CMAUP Plant Collective Molecular Activities

Plant Name: aristolochia constricta

Taxonomic Information:

Plant ID: NPO33321
Plant Latin Name: aristolochia constricta
Taxonomy Genus: Aristolochia
Taxonomy Family: Aristolochiaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: 92853-1

Used in Medicines:

Country/Region:

Ecuador

Traditional Medicine System:

Geographical Distribution:

Brazil; Honduras; Peru; Venezuela; Costa Rica; Colombia; Bolivia; Nicaragua; Ecuador

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
SLC superfamily of solute carriers	SLC6A3; SLC6A2;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
SLC superfamily of solute carriers	SLC6A3	Dopamine transporter	Q01959	CHEMBL238
SLC superfamily of solute carriers	SLC6A2	Norepinephrine transporter	P23975	CHEMBL222

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0023052; signaling	GO:0051583; dopamine uptake involved in synaptic transmission	4.823E-07	1.750E-03	SLC6A2, SLC6A3
MF	GO:0005215; transporter activity	GO:0005330; dopamine:sodium symporter activity	9.649E-08	1.750E-03	SLC6A2, SLC6A3
MF	GO:0005215; transporter activity	GO:0005328; neurotransmitter:sodium symporter activity	6.104E-06	1.108E-02	SLC6A2, SLC6A3
CC	GO:0016020; membrane	GO:0045121; membrane raft	1.348E-03	5.314E-01	SLC6A2, SLC6A3
CC	GO:0044464; cell part	GO:0043005; neuron projection	9.604E-03	1.000E+00	SLC6A2, SLC6A3
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	2.889E-02	1.000E+00	SLC6A2, SLC6A3
CC	GO:0044456; synapse part	GO:0098793; presynapse	3.394E-02	1.000E+00	SLC6A3

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.788E-03	2.259E-02	CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	9.169E-03	2.259E-02	CYP3A4
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	9.765E-03	2.259E-02	SLC6A3
09160 Human Diseases	09164 Substance dependence	hsa05031	Amphetamine addiction	1.333E-02	2.259E-02	SLC6A3
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.155E-02	2.259E-02	CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.294E-02	2.259E-02	CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.373E-02	2.259E-02	CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.452E-02	2.259E-02	CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.413E-02	2.259E-02	CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.630E-02	2.282E-02	CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases