CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Peptide receptor (family A GPCR)	TSHR;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD; PPARG;
Enzyme_unclassified	ALOX15; HPGD;
Transcription Factor	NFKB1;
Unclassified	HTT; FABP3; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	CHEMBL235
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514

Showing 1 to 10 of 12 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	5.250E-09	2.858E-05	FFAR4, NFKB1, PPARA, PPARD, PPARG
BP	GO:0051179; localization	GO:0015908; fatty acid transport	6.408E-08	1.073E-04	FABP3, PPARA, PPARD, PPARG
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	3.534E-06	2.138E-03	PPARA, PPARG
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	5.300E-06	2.626E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	5.300E-06	2.626E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	5.300E-06	2.626E-03	ALOX15, HPGD
BP	GO:0050896; response to stimulus	GO:0042060; wound healing	1.306E-05	4.819E-03	ALOX15, PPARA, PPARD
BP	GO:0050896; response to stimulus	GO:0070542; response to fatty acid	1.465E-05	5.251E-03	FABP3, FFAR1, PPARG
BP	GO:0008152; metabolic process	GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter	1.940E-05	5.949E-03	PPARA, PPARD
BP	GO:0009987; cellular process	GO:0010745; negative regulation of macrophage derived foam cell differentiation	2.749E-05	7.675E-03	PPARA, PPARG

Showing 1 to 10 of 19 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.998E-04	4.662E-03	PPARA, NFKB1, TSHR
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	6.289E-08	4.402E-06	FABP3, PPARG, PPARA, PPARD
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	7.791E-04	1.091E-02	PPARA, NFKB1
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	1.399E-03	1.495E-02	PPARG, NFKB1
09150 Organismal Systems	09158 Development	hsa04380	Osteoclast differentiation	2.732E-03	1.941E-02	PPARG, NFKB1
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	1.486E-04	4.662E-03	HPGD, PPARG, NFKB1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	5.171E-04	9.050E-03	NFKB1, PPARD
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.495E-03	1.495E-02	PPARG, NFKB1, PPARD
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	1.874E-03	1.640E-02	PPARA, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	2.773E-03	1.941E-02	PPARA, NFKB1

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; FFAR1;

Showing 1 to 4 of 4 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Carthamus oxyacantha

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities