CMAUP Plant Collective Molecular Activities

Plant Name: Nelumbo nucifera

Taxonomic Information:

Plant ID: NPO3478
Plant Latin Name: Nelumbo nucifera
Taxonomy Genus: Nelumbo
Taxonomy Family: Nelumbonaceae

Plant External Links:

NCBI TaxonomyDB: 4432
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Indonesia; India; Malaysia; China; Thailand; South Korea

Traditional Medicine System:

Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; Kampo; TCM

Medicinal Functions:

Antidiarrhoeal; Astringent; Cancer; Cardiotonic; Febrifuge; Hypotensive; Miscellany; Miscellany; Resolvent; Stomachic; Styptic; Tonic; Vasodilator

Geographical Distribution:

Indonesia; India; Malaysia; China; Thailand; South Korea

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Small molecule receptor (family A GPCR)	FFAR1; FFAR4; DRD2; HTR1A;
Hydrolase	ACHE;
Enzyme_unclassified	TDP1; RECQL; GLO1; PGD; ALOX12; HSD17B2; HSD17B10; NOX4; ALOX15; APEX1; POLB;
Miscellaneous ion channel	BCL2;
Isomerase	TOP2A;
Protein Kinase	PIM1; MET; AXL; FLT3; CDK1; MAPK1; KDR; IGF1R; AURKB;
Lyase	CA2; CA12; CA14; CA7; CA4;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	TYR;
Lysine demethylase	KDM4E;
Metallo protease	MMP9; MMP1; MMP12; MMP2;
Transcription Factor	AHR; HIF1A; NFKB1;
Transferase	FUT7;
Unclassified	LMNA; FABP3; FABP5; FABP4;
Methyl-lysine/arginine binding protein	L3MBTL1; SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	GLO1	Glyoxalase I	Q04760	CHEMBL2424
Enzyme_unclassified	PGD	6-phosphogluconate dehydrogenase	P52209	CHEMBL3404
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Isomerase	TOP2A	DNA topoisomerase II alpha	P11388	CHEMBL1806
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Miscellaneous ion channel	BCL2	Apoptosis regulator Bcl-2	P10415	CHEMBL4860
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Small molecule receptor (family A GPCR)	DRD2	Dopamine D2 receptor	P14416	CHEMBL217
Small molecule receptor (family A GPCR)	HTR1A	Serotonin 1a (5-HT1a) receptor	P08908	CHEMBL214
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.010E-10	7.988E-07	CA12, CA14, CA2, CA4, CA7
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	2.105E-08	1.273E-05	ALOX12, BCL2, CDK1, DRD2, FLT3, HIF1A, HTR1A, IGF1R, KDR, MAPK1, MMP12, MMP2, MMP9, PIM1, TSHR
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.700E-07	7.257E-05	CA12, CA14, CA2, CA4, CA7
BP	GO:0065007; biological regulation	GO:0010817; regulation of hormone levels	1.947E-07	8.023E-05	ACHE, CYP1A1, CYP1B1, DRD2, FFAR1, FFAR4, HIF1A, HSD17B2, HTR1A, NFKB1, NR1H4
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	7.639E-07	2.411E-04	BCL2, CYP1A1, DRD2, HIF1A, LMNA, MMP2, NOX4, PPARA
BP	GO:0050896; response to stimulus	GO:0033993; response to lipid	8.365E-07	2.530E-04	AXL, BCL2, CA2, CYP1A1, CYP1A2, FABP3, FFAR1, FLT3, HSD17B2, NFKB1, NR1H4, TYR
MF	GO:0005488; binding	GO:0005504; fatty acid binding	1.058E-06	2.879E-04	FABP3, FABP4, FABP5, FFAR4
BP	GO:0050896; response to stimulus	GO:0010039; response to iron ion	1.880E-06	4.706E-04	BCL2, CYP1A1, DRD2, HIF1A
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.730E-06	6.392E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.885E-06	6.663E-04	CA12, CA2, CA4, CA7, GLO1, L3MBTL1, MMP1, MMP12, MMP2, MMP9, NR1H4, PPARA
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.483E-06	7.738E-04	CA12, CA2, CA4, CA7
BP	GO:0032502; developmental process	GO:0007568; aging	4.501E-06	9.516E-04	APEX1, AURKB, BCL2, CDK1, CYP1A1, NOX4, POLB
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	4.970E-06	1.031E-03	HIF1A, MMP1, MMP12, MMP2, MMP9
BP	GO:0050896; response to stimulus	GO:0035094; response to nicotine	5.923E-06	1.183E-03	BCL2, DRD2, MAPK1, NFKB1
MF	GO:0005488; binding	GO:0008134; transcription factor binding	6.576E-06	1.267E-03	AHR, APEX1, BCL2, FLT3, HIF1A, MAPK1, NFKB1, NR1H4, PIM1, PPARA
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	7.976E-06	1.498E-03	ALOX12, ALOX15, APEX1, CYP1A1, CYP1A2, CYP1B1, HSD17B10, HSD17B2, KDM4E, NOX4, PGD, TYR
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	8.255E-06	1.498E-03	APEX1, POLB
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	8.255E-06	1.498E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	8.255E-06	1.498E-03	ALOX12, ALOX15
MF	GO:0005488; binding	GO:0019825; oxygen binding	8.640E-06	1.555E-03	CYP1A1, CYP1A2, CYP1B1, NOX4
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	1.384E-05	2.336E-03	HIF1A, MMP1, MMP12, MMP2, MMP9
BP	GO:0050896; response to stimulus	GO:0071417; cellular response to organonitrogen compound	1.716E-05	2.768E-03	APEX1, IGF1R, MAPK1, MMP2, NFKB1, NOX4, NR1H4, TSHR
BP	GO:0050896; response to stimulus	GO:0009725; response to hormone	1.743E-05	2.791E-03	APEX1, BCL2, CA2, CYP1A2, FABP3, FFAR4, FLT3, NFKB1, PPARA, TSHR
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	2.472E-05	3.541E-03	CA2, CA7
BP	GO:0019740; nitrogen utilization	GO:0006808; regulation of nitrogen utilization	2.472E-05	3.541E-03	BCL2, NR1H4
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	2.472E-05	3.541E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	2.472E-05	3.541E-03	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:0070988; demethylation	2.561E-05	3.621E-03	APEX1, CYP1A1, CYP1A2, KDM4E
MF	GO:0060089; molecular transducer activity	GO:0038023; signaling receptor activity	2.778E-05	3.877E-03	AHR, AXL, DRD2, FFAR1, FFAR4, FLT3, HTR1A, IGF1R, KDR, MET, NPSR1, NR1H4, PPARA, TSHR
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	2.924E-05	4.055E-03	APEX1, AXL, CDK1, CYP1B1
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	2.958E-05	4.077E-03	CYP1A1, CYP1A2, CYP1B1
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	3.008E-05	4.094E-03	BCL2, CA2, CA7, DRD2, KDR, NPSR1
BP	GO:0008152; metabolic process	GO:0030574; collagen catabolic process	3.761E-05	4.874E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	3.923E-05	4.995E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	3.923E-05	4.995E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0042802; identical protein binding	4.312E-05	5.459E-03	ACHE, BCL2, DRD2, FLT3, IGF1R, KDR, L3MBTL1, MAPK1, MET, MMP9, NFKB1, SMN1, SMN2, TOP2A, TYR
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	4.935E-05	6.140E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	5.074E-05	6.242E-03	FABP3, FABP4, FABP5
BP	GO:0008152; metabolic process	GO:0010557; positive regulation of macromolecule biosynthetic process	5.512E-05	6.699E-03	AHR, AURKB, CDK1, DRD2, HIF1A, IGF1R, KDR, MAPK1, MET, MMP12, NFKB1, NOX4, NR1H4, PPARA, TOP2A
BP	GO:0009987; cellular process	GO:0050714; positive regulation of protein secretion	5.941E-05	7.071E-03	ACHE, DRD2, FFAR1, HIF1A, MMP12, NR1H4
BP	GO:0009987; cellular process	GO:0010638; positive regulation of organelle organization	6.390E-05	7.551E-03	ALOX15, AURKB, BCL2, HIF1A, KDR, MAPK1, MET, MMP9, NOX4
BP	GO:0050896; response to stimulus	GO:1901652; response to peptide	6.415E-05	7.551E-03	APEX1, FABP3, FFAR4, IGF1R, NFKB1, PPARA, TSHR
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	6.650E-05	7.702E-03	APEX1, CYP1A1, CYP1B1, FLT3, MAPK1, NFKB1, NOX4
BP	GO:0009987; cellular process	GO:0071345; cellular response to cytokine stimulus	7.140E-05	8.097E-03	ALOX15, AXL, FABP4, FLT3, HIF1A, MAPK1, NFKB1
BP	GO:0009987; cellular process	GO:0022617; extracellular matrix disassembly	8.098E-05	8.849E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	8.209E-05	8.849E-03	ALOX12, ALOX15
MF	GO:0005488; binding	GO:0046982; protein heterodimerization activity	8.715E-05	9.257E-03	AHR, AXL, BCL2, DRD2, HIF1A, NFKB1, TOP2A, TYR
BP	GO:0009987; cellular process	GO:0007169; transmembrane receptor protein tyrosine kinase signaling pathway	8.961E-05	9.465E-03	AXL, FLT3, IGF1R, KDR, MAPK1, MET, MMP2, MMP9
CC	GO:0016020; membrane	GO:0005886; plasma membrane	8.998E-05	9.465E-03	ACHE, ALOX12, ALOX15, AXL, CA12, CA14, CA2, CA4, DRD2, FABP5, FFAR1, FFAR4, FLT3, GLO1, HSD17B10, HTR1A, IGF1R, KDR, L3MBTL1, MAPK1, MET, MMP2, NPSR1, PIM1, TDP1, TSHR

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.339E-07	1.071E-05	FLT3, MMP1, MMP2, BCL2, MAPK1, HIF1A, MET, MMP9, NFKB1, IGF1R
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	8.645E-10	1.383E-07	CA12, CA2, CA4, CA7, CA14
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.523E-06	6.092E-05	MMP2, KDR, MAPK1, HIF1A, MMP9, MET, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.406E-06	6.092E-05	FABP3, FABP4, FABP5, MMP1, PPARA
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	9.256E-06	2.307E-04	MMP2, PIM1, BCL2, MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	5.167E-06	1.654E-04	MMP1, MMP2, MAPK1, MMP9
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.153E-05	2.307E-04	HSD17B2, CYP1A1, CYP1B1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	1.019E-05	2.307E-04	BCL2, MAPK1, HIF1A, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.846E-05	2.786E-04	PIM1, BCL2, CYP1B1, MAPK1, MMP9, MET, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.931E-05	2.786E-04	HTR1A, MAPK1, PPARA, DRD2, NFKB1, TSHR
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.950E-05	2.786E-04	FLT3, PIM1, MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	3.705E-05	4.560E-04	FLT3, MAPK1, MET, HIF1A
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.128E-04	1.289E-03	BCL2, MAPK1, NFKB1, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.090E-05	2.786E-04	CYP1A2, HSD17B2, CYP1A1, CYP1B1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	2.515E-04	2.367E-03	KDR, BCL2, MAPK1, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	1.471E-04	1.569E-03	FLT3, MMP9, MET, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	3.723E-04	2.979E-03	KDR, BCL2, MAPK1, MET, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	3.075E-04	2.589E-03	KDR, MAPK1, DRD2, MET, IGF1R
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.735E-04	2.431E-03	ALOX15, HTR1A, MAPK1, ALOX12
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	4.298E-04	3.275E-03	KDR, MAPK1, MET, NFKB1, IGF1R
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	6.370E-04	4.633E-03	LMNA, BCL2, MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	7.455E-04	5.186E-03	BCL2, MAPK1, MMP9, NFKB1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.909E-04	1.909E-03	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	1.038E-03	6.646E-03	MAPK1, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	8.397E-04	5.598E-03	MAPK1, MET, HIF1A
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.171E-03	6.938E-03	MAPK1, MET, IGF1R
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.126E-03	6.927E-03	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.574E-03	8.997E-03	CYP1A2, CYP1A1, CYP1B1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	HTR1A;
K00-K95: Diseases of the digestive system	Dermal necrosis	K05	DRD2;
O00-O9A: Pregnancy, childbirth and the puerperium	Postpartum haemorrhage	O72	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Hypoactive sexual desire disorder	F52.0	HTR1A;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
NA: NA	Edema	NA	CA2;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3; BCL2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD2;
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3; DRD2; BCL2;
K00-K95: Diseases of the digestive system	Gastrointestinal problems	K30-K31, Q40-Q41	DRD2;
C00-D49: Neoplasms	CLL	NA	FLT3;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MMP12; DRD2;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	BCL2;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET; DRD2;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	DRD2;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2;
E00-E89: Endocrine, nutritional and metabolic diseases	Acromegaly	E22.0	DRD2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MMP1; TYR;
NA: NA	Schizoaffective disorders	NA	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; HTR1A;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
NA: NA	False perceptions	NA	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	HTR1A;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
J00-J99: Diseases of the respiratory system	Asthma	J45	MMP12; DRD2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	MMP12;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperprolactinemia	E22.1	DRD2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
I00-I99: Diseases of the circulatory system	Hypotension	I95	DRD2;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR; MMP2;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
NA: NA	Cervical dystonia	NA	HTR1A;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	DRD2;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Idiopathic thrombocytopenic purpura	D69.3	DRD2;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
C00-D49: Neoplasms	Melanoma	C43	KDR; TYR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
NA: NA	Malignant phaeochromocytoma	NA	DRD2;
NA: NA	Malignant essential hypertension	NA	DRD2;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Carcinoid syndrome	E34.0	DRD2;
NA: NA	Bulimia nervosa	NA	HTR1A;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; NFKB1; FLT3; ACHE; HIF1A; MMP9; MAPK1; MMP2; BCL2;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
I00-I99: Diseases of the circulatory system	Maintain blood pressure in hypotensive states	I10	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	DRD2; HTR1A;
I00-I99: Diseases of the circulatory system	Pulmonary hypertension	I27.0, I27.2	DRD2;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
I00-I99: Diseases of the circulatory system	Cardiotonic	I50	DRD2;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Huntington's disease	F02.2, G10	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Migraine headaches	G43	DRD2;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2; DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychosis	F20-F29	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Bipolar disorder	F31, F40-F42	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE; DRD2; HTR1A;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; MMP2;
NA: NA	Peripheral vasoconstriction	NA	DRD2;
NA: NA	Peripheral sensory neuropathies	NA	HTR1A;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3; BCL2;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; AHR; BCL2;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
NA: NA	Itching	NA	DRD2;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
NA: NA	Social phobia	NA	HTR1A;
C00-D49: Neoplasms	Solid tumours	C00-D48	TOP2A; MET; AURKB; IGF1R; KDR; FLT3; HIF1A; MMP9; MAPK1; MMP2;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL; DRD2;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR; MMP2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MMP12; DRD2;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	DRD2;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	HTR1A;
NA: NA	Episode	NA	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	DRD2;
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
I00-I99: Diseases of the circulatory system	Cardiac failure	I50	DRD2;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; BCL2;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	DRD2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R; ACHE; DRD2; HTR1A;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3; MMP2;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE; DRD2; HTR1A;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; DRD2; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD2; HTR1A;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; MMP9;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; FFAR1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nausea	R11	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	HTR1A;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
G00-G99: Diseases of the nervous system G00-G99	Lateral sclerosis	G12.2	HTR1A;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3; BCL2;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
NA: NA	Vomiting	NA	DRD2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Advanced stage Parkinson's disease	F02.3, G20	DRD2;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
NA: NA	Schizoaffective disorder	NA	HTR1A;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
NA: NA	Anxiety disorders	NA	HTR1A;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
NA: NA	HIV infections	NA	AHR;
G00-G99: Diseases of the nervous system G00-G99	Amyotrophic lateral sclerosis	G12.2	BCL2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
H00-H59: Diseases of the eye and adnexa	Ophthalmic disease	H00-H59	DRD2;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE; CA2;
NA: NA	Hyperaemia	NA	DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	HTR1A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Depressive fatigue	R53.82	DRD2;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD2; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	HTR1A;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2;
J00-J99: Diseases of the respiratory system	Bronchitis	J20-J21, J42	DRD2;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	DRD2; HTR1A;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
NA: NA	Benign prostatic hypertrophy	NA	DRD2;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Generalized anxiety disorder	F32, F40-F42, F41.1	HTR1A;
C00-D49: Neoplasms	Ocular cancer	C69	APEX1;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced melanoma	C43	BCL2;
NA: NA	Corneal vascularity	NA	DRD2;
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	HTR1A;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR;
NA: NA	GIST	NA	FLT3;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; DRD2;
J00-J99: Diseases of the respiratory system	Nasal congestion	J34.89	DRD2;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases