Plant Name: Carthamus oxyacantha
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 5.250E-09 | 2.858E-05 | FFAR4, NFKB1, PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 6.408E-08 | 1.073E-04 | FABP3, PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0010891; negative regulation of sequestering of triglyceride | 3.534E-06 | 2.138E-03 | PPARA, PPARG |
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 5.300E-06 | 2.626E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0010871; negative regulation of receptor biosynthetic process | 5.300E-06 | 2.626E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:2001300; lipoxin metabolic process | 5.300E-06 | 2.626E-03 | ALOX15, HPGD |
| BP | GO:0050896; response to stimulus | GO:0042060; wound healing | 1.306E-05 | 4.819E-03 | ALOX15, PPARA, PPARD |
| BP | GO:0050896; response to stimulus | GO:0070542; response to fatty acid | 1.465E-05 | 5.251E-03 | FABP3, FFAR1, PPARG |
| BP | GO:0008152; metabolic process | GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter | 1.940E-05 | 5.949E-03 | PPARA, PPARD |
| BP | GO:0051179; localization | GO:0060099; regulation of phagocytosis, engulfment | 1.940E-05 | 5.949E-03 | ALOX15, PPARG |
Showing 1 to 10 of 20 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa03320 | PPAR signaling pathway_Homo sapiens_hsa03320 | 6.289E-08 | 4.402E-06 | FABP3; PPARG; PPARA; PPARD |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.998E-04 | 4.662E-03 | PPARA; NFKB1; TSHR |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 3.067E-03 | 1.952E-02 | LMNA; NFKB1 |
| hsa04211 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 1.399E-03 | 1.495E-02 | PPARG; NFKB1 |
| hsa04380 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.732E-03 | 1.941E-02 | PPARG; NFKB1 |
| hsa04920 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 7.791E-04 | 1.091E-02 | PPARA; NFKB1 |
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 1.874E-03 | 1.640E-02 | PPARA; NFKB1 |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 3.556E-03 | 2.075E-02 | PPARA; NFKB1 |
| hsa05016 | Huntington's disease_Homo sapiens_hsa05016 | 5.737E-03 | 3.089E-02 | HTT; PPARG |
| hsa05160 | Hepatitis C_Homo sapiens_hsa05160 | 2.773E-03 | 1.941E-02 | PPARA; NFKB1 |
Showing 1 to 10 of 13 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| C00-D49: Neoplasms | Cancer | C00-C96 | NFKB1 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PPARD; PPARD; PPARG |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | PPARD |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | FFAR1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | PPARD |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dyslipidaemias | E78 | PPARD; PPARD |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | FFAR1; PPARG |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | FFAR1; PPARD; PPARG; PPARG; NFKB1 |
Showing 1 to 10 of 23 entries