Plant Name: Swertia hickinii
Taxonomic Information:
Plant ID: NPO3381
Plant Latin Name: Swertia hickinii
Taxonomy Genus: Swertia
Taxonomy Family: Gentianaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| CA2; CA1; CA12; CA9; | |
| AR; | |
| HPGD; TNKS; PARP1; TNKS2; | |
| TP53; | |
| RAB9A; NPC1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP19A1; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | TNKS | Tankyrase-1 | O95271 | CHEMBL6164 |
| Enzyme_unclassified | PARP1 | Poly [ADP-ribose] polymerase-1 | P09874 | CHEMBL3105 |
| Enzyme_unclassified | TNKS2 | Tankyrase-2 | Q9H2K2 | CHEMBL6154 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Nuclear hormone receptor subfamily 3 group C | AR | Androgen Receptor | P10275 | CHEMBL1871 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 2.346E-10 | 5.108E-06 | CA1, CA12, CA2, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.003E-08 | 7.283E-05 | CA1, CA12, CA2, CA9 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 2.305E-08 | 1.004E-04 | CA1, CA12, CA2, CA9 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 2.282E-08 | 1.004E-04 | AR, CA1, CA12, CA2, CA9, PARP1, TNKS, TP53 |
| MF | GO:0003824; catalytic activity | GO:0003950; NAD+ ADP-ribosyltransferase activity | 7.803E-07 | 1.307E-03 | PARP1, TNKS, TNKS2 |
| BP | GO:0065007; biological regulation | GO:1904357; negative regulation of telomere maintenance via telomere lengthening | 8.775E-07 | 1.365E-03 | PARP1, TNKS, TNKS2 |
| BP | GO:0008152; metabolic process | GO:0070213; protein auto-ADP-ribosylation | 2.924E-06 | 3.746E-03 | TNKS, TNKS2 |
| BP | GO:0008152; metabolic process | GO:0070212; protein poly-ADP-ribosylation | 7.305E-06 | 7.648E-03 | PARP1, TNKS |
| MF | GO:0003824; catalytic activity | GO:0004064; arylesterase activity | 7.305E-06 | 7.648E-03 | CA1, CA2 |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 7.727E-06 | 7.648E-03 | CA2, CA9, HPGD, TSHR |
| CC | GO:0043226; organelle | GO:0000242; pericentriolar material | 9.200E-05 | 3.928E-02 | TNKS, TNKS2 |
| CC | GO:0043226; organelle | GO:0000784; nuclear chromosome, telomeric region | 1.051E-04 | 4.317E-02 | PARP1, TNKS, TNKS2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 3.556E-10 | 1.920E-08 | CA12, CA1, CA2, CA9 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 1.721E-03 | 4.647E-02 | AR, TP53 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 4.190E-03 | 5.656E-02 | PARP1, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 3.959E-03 | 5.656E-02 | RAB9A, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 6.827E-03 | 7.373E-02 | HPGD, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05214 | Glioma | 4.457E-02 | 9.420E-02 | TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05210 | Colorectal cancer | 4.255E-02 | 9.420E-02 | TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 4.524E-02 | 9.420E-02 | TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 4.591E-02 | 9.420E-02 | TP53 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 3.986E-02 | 9.420E-02 | CYP19A1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53; |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR; |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TP53; |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR; |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53; |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53; |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53; |
| C00-D49: Neoplasms | Cancer | C00-C96 | TP53; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
