regulation of cellular response to stress	1.806E-05	7.529E-02	IL1B, MAPT, MMP3, PTPN1
BP	GO:0009987; cellular process	GO:0010941; regulation of cell death	2.469E-05	7.529E-02	CASP1, IL1B, MAPT, MMP3, PTPN1
BP	GO:0009987; cellular process	GO:0030947; regulation of vascular endothelial growth factor receptor signaling pathway	2.605E-05	7.529E-02	IL1B, PTPN1
BP	GO:0050896; response to stimulus	GO:0046627; negative regulation of insulin receptor signaling pathway	3.484E-05	7.529E-02	IL1B, PTPN1
MF	GO:0005488; binding	GO:0051721; protein phosphatase 2A binding	3.029E-05	7.529E-02	MAPT, PTPN1
MF	GO:0005488; binding	GO:0019904; protein domain specific binding	8.551E-04	2.731E-01	CASP1, IL1B, MAPT
CC	GO:0044464; cell part	GO:0097443; sorting endosome	1.863E-03	3.221E-01	PTPN1
MF	GO:0003824; catalytic activity	GO:0001758; retinal dehydrogenase activity	2.173E-03	3.221E-01	AKR1B10
CC	GO:0044464; cell part	GO:0005764; lysosome	2.896E-03	3.427E-01	AKR1B10, IL1B
MF	GO:0005488; binding	GO:0034452; dynactin binding	3.412E-03	3.660E-01	MAPT
MF	GO:0003824; catalytic activity	GO:0097200; cysteine-type endopeptidase activity involved in execution phase of apoptosis	4.032E-03	3.973E-01	CASP1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.106E-04	1.979E-03	IL1B, CASP1
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	1.188E-04	1.979E-03	IL1B, CASP1
09150 Organismal Systems	09151 Immune system	hsa04623	Cytosolic DNA-sensing pathway	1.500E-04	1.979E-03	IL1B, CASP1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	2.061E-04	1.979E-03	IL1B, CASP1
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	4.432E-04	2.533E-03	IL1B, MMP3
09160 Human Diseases	09162 Immune diseases	hsa05323	Rheumatoid arthritis	2.969E-04	1.979E-03	IL1B, MMP3
09160 Human Diseases	09167 Infectious diseases	hsa05132	Salmonella infection	2.711E-04	1.979E-03	IL1B, CASP1
09160 Human Diseases	09167 Infectious diseases	hsa05164	Influenza A	1.116E-03	4.959E-03	IL1B, CASP1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.029E-03	4.959E-03	IL1B, MAPT
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	2.348E-03	9.393E-03	IL1B, MAPT

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	CASP1;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	CASP1;
A00-B99: Certain infectious and parasitic diseases	HCV infection	B17.1, B18.2	MMP3;
I00-I99: Diseases of the circulatory system	Ischemic stroke	I61-I63	MMP3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	CASP1; MMP3;
I00-I99: Diseases of the circulatory system	Myocardial infarction	I21, I22	MMP3;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
H00-H59: Diseases of the eye and adnexa	Corneal ulcers	H16.0	MMP3;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases