Plant Name: murraya alata
Taxonomic Information:
Plant ID: NPO33003
Plant Latin Name: murraya alata
Taxonomy Genus: Murraya
Taxonomy Family: Rutaceae
Plant External Links:
NCBI TaxonomyDB:
1224772
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| PDE4D; | |
| CA1; CA7; CA5A; CA4; CA6; CA12; CA9; CA13; CA14; | |
| XPO1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Lyase | CA13 | Carbonic anhydrase XIII | Q8N1Q1 | CHEMBL3912 |
| Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Phosphodiesterase 4 | PDE4D | Phosphodiesterase 4D | Q08499 | CHEMBL288 |
| Unclassified | XPO1 | Exportin-1 | O14980 | CHEMBL5661 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 1.404E-09 | 2.864E-06 | CA1, CA12, CA13, CA4, CA5A, CA6, CA7, CA9 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 2.672E-28 | 5.818E-24 | CA1, CA12, CA13, CA14, CA4, CA5A, CA6, CA7, CA9 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 3.775E-23 | 4.110E-19 | CA1, CA12, CA13, CA14, CA4, CA5A, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.036E-20 | 4.513E-17 | CA1, CA12, CA13, CA4, CA5A, CA6, CA7, CA9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 9.487E-28 | 9.487E-27 | CA12, CA1, CA5A, CA4, CA7, CA6, CA9, CA14, CA13 |
| 09150 Organismal Systems | 09155 Excretory system | hsa04964 | Proximal tubule bicarbonate reclamation | 1.258E-02 | 6.290E-02 | CA4 |
| 09120 Genetic Information Processing | 09122 Translation | hsa03008 | Ribosome biogenesis in eukaryotes | 4.789E-02 | 1.174E-01 | XPO1 |
| 09160 Human Diseases | 09164 Substance dependence | hsa05032 | Morphine addiction | 4.894E-02 | 1.174E-01 | PDE4D |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05164 | Influenza A | 9.217E-02 | 1.174E-01 | XPO1 |
| 09120 Genetic Information Processing | 09122 Translation | hsa03013 | RNA transport | 9.066E-02 | 1.174E-01 | XPO1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 1.042E-01 | 1.174E-01 | PDE4D |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05169 | Epstein-Barr virus infection | 1.057E-01 | 1.174E-01 | XPO1 |
| 09100 Metabolism | 09104 Nucleotide metabolism | hsa00230 | Purine metabolism | 9.267E-02 | 1.174E-01 | PDE4D |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05166 | HTLV-I infection | 1.331E-01 | 1.331E-01 | XPO1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
