CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Lyase	CA2; CA1; CA12; CA9;
Nuclear hormone receptor subfamily 3 group C	AR;
Enzyme_unclassified	HPGD; TNKS; PARP1; TNKS2;
Transcription Factor	TP53;
Unclassified	RAB9A; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	TNKS	Tankyrase-1	O95271	CHEMBL6164
Enzyme_unclassified	PARP1	Poly [ADP-ribose] polymerase-1	P09874	CHEMBL3105
Enzyme_unclassified	TNKS2	Tankyrase-2	Q9H2K2	CHEMBL6154
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Nuclear hormone receptor subfamily 3 group C	AR	Androgen Receptor	P10275	CHEMBL1871

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.003E-08	7.283E-05	CA1, CA12, CA2, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.305E-08	1.004E-04	CA1, CA12, CA2, CA9
BP	GO:0065007; biological regulation	GO:1904357; negative regulation of telomere maintenance via telomere lengthening	8.775E-07	1.365E-03	PARP1, TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0070213; protein auto-ADP-ribosylation	2.924E-06	3.746E-03	TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0070212; protein poly-ADP-ribosylation	7.305E-06	7.648E-03	PARP1, TNKS
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	7.727E-06	7.648E-03	CA2, CA9, HPGD, TSHR
CC	GO:0043226; organelle	GO:0000242; pericentriolar material	9.200E-05	3.928E-02	TNKS, TNKS2
CC	GO:0043226; organelle	GO:0000784; nuclear chromosome, telomeric region	1.051E-04	4.317E-02	PARP1, TNKS, TNKS2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.346E-10	5.108E-06	CA1, CA12, CA2, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.282E-08	1.004E-04	AR, CA1, CA12, CA2, CA9, PARP1, TNKS, TP53

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.556E-10	1.920E-08	CA12, CA1, CA2, CA9
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3.986E-02	9.420E-02	CYP19A1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	4.190E-03	5.656E-02	PARP1, TP53
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.721E-03	4.647E-02	AR, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	3.959E-03	5.656E-02	RAB9A, TP53
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	6.827E-03	7.373E-02	HPGD, TP53
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	4.457E-02	9.420E-02	TP53
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	4.255E-02	9.420E-02	TP53
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	4.524E-02	9.420E-02	TP53
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	4.591E-02	9.420E-02	TP53

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Cancer	C00-C96	TP53;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Swertia hickinii

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities