CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.346E-10	5.108E-06	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.003E-08	7.283E-05	CA12, CA2, CA4, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.305E-08	1.255E-04	CA12, CA2, CA4, CA7
MF	GO:0005488; binding	GO:0008270; zinc ion binding	6.040E-07	1.461E-03	ALPI, CA12, CA2, CA4, CA7, PPARA, PPARD
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.463E-06	2.896E-03	CA2, CA7

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	3.556E-10	1.316E-08	CA12; CA2; CA4; CA7
hsa04964	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.142E-04	2.112E-03	CA2; CA4
hsa00052	Galactose metabolism_Homo sapiens_hsa00052	1.957E-04	2.414E-03	GAA; AKR1B1
hsa03320	PPAR signaling pathway_Homo sapiens_hsa03320	1.039E-03	9.613E-03	PPARA; PPARD

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
NA: NA	Edema	NA	CA2
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PPARD
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	PPARD
J00-J99: Diseases of the respiratory system	Asthma	J45	PDE5A
NA: NA	Raynaud's disease	NA	PDE5A; PDE5A
C00-D49: Neoplasms	Colorectal cancer	C18-C21	PDE5A
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	PDE5A
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	PDE5A
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	PPARD
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	PDE5A; PDE5A
NA: NA	Dyslipidemia	NA	PPARD
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	PDE5A
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; CA4
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4; CA4
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	PPARD
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Erectile dysfunction	F52.2, N48.4	PDE5A; PDE5A
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PPARD; PPARD
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD; PPARD
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	PDE5A
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	PPARD

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Epimedium brevicornum

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases