CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADRA2C;
Protein Kinase	DYRK2; DYRK3; HASPIN; DYRK1A; DYRK1B; CLK1;
Oxidoreductase	MAOA;
Unclassified	MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Protein Kinase	DYRK2	Dual-specificity tyrosine-phosphorylation regulated kinase 2	Q92630	CHEMBL4376
Protein Kinase	DYRK3	Dual-specificity tyrosine-phosphorylation regulated kinase 3	O43781	CHEMBL4575
Protein Kinase	HASPIN	Serine/threonine-protein kinase haspin	Q8TF76	CHEMBL1075163
Protein Kinase	DYRK1A	Dual-specificity tyrosine-phosphorylation regulated kinase 1A	Q13627	CHEMBL2292
Protein Kinase	DYRK1B	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Q9Y463	CHEMBL5543
Protein Kinase	CLK1	Dual specificty protein kinase CLK1	P49759	CHEMBL4224
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Showing 1 to 10 of 10 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	1.901E-08	1.121E-04	CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3
MF	GO:0003824; catalytic activity	GO:0004712; protein serine/threonine/tyrosine kinase activity	9.495E-12	2.068E-07	CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3
MF	GO:0003824; catalytic activity	GO:0004713; protein tyrosine kinase activity	1.658E-08	1.121E-04	CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3
MF	GO:0003824; catalytic activity	GO:0004674; protein serine/threonine kinase activity	3.122E-08	1.360E-04	CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, HASPIN

Showing 1 to 4 of 4 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.737E-04	4.170E-03	MAOA, CYP1A2
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5.185E-04	6.222E-03	MAOA, CYP1A2

Showing 1 to 2 of 2 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	ADRA2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2C; MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	ADRA2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	ADRA2C; MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	MAOA;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	MAOA;

Showing 1 to 10 of 31 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Symplocos setchuensis

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities