Plant Name: Carthamus oxyacantha
Taxonomic Information:
Plant ID: NPO30718
Plant Latin Name: Carthamus oxyacantha
Taxonomy Genus: Carthamus
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| FFAR1; FFAR4; | |
| TSHR; | |
| PPARA; PPARD; PPARG; | |
| ALOX15; HPGD; | |
| NFKB1; | |
| HTT; FABP3; LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group C | PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | CHEMBL235 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Small molecule receptor (family A GPCR) | FFAR1 | Free fatty acid receptor 1 | O14842 | CHEMBL4422 |
| Small molecule receptor (family A GPCR) | FFAR4 | G-protein coupled receptor 120 | Q5NUL3 | CHEMBL5339 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 5.250E-09 | 2.858E-05 | FFAR4, NFKB1, PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 6.408E-08 | 1.073E-04 | FABP3, PPARA, PPARD, PPARG |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 3.321E-06 | 2.066E-03 | PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0010891; negative regulation of sequestering of triglyceride | 3.534E-06 | 2.138E-03 | PPARA, PPARG |
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 5.300E-06 | 2.626E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0010871; negative regulation of receptor biosynthetic process | 5.300E-06 | 2.626E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:2001300; lipoxin metabolic process | 5.300E-06 | 2.626E-03 | ALOX15, HPGD |
| MF | GO:0005488; binding | GO:0050543; icosatetraenoic acid binding | 5.300E-06 | 2.626E-03 | FABP3, PPARG |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 5.840E-06 | 2.764E-03 | PPARA, PPARD, PPARG |
| MF | Unclassified; | GO:0004872; receptor activity | 1.193E-05 | 4.477E-03 | FFAR1, FFAR4, HPGD, PPARA, PPARD, PPARG, TSHR |
| BP | GO:0050896; response to stimulus | GO:0042060; wound healing | 1.306E-05 | 4.819E-03 | ALOX15, PPARA, PPARD |
| BP | GO:0050896; response to stimulus | GO:0070542; response to fatty acid | 1.465E-05 | 5.251E-03 | FABP3, FFAR1, PPARG |
| MF | GO:0060089; molecular transducer activity | GO:0004955; prostaglandin receptor activity | 1.588E-05 | 5.576E-03 | HPGD, PPARG |
| MF | GO:0005488; binding | GO:0008134; transcription factor binding | 1.733E-05 | 5.716E-03 | HTT, NFKB1, PPARA, PPARD, PPARG |
| BP | GO:0008152; metabolic process | GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter | 1.940E-05 | 5.949E-03 | PPARA, PPARD |
| BP | GO:0009987; cellular process | GO:0010745; negative regulation of macrophage derived foam cell differentiation | 2.749E-05 | 7.675E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0046321; positive regulation of fatty acid oxidation | 3.206E-05 | 8.727E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0032966; negative regulation of collagen biosynthetic process | 3.206E-05 | 8.727E-03 | PPARD, PPARG |
| BP | GO:0051179; localization | GO:0032368; regulation of lipid transport | 3.506E-05 | 9.425E-03 | NFKB1, PPARA, PPARG |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 6.289E-08 | 4.402E-06 | FABP3, PPARG, PPARA, PPARD |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 1.998E-04 | 4.662E-03 | PPARA, NFKB1, TSHR |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 1.486E-04 | 4.662E-03 | HPGD, PPARG, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 5.171E-04 | 9.050E-03 | NFKB1, PPARD |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 1.495E-03 | 1.495E-02 | PPARG, NFKB1, PPARD |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04920 | Adipocytokine signaling pathway | 7.791E-04 | 1.091E-02 | PPARA, NFKB1 |
| 09150 Organismal Systems | 09149 Aging | hsa04211 | Longevity regulating pathway - mammal | 1.399E-03 | 1.495E-02 | PPARG, NFKB1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 1.874E-03 | 1.640E-02 | PPARA, NFKB1 |
| 09150 Organismal Systems | 09158 Development | hsa04380 | Osteoclast differentiation | 2.732E-03 | 1.941E-02 | PPARG, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 2.773E-03 | 1.941E-02 | PPARA, NFKB1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Cancer | C00-C96 | NFKB1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | FFAR1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | FFAR1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1; FFAR1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
