CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Oxidoreductase	PTGS1; PTGS2;
Enzyme_unclassified	IDH1;
Bromodomain	EP300;
Transferase	FASN;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Bromodomain	EP300	Histone acetyltransferase p300	Q09472	CHEMBL3784
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	IDH1	Isocitrate dehydrogenase [NADP] cytoplasmic	O75874	CHEMBL2007625
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Oxidoreductase	PTGS2	Cyclooxygenase-2	P35354	CHEMBL230
Transferase	FASN	Fatty acid synthase	P49327	CHEMBL4158

Showing 1 to 6 of 6 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	1.240E-06	5.905E-03	CYP19A1, FASN, IDH1, PTGS1, PTGS2
BP	GO:0008152; metabolic process	GO:0006633; fatty acid biosynthetic process	1.688E-06	6.126E-03	FASN, PTGS1, PTGS2
BP	GO:0008152; metabolic process	GO:0019371; cyclooxygenase pathway	4.417E-06	1.136E-02	PTGS1, PTGS2
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	1.939E-03	2.994E-01	CYP19A1, PTGS1, PTGS2
CC	GO:0043226; organelle	GO:0043231; intracellular membrane-bounded organelle	4.354E-03	5.181E-01	CYP19A1, EP300, FASN, IDH1, PTGS1, PTGS2
MF	GO:0003824; catalytic activity	GO:0004666; prostaglandin-endoperoxide synthase activity	8.041E-08	8.755E-04	PTGS1, PTGS2
MF	GO:0005488; binding	GO:0020037; heme binding	5.603E-06	1.136E-02	CYP19A1, PTGS1, PTGS2
MF	GO:0016209; antioxidant activity	GO:0004601; peroxidase activity	7.563E-05	5.312E-02	PTGS1, PTGS2

Showing 1 to 8 of 8 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.407E-04	1.794E-03	PTGS2, PTGS1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	8.967E-03	4.573E-02	IDH1
09100 Metabolism	09103 Lipid metabolism	hsa00061	Fatty acid biosynthesis	3.894E-03	2.837E-02	FASN
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	9.129E-05	1.794E-03	PTGS2, CYP19A1
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.147E-04	1.794E-03	PTGS2, PTGS1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.594E-04	4.686E-03	PTGS2, PTGS1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	3.169E-03	2.694E-02	EP300, PTGS2
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	5.592E-03	3.169E-02	EP300, PTGS2
Unclassified	Unclassified	hsa01100	Metabolic pathways	5.154E-06	2.628E-04	FASN, IDH1, PTGS2, CYP19A1, PTGS1
Unclassified	Unclassified	hsa01210	2-Oxocarboxylic acid metabolism	5.090E-03	3.169E-02	IDH1

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS1;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	PTGS1;
E00-E89: Endocrine, nutritional and metabolic diseases	Dietary shortage	E40-E46	PTGS1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	PTGS1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	PTGS1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	PTGS1;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PTGS1;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	PTGS1;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	PTGS1;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	PTGS1;

Showing 1 to 10 of 15 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: garcinia esculenta

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities