Plant Name: murraya alata
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 1.404E-09 | 2.864E-06 | CA1, CA12, CA13, CA4, CA5A, CA6, CA7, CA9 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 2.672E-28 | 5.818E-24 | CA1, CA12, CA13, CA14, CA4, CA5A, CA6, CA7, CA9 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 3.775E-23 | 4.110E-19 | CA1, CA12, CA13, CA14, CA4, CA5A, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.036E-20 | 4.513E-17 | CA1, CA12, CA13, CA4, CA5A, CA6, CA7, CA9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 9.487E-28 | 9.487E-27 | CA12; CA1; CA5A; CA4; CA7; CA6; CA9; CA14; CA13 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Breast cancer | C50 | CA9 |
| J00-J99: Diseases of the respiratory system | Bronchitis | J20-J21, J42 | PDE4D |
| C00-D49: Neoplasms | Cancer | C00-C96 | CA1; CA9; XPO1 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9 |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | PDE4D; PDE4D |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9; XPO1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | PDE4D |
| L00-L99: Diseases of the skin and subcutaneous tissue | Atopic dermatitis | L00-L99 | PDE4D |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | CA1; CA1 |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | CA4; CA4 |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA4 |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA1 |
| J00-J99: Diseases of the respiratory system | Emphysema | J43 | PDE4D |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1 |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| J00-J99: Diseases of the respiratory system | Chronic obstructive pulmonary disease | J40-J44, J47 | PDE4D; PDE4D; PDE4D |