CMAUP Plant Collective Molecular Activities

Plant Name: aristolochia constricta

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	SLC6A2; SLC6A2; SLC6A2; SLC6A2
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	SLC6A2
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
C00-D49: Neoplasms	Neuroendocrine cancer	C7A	SLC6A2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Bipolar disorder	F31, F40-F42	SLC6A2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; SLC6A2
I00-I99: Diseases of the circulatory system	Heart failure	I50	SLC6A2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	SLC6A2; SLC6A2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	SLC6A2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	SLC6A2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	SLC6A2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cancer pain	R52, G89	SLC6A2
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	SLC6A2
C00-D49: Neoplasms	Neuroblastoma	C74.1, C74.9, C75.4, C75.5, D35.0, D35.5, D35.6, D44.6, D44.7	SLC6A2

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases