Plant Name: Symplocos setchuensis
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| HTR7; HTR2C; ADRA2C; ADRA2A; ADRA2B; HTR6; | |
| NPSR1; | |
| CSNK1D; PIM3; DYRK1B; DYRK2; CLK1; DYRK3; DYRK1A; HASPIN; | |
| MAOA; | |
| ALDH1A1; | |
| HIF1A; NFKB1; | |
| SLC6A2; | |
| NISCH; MAPT; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Oxidoreductase | MAOA | Monoamine oxidase A | P21397 | CHEMBL1951 |
| Peptide receptor (family A GPCR) | NPSR1 | Neuropeptide S receptor | Q6W5P4 | CHEMBL5162 |
| Protein Kinase | CSNK1D | Casein kinase I delta | P48730 | CHEMBL2828 |
| Protein Kinase | PIM3 | Serine/threonine-protein kinase PIM3 | Q86V86 | CHEMBL5407 |
| Protein Kinase | DYRK1B | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | Q9Y463 | CHEMBL5543 |
Showing 1 to 10 of 26 entries
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0065007; biological regulation | GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway | 9.733E-09 | 4.239E-05 | ADRA2A, ADRA2B, ADRA2C |
| BP | GO:0009987; cellular process | GO:0032811; negative regulation of epinephrine secretion | 9.733E-09 | 4.239E-05 | ADRA2A, ADRA2B, ADRA2C |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 4.857E-08 | 1.058E-04 | CYP1A2, CYP2D6, CYP3A4 |
| BP | GO:0009987; cellular process | GO:0010700; negative regulation of norepinephrine secretion | 1.358E-07 | 2.075E-04 | ADRA2A, ADRA2B, ADRA2C |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 5.313E-07 | 6.806E-04 | CYP1A2, CYP2D6, CYP3A4 |
| BP | GO:0009987; cellular process | GO:0071880; adenylate cyclase-activating adrenergic receptor signaling pathway | 2.733E-06 | 2.204E-03 | ADRA2A, ADRA2B, ADRA2C |
| BP | GO:0009987; cellular process | GO:0007210; serotonin receptor signaling pathway | 4.834E-06 | 2.899E-03 | HTR2C, HTR6, HTR7 |
| BP | Unclassified; | GO:0098664; G-protein coupled serotonin receptor signaling pathway | 4.834E-06 | 2.899E-03 | HTR2C, HTR6, HTR7 |
| BP | GO:0008152; metabolic process | GO:0018108; peptidyl-tyrosine phosphorylation | 5.332E-06 | 3.056E-03 | CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3 |
| BP | GO:0008152; metabolic process | GO:0009822; alkaloid catabolic process | 5.640E-06 | 3.138E-03 | CYP2D6, CYP3A4 |
Showing 1 to 10 of 20 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 2.769E-03 | 2.031E-02 | CYP1A2; CYP3A4 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 6.732E-03 | 3.950E-02 | CYP1A2 |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.326E-03 | 1.588E-02 | MAOA; CYP1A2 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 6.967E-04 | 1.022E-02 | CYP1A2; CYP3A4 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 9.064E-05 | 1.994E-03 | CYP1A2; ALDH1A1; CYP3A4 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.281E-04 | 2.255E-03 | CYP2D6; CYP1A2; CYP3A4 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.144E-06 | 6.290E-05 | MAOA; CYP2D6; CYP1A2; CYP3A4 |
| hsa04020 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.789E-03 | 1.747E-02 | HTR6; HTR7; HTR2C |
| hsa04022 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.443E-03 | 1.588E-02 | ADRA2C; ADRA2B; ADRA2A |
| hsa04066 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 8.477E-03 | 4.663E-02 | HIF1A; NFKB1 |
Showing 1 to 10 of 16 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6 |
| C00-D49: Neoplasms | Cancer | C00-C96 | HIF1A; NFKB1 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | HIF1A |
| C00-D49: Neoplasms | Aggressive non-hodgkin's lymphoma | C81, C81-C86, C82-C85, C91-C95 | HTR2C |
| C00-D49: Neoplasms | Neuroendocrine cancer | C7A | SLC6A2 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | HIF1A |
| C00-D49: Neoplasms | Neuroblastoma | C74.1, C74.9, C75.4, C75.5, D35.0, D35.5, D35.6, D44.6, D44.7 | SLC6A2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic nephropathy | E11.21 | ADRA2C |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | ADRA2C; SLC6A2; HTR2C; HTR2C; HTR6 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | HTR2C |
Showing 1 to 10 of 60 entries