CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
I00-I99: Diseases of the circulatory system	Vasculitis	I77.6, I80	IL1B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	CASP1
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	CASP1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	IL1B
NA: NA	Colour dead tissues	NA	PTPN1
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IL1B
NA: NA	Cryopyrin-associated periodic syndromes	NA	IL1B
A00-B99: Certain infectious and parasitic diseases	HCV infection	B17.1, B18.2	MMP3
I00-I99: Diseases of the circulatory system	Ischemic stroke	I61-I63	MMP3
NA: NA	Opioid-related disorders	NA	IL1B
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP3; IL1B
M00-M99: Diseases of the musculoskeletal system and connective tissue	Acute gout flare	M10	IL1B
NA: NA	Amyotropic lateral sclerosis	NA	IL1B
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MMP3; IL1B; CASP1
I00-I99: Diseases of the circulatory system	Myocardial infarction	I21, I22	MMP3
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercalcemia	E83.5	IL1B
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	IL1B
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	IL1B
NA: NA	Urticaria	NA	IL1B
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Immune disorder	D80-D89	IL1B
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	IL1B
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT; IL1B
C00-D49: Neoplasms	Cancer	C00-C96	IL1B
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; IL1B
H00-H59: Diseases of the eye and adnexa	Corneal ulcers	H16.0	MMP3

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Leucas aspera

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases