Plant Name: Linum album
Taxonomic Information:
Plant ID: NPO3158
Plant Latin Name: Linum album
Taxonomy Genus: Linum
Taxonomy Family: Linaceae
Plant External Links:
NCBI TaxonomyDB:
191219
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| Oxidoreductase | HMGCR | HMG-CoA reductase | P04035 | CHEMBL402 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0050896; response to stimulus | GO:0061179; negative regulation of insulin secretion involved in cellular response to glucose stimulus | 9.317E-04 | 1.000E+00 | HMGCR |
| BP | GO:0051179; localization | GO:0042908; xenobiotic transport | 1.035E-03 | 1.000E+00 | ABCG2 |
| BP | GO:0008152; metabolic process | GO:0046415; urate metabolic process | 1.346E-03 | 1.000E+00 | ABCG2 |
| BP | GO:0032502; developmental process | GO:0045445; myoblast differentiation | 2.380E-03 | 1.000E+00 | HMGCR |
| BP | GO:0051179; localization | GO:0033344; cholesterol efflux | 2.484E-03 | 1.000E+00 | ABCG2 |
| BP | Unclassified; | GO:0097756; negative regulation of blood vessel diameter | 4.034E-03 | 1.000E+00 | HMGCR |
| BP | GO:0007610; behavior | GO:0008542; visual learning | 4.964E-03 | 1.000E+00 | HMGCR |
| BP | GO:0051179; localization | GO:0006855; drug transmembrane transport | 6.616E-03 | 1.000E+00 | ABCG2 |
| BP | GO:0008283; cell proliferation | GO:0048661; positive regulation of smooth muscle cell proliferation | 7.854E-03 | 1.000E+00 | HMGCR |
| BP | GO:0050896; response to stimulus | GO:0045471; response to ethanol | 1.198E-02 | 1.000E+00 | HMGCR |
| BP | GO:0032501; multicellular organismal process | GO:0097746; regulation of blood vessel diameter | 1.280E-02 | 1.000E+00 | HMGCR |
| BP | GO:0009987; cellular process | GO:0051262; protein tetramerization | 1.516E-02 | 1.000E+00 | HMGCR |
| BP | GO:0050896; response to stimulus | GO:0007584; response to nutrient | 1.988E-02 | 1.000E+00 | HMGCR |
| BP | GO:0009987; cellular process | GO:0070374; positive regulation of ERK1 and ERK2 cascade | 2.029E-02 | 1.000E+00 | HMGCR |
| BP | GO:0032502; developmental process | GO:0007568; aging | 2.378E-02 | 1.000E+00 | HMGCR |
| CC | GO:0016020; membrane | GO:0031090; organelle membrane | 1.976E-02 | 1.000E+00 | ABCG2, HMGCR |
| CC | GO:0032991; macromolecular complex | GO:0043235; receptor complex | 3.306E-02 | 1.000E+00 | ABCG2 |
| MF | GO:0005215; transporter activity | GO:0008559; xenobiotic transmembrane transporting ATPase activity | 7.247E-04 | 1.000E+00 | ABCG2 |
| MF | GO:0005488; binding | GO:0042803; protein homodimerization activity | 1.692E-03 | 1.000E+00 | ABCG2, HMGCR |
| MF | GO:0005488; binding | GO:0051721; protein phosphatase 2A binding | 2.897E-03 | 1.000E+00 | HMGCR |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.243E-05 | 6.213E-05 | HMGCR, ABCG2 |
| 09100 Metabolism | 09109 Metabolism of terpenoids and polyketides | hsa00900 | Terpenoid backbone biosynthesis | 2.199E-03 | 5.497E-03 | HMGCR |
| 09130 Environmental Information Processing | 09131 Membrane transport | hsa02010 | ABC transporters | 4.395E-03 | 7.325E-03 | ABCG2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04152 | AMPK signaling pathway | 1.236E-02 | 1.545E-02 | HMGCR |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 1.201E-01 | 1.201E-01 | HMGCR |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
