CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
NA: NA	Rheumatold arthritis	NA	PTGS1; PTGS2; PTGS2; PTGS2
C00-D49: Neoplasms	Hematological malignancies	C81-C86	IDH1
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1
NA: NA	Gram-positive bacterial infection	NA	FASN
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	PTGS2; PTGS2; PTGS2; PTGS2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Knee osteoarthritis	M15-M19, M47	PTGS2
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	PTGS1
S00-T88: Injury, poisoning and certain other consequences of external causes	Hyperthermia	T68	PTGS2
NA: NA	Joint and muscular pain	NA	PTGS2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PTGS2; PTGS2
J00-J99: Diseases of the respiratory system	Asthma	J45	PTGS2
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PTGS1; PTGS2
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	PTGS2
E00-E89: Endocrine, nutritional and metabolic diseases	Dietary shortage	E40-E46	PTGS1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	PTGS2
A00-B99: Certain infectious and parasitic diseases	Mycobacterium tuberculosis infection	A15-A19	FASN
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTGS2
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	PTGS1; PTGS2; PTGS2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Ankylosing spondylitis	M08.1, M45	PTGS2
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	PTGS1
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	PTGS2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	PTGS2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	PTGS1; PTGS2; PTGS2; PTGS2; PTGS2; PTGS2; PTGS2
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	PTGS1
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1
C00-D49: Neoplasms	Pancreatic cancer	C25	PTGS2
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	PTGS1; PTGS2; PTGS2; PTGS2; PTGS2
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	PTGS2
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	FASN
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Dramatic weight loss	R63.4	FASN
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	PTGS1
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	PTGS2; CYP19A1
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	PTGS1; PTGS2; PTGS2; PTGS2; PTGS2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Moderate to severe rheumatoid arthritis	M05-M06	PTGS2
NA: NA	Miosis during ocular surgery	NA	PTGS1
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	FASN
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS1; PTGS2
C00-D49: Neoplasms	Colorectal cancer	C18-C21	PTGS1
K00-K95: Diseases of the digestive system	Colon polyps	K63.5	PTGS2
C00-D49: Neoplasms	Cancer	C00-C96	PTGS2; FASN
S00-T88: Injury, poisoning and certain other consequences of external causes	Postoperative inflammation	T81	PTGS1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: garcinia esculenta

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases