Plant Name: garcinia esculenta
Taxonomic Information:
Plant ID: NPO32711
Plant Latin Name: garcinia esculenta
Taxonomy Genus: Garcinia
Taxonomy Family: Clusiaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| PTGS1; PTGS2; | |
| IDH1; | |
| EP300; | |
| FASN; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP19A1; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Bromodomain | EP300 | Histone acetyltransferase p300 | Q09472 | CHEMBL3784 |
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Enzyme_unclassified | IDH1 | Isocitrate dehydrogenase [NADP] cytoplasmic | O75874 | CHEMBL2007625 |
| Oxidoreductase | PTGS1 | Cyclooxygenase-1 | P23219 | CHEMBL221 |
| Oxidoreductase | PTGS2 | Cyclooxygenase-2 | P35354 | CHEMBL230 |
| Transferase | FASN | Fatty acid synthase | P49327 | CHEMBL4158 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004666; prostaglandin-endoperoxide synthase activity | 8.041E-08 | 8.755E-04 | PTGS1, PTGS2 |
| BP | GO:0008152; metabolic process | GO:0055114; oxidation-reduction process | 1.240E-06 | 5.905E-03 | CYP19A1, FASN, IDH1, PTGS1, PTGS2 |
| BP | GO:0008152; metabolic process | GO:0006633; fatty acid biosynthetic process | 1.688E-06 | 6.126E-03 | FASN, PTGS1, PTGS2 |
| BP | GO:0008152; metabolic process | GO:0019371; cyclooxygenase pathway | 4.417E-06 | 1.136E-02 | PTGS1, PTGS2 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 5.603E-06 | 1.136E-02 | CYP19A1, PTGS1, PTGS2 |
| MF | GO:0016209; antioxidant activity | GO:0004601; peroxidase activity | 7.563E-05 | 5.312E-02 | PTGS1, PTGS2 |
| CC | GO:0016020; membrane | GO:0005789; endoplasmic reticulum membrane | 1.939E-03 | 2.994E-01 | CYP19A1, PTGS1, PTGS2 |
| CC | GO:0043226; organelle | GO:0043231; intracellular membrane-bounded organelle | 4.354E-03 | 5.181E-01 | CYP19A1, EP300, FASN, IDH1, PTGS1, PTGS2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 5.154E-06 | 2.628E-04 | FASN, IDH1, PTGS2, CYP19A1, PTGS1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 9.129E-05 | 1.794E-03 | PTGS2, CYP19A1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 1.147E-04 | 1.794E-03 | PTGS2, PTGS1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 1.407E-04 | 1.794E-03 | PTGS2, PTGS1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 4.594E-04 | 4.686E-03 | PTGS2, PTGS1 |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 3.169E-03 | 2.694E-02 | EP300, PTGS2 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 5.592E-03 | 3.169E-02 | EP300, PTGS2 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00020 | Citrate cycle (TCA cycle) | 8.967E-03 | 4.573E-02 | IDH1 |
| Unclassified | Unclassified | hsa01210 | 2-Oxocarboxylic acid metabolism | 5.090E-03 | 3.169E-02 | IDH1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00061 | Fatty acid biosynthesis | 3.894E-03 | 2.837E-02 | FASN |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| NA: NA | Rheumatold arthritis | NA | PTGS1; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Acne vulgaris | L70.0 | PTGS1; |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | PTGS1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dietary shortage | E40-E46 | PTGS1; |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | PTGS1; |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | PTGS1; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | PTGS1; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatitis | L20-L30 | PTGS1; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | PTGS1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | PTGS1; |
| N00-N99: Diseases of the genitourinary system | Dysmenorrhea | N94.4-N94.6 | PTGS1; |
| NA: NA | Miosis during ocular surgery | NA | PTGS1; |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | PTGS1; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | PTGS1; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Postoperative inflammation | T81 | PTGS1; |
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>> Targets derived from weak experimental activities
