Plant Name: Carthamus oxyacantha
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 5.250E-09 | 2.858E-05 | FFAR4, NFKB1, PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 6.408E-08 | 1.073E-04 | FABP3, PPARA, PPARD, PPARG |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 3.321E-06 | 2.066E-03 | PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0010891; negative regulation of sequestering of triglyceride | 3.534E-06 | 2.138E-03 | PPARA, PPARG |
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 5.300E-06 | 2.626E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0010871; negative regulation of receptor biosynthetic process | 5.300E-06 | 2.626E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:2001300; lipoxin metabolic process | 5.300E-06 | 2.626E-03 | ALOX15, HPGD |
| MF | GO:0005488; binding | GO:0050543; icosatetraenoic acid binding | 5.300E-06 | 2.626E-03 | FABP3, PPARG |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 5.840E-06 | 2.764E-03 | PPARA, PPARD, PPARG |
| MF | Unclassified; | GO:0004872; receptor activity | 1.193E-05 | 4.477E-03 | FFAR1, FFAR4, HPGD, PPARA, PPARD, PPARG, TSHR |
| BP | GO:0050896; response to stimulus | GO:0042060; wound healing | 1.306E-05 | 4.819E-03 | ALOX15, PPARA, PPARD |
| BP | GO:0050896; response to stimulus | GO:0070542; response to fatty acid | 1.465E-05 | 5.251E-03 | FABP3, FFAR1, PPARG |
| MF | GO:0060089; molecular transducer activity | GO:0004955; prostaglandin receptor activity | 1.588E-05 | 5.576E-03 | HPGD, PPARG |
| MF | GO:0005488; binding | GO:0008134; transcription factor binding | 1.733E-05 | 5.716E-03 | HTT, NFKB1, PPARA, PPARD, PPARG |
| BP | GO:0008152; metabolic process | GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter | 1.940E-05 | 5.949E-03 | PPARA, PPARD |
| BP | GO:0051179; localization | GO:0060099; regulation of phagocytosis, engulfment | 1.940E-05 | 5.949E-03 | ALOX15, PPARG |
| BP | GO:0009987; cellular process | GO:0010745; negative regulation of macrophage derived foam cell differentiation | 2.749E-05 | 7.675E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0046321; positive regulation of fatty acid oxidation | 3.206E-05 | 8.727E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0032966; negative regulation of collagen biosynthetic process | 3.206E-05 | 8.727E-03 | PPARD, PPARG |
| BP | GO:0051179; localization | GO:0032368; regulation of lipid transport | 3.506E-05 | 9.425E-03 | NFKB1, PPARA, PPARG |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa03320 | PPAR signaling pathway_Homo sapiens_hsa03320 | 6.289E-08 | 4.402E-06 | FABP3; PPARG; PPARA; PPARD |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.998E-04 | 4.662E-03 | PPARA; NFKB1; TSHR |
| hsa05202 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.486E-04 | 4.662E-03 | HPGD; PPARG; NFKB1 |
| hsa05221 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 5.171E-04 | 9.050E-03 | NFKB1; PPARD |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 1.495E-03 | 1.495E-02 | PPARG; NFKB1; PPARD |
| hsa04920 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 7.791E-04 | 1.091E-02 | PPARA; NFKB1 |
| hsa04211 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 1.399E-03 | 1.495E-02 | PPARG; NFKB1 |
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 1.874E-03 | 1.640E-02 | PPARA; NFKB1 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 3.067E-03 | 1.952E-02 | LMNA; NFKB1 |
| hsa04380 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.732E-03 | 1.941E-02 | PPARG; NFKB1 |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 3.556E-03 | 2.075E-02 | PPARA; NFKB1 |
| hsa05160 | Hepatitis C_Homo sapiens_hsa05160 | 2.773E-03 | 1.941E-02 | PPARA; NFKB1 |
| hsa05016 | Huntington's disease_Homo sapiens_hsa05016 | 5.737E-03 | 3.089E-02 | HTT; PPARG |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PPARD; PPARD; PPARG |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| C00-D49: Neoplasms | Cancer | C00-C96 | NFKB1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | PPARG |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | PPARG; PPARG |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | PPARD |
| NA: NA | Dyslipidemia | NA | PPARD |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | PPARG |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | PPARG |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | FFAR1 |
| K00-K95: Diseases of the digestive system | Non-alcoholic fatty liver disease | K76.0 | PPARD; PPARG |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Nicotine dependence | F17 | PPARG |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | PPARD |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dyslipidaemias | E78 | PPARD; PPARD |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | FFAR1; PPARG |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | FFAR1; PPARD; PPARG; PPARG; NFKB1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 1 diabetes | E10 | PPARD; PPARG |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Drug abuse | F10-F19 | PPARG |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | PPARD |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | PPARD |
| H00-H59: Diseases of the eye and adnexa | Ocular inflammation | H16.229 | PPARG |