CMAUP Plant Collective Molecular Activities

Plant Name: Epimedium brevicornum

Taxonomic Information:

Plant ID: NPO31054
Plant Latin Name: Epimedium brevicornum
Taxonomy Genus: Epimedium
Taxonomy Family: Berberidaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	ALPI; AKR1B1; POLB;
Phosphodiesterase 5	PDE5A;
Hydrolase	GAA;
Lyase	CA2; CA7; CA4; CA12;
Nuclear hormone receptor subfamily 1 group C	PPARD; PPARA;
Lysine demethylase	KDM4E;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALPI	Intestinal alkaline phosphatase	P09923	CHEMBL5573
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Phosphodiesterase 5	PDE5A	Phosphodiesterase 5A	O76074	CHEMBL1827
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.346E-10	5.108E-06	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.003E-08	7.283E-05	CA12, CA2, CA4, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.305E-08	1.255E-04	CA12, CA2, CA4, CA7
MF	GO:0005488; binding	GO:0008270; zinc ion binding	6.040E-07	1.461E-03	ALPI, CA12, CA2, CA4, CA7, PPARA, PPARD
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.463E-06	2.896E-03	CA2, CA7
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	2.188E-05	3.403E-02	CA2, CA7
BP	GO:0008152; metabolic process	GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter	2.673E-05	3.880E-02	PPARA, PPARD

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.556E-10	1.316E-08	CA12, CA2, CA4, CA7
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.142E-04	2.112E-03	CA2, CA4
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.957E-04	2.414E-03	GAA, AKR1B1
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.039E-03	9.613E-03	PPARA, PPARD
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	8.286E-03	6.018E-02	PPARA, TSHR
09150 Organismal Systems	09155 Excretory system	hsa04966	Collecting duct acid secretion	1.874E-02	9.105E-02	CA2
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2.492E-02	9.105E-02	AKR1B1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	3.918E-02	9.105E-02	PPARD
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	4.858E-02	9.105E-02	TSHR
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	9.759E-03	6.018E-02	ALPI

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases